Receptor editing in positive and negative selection of B lymphopoiesis

Journal of Immunology

Volumn 173, Issue 7, 2004, Pages 4265-4271

  Edry, Efrat ^a   Melamed, Doron ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN RECEPTOR GENE; B LYMPHOCYTE; B LYMPHOCYTE MATURATION; B LYMPHOPOIESIS; CELL ACTIVATION; CELL MATURATION; CELL SURVIVAL; CHEMICAL MODIFICATION; GENE REARRANGEMENT; GENETIC RECOMBINATION; GENETIC SELECTION; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; LYMPHOPOIESIS; NEGATIVE SELECTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR EDITING; RECEPTOR GENE; RECEPTOR SELECTION; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 4644229948     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.7.4265     Document Type: Short Survey

References (92)

1. Nemazee, D. 2000. Receptor selection in B and T lymphocytes. Annu. Rev. Immunol. 18:19.
2. Loder, F., B. Mutschler, R. J. Ray, C. J. Paige, P. Sideras, R. Torres, M. C. Lamers, and R. Carsetti. 1999. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 190:75.
3. Meffre, E., R. Casellas, and M. C. Nussenzweig. 2000. Antibody regulation of B cell development. Nat. Immunol. 1:379.
4. Reth, M., J. Wienands, and W. W. Schamel. 2000. An unsolved problem of the clonal selection theory and the model of an oligomeric B-cell antigen receptor. Immunol. Rev. 176:10.
5. Rolink, A. G., C. Schaniel, J. Andersson, and F. Melchers. 2001. Selection events operating at various stages in B cell development. Curr. Opin. Immunol. 13:202.
6. Martin, F., and J. F. Kearney. 2000. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk. Immunity 12:39.
7. Melchers, F., E. ten Boekel, T. Yamagami, J. Andersson, and A. Rolink. 1999. The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci. Semin. Immunol. 11:307.
8. Constantinescu, A., and M. S. Schlissel. 1997. Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development. J. Exp. Med. 185:609.
9. Bradl, H., and H. M. Jack. 2001. Surrogate light chain-mediated interaction of a soluble pre-B cell receptor with adherent cell lines. J. Immunol. 167:6403.
10. Fuentes-Panana, E. M., G. Bannish, and J. G. Monroe. 2004. Basal B-cell receptor signaling in B lymphocytes: mechanisms of regulation and role in positive selection, differentiation, and peripheral survival. Immunol. Rev. 197:26.
11. Gauld, S. B., J. M. Dal Porto, and J. C. Cambier. 2002. B cell antigen receptor signaling: roles in cell development and disease. Science 296:1641.
12. Niiro, H., and E. A. Clark. 2002. Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2:945.
13. Reth, M. G., S. Jackson, and F. W. Alt. 1986. VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments. EMBO J. 5:2131.
14. Gu, H., D. Kitamura, and K. Rajewsky. 1991. B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames. Cell 65:47.
15. Loffert, D., A. Ehlich, W. Muller, and K. Rajewsky. 1996. Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity 4:133.
16. H to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production. Nature 322:840.
17. H gene replacement events in a B cell lymphoma. J. Immunol. 142:4475.
18. Radic, M. Z., and M. Zouali. 1996. Receptor editing, immune diversification, and self-toletance. Immunity 5:505.
19. H replacement is unlikely to contribute significantly to receptor editing due to an ineffectual embedded recombination signal sequence. Mol. Immunol. 35:227.
20. Pelanda, R., S. Schwers, E. Sonoda, R. M. Torres, D. Nemazee, and K. Rajewsky. 1997. Receptor editing in a transgenic mouse model: site, efficiency and role in B cell tolerance and antibody diversification. Immunity 7:765.
21. Chen, C., Z. Nagy, E. L. Prak, and M. Weigert. 1995. Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity 3:747.
22. Pewzner-Jung, Y., D. Friedmann, E. Sonoda, S. Jung, K. Rajewsky, and D. Eliat. 1998. B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain. J. Immunol. 161:4634.
23. Sonoda, E., J. Y. Pewzner, S. Schwers, S. Taki, S. Jung, D. Eilat, and K. Rajewsky. 1997. B cell development under the condition of allelic inclusion. Immunity 6:225.
24. H gene replacement occurs in the spleen and bone marrow of non-autoimmune quasi-monoclonal mice. Eur. J. Immunol. 28:3362.
25. Cascalho, M., A. Ma, S. Lee, L. Masat, and M. Wabl. 1996. A quasi-monoclonal mouse. Science 272:1649.
26. Itoh, K., E. Meffre, E. Albesiano, A. Farber, D. Dines, P. Stein, S. E. Asnis, R. A. Furie, R. I. Jain, and N. Chiorazzi. 2000. Immunoglobulin heavy chain variable region gene replacement as a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes. J. Exp. Med. 192:1151.
27. H gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity 7:357.
28. Kline, G. H., L. Hartwell, G. B. Beck-Engeser, U. Keyna, S. Zaharevitz, N. R. Klinman, and H. M. Jack. 1998. Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional μ heavy chains. J. Immunol. 161:1608.
29. H gene replacement to the primary B cell repertoire. Immunity 19:21.
30. Wilson, P. C., K. Wilson, Y. J. Liu, J. Banchereau, V. Pascual, and J. D. Capra. 2000. Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes. J. Exp. Med. 191:1881.
31. Nemazee, D., and M. Weigert. 2000. Revising B cell receptors. J. Exp. Med. 191:1813.
32. Osmond, D. G. 1991. Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs. Curr. Opin. Immunol. 3:179.
33. Gu, H., D. Tarlinton, W. Muller, K. Rajewsky, and I. Forster. 1991. Most peripheral B cells in mice are ligand selected. J. Exp. Med. 173:1357.
34. Benschop, R. J., E. Brandi, A. C. Chan, and J. C. Cambier. 2001. Unique signaling properties of B cell antigen receptor in mature and immature B cells: implications for tolerance and activation. J. Immunol. 167:4172.
35. Sproul, T. W., S. Malapati, J. Kim, and S. K. Pierce. 2000. Cutting edge: B cell antigen receptor signaling occurs outside lipid rafts in immature B cells. J. Immunol. 165:6020.
36. Wang, L. D., J. Lopes, A. B. Cooper, M. Dang-Lawson, L. Matsuuchi, and M. R. Clark. 2004. Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor. Proc. Natl. Acad. Sci. USA 101:1027.
37. Kraus, M., L. I. Pao, A. Reichlin, Y. Hu, B. Canono, J. C. Cambier, M. C. Nussenzweig, and K. Rajewsky. 2001. Interference with immunoglobulin (Ig)α immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igβ cytoplasmic tail. J. Exp. Med. 194:455.
38. Fujimoto, M., J. C. Poe, M. Hasegawa, and T. F. Tedder. 2000. CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification. Immunol. Res. 22:281.
39. Roose, J. P., M. Diehn, M. G. Tomlinson, J. Lin, A. A. Alizadeh, D. Botstein, P. O. Brown, and A. Weiss. 2003. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol. 1:E53.
40. Bannish, G., E. M. Fuentes-Panana, J. C. Cambier, W. S. Pear, and J. G. Monroe. 2001. Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis. J. Exp. Med. 194:1583.
41. Wang, H., and S. H. Clarke. 2003. Evidence for a ligand-mediated positive selection signal in differentiation to a mature B cell. J. Immunol. 171:6381.
42. Keren, Z., E. Diamant, O. Ostrovsky, E. Bengal, and D. Melamed. 2004. Modification of ligand-independent B cell receptor tonic signals activates receptor editing in immature B lymphocytes. J. Biol. Chem. 279:13418.
43. Casola, S., K. L. Otipoby, M. Alimzhanov, S. Humme, N. Uyttersprot, J. L. Kutok, M. C. Carroll, and K. Rajewsky. 2004. B cell receptor signal strength determines B cell fate. Nat. Immunol. 5:317.
44. Rickert, R. C., K. Rajewsky, and J. Roes. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376:352.
45. Buhl, A. M., D. Nemazee, J. C. Cambier, R. Rickert, and M. Hertz. 2000. B-cell antigen receptor competence regulates B-lymphocyte selection and survival. Immunol. Rev. 176:141.
46. Shivtiel, S., N. Leider, O. Sadeh, Z. Kraiem, and D. Melamed. 2002. Impaired light chain allelic exclusion and lack of positive selection in immature B cells expressing incompetent receptor deficient of CD19. J. Immunol. 168:5596.
47. Meade, J., C. Fernandez, and M. Turner. 2002. The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: rescue by over-expression of Bcl-2. Eur. J. Immunol. 32:1029.
48. Kouskoff, V., G. Lacaud, K. Pape, M. Rettet, and D. Nemazee. 2000. B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection. Proc. Natl. Acad. Sci. USA 97:7435.
49. Watanabe, N., S. Nisitani, K. Ikuta, M. Suzuki, T. Chiba, and T. Honjo. 1999. Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment. J. Exp. Med. 190:461.
50. Healy, J. I., and C. C. Goodnow. 1998. Positive versus negative signaling by lymphocyte antigen receptors. Annu. Rev. Immunol. 16:645.
51. Gaudin, E., Y. Hao, M. M. Rosado, R. Chaby, R. Girard, and A. A. Freitas. 2004. Positive selection of B cells expressing low densities of self-reactive BCRs. J. Exp. Med. 299:843.
52. Lam, K. P., and K. Rajewsky. 1999. B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development. J. Exp. Med. 190:471.
53. Nemazee, D. 1996. Antigen receptor "capacity" and the sensitivity of self-tolerance. Immunol. Today 17:25.
54. Wardemann, H., S. Yurasov, A. Schaefer, J. W. Young, E. Meffre, and M. C. Nussenzweig. 2003. Predominant autoantibody production by early human B cell precursors. Science 301:1374.
55. κ segment in a murine B cell line. J. Exp. Med. 170:1.
56. + B cells can continue to rearrange κ and λ chain gene loci. J. Exp. Med. 178:1263.
57. Melamed, D., and D. Nemazee. 1997. Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest, Proc. Natl. Acad. Sci. USA 94:9267.
58. Gay, D., T. Saunders, S. Camper, and M. Weigert. 1993. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177:999.
59. Tiegs, S. L., D. M. Russell, and D. Nemazee. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1009.
60. Spanopoulou, E., C. A. Roman, L. M. Corcoran, M. S. Schlissel, D. P. Silver, D. Nemazee, M. C. Nussenzweig, S. A. Shinton, R. R. Hardy, and D. Baltimore. 1994. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8:1030.
61. Hartley, S. B., M. P. Cooke, D. A. Fulcher, A. W. Harris, S. Gory, A. Basten, and C. C. Goodnow. 1993. Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell 72:325.
62. - bone marrow B cells in vitro. Immunity 6:429.
63. Chen, C., E. L. Prak, and M. Weigert. 1997. Editing disease-associated autoantibodies. Immunity 6:97.
64. Radic, M. Z., J. Erikson, S. Litwin, and M. Weigert. 1993. B lymphocytes may escape tolerance by revising their antigen receptors. J. Exp. Med. 177:1165.
65. Li, H., Y. Jiang, E. L. Prak, M. Radic, and M. Weigert. 2001. Editors and editing of anti-DNA receptors. Immunity 15:947.
66. Retter, M. W., and D. Nemazee. 1998. Receptor editing occurs frequently during normal B cell development. J. Exp. Med. 188:1231.
67. Meffre, E., A. Schaefer, H. Wardemann, P. Wilson, E. Davis, and M. C. Nussenzweig. 2004. Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies. J. Exp. Med. 199:145.
68. Casellas, R., T. A. Shih, M. Kleinewietfeld, J. Rakonjac, D. Nemazee, K. Rajewsky, and M. C. Nussenzweig. 2001. Contribution of receptor editing to the antibody repertoire. Science 291:1541.
69. Bassing, C. H., W. Swat, and F. W. Alt. 2002. The mechanism and regulation of chromosomal V(D)J recombination. Cell 109 (Suppl.):S45.
70. Shivtiel, S., N. Leider, and D. Melamed. 2002. Receptor editing in CD45-deficient immature B cells. Eur. J. Immunol. 32:2264.
71. Dingjan, G. M., S. Middendorp, K. Dahlenborg, A. Maas, F. Grosveld, and R. W. Hendriks. 2001. Bruton's tyrosine kinase regulates the activation of gene rearrangements at the λ light chain locus in precursor B cells in the mouse. J. Exp. Med. 193:1169.
72. Lang, J., M. Jackson, L. Teyton, A. Brunmark, K. Kane, and D. Nemazee. 1996. B-cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen. J. Exp. Med. 184:1685.
73. Leider, N., and D. Melamed. 2003. Differential c-Myc responsiveness to B cell receptor ligation in B cell-negative selection. J. Immunol. 171:2446.
74. Melamed, D., R. J. Benschop, J. C. Cambier, and D. Nemazee. 1998. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell 92:173.
75. Yachimovich, N., G. Mostoslavsky, Y. Yarkoni, I. Verbovetski, and D. Eilat. 2002. The efficiency of B cell receptor (BCR) editing is dependent on BCR light chain rearrangement status. Eur. J. Immunol. 32:1164.
76. neg) undergo a light chain receptor editing response to soluble self-antigen. J. Immunol. 171:678.
77. Carsetti, R., G. Kohler, and M. C. Lamers. 1995. Transitional B cells are the target of negative selection in the B cell compartment. J. Exp. Med. 181:2129.
78. Sandel, P. C., and J. G. Monroe. 1999. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter. Immunity 10:289.
79. Sandel, P. C., M. Gendelman, G. Kelsoe, and J. G. Monroe. 2001. Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement. J. Immunol. 166:5935.
80. Lang, J., B. Arnold, G. Hammerling, A. W. Harris, S. Korsmeyer, D. Russell, A. Strasser, and D. Nemazee. 1997. Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells. J. Exp. Med. 186:1513.
81. Brard, F., M. Shannon, E. L. Prak, S. Litwin, and M. Weigert. 1999. Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice. J. Exp. Med. 190:691.
82. Kuwata, N., H. Igarashi, T. Ohmura, S. Aizawa, and N. Sakaguchi. 1999. Cutting edge: absence of expression of RAG1 in peritoneal B-1 cells detected by knocking into RAG1 locus with green fluorescent protein gene. J. Immunol. 163:6355.
83. Monroe, R. J., K. J. Seidl, F. Gaertner, S. Han, F. Chen, J. Sekiguchi, J. Wang, R. Ferrini, L. Davidson, G. Kelsoe, and F. W. Alt. 1999. RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity 11:201.
84. Yu, W., H. Nagaoka, M. Jankovic, Z. Misulovin, H. Suh, A. Rolink, F. Melchers, E. Meffre, and M. C. Nussenzweig. 1999. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 400:682.
85. Gartner, F., F. W. Alt, R. J. Monroe, and K. J. Seidl. 2000. Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice. J. Exp. Med. 192:1745.
86. Nagaoka, H., G. Gonzalez-Aseguinolaza, M. Tsuji, and M. C. Nussenzweig. 2000. Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production. J. Exp. Med. 191:2113.
87. Melamed, D., E. Miri, N. Leider, and D. Nemazee. 2000. Unexpected autoantibody production in membrane Igμ-deficient/lpr mice. J. Immunol. 165:4353.
88. Goossens, T., A. Brauninger, U. Klein, R. Kuppers, and K. Rajewsky. 2001. Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermuration. Eur. J. Immunol. 31:3638.
89. Lam, K. P., R. Kuhn, and K. Rajewsky. 1997. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90:1073.
90. Melchers, F., E. ten Boekel, T. Seidl, X. C. Kong, T. Yamagami, K. Onishi, T. Shimizu, A. G. Rolink, and J. Andersson. 2000. Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells. Immunol. Rev. 175:33.
91. Minegishi, Y., and M. E. Conley. 2001. Negative selection at the pre-BCR checkpoint elicited by human μ heavy chains with unusual CDR3 regions. Immunity 14:631.
92. Sun, T., M. R. Clark, and U. Storb. 2002. A point mutation in the constant region of Igλ1 prevents normal B cell development due to defective BCR signaling. Immunity 16:245.