BCR ligation induces receptor editing in IgM+IgD- bone marrow B cells in vitro

Immunity

Volumn 6, Issue 4, 1997, Pages 429-436

  Hertz, Marc ^a   Nemazee, David ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN D; IMMUNOGLOBULIN M; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BONE MARROW; FLOW CYTOMETRY; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030981639     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80286-1     Document Type: Article

References (31)

1. Arakawa, H., Shimizu, T., and Takeda, S. (1995). Re-evaluation of the probabilities for productive rearrangements on the κ and λ loci. Int. Immunol. 8, 91-99.
2. Best, C.G., Kemp, J.D., and Waldschmidt, T.J. (1995). Murine B-cell subsets defined by CD23. Methods: A Companion to Meth. Enzymol. 8, 3-10.
3. Gay, D., Saunders, T., Camper, S., and Weigert, M. (1993). Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177, 999-1008.
4. Harada, K., and Yamagishi, H. (1991). Lack of feedback inhibition of Vκ gene rearrangement by productively rearranged alleles. J. Exp. Med. 173, 409-415.
5. Hardy, R.R., Carmack, C.E., Shinton, S.A., Kemp, J.D., and Hayakawa, K. (1991). Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173, 1213-1225.
6. Hartley, S.B., Cooke, M.P., Fulcher, D.A., Harris, A.W., Cory, S., Basten, A., and Goodnow, C.C. (1993). Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell 72, 325-335.
7. Hodgkin, P.D., Lee, J.-H., and Lyons, A.B. (1996). B cell differentiation and isotype switching is related to division and cycle number. J. Exp. Med. 184, 277-281.
8. Klinman, N.R. (1996). The "clonal selection hypothesis" and current concepts of B cell tolerance. Immunity 5, 189-195.
9. Lang, J., Jackson, M., Teyton, L., Brunmark, A., Kane, K., and Nemazee, D. (1996). B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigens. J. Exp. Med. 184, 1685-1697.
10. Li, Y.S., Hayakawa, K., and Hardy, R.R. (1993). The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178, 951-960.
11. Lyons, A.B., and Parish, C.R. (1994). Determination of lymphocyte division by flow cytometry. J. Immunol. Meth. 171, 131-137.
12. Ma, A., Fisher, P., Dildrop, R., Oltz, E., Rathbun, G., Achacoso, P., Stall, A., and Alt, F.W. (1992). Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines. EMBO J. 11, 2727-2734.
13. Monroe, J.G. (1996). Tolerance sensitivity of immature-stage B cells: can developmentally regulated B cell antigen receptor (BCR) signal transduction play a role? J. Immunol. 156, 2657-2660.
14. Nemazee, D. (1996). Antigen receptor 'capacity' and the sensitivity of self-tolerance, Immunol. Today 17, 25-29.
15. Nisitani, S., Tsubata, T., Murakami, M., Okamoto, M., and Honjo, T. (1993). The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. J. Exp. Med. 178, 1247-1254.
16. Norvell, A., Mandik, L., and Monroe, J.G. (1995). Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis. J. Immunol. 154, 4404-4413.
17. Nossal, G.J., and Pike, B.L. (1975). Evidence for the clonal abortion theory of B-lymphocyte tolerance. J. Exp. Med. 141, 904-917.
18. Prak, E.L., and Weigert, M. (1995). Light chain replacement: a new model for antibody gene rearrangement. J. Exp. Med. 182, 541-548.
19. Prak, E.L., Trounstine, M., Huszar, D., and Weigert, M. (1994). Light chain editing in κ-deficient animals: a potential mechanism of B cell tolerance. J. Exp. Med. 180, 1805-1815.
20. Radic, M.Z., and Zouali, M. (1996). Receptor editing, immune diversification, and self-tolerance. Immunity 5, 505-511.
21. Radic, M.Z., Erikson, J., Litwin, S., and Weigert, M. (1993). B lymphocytes may escape tolerance by revising their antigen receptors. J. Exp. Med. 177, 1165-1173.
22. Raff, M.C., Owen, J.T., Cooper, M.D., Lawton, A.R., III, Megson, M., and Gathings, W.E. (1975). Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. J. Exp. Med. 142, 1052-1063.
23. Rajewsky, K. (1996). Clonal selection and learning in the antibody system. Nature 381, 751-758.
24. Rolink, A., Grawunder, U., Haasner, D., Strasser, A., and Melchers, F. (1993). Immature surface Ig+ B cells can continue to rearrange κ and λ L chain gene loci. J. Exp. Med. 178, 1263-1270.
25. Russell, D.M., Dembic, Z., Morahan, G., Miller, J.F., Burki, K., and Nemazee, D. (1991). Peripheral deletion of self-reactive B cells. Nature 354, 308-311.
26. Sidman, C.L., and Unanue, E.R. (1975). Receptor-mediated inactivation of early B lymphocytes. Nature 257, 149-151.
27. Storb, U., Roth, P., and Kurtz, B.K. (1994). γ2b transgenic mice as a model for the role of immunoglobulins in B cell development, Immunol. Res. 13, 291-298.
28. Strasser, A., Whittingham, S., Vaux, D.L., Bath, M.L., Adams, J.M., Cory, S., and Harris, A.W. (1991). Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci. USA 88, 8661-8665.
29. Tiegs, S.L., Russell, D.M., and Nemazee, D. (1993). Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177, 1009-1020.
30. Verkoczy, L.K., Stiernhdm, B.J., and Berinstein, N.L. (1995). Upregulation of recombination activating gene expression by signal transduction through the surface Ig receptor. J. Immunol. 154, 5136-5143.
31. Weiner, H.L., Moorhead, J.W., and Claman, H.N. (1976). Anti-immunoglobulin stimulation of murine lymphocytes. I. Age dependency of the proliferative response. J. Immunol. 116, 1656-1661.