Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice

Journal of Experimental Medicine

Volumn 192, Issue 12, 2000, Pages 1745-1754

  Gärtner, Frank ^b   Alt, Frederick W ^a   Monroe, Robert J ^b   Seidl, Katherine J ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b NONE

Author keywords

Alum; Germinal center; Immunoglobulin re rearrangement; Receptor editing

Indexed keywords

ALUMINUM HYDROXIDE; CD40 ANTIGEN; CYTOKINE; GENE PRODUCT; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 4; INTERLEUKIN 7; LIPOPOLYSACCHARIDE; LYMPHOCYTE SURFACE MARKER; MITOGENIC AGENT; RAG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL LINEAGE; FUSION GENE; GENE EXPRESSION; GENETIC RECOMBINATION; GERMINAL CENTER; IMMUNIZATION; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; SPLEEN; SPLEEN CELL;

ADOPTIVE TRANSFER; ALUM COMPOUNDS; ANIMALS; ANTIGENS, CD40; B-LYMPHOCYTES; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL LINEAGE; CELLS, CULTURED; CHEMOTAXIS, LEUKOCYTE; DNA-BINDING PROTEINS; FLOW CYTOMETRY; GAMMA-GLOBULINS; GENES, RAG-1; IMMUNIZATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; RECOMBINANT FUSION PROTEINS; SPLEEN;

EID: 0034684650     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.12.1745     Document Type: Article

References (51)

1. Merchanism and control of immunoglobulin gene rearrangement. 2nd ed
2. Two waves of recombinase gene expression in developing thymocytes
3. Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement
4. The regulated expression of B lineage-associated genes during B cell differentiation in bone marrow and fetal liver
5. Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5′ of RAG2
6. B cell development in the mouse from early progenitors to mature B cells
7. Transitional B cells are the target of negative selection in the B cell compartment
8. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity
9. hi and exhibit unique signaling characteristics
10. Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells
11. RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues
12. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization
13. Murine B lymphopoiesis: Towards a unified model
14. Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells
15. V(D)J recombinase activity in a subset of germinal center B lymphocytes
16. Characterization of B cells expressing recombination activating genes in germinal centers of immunized mouse lymph nodes
17. Expression of recombination activating genes in germinal center B cells: Involvement of interleukin 7 (IL-7) and the IL-7 receptor
18. V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling
19. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells
20. Rearrangement of lambda light chain genes in mature B cells in vitro and in vivo. Function of reexpressed recombination-activating gene (RAG) products
21. V(D)J recombination in mature B cells: A mechanism for altering antibody responses
22. Revising B cell receptors
23. Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production
24. Distinctive characteristics of germinal center B cells
25. Receptor editing, immune diversification, and self-tolerance
26. Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells
27. Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest
28. - bone marrow B cells in vitro
29. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
30. RAG-1-deficient mice have no mature B and T lymphocytes
31. Cutting edge: Absence of expression of RAG1 in peritoneal B-1 cells detected by knocking into RAG1 locus with green flourescent protein gene
32. Humoral immune responses in CD40 ligand-deficient mice
33. Ig VH hypermutation is absent in the germinal centers of aged mice
34. B cells genetically deficient in the c-Rel transactivation domain have selective defects in germline CH transcription and Ig class switching
35. Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses
36. + T cell functions
37. Peanut lectin binding properties of germinal centres of mouse lymphoid tissue
38. B lymphocytes express and lose syndecan at specific stages of differentiation
39. Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes
40. Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice
41. Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire
42. 125I anti-IgM antibody
43. Characterization of a novel cell-surface molecule expressed on subpopulations of activated T and B cells
44. The germinal center: A crucible for lymphocyte selection
45. Life and death in germinal centers (redux)
46. B lineage differentiation stages resolved by multiparameter flow cytometry
47. How B-precursor cells are driven to cycle
48. Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment
49. An ancient system of host defense
50. Seeking wisdom in innate immunity
51. Population dynamics of bone marrow B lymphocytes