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Volumn 185, Issue 4, 1997, Pages 609-620

Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; DOUBLE STRANDED DNA; GENE PRODUCT; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE ANTIGEN; RECOMBINASE; RNA;

EID: 0031019217     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.4.609     Document Type: Article
Times cited : (108)

References (58)
  • 1
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
    • Lewis, S.M. 1994. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56:27-150.
    • (1994) Adv. Immunol. , vol.56 , pp. 27-150
    • Lewis, S.M.1
  • 6
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M.A., D.G. Schatz, C. Gorka, and D. Baltimore. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science (Wash. DC). 248:1517-1523.
    • (1990) Science (Wash. DC) , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 7
    • 0024846088 scopus 로고
    • The V(D)J recombination activating gene. RAG-1
    • Schatz, D.G., M.A. Oettinger, and D. Baltimore. 1989. The V(D)J recombination activating gene. RAG-1. Cell. 59: 1035-1048.
    • (1989) Cell , vol.59 , pp. 1035-1048
    • Schatz, D.G.1    Oettinger, M.A.2    Baltimore, D.3
  • 9
    • 0025868702 scopus 로고
    • Resolution and characterization of proD and pre-pro-B cell stages in normal mouse bone marrow
    • Hardy, R.R., C.E. Carmack, S.A. Shinton, J.D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of proD and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213-1225.
    • (1991) J. Exp. Med. , vol.173 , pp. 1213-1225
    • Hardy, R.R.1    Carmack, C.E.2    Shinton, S.A.3    Kemp, J.D.4    Hayakawa, K.5
  • 10
    • 0025193047 scopus 로고
    • The proteins encoded by the VpreB and λ5 pre-B cell-specific genes can associate with each other and with μ heavy chain
    • Karasuyama, H., A. Kudo, and F. Melchers. 1990. The proteins encoded by the VpreB and λ5 pre-B cell-specific genes can associate with each other and with μ heavy chain. J. Exp. Med. 172:969-972.
    • (1990) J. Exp. Med. , vol.172 , pp. 969-972
    • Karasuyama, H.1    Kudo, A.2    Melchers, F.3
  • 11
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature (Lond.). 381:751-758.
    • (1996) Nature (Lond.) , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 12
    • 0028203302 scopus 로고
    • Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage
    • Melchers, F., E. Haasner, U. Grawunder, C. Kalberer, H. Karasuyama, T. Winkler, and T. Rolink. 1994. Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Ann. Rev. Immunol. 12:209-225.
    • (1994) Ann. Rev. Immunol. , vol.12 , pp. 209-225
    • Melchers, F.1    Haasner, E.2    Grawunder, U.3    Kalberer, C.4    Karasuyama, H.5    Winkler, T.6    Rolink, T.7
  • 14
    • 0026583842 scopus 로고
    • Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion
    • Kitamura, D., and K. Rajewsky. 1992. Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion. Nature (Lond.). 356:154-156.
    • (1992) Nature (Lond.) , vol.356 , pp. 154-156
    • Kitamura, D.1    Rajewsky, K.2
  • 15
    • 0027476466 scopus 로고
    • Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development
    • Ehlich, A., S. Schall, H. Gu, D. Kitamura, W. Muller, and K. Rajewsky. 1993. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell. 72:695-704.
    • (1993) Cell , vol.72 , pp. 695-704
    • Ehlich, A.1    Schall, S.2    Gu, H.3    Kitamura, D.4    Muller, W.5    Rajewsky, K.6
  • 16
    • 0027275497 scopus 로고
    • The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
    • Li, Y.-L., K. Hayakawa, and R.R. Hardy. 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951-960.
    • (1993) J. Exp. Med. , vol.178 , pp. 951-960
    • Li, Y.-L.1    Hayakawa, K.2    Hardy, R.R.3
  • 17
    • 0028068082 scopus 로고
    • Immunoglobulin heavy-chain protein controls B cell development by regulating germline transcription and retargeting V(D)J recombination
    • Schlissel, M.S., and T. Morrow. 1994. Immunoglobulin heavy-chain protein controls B cell development by regulating germline transcription and retargeting V(D)J recombination. J. Immunol. 153:1645-1657.
    • (1994) J. Immunol. , vol.153 , pp. 1645-1657
    • Schlissel, M.S.1    Morrow, T.2
  • 18
    • 0023513107 scopus 로고
    • Development ot the primary antibody repertoire
    • Alt, F., T. Blackwell, and G. Yancopoulos. 1987. Development ot the primary antibody repertoire. Science (Wash. DC). 238:1079-1087.
    • (1987) Science (Wash. DC) , vol.238 , pp. 1079-1087
    • Alt, F.1    Blackwell, T.2    Yancopoulos, G.3
  • 19
    • 0025350645 scopus 로고
    • The protecton: The unit of humoral immunity selected by evolution
    • Cohn, M., and R.E. Langman. 1990. The protecton: the unit of humoral immunity selected by evolution. Immunol. Rev. 115:7-147.
    • (1990) Immunol. Rev. , vol.115 , pp. 7-147
    • Cohn, M.1    Langman, R.E.2
  • 20
    • 0020455463 scopus 로고
    • A theory of allelic and isotypic exclusion for immunoglobulin genes
    • Wabl, M., and C. Steinberg. 1982. A theory of allelic and isotypic exclusion for immunoglobulin genes. Proc. Natl. Acad. Sci. USA. 79:6976-6978.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 6976-6978
    • Wabl, M.1    Steinberg, C.2
  • 21
    • 0026698261 scopus 로고
    • Allelic exclusion model questioned (I)
    • Wabl, M., and C. Steinberg. 1992. Allelic exclusion model questioned (I), Nature (Lond.). 359:370-371.
    • (1992) Nature (Lond.) , vol.359 , pp. 370-371
    • Wabl, M.1    Steinberg, C.2
  • 23
    • 0028466384 scopus 로고
    • Analysis ot the B-cell progenitor compartment at the level of single cells
    • Ehlich, A., V. Martin, W. Müller, and K. Rajewski. 1994. Analysis ot the B-cell progenitor compartment at the level of single cells. Curr. Biol. 4:573-579.
    • (1994) Curr. Biol. , vol.4 , pp. 573-579
    • Ehlich, A.1    Martin, V.2    Müller, W.3    Rajewski, K.4
  • 24
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature (Lond.). 302:575-581.
    • (1983) Nature (Lond.) , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 25
    • 0026762509 scopus 로고
    • V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals
    • Roth, D.B., P. Nakajima, J.P. Menetski, M.J. Bosma, and M. Gellert. 1992. V(D)J recombination in mouse thymocytes: double-strand breaks near T cell receptor δ rearrangement signals. Cell. 69:41-53.
    • (1992) Cell , vol.69 , pp. 41-53
    • Roth, D.B.1    Nakajima, P.2    Menetski, J.P.3    Bosma, M.J.4    Gellert, M.5
  • 26
    • 0026792892 scopus 로고
    • V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
    • Roth, D.B., J.P. Menetski, P.B. Nakajima, M.J. Bosma, and M. Gellert. 1992. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell. 70:1-9.
    • (1992) Cell , vol.70 , pp. 1-9
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.B.3    Bosma, M.J.4    Gellert, M.5
  • 27
    • 0027769386 scopus 로고
    • Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′ phosphorylated, RAG-dependent and cell cycle regulated
    • Schlissel, M.S., A. Constantinescu, T. Morrow, M. Baxter, and A. Peng. 1993. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′ phosphorylated, RAG-dependent and cell cycle regulated. Genes & Dev. 7:2520-2532.
    • (1993) Genes & Dev. , vol.7 , pp. 2520-2532
    • Schlissel, M.S.1    Constantinescu, A.2    Morrow, T.3    Baxter, M.4    Peng, A.5
  • 28
    • 0027491330 scopus 로고
    • Characterization of broken DNA molecules associated with V(D)J recombination
    • Roth, D.B., C. Zhu, and M. Gellert. 1993. Characterization of broken DNA molecules associated with V(D)J recombination. Proc. Natl. Acad. Sci. USA. 90:10788-10792.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10788-10792
    • Roth, D.B.1    Zhu, C.2    Gellert, M.3
  • 29
    • 0028801363 scopus 로고
    • Formation and resolution of double-strand break intermediates in V(D)J rearrangement
    • Ramsden, D.A., and M. Gellert. 1995. Formation and resolution of double-strand break intermediates in V(D)J rearrangement. Genes & Dev. 9:2409-2420.
    • (1995) Genes & Dev. , vol.9 , pp. 2409-2420
    • Ramsden, D.A.1    Gellert, M.2
  • 30
    • 0023022625 scopus 로고
    • The c-myc oncogene perturbs B lymphocyte development in Em-myc transgenic mice
    • Langdon, W.Y., A.W. Harris, S. Cory, and J.M. Adams. 1986. The c-myc oncogene perturbs B lymphocyte development in Em-myc transgenic mice. Cell. 47:11-18.
    • (1986) Cell , vol.47 , pp. 11-18
    • Langdon, W.Y.1    Harris, A.W.2    Cory, S.3    Adams, J.M.4
  • 32
    • 0027478391 scopus 로고
    • Receptor editing in self-reactive bone marrow B cells
    • Tiegs, S.S., D.M. Russell, and D. Nemazee. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177: 1009-1020.
    • (1993) J. Exp. Med. , vol.177 , pp. 1009-1020
    • Tiegs, S.S.1    Russell, D.M.2    Nemazee, D.3
  • 33
    • 0027499537 scopus 로고
    • Receptor Editing: An approach by autoreactive B cells to escape tolerance
    • Gay, D., T. Saunders, S. Camper, and M. Weigert. 1993. Receptor Editing: An approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177:999-1008.
    • (1993) J. Exp. Med. , vol.177 , pp. 999-1008
    • Gay, D.1    Saunders, T.2    Camper, S.3    Weigert, M.4
  • 36
    • 0026061995 scopus 로고
    • A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification
    • Schmid, I., C.H. Uittenbogaart, and J.V. Giorgi. 1991. A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification. Cytometry. 12:279-285.
    • (1991) Cytometry , vol.12 , pp. 279-285
    • Schmid, I.1    Uittenbogaart, C.H.2    Giorgi, J.V.3
  • 38
    • 0026032665 scopus 로고
    • Virally-transformed pre-B cells show ordered activation but not inactivation of immunoglobin gene rearrangement and transcription
    • Schlissel, M.S., L.M. Corcoran, and D. Baltimore. 1991. Virally-transformed pre-B cells show ordered activation but not inactivation of immunoglobin gene rearrangement and transcription J. Exp. Med. 173:711-720.
    • (1991) J. Exp. Med. , vol.173 , pp. 711-720
    • Schlissel, M.S.1    Corcoran, L.M.2    Baltimore, D.3
  • 39
    • 0028027360 scopus 로고
    • IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development
    • Rolink, A., U. Grawunder, T.H. Winkler, H. Karasuyama, and F. Melchers. 1994. IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int. Immunol. 6:1257-1264.
    • (1994) Int. Immunol. , vol.6 , pp. 1257-1264
    • Rolink, A.1    Grawunder, U.2    Winkler, T.H.3    Karasuyama, H.4    Melchers, F.5
  • 40
    • 0026538739 scopus 로고
    • Enumeration and characterization of DJH structures in mouse fetal liver
    • Chang, Y., C.J. Paige, and G.E. Wu. 1992. Enumeration and characterization of DJH structures in mouse fetal liver. EMBO (Eur. Mol. Biol. Organ.) J. 11:1891-1899.
    • (1992) EMBO (Eur. Mol. Biol. Organ.) J. , vol.11 , pp. 1891-1899
    • Chang, Y.1    Paige, C.J.2    Wu, G.E.3
  • 41
    • 0024850724 scopus 로고
    • Mechanism and developmental program of immunoglobulin gene rearrangement in mammals
    • Blackwell, T.K., and F.W. Alt. 1989. Mechanism and developmental program of immunoglobulin gene rearrangement in mammals. Annu. Rev. Genet. 23:605-636.
    • (1989) Annu. Rev. Genet. , vol.23 , pp. 605-636
    • Blackwell, T.K.1    Alt, F.W.2
  • 42
    • 0027296517 scopus 로고
    • Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation
    • Lin, W.-C., and S. Desiderio. 1993. Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation. Science (Wash. DC.). 260:953-959.
    • (1993) Science (Wash. DC.) , vol.260 , pp. 953-959
    • Lin, W.-C.1    Desiderio, S.2
  • 43
    • 0028223271 scopus 로고
    • Cell cycle regulation of V(D)J recombination-activating protein RAG-2
    • Lin, W.C., and S. Desiderio. 1994. Cell cycle regulation of V(D)J recombination-activating protein RAG-2. Proc. Natl. Acad. Sci. USA. 91:2733-2737.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 2733-2737
    • Lin, W.C.1    Desiderio, S.2
  • 44
    • 0028828269 scopus 로고
    • Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement
    • Grawunder, U., T.M.J. Leu, D.G. Schatz, A. Werner, A. Rolink, F. Melchers, and T.H. Winkler. 1995. Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity. 3:601-608.
    • (1995) Immunity , vol.3 , pp. 601-608
    • Grawunder, U.1    Leu, T.M.J.2    Schatz, D.G.3    Werner, A.4    Rolink, A.5    Melchers, F.6    Winkler, T.H.7
  • 46
    • 0024435908 scopus 로고
    • Activation of immunoglobulin kappa gene rearrangement corelates with induction of germline kappa gene transcription
    • Schlissel, M., and D. Baltimore. 1989. Activation of immunoglobulin kappa gene rearrangement corelates with induction of germline kappa gene transcription. Cell. 58:1001-1007.
    • (1989) Cell , vol.58 , pp. 1001-1007
    • Schlissel, M.1    Baltimore, D.2
  • 47
    • 0029886467 scopus 로고    scopus 로고
    • Surrrogate light chain expression is required to establish Iimmunoglobulin heavy chain allelic exclusion during early B cell development
    • Löffert, D., A. Ehlich, W. Muller, and K. Rajewsky. 1996. Surrrogate light chain expression is required to establish Iimmunoglobulin heavy chain allelic exclusion during early B cell development. Immunity. 4:133-144.
    • (1996) Immunity , vol.4 , pp. 133-144
    • Löffert, D.1    Ehlich, A.2    Muller, W.3    Rajewsky, K.4
  • 49
    • 0029947546 scopus 로고    scopus 로고
    • The transition of pre-BI to pre-BII cells is dependent on the Vh structure of the μ/surrogate L chain receptor
    • Ye, J., S.K. McCray, and S.H. Clarke. 1996. The transition of pre-BI to pre-BII cells is dependent on the Vh structure of the μ/surrogate L chain receptor. EMBO (Eur. Mol. Biol. Organ.) J. 15:1524-1533.
    • (1996) EMBO (Eur. Mol. Biol. Organ.) J. , vol.15 , pp. 1524-1533
    • Ye, J.1    McCray, S.K.2    Clarke, S.H.3
  • 50
    • 0029894165 scopus 로고    scopus 로고
    • Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro
    • Stanhope-Baker, P., K.M. Hudson, A.L. Shaffer, A. Constantinuescu, and M.S. Schlissel. 1996. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. Cell. 85:887-897.
    • (1996) Cell , vol.85 , pp. 887-897
    • Stanhope-Baker, P.1    Hudson, K.M.2    Shaffer, A.L.3    Constantinuescu, A.4    Schlissel, M.S.5
  • 51
    • 0344553913 scopus 로고
    • An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement
    • Chen, Y.Y., L.C. Wang, M.S. Huang, and N. Rosenberg. 1994. An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement. Genes & Dev. 8: 688-697.
    • (1994) Genes & Dev. , vol.8 , pp. 688-697
    • Chen, Y.Y.1    Wang, L.C.2    Huang, M.S.3    Rosenberg, N.4
  • 52
    • 0022382048 scopus 로고
    • Preferential rearrangement of the immunoglobulin kappa chain joining region Jκ1 and jκ2 segments in mouse spleen DNA
    • Nishi, M., T. Kataoka, and T. Honjo. 1985. Preferential rearrangement of the immunoglobulin kappa chain joining region Jκ1 and jκ2 segments in mouse spleen DNA. Proc. Natl. Acad. Sci. USA. 82:6399-6403.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 6399-6403
    • Nishi, M.1    Kataoka, T.2    Honjo, T.3
  • 53
    • 0021257290 scopus 로고
    • Different joining J regions of the murine kappa immunoglobulin light chain locus are used at markedly different frequencies
    • Wood, D.L., and C. Coleclough. 1984. Different joining J regions of the murine kappa immunoglobulin light chain locus are used at markedly different frequencies. Proc. Natl. Acad. Sci. USA. 81:4756-4760
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 4756-4760
    • Wood, D.L.1    Coleclough, C.2
  • 54
    • 0026721377 scopus 로고
    • Exclusion and Inclusion of α and β T cell receptor alleles
    • Borgulya, P., H. Kishi, Y. Uematsu, and H. von Boehmer. 1992. Exclusion and Inclusion of α and β T cell receptor alleles. Cell. 69:529-537.
    • (1992) Cell , vol.69 , pp. 529-537
    • Borgulya, P.1    Kishi, H.2    Uematsu, Y.3    Von Boehmer, H.4
  • 55
    • 0026661878 scopus 로고
    • Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression
    • Brandle, D., C. Muller, T. Rulicke, H. Hengartner, and H. Pircher. 1992. Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression. Proc. Natl. Acad. Sci. USA. 89:9529-9533.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9529-9533
    • Brandle, D.1    Muller, C.2    Rulicke, T.3    Hengartner, H.4    Pircher, H.5
  • 57
    • 0028182887 scopus 로고
    • Positive and negative selection of antibody repertoires during B cell differentiation
    • Grandien, A., Y. Modigliani, A. Freitas, J. Andersson, and A. Coutinho. 1994. Positive and negative selection of antibody repertoires during B cell differentiation. Immunol. Rev. 137: 52-89.
    • (1994) Immunol. Rev. , vol.137 , pp. 52-89
    • Grandien, A.1    Modigliani, Y.2    Freitas, A.3    Andersson, J.4    Coutinho, A.5


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