B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development

Journal of Experimental Medicine

Volumn 190, Issue 4, 1999, Pages 471-477

  Lam, Kong Peng ^a   Rajewsky, Klaus ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Allelic inclusion; B 1 cells; B 2 cells; Gene targeting; Immunoglobulin heavy chain

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY;

ALLELE; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; GENE LOCUS; GENE TARGETING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR DENSITY; TRANSGENE;

ALLELES; ANIMALS; B-LYMPHOCYTE SUBSETS; CELL DIFFERENTIATION; GENE TARGETING; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, MUTANT STRAINS; MUTAGENESIS, INSERTIONAL; PERITONEAL CAVITY; READING FRAMES; RECEPTORS, ANTIGEN, B-CELL; SPLEEN;

EID: 0033575778     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.4.471     Document Type: Article

References (27)

1. Herzenberg, L.A., A.M. Stall, P.A. Lalor, C. Sidman, W.A. Moore, D. Parks, and L.A. Herzenberg. 1986. The Ly-1 B cell lineage. Immunol. Rev. 93:81-102.
2. Kantor, A.B., and L.A. Herzenberg. 1993. Origin of murine B cell lineages. Annu. Rev. Immunol. 11:501-538.
3. Lalor, P.A., and G. Morahan. 1990. The peritoneal Ly-1 (CD5) B cell repertoire is unique among murine B cell repertoires. Eur. J. Immunol. 20:485-492.
4. + B cell lymphomas. J. Immunol. 141:2788-2796.
5. Haughton, G., L.W. Arnold, A.C. Whitmore, and S.H. Clarke. 1993. B-1 cells are made, not born. Immunol. Today. 14:84-87.
6. Wortis, H.H. 1992. Surface markers, heavy chain sequences and B cell lineages. Int. Rev. Immunol. 8:235-246.
7. +) B cells that recognize phosphatidyl choline. J. Exp. Med. 169:1869-1877.
8. Arnold, L.W., C.A. Pennell, S.K. McCray, and S.H. Clarke. 1994. Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression. J. Exp. Med. 179:1585-1595.
9. Reth, M., G.J. Hammerling, and K. Rajewsky. 1978. Analysis of the repertoire of anti-NP antibodies in C57B1/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response. Eur. J. Immunol. 8:393-400.
10. Pewzner-Jung, Y., D. Friedmann, E. Sonoda, S. Jung, K. Rajewsky, and D. Eilat. 1998. B cell deletion, anergy, and receptor-editing in "knock-in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain. J. Immunol. 161:4634-4645.
11. Lam, K.-P., R. Kuhn, and K. Rajewsky. 1997. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell. 90:1073-1083.
12. Lam, K.-P., and A.M. Stall. 1994. Major histocompatibility complex class II expression distinguishes two distinct B cell developmental pathways during ontogeny. J. Exp. Med. 180: 507-516.
13. Laird, P.W., A. Zijderveld, K. Linders, M.A. Rudnicki, R. Jaenisch, and A. Berns. 1991. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19:4293.
14. Taki, S., M. Meiering, and K. Rajewsky. 1993. Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus. Science. 262:1268-1271.
15. Sonoda, E., Y. Pewzner-Jung, S. Schwers, S. Taki, S. Jung, D. Eilat, and K. Rajewsky. 1997. B cell development under the condition of allelic inclusion. Immunity. 6:225-233.
16. Pelanda, K., S. Schwers, E. Sonoda, R.M. Torres, D. Nemazee, and K. Rajewsky. 1997. Receptor-editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity. 7:765-775.
17. H region of the immunoglobulin heavy chain locus. Eur. J. Immunol. 25:1888-1896.
18. Chen, C., Z. Nagy, E.L. Prak, and M. Weigert. 1995. Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity. 3:747-755.
19. Cascalho, M., A. Ma, S. Lee, L. Masat, and M. Wabl. 1996. A quasi-monoclonal mouse. Science. 272:1649-1652.
20. - B cells with anti-Ig, but not LPS, induces surface CD5: two B-cell activation pathways. Int. Immunol. 3:467-476.
21. Rickert, R., K. Rajewsky, and J. Roes. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature. 376:352-355.
22. Engel, P., L.J. Zhou, D.C. Ord, R. Sato, B. Koller, and T.F. Tedder. 1995. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity. 3:39-50.
23. Satterthwaite, A.B., Z. Li, and O.N. Witte. 1998. Btk function in B cell development and response. Semin. Immunol. 10: 309-316.
24. Hibbs, M.L., D.M. Tarlinton, J. Armes, D. Grail, G. Hodgson, R. Maglitto, S.A. Stacker, and A.R. Dunn. 1995. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell. 83:301-311.
25. Nishizumi, H., I. Taniuchi, Y. Yamanashi, D. Kitamura, D. Ilic, S. Mori, T. Watanabe, and T. Yamamoto. 1995. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity. 3:549-560.
26. Sidman, C.L., L.D. Shultz. R.R. Hardy, K. Hayakawa, and L.A. Herzenberg. 1986. Production of immunoglobulin isotypes by Ly-1+ B cells in viable motheaten and normal mice. Science. 232:1423-1425.
27. + B cell precursor in B-1 cell differentiation. J. Exp. Med. 187:1325-1334.