Involvement of cyclophilin D in the activation of a mitochondrial pore by Ca2+ and oxidant stress

European Journal of Biochemistry

Volumn 238, Issue 1, 1996, Pages 166-172

  Tanveer, Ahmed ^a   Virji, Sukaina ^a   Andreeva, Larisa ^a   Totty, Nicholas F ^b   Hsuan, J Justin ^a,b   Ward, John M ^a   Crompton, Martin ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Calcium; Cyclophilin; Oxidant stress

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENYLATE KINASE; CALCIUM; CYCLOPHILIN; CYCLOPHILLIN D; CYCLOSPORIN A DERIVATIVE; ISOMERASE; MALATE DEHYDROGENASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CHANNEL GATING; CONTROLLED STUDY; CYTOCHEMISTRY; ENZYME ACTIVITY; LIVER MITOCHONDRION; MALE; NONHUMAN; OXIDATIVE STRESS; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; RAT; SEQUENCE ANALYSIS; SUBMITOCHONDRIAL PARTICLE;

ADENOSINE DIPHOSPHATE; AMINO ACID ISOMERASES; AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CARRIER PROTEINS; CYCLOPHILINS; CYCLOSPORINE; HUMANS; ION CHANNEL GATING; MALE; MITOCHONDRIA, LIVER; MOLECULAR SEQUENCE DATA; PEPTIDYLPROLYL ISOMERASE; PHOTOCHEMISTRY; RATS; RATS, SPRAGUE-DAWLEY; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA;

EID: 0030004759     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0166q.x     Document Type: Article

References (41)

1. Galat, A. (1993) Peptidylproline cis-trans isomerases: immunophilins, Eur. J. Biochem. 216, 689-707.
2. Fischer, G. & Schmidt, F. X. (1990) The mechanism of protein folding. Implications of in vitro folding models for de novo protein folding and translocation, Biochemistry 29, 2205-2212.
3. Lodish, H. F. & Kong, N. (1991) Cyclosporin A inhibits an initial step in folding of transferrin in the endoplasmic reticulum, J. Biol. Chem. 266, 14835-14838.
4. Stamnes, M. A., Shieh, B. H., Chuman, L., Harris, G. L. & Zuker, C. S. (1991) The cyclophilin homologue ninaA is a tissue specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsins, Cell 65, 219-227.
5. Hoffman, K. & Handschumacher, R. E. (1995) Cyclophilin 40: evidence for a dimeric complex with hsp90, Biochem. J. 307, 5-8.
6. Rinfret, A., Collins, C., Menard, R. & Andersen, S. K. (1994) The N-terminal cyclophilin homologous domain of a 150 kDa tumor recognition molecule exhibits both peptidylprolyl cis-trans isomerase and chaperone activities, Biochemistry 33, 1668-1673.
7. Fruman, D. A., Klee, C. B., Bierer, B. E. & Burokoff, S. J. (1992) Calcineurin phosphatase activity in T-lymphocytes is inhibited by FK-506 and cyclosporin A, Proc. Natl Acad. Sci. USA 89, 3686-3690.
8. Swanson, S. K., Born, T., Zydowsky, L. D., Cho, H., Chang, H., Walsh, C. & Rusnak, F. (1992) Cyclosporin mediated inhibition of bovine calcineurin by cyclophilins A and B, Proc. Natl Acad. Sci. USA 89, 3741-3745.
9. 2+ release channel of sarcoplasmic reticulum is modulated by FK506 binding protein. J. Biol. Chem. 268, 22992-22999.
10. 2+ activated hydrophilic channel of the mitochondrial inner membrane by nucleotides, J. Membr. Biol. 54, 231-236.
11. 2+ overload. Eur. J. Biochem. 178, 489-501.
12. Crompton, M. & Costi, A. (1990) A heart mitochondrial pore of possible relevance to reperfusion injury, Biochem. J. 266, 33-39.
13. Szabo, I., Bernardi, P. & Zoratti, M. (1992) Modulation of the mitochondrial megachannel by divalent cations and protons. J. Biol. Chem. 267, 2940-2946.
14. 2+ dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress, Biochem. J. 25, 357-360.
15. Griffiths, E. J. & Halestrap, A. P. (1995) Mitochondrial non-specific pores remain closed during cardiac ischaemia but open during reperfusion, Biochem. J. 307, 93-98.
16. Niemenen, A., Saylor, A. K., Tesfai, S. A., Herman, B. & LeMasters, J. J. (1995) Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butyl-hydroperoxide, Biochem. J. 307, 99-106.
17. Pastorino, J. B., Snyder, J. W., Serroni, A., Hoek, J. B. & Farber, J. L. (1993) Cyclosporin and carnitine prevent the anoxic death of cultured myocytes by inhibiting the mitochondrial permeability transition, J. Biol. Chem. 268, 13791-13798.
18. Imberti, R., Niemenen, A., Herman, B. & LeMasters, J. J. (1992) Synergism of cyclosporin A and phospholipase inhibitors in protecting against lethal injury to rat hepatocytes from oxidant chemicals, Res. Commun. Chem. Pathol. Pharmacol. 78, 27-38.
19. Nazareth, W., Yafei, N. & Crompton, M. (1991) Inhibition of anoxia induced injury in heart myocytes by cyclosporin A. J. Mol. Cell. Cardiol. 23, 1351-1354.
20. Griffiths, E. J. & Halestrap, A. P. (1993) Protection by cyclosporin A of ischaemia/reperfusion induced damage in isolated rat hearts, J. Mol. Cell. Cardiol. 25, 1461-1469.
21. 2+-dependent pore, Eur. J. Biochem. 194. 671-679.
22. 2+ overload by inhibiting a matrix peptidylprolyl cis-trans isomerase, Biochem. J. 274, 611-614.
23. Connern, C. P. & Halestrap, A. P. (1994) Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium sensitive non-specific channel, Biochem. J. 302, 321-324.
24. 2+-activated inner membrane pore of heart mitochondria, Eur. J. Biochem. 230, 1125-1132.
25. Andreeva, L. & Crompton, M. (1994) An ADP-sensitive cyclosporin-A-binding protein in rat liver mitochondria. Eur. J. Biochem. 221, 261-268.
26. Totty, N. F., Waterfield, M. D. & Hsuan, J. J. (1992) Accelerated high sensitivity microsequencing of proteins and peptides using a miniature reaction cartridge, Protein Sci. 1, 1215-1224.
27. Pedersen, P. L., Greenawalt, J. W., Reynafarje, B. A., Hullihen, J., Decker, G. L., Soper, J. W. & Bustamente, E. (1979) Preparation and characterization of mitochondria and submitochondrial particles from rat liver and liver-derived tissues. Methods Cell Biol. 20, 411-481.
28. Foxwell, B. M., Mackie, A., Ling, V. & Ryfiel, B. (1989) Identification of the multidrug resistance P-glycoprotein as a cyclosporin A binding protein, Mol. Pharmacol. 36, 543-549.
29. Crompton, M., McGuinness, O. M. & Nazareth, W. (1992) The involvement of cyclosporin A binding proteins in regulating and uncoupling mitochondrial energy transduction, Biochim. Biophys. Acta 1101, 214-217.
30. Connern, C. P. & Halestrap, A. P. (1992) Purification and N-terminal sequencing of a peptidylprolyl cis-trans isomerase of rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin, Biochem. J. 284, 381-385.
31. Bergsma, D. J., Eder, C., Gross, M., Kersten, H., Sylvester, D., Appelbaum, E., Cusimano, D., Livi, G. P., McLaughlin, M. M., Kosyan, K., Porter, T. G., Silverman, C., Dunnington, D., Hand, A., Prichett, W. P., Bossard, M. J., Brandt, M. & Levy, M. A. (1991) The cyclophilin multigene family of peptidylprolyl isomerases. J. Biol. Chem. 266, 23204-23214.
32. Danielson, P. E., Forss-Petter, S., Brow, M. A., Calavetta, L., Douglas, J., Milner, R. J. & Sutcliffe, J. G. (1988) p1B15: A cDNA clone of the rat mRNA encoding cyclophilin, DNA (NY) 7, 261-267.
33. Friedman, J. & Weissman, I. (1991) Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin, one in the presence and one in the absence of CSA, Cell 66, 799-806.
34. 2+ storage protein calreticulin, J. Cell Biol. 116, 113-125.
35. 2+ induced swelling of mitochondria by cyclosporin A is probably caused by binding to a matrix peptidylprolyl cis-trans isomerase and preventing its binding to the adenine nucleotide translocase, Biochem. J. 268, 153-160.
36. 2+ uniporter, Biochem. J. 302, 181-185.
37. Szabo, I. & Zoratti, M. (1992) The mitochondrial megachannel is the permeability transition pore, J. Bioenerg. Biomembr. 24, 111-117.
38. Novgorodov, S. A., Gudz, T. I., Brierley, G. P. & Pfeiffer, D. R. (1994) Magnesium modulates the sensitivity of the mitochondrial permeability transition pore to cyclosporin A and ADP, Arch. Biochem. Biophys. 311, 219-228.
39. Skulachev, V. P. (1990) Power transmission along biological membranes, J. Membr. Biol. 114, 97-112.
40. Konstantinova, S. A., Mannella, C. A., Skulachev, V. P. & Zorov, D. B. (1995) Immunoelectronmicroscopic study of the distribution of porin on the outer membranes of rat heart mitochondria, J. Bioenerg. Biomembr. 27, 93-100.
41. McEnery, M. W., Snowman, A. M., Trifiletti, S. R. & Snyder, S. H. (1992) Isolation of the mitochondrial benzodiazepine receptor. Association with the voltage dependent anion channel and the adenine nucleotide carrier, Proc. Natl Acad. Sci. USA 89, 3170-3174.