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Volumn 4, Issue 2, 1996, Pages 133-144

Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 0029886467     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80678-0     Document Type: Article
Times cited : (147)

References (77)
  • 2
    • 0019846013 scopus 로고
    • Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes
    • Alt, F., Rosenberg, N., Lewis, S., Thomas, E., and Baltimore, D. (1981). Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: rearrangement of heavy but not light chain genes. Cell 27, 381-390.
    • (1981) Cell , vol.27 , pp. 381-390
    • Alt, F.1    Rosenberg, N.2    Lewis, S.3    Thomas, E.4    Baltimore, D.5
  • 4
    • 0005868202 scopus 로고
    • Expression of the VpreB/λ5/m pseudo-Ig complex correlates with downregulated RAG-1 expression and V(D)J type recombination: A mechanism for allelic exclusion at the IgH locus
    • Bauer, S.R., and Scheuermann, R.H. (1993). Expression of the VpreB/λ5/m pseudo-Ig complex correlates with downregulated RAG-1 expression and V(D)J type recombination: a mechanism for allelic exclusion at the IgH locus. Transgene 1, 33-45.
    • (1993) Transgene , vol.1 , pp. 33-45
    • Bauer, S.R.1    Scheuermann, R.H.2
  • 5
    • 0019442186 scopus 로고
    • Heavy chain variable region contribution to the b-NP family of antibodies: Somatic mutation evident in a gamma-2a variable region
    • Bothwell, A.L.M., Paskind, M., Reth, M., Imanishi-Kari, T., Rajewsky, K., and Baltimore, D. (1981). Heavy chain variable region contribution to the b-NP family of antibodies: somatic mutation evident in a gamma-2a variable region. Cell 24, 625-637.
    • (1981) Cell , vol.24 , pp. 625-637
    • Bothwell, A.L.M.1    Paskind, M.2    Reth, M.3    Imanishi-Kari, T.4    Rajewsky, K.5    Baltimore, D.6
  • 6
    • 0028346563 scopus 로고
    • Signal transduction by the B cell antigen receptor and its coreceptors
    • Cambier, J.C., Pleiman, C.M., and Clark, M.R. (1994). Signal transduction by the B cell antigen receptor and its coreceptors. Annu. Rev. Immunol. 12, 457-486.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 457-486
    • Cambier, J.C.1    Pleiman, C.M.2    Clark, M.R.3
  • 9
    • 0025350645 scopus 로고
    • The protecton: The unit of humoral immunity selected by evolution
    • Cohn, M., and Langman, R.E. (1990). The protecton: the unit of humoral immunity selected by evolution. Immunol. Rev. 115, 7-147.
    • (1990) Immunol. Rev. , vol.115 , pp. 7-147
    • Cohn, M.1    Langman, R.E.2
  • 10
    • 0019494043 scopus 로고
    • Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
    • Coleclough, C., Perry, R.P., Karjalainen, K., and Weigert, M. (1981). Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature 290, 372-378.
    • (1981) Nature , vol.290 , pp. 372-378
    • Coleclough, C.1    Perry, R.P.2    Karjalainen, K.3    Weigert, M.4
  • 11
    • 0029001936 scopus 로고
    • Analysis of immunoglobulin gene rearrangements in single B cells
    • Ehlich, A., and Küppers. R. (1995). Analysis of immunoglobulin gene rearrangements in single B cells. Curr. Opin. Immunol. 7, 281-284.
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 281-284
    • Ehlich, A.1    Küppers, R.2
  • 12
    • 0027476466 scopus 로고
    • Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development
    • Ehlich, A., Schaal, S., Gu, H., Kitamura, D., Müller, W., and Rajewsky, K. (1993). Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72, 695-704.
    • (1993) Cell , vol.72 , pp. 695-704
    • Ehlich, A.1    Schaal, S.2    Gu, H.3    Kitamura, D.4    Müller, W.5    Rajewsky, K.6
  • 13
    • 0028466384 scopus 로고
    • Analysis of the B cell progenitor compartment at the level of single cells
    • Ehlich, A., Martin, V., Müller, W., and Rajewsky, K. (1994). Analysis of the B cell progenitor compartment at the level of single cells. Curr. Biol. 4, 573-583.
    • (1994) Curr. Biol. , vol.4 , pp. 573-583
    • Ehlich, A.1    Martin, V.2    Müller, W.3    Rajewsky, K.4
  • 14
    • 0025184095 scopus 로고
    • Lack of N-regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences
    • Feeney, A.J. (1990). Lack of N-regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences. J. Exp. Med. 172, 1377-1390.
    • (1990) J. Exp. Med. , vol.172 , pp. 1377-1390
    • Feeney, A.J.1
  • 15
    • 0028828269 scopus 로고
    • Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement
    • Grawunder, U., Leu, T.M.J., Schatz, D.G., Werner, A., Rolink, A.G., Melchers, F., and Winkler, T.H. (1995). Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity 3, 601-608.
    • (1995) Immunity , vol.3 , pp. 601-608
    • Grawunder, U.1    Leu, T.M.J.2    Schatz, D.G.3    Werner, A.4    Rolink, A.G.5    Melchers, F.6    Winkler, T.H.7
  • 16
    • 0025335392 scopus 로고
    • H joining: Implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation
    • H joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation. EMBO J. 9, 2133-2410.
    • (1990) EMBO J. , vol.9 , pp. 2133-2410
    • Gu, H.1    Förster, I.2    Rajewsky, K.3
  • 19
    • 0027280936 scopus 로고
    • Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
    • Gu, H., Zou, Y.-R., and Rajewsky, K. (1993). Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73, 1155-1164.
    • (1993) Cell , vol.73 , pp. 1155-1164
    • Gu, H.1    Zou, Y.-R.2    Rajewsky, K.3
  • 21
    • 0025868702 scopus 로고
    • Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
    • Hardy, R.R., Carmack, C.E., Shinton, S.A., Kemp, J.D., and Hayakawa, K. (1991). Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173, 1213-1225.
    • (1991) J. Exp. Med. , vol.173 , pp. 1213-1225
    • Hardy, R.R.1    Carmack, C.E.2    Shinton, S.A.3    Kemp, J.D.4    Hayakawa, K.5
  • 23
    • 0027223378 scopus 로고
    • Endogenous Ig production in mu transgenic mice. II. Anti-Ig reactivity and apparent double allotype expression
    • Imanishi-Kari, T., Huang, C.A., Iacomini, J., and Yannoutsos, N. (1993). Endogenous Ig production in mu transgenic mice. II. Anti-Ig reactivity and apparent double allotype expression. J. Immunol. 150, 3327-3346.
    • (1993) J. Immunol. , vol.150 , pp. 3327-3346
    • Imanishi-Kari, T.1    Huang, C.A.2    Iacomini, J.3    Yannoutsos, N.4
  • 24
    • 0025895046 scopus 로고
    • Molecular requirements for the μ-induced light chain gene rearrangement in pre-B cells
    • Iglesias, A., Kopf, M., Williams, G.S., Bühler, B., and Köhler, G. (1991). Molecular requirements for the μ-induced light chain gene rearrangement in pre-B cells. EMBO J. 10, 2147-2156.
    • (1991) EMBO J. , vol.10 , pp. 2147-2156
    • Iglesias, A.1    Kopf, M.2    Williams, G.S.3    Bühler, B.4    Köhler, G.5
  • 25
    • 0001509494 scopus 로고
    • Reading of D genes in variable frames as a source of antibody diversity
    • Kaartinen, M., and Mäkelä, O. (1985). Reading of D genes in variable frames as a source of antibody diversity. Immunol. Today 6, 324-330.
    • (1985) Immunol. Today , vol.6 , pp. 324-330
    • Kaartinen, M.1    Mäkelä, O.2
  • 27
    • 0025193047 scopus 로고
    • The proteins encoded by the VpreB and λ5 pre-B cell-specific genes can associate with each other and with μ heavy chain
    • Karasuyama, H., Kudo, A., and Melchers, F. (1990). The proteins encoded by the VpreB and λ5 pre-B cell-specific genes can associate with each other and with μ heavy chain. J. Exp. Med. 172, 969-972.
    • (1990) J. Exp. Med. , vol.172 , pp. 969-972
    • Karasuyama, H.1    Kudo, A.2    Melchers, F.3
  • 28
    • 0028179068 scopus 로고
    • The expression of VpreB/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mice
    • Karasuyama, H., Rolink, A., Shinkai, Y., Young, F., Alt, F.W., and Melchers, F. (1993). The expression of VpreB/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mice. Cell 77, 133-143.
    • (1993) Cell , vol.77 , pp. 133-143
    • Karasuyama, H.1    Rolink, A.2    Shinkai, Y.3    Young, F.4    Alt, F.W.5    Melchers, F.6
  • 29
    • 0026583842 scopus 로고
    • Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion
    • Kitamura, D., and Rajewsky, K. (1992). Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion. Nature 356, 154-156.
    • (1992) Nature , vol.356 , pp. 154-156
    • Kitamura, D.1    Rajewsky, K.2
  • 30
    • 0025852445 scopus 로고
    • A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
    • Kitamura, D., Roes, J., Kühn, R., and Rajewsky, K. (1991). A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350, 423-426.
    • (1991) Nature , vol.350 , pp. 423-426
    • Kitamura, D.1    Roes, J.2    Kühn, R.3    Rajewsky, K.4
  • 32
    • 0019188771 scopus 로고
    • Immunoglobulin chain loss in hybridoma lines
    • Köhler, G. (1980). Immunoglobulin chain loss in hybridoma lines. Proc. Natl. Acad. Sci. USA 77, 2197-2199.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 2197-2199
    • Köhler, G.1
  • 33
    • 0024791338 scopus 로고
    • Junctional sequences of T cell receptor γδ T cell lineages and for a novel intermediate of V-(D)-J joining
    • Lafaille, J.J., DeCloux, A., Bonneville, M., Takagaki, Y., and Tonegawa, S. (1989). Junctional sequences of T cell receptor γδ T cell lineages and for a novel intermediate of V-(D)-J joining. Cell 59, 859-870.
    • (1989) Cell , vol.59 , pp. 859-870
    • Lafaille, J.J.1    DeCloux, A.2    Bonneville, M.3    Takagaki, Y.4    Tonegawa, S.5
  • 34
    • 0027521777 scopus 로고
    • A high frequency of hybridomas from M54 mu heavy chain transgenic mice initially co-express transgenic and rearranged endogenous mu genes
    • Lam, K.P., Herzenberg, L.A., and Stall, A.M. (1993). A high frequency of hybridomas from M54 mu heavy chain transgenic mice initially co-express transgenic and rearranged endogenous mu genes. Int. Immunol. 5, 1011-1022.
    • (1993) Int. Immunol. , vol.5 , pp. 1011-1022
    • Lam, K.P.1    Herzenberg, L.A.2    Stall, A.M.3
  • 35
    • 0023216961 scopus 로고
    • The E-T (Elephant-Tadpole) paradox necessitates the concept of a unit of B-cell function: The protecton
    • Langman, R.E., and Cohn, M. (1987). The E-T (Elephant-Tadpole) paradox necessitates the concept of a unit of B-cell function: the protecton. Mol. Immunol. 24, 675-697.
    • (1987) Mol. Immunol. , vol.24 , pp. 675-697
    • Langman, R.E.1    Cohn, M.2
  • 36
    • 0027400889 scopus 로고
    • Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation
    • Lassoued, K., Nunez, C.A., Billips, L., Kubagawa, H., Monteiro, R.C., LeBien, T.W., and Cooper, M.D. (1993). Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation. Cell 73, 73-86.
    • (1993) Cell , vol.73 , pp. 73-86
    • Lassoued, K.1    Nunez, C.A.2    Billips, L.3    Kubagawa, H.4    Monteiro, R.C.5    LeBien, T.W.6    Cooper, M.D.7
  • 37
    • 0022374773 scopus 로고
    • Cm-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon
    • Lennon, G.G., and Perry, R.P. (1985). Cm-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon. Nature 318, 475-478.
    • (1985) Nature , vol.318 , pp. 475-478
    • Lennon, G.G.1    Perry, R.P.2
  • 38
    • 0021255402 scopus 로고
    • Monoclonal antibodies specific for murine IgM. I. Characterization of antigenic determinants on the four constant domains of the μ heavy chain
    • Leptin, M., Potash, M.J., Grützmann, R., Heusser, C., Shulman, M., Köhler, G., and Melchers, F. (1984). Monoclonal antibodies specific for murine IgM. I. Characterization of antigenic determinants on the four constant domains of the μ heavy chain. Eur. J. Immunol. 14, 534.
    • (1984) Eur. J. Immunol. , vol.14 , pp. 534
    • Leptin, M.1    Potash, M.J.2    Grützmann, R.3    Heusser, C.4    Shulman, M.5    Köhler, G.6    Melchers, F.7
  • 39
    • 0028223271 scopus 로고
    • Cell cycle regulation of V(D)J recombination-activating protein RAG-2
    • Lin, W.-C., and Desiderio, S. (1994). Cell cycle regulation of V(D)J recombination-activating protein RAG-2. Proc. Natl. Acad. Sci. USA 91, 2733-2737. Lin, W.-C., and Desiderio, S. (1995). V(D)J recombination and the cell cycle. Immunol. Today 16, 279-289.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 2733-2737
    • Lin, W.-C.1    Desiderio, S.2
  • 40
    • 0029014910 scopus 로고
    • V(D)J recombination and the cell cycle
    • Lin, W.-C., and Desiderio, S. (1994). Cell cycle regulation of V(D)J recombination-activating protein RAG-2. Proc. Natl. Acad. Sci. USA 91, 2733-2737. Lin, W.-C., and Desiderio, S. (1995). V(D)J recombination and the cell cycle. Immunol. Today 16, 279-289.
    • (1995) Immunol. Today , vol.16 , pp. 279-289
    • Lin, W.-C.1    Desiderio, S.2
  • 41
    • 0028182885 scopus 로고
    • Early B cell development in the mouse: Insights from mutations introduced by gene targeting
    • Löffert, D., Schaal, S., Ehlich, A., Hardy, R.R., Zou, Y.-R., Müller, W., and Rajewsky, K. (1994). Early B cell development in the mouse: insights from mutations introduced by gene targeting. Immunol. Rev. 137, 135-153.
    • (1994) Immunol. Rev. , vol.137 , pp. 135-153
    • Löffert, D.1    Schaal, S.2    Ehlich, A.3    Hardy, R.R.4    Zou, Y.-R.5    Müller, W.6    Rajewsky, K.7
  • 42
    • 0023685531 scopus 로고
    • Feedback inhibition of immunoglobulin gene rearrangement by membrane μ, but not by secreted μ heavy chains
    • Manz, J., Denis, K., Witte, O., Brinser, R., and Storb, U. (1988). Feedback inhibition of immunoglobulin gene rearrangement by membrane μ, but not by secreted μ heavy chains. J. Exp. Med. 168, 1363-1381.
    • (1988) J. Exp. Med. , vol.168 , pp. 1363-1381
    • Manz, J.1    Denis, K.2    Witte, O.3    Brinser, R.4    Storb, U.5
  • 43
    • 0025201204 scopus 로고
    • Analysis of junctional diversity during B lymphocyte development
    • Meek, K. (1990). Analysis of junctional diversity during B lymphocyte development. Science 250, 820-823.
    • (1990) Science , vol.250 , pp. 820-823
    • Meek, K.1
  • 44
    • 0025216585 scopus 로고
    • High gradient magnetic cell separation with MACS
    • Miltenyi, S., Müller, W., Weichel, W., and Radbruch, A. (1990). High gradient magnetic cell separation with MACS. Cytometry 11, 231-238.
    • (1990) Cytometry , vol.11 , pp. 231-238
    • Miltenyi, S.1    Müller, W.2    Weichel, W.3    Radbruch, A.4
  • 47
    • 0023189116 scopus 로고
    • Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin μ
    • Nussenzweig, M.C., Shaw, A.C., Sinn, E., Danner, D.B., Holmes, K.L., Morse, H.C., III, and Leder, P. (1988). Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin μ. Science 236, 816-819.
    • (1988) Science , vol.236 , pp. 816-819
    • Nussenzweig, M.C.1    Shaw, A.C.2    Sinn, E.3    Danner, D.B.4    Holmes, K.L.5    Morse H.C. III6    Leder, P.7
  • 48
    • 0026932844 scopus 로고
    • Allelic exclusion model questioned (II)
    • Oancea, A., and Shulman, M.J. (1993). Allelic exclusion model questioned (II). Nature 359, 371.
    • (1993) Nature , vol.359 , pp. 371
    • Oancea, A.1    Shulman, M.J.2
  • 49
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M.A., Schatz, D.G., Gorka, C., and Baltimore, D. (1990). RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517-1522.
    • (1990) Science , vol.248 , pp. 1517-1522
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 50
    • 0028988692 scopus 로고
    • The role of Igβ in precursor B cell transition and allelic exclusion
    • Papavasiliou, F., Misulovin, Z., Suh, H., and Nussenzweig, M.C. (1995). The role of Igβ in precursor B cell transition and allelic exclusion. Science 268, 409-411.
    • (1995) Science , vol.268 , pp. 409-411
    • Papavasiliou, F.1    Misulovin, Z.2    Suh, H.3    Nussenzweig, M.C.4
  • 51
    • 0023268632 scopus 로고
    • Formation of disulfide-linked μ2ω2 tetramers in pre-B cells by the 18 KD ω-immunoglobulin light chain
    • Pillai, S., and Baltimore, D. (1987). Formation of disulfide-linked μ2ω2 tetramers in pre-B cells by the 18 KD ω-immunoglobulin light chain. Nature 329, 172-174.
    • (1987) Nature , vol.329 , pp. 172-174
    • Pillai, S.1    Baltimore, D.2
  • 52
    • 0026553004 scopus 로고
    • Early and late B-cell development in the mouse
    • Rajewsky, K. (1992). Early and late B-cell development in the mouse. Curr. Opin. Immunol. 4, 171-176.
    • (1992) Curr. Opin. Immunol. , vol.4 , pp. 171-176
    • Rajewsky, K.1
  • 54
    • 0027538326 scopus 로고
    • B-lineage cells in μ-transgenic seid mouse proliferate in response to IL-7 but fail to show evidence of immunoglobulin light chain gene rearrangement
    • Reichman-Fried, M., Bosma, M.J., and Hardy, R.R. (1993). B-lineage cells in μ-transgenic seid mouse proliferate in response to IL-7 but fail to show evidence of immunoglobulin light chain gene rearrangement. Int. Immunol. 5, 303-310.
    • (1993) Int. Immunol. , vol.5 , pp. 303-310
    • Reichman-Fried, M.1    Bosma, M.J.2    Hardy, R.R.3
  • 55
    • 0021678303 scopus 로고
    • H gene segment rearrangements in lymphoid cells
    • H gene segment rearrangements in lymphoid cells. Nature 312, 418-423.
    • (1984) Nature , vol.312 , pp. 418-423
    • Reth, M.G.1    Alt, F.W.2
  • 56
    • 0021933994 scopus 로고
    • Regulated progression of a cultured pre-B-cell line to the B-cell stage
    • Reth, M.G., Ammirati, P., Jackson, S., and Alt, F.W. (1985). Regulated progression of a cultured pre-B-cell line to the B-cell stage. Nature 317, 353-355.
    • (1985) Nature , vol.317 , pp. 353-355
    • Reth, M.G.1    Ammirati, P.2    Jackson, S.3    Alt, F.W.4
  • 57
    • 0029017294 scopus 로고
    • Mouse-anti-mouse-IgD monoclonal antibodies generated in IgD-deficient mice
    • Roes, J., Müller, W., and Rajewsky, K. (1995). Mouse-anti-mouse-IgD monoclonal antibodies generated in IgD-deficient mice. J. Immunol. Meth. 183, 231-237.
    • (1995) J. Immunol. Meth. , vol.183 , pp. 231-237
    • Roes, J.1    Müller, W.2    Rajewsky, K.3
  • 58
    • 0025766890 scopus 로고
    • Molecular and cellular origins of B lymphocyte diversity
    • Rolink, A., and Melchers, F. (1991). Molecular and cellular origins of B lymphocyte diversity. Cell 66, 1081-1094.
    • (1991) Cell , vol.66 , pp. 1081-1094
    • Rolink, A.1    Melchers, F.2
  • 59
    • 0021993025 scopus 로고
    • Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line
    • Rusconi, S., and Köhler, G. (1985). Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line. Nature 314, 330-334.
    • (1985) Nature , vol.314 , pp. 330-334
    • Rusconi, S.1    Köhler, G.2
  • 60
    • 0024846088 scopus 로고
    • The V(D)J recombination activating gene, RAG-1
    • Schatz, D.G., Oettinger, M.A., and Baltimore, D. (1989). The V(D)J recombination activating gene, RAG-1. Cell 59, 1035-1048.
    • (1989) Cell , vol.59 , pp. 1035-1048
    • Schatz, D.G.1    Oettinger, M.A.2    Baltimore, D.3
  • 63
    • 0018082103 scopus 로고
    • Monoclonal xenogeneic antibodies to murine cell surface antigens: Identification of novel leukocyte differentiation antigens
    • Springer, T., Galfrè, G., Secher, D.S., and Milstein, C. (1978). Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur. J. Immunol. 8, 539-551.
    • (1978) Eur. J. Immunol. , vol.8 , pp. 539-551
    • Springer, T.1    Galfrè, G.2    Secher, D.S.3    Milstein, C.4
  • 65
    • 0027691148 scopus 로고
    • Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus
    • Taki, S., Meiering, M., and Rajewsky, K. (1993). Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus. Science 262, 1268-1271.
    • (1993) Science , vol.262 , pp. 1268-1271
    • Taki, S.1    Meiering, M.2    Rajewsky, K.3
  • 66
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa, S. (1983). Somatic generation of antibody diversity. Nature 302, 575-581.
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 67
    • 0025146189 scopus 로고
    • The products of the pre-B cell-specific genes (λ5 and VpreB) and the immunoglobulin μ chain form a complex that is transported onto the cell surface
    • Tsubata, T., and Reth, M.G. (1990). The products of the pre-B cell-specific genes (λ5 and VpreB) and the immunoglobulin μ chain form a complex that is transported onto the cell surface. J. Exp. Med. 172, 973-976.
    • (1990) J. Exp. Med. , vol.172 , pp. 973-976
    • Tsubata, T.1    Reth, M.G.2
  • 68
    • 0025782803 scopus 로고
    • Cell surface expression of the short immunoglobulin μ chain (Dμ protein) in murine pre-B cells is differently regulated from that of the intact μ chain
    • Tsubata, T., Tsubata, R., and Reth, M.G. (1991). Cell surface expression of the short immunoglobulin μ chain (Dμ protein) in murine pre-B cells is differently regulated from that of the intact μ chain. Eur. J. Immunol. 21, 1359-1363.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1359-1363
    • Tsubata, T.1    Tsubata, R.2    Reth, M.G.3
  • 69
    • 0026753294 scopus 로고
    • Crosslinking of the cell surface immunoglobulin (μ-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin K locus
    • Tsubata, T., Tsubata, R., and Reth, M.G. (1992). Crosslinking of the cell surface immunoglobulin (μ-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin K locus. Int. Immunol. 4, 637-641.
    • (1992) Int. Immunol. , vol.4 , pp. 637-641
    • Tsubata, T.1    Tsubata, R.2    Reth, M.G.3
  • 71
    • 0020455463 scopus 로고
    • A theory of allelic and isotypic exclusion for immunoglobulin genes
    • Wabl, M., and Steinberg, C. (1982). A theory of allelic and isotypic exclusion for immunoglobulin genes. Proc. Natl. Acad. Sci. USA 79, 6976-6978.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 6976-6978
    • Wabl, M.1    Steinberg, C.2
  • 72
    • 0026698261 scopus 로고
    • Allelic exclusion model questioned (I)
    • Wabl, M., and Steinberg, C. (1993). Allelic exclusion model questioned (I). Nature 359, 370-371.
    • (1993) Nature , vol.359 , pp. 370-371
    • Wabl, M.1    Steinberg, C.2
  • 73
    • 0019434264 scopus 로고
    • M isalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene
    • Walfield, A., Selsing, E., and Storb, U. (1981). M isalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene. Nucl. Acids Res. 9, 1101-1109.
    • (1981) Nucl. Acids Res. , vol.9 , pp. 1101-1109
    • Walfield, A.1    Selsing, E.2    Storb, U.3
  • 74
    • 0022385230 scopus 로고
    • A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes
    • Weaver, D., Costantini, F., Imanishi-Kari, T., and Baltimore, D. (1985). A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes. Cell 42, 117-127.
    • (1985) Cell , vol.42 , pp. 117-127
    • Weaver, D.1    Costantini, F.2    Imanishi-Kari, T.3    Baltimore, D.4
  • 75
    • 0025601012 scopus 로고
    • The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response
    • Weiss, U., and Rajewsky, K. (1990). The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response. J. Exp. Med. 172, 1681-1689.
    • (1990) J. Exp. Med. , vol.172 , pp. 1681-1689
    • Weiss, U.1    Rajewsky, K.2
  • 76
    • 0028935407 scopus 로고
    • Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface
    • Winkler, T.H., Rolink, A., Melchers, F., and Karasuyama, H. (1995). Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface. Eur. J. Immunol. 25, 446-450.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 446-450
    • Winkler, T.H.1    Rolink, A.2    Melchers, F.3    Karasuyama, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.