Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice

EMBO Journal

Volumn 21, Issue 11, 2002, Pages 2591-2601

  Kallio, Marko ^a   Chang, Yunhua ^a   Manuel, Martine ^a   Alastalo, Tero Pekka ^a   Rallu, Murielle ^a   Gitton, Yorick ^a   Pirkkala, Lila ^a   Loones, Marie Thérèse ^a   Paslaru, Liliana ^a   Larney, Severine ^a   Hiard, Sophie ^a   Morange, Michel ^a   Sistonen, Lea ^a   Mezger, Valérie ^a  

^a ECOLE NORMALE SUPÉRIEURE   (France)

Author keywords

Apoptosis; Brain defects; Defects; Gametogenesis; GametogenesistHSF2; HSF2; Synaptonemal complex

Indexed keywords

HEAT SHOCK FACTOR 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; BRAIN MALFORMATION; CHROMOSOME PAIRING; CONTROLLED STUDY; EMBRYO DEVELOPMENT; FEMALE; MALE; MEIOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SIGNAL TRANSDUCTION; SPERMATOCYTE; SPERMATOGENESIS; SUBFERTILITY; SYNAPTONEMAL COMPLEX;

ALLELES; ANIMALS; APOPTOSIS; BETA-GALACTOSIDASE; BLOTTING, WESTERN; BRAIN; CHROMOSOMES; EMBRYO; FEMALE; FERTILITY; GENETIC VECTORS; GENOTYPE; HEAT-SHOCK PROTEINS; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; INFERTILITY, FEMALE; LAC OPERON; MALE; MEIOSIS; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; OVARY; PROMOTER REGIONS (GENETICS); RECOMBINATION, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX FACTORS; TESTIS; TIME FACTORS; TRANSCRIPTION FACTORS;

ANIMALIA; VERTEBRATA;

EID: 18444415138     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.11.2591     Document Type: Article

References (48)

1. Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium
2. Chromosone synapsis defects and sexually dimorphic meiotic progression in mice lacking Spol I
3. Evidence for the involvement of mouse heat shock factor 1 in the atypical expression of hsp70.1 heat shock gene during mouse zygotic genome activation
4. Maternal effect of Hsfl on reproductive success
5. Kinetics of spermatogenesis in mammals: Seminiferous epithelium cycle and spermatogonia renewal
6. Role of heat shock protein HSP70-2 in spermatogenesis
7. The role of the oocyte in folliculogenesis
8. Complex expression of murine heat shock transcription factors
9. Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice
10. Stage-specific apoptosis of male germ cells in the rat: Mechanism of cell death studied by supravital squash preparations
11. Regulation of protein phosphatase 2A activity by heat shock transcription factor 2
12. Multiple functions of Drosophila heat shock transcription factor in vivo
13. Sequence of the IacZ gene of Escherichia coli
14. 2/M transition
15. An analysis of meiotic impairment and of sex chromosome associations throughout meiosis in XYY mice
16. Genomic structure and chromosomal localization of the mouse Hsf2 gene and promoter sequences
17. Role of the heat-shock response in the life and death of proteins
18. Targeted disruption of heat shock transcription factor I abolishes thermotolerance and protection against heat-inducible apoptosis
19. Heat shock factor 2-like activity in mouse blastocysts
20. Detection of heat shock element-binding activities by gel shift assay during mouse preimplantation development
21. Get to know your stem cells
22. Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1
23. Identification and enzyme quantitation of the stages of the seminiferous epithelial wave in the rat
24. Transillumination phase contrast microscopic techniques for evaluation of male germ cell toxicity and mutagenicity
25. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
26. Targeted disruption of the mouse estrogen sulfotransferase gene reveals a role of estrogen metabolism in intracrine and paracrine estrogen regulation
27. Function and regulation of heat shock factor 2 during mouse embryogenesis
28. The pachytene checkpoint
29. The mouse Spo11 gene is required for meiotic chromosome synapsis
30. Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability
31. Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity and nuclear localization and can occur in the absence of stress
32. Expression of heat shock factor 2 in mouse testis: Potential role as a regulator of heat-shock protein gene expression during spermatogenesis
33. Targeted inactivation of Dp71, the major non-muscle product of the DMD gene: Differential activity of the Dp71 promoter during development
34. Localization of SCP2 and SCP3 protein molecules within synaptonemal complexes of the rat
35. Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2
36. Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos
37. BrdU as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone
38. Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice
39. Distinct roles of PPI and PP2A-like phosphatases in control of microtubule dynamics during mitosis
40. Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure
41. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V
42. Mice lacking HSP90β fail to develop a placental labyrinth
43. Hanging on to your homolog: The roles of pairing, synapsis and recombination in the maintenance of homolog adhesion
44. Heat shock transcription factors: Structure and regulation
45. Growth retardation, female infertility, placental insufficiency and susceptibility to endotoxemia in mice lacking HSF1
46. Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes
47. The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis and male fertility