Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death

Journal of Biological Chemistry

Volumn 281, Issue 14, 2006, Pages 9616-9622

  Westerheide, Sandy D ^a   Kawahara, Tiara L A ^a,b   Orton, Kai ^a   Morimoto, Richard I ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENES; ONCOLOGY; PROTEINS; TISSUE; TUMORS;

CANCER TREATMENTS; STRESS-INDUCED CELL DEATH; TRIMER FORMATION;

CELLS;

CHAPERONE; DITERPENE; DNA; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; TRIPTOLIDE; ANTINEOPLASTIC AGENT; DNA BINDING PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR; PHENANTHRENE DERIVATIVE; TRANSCRIPTION FACTOR;

ADAPTATION; ARTICLE; CELL DEATH; CELL SURVIVAL; DNA BINDING; DRUG ACTIVITY; GENE EXPRESSION; GENE REPRESSION; HEAT SHOCK RESPONSE; HELA CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRESS; TRANSACTIVATION; BIOSYNTHESIS; DRUG EFFECT; GENE EXPRESSION REGULATION; PROMOTER REGION;

ANTINEOPLASTIC AGENTS; CELL DEATH; DITERPENES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HELA CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; PHENANTHRENES; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 33646900838     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512044200     Document Type: Article

References (41)

1. Ciocca, D. R., and Calderwood, S. K. (2005) Cell Stress Chaperones 10, 86-103
2. Pratt, W. B., and Toft, D. O. (2003) Exp. Biol. Med. (Maywood) 228, 111-133
3. Mosser, D. D., and Morimoto, R. I. (2004) Oncogene 23, 2907-2918
4. Whitesell, L., Bagatell, R., and Falsey, R. (2003) Curr. Cancer Drug Targets 3, 349-358
5. Nylandsted, J., Rohde, M., Brand, K., Bastholm, L., Elling, F., and Jaattela, M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 7871-7876
6. Nylandsted, J., Wick, W., Hirt, U. A., Brand, K., Rohde, M., Leist, M., Weller, M., and Jaattela, M. (2002) Cancer Res. 62, 7139-7142
7. Rocchi, P., So, A., Kojima, S., Signaevsky, M., Beraldi, E., Fazli, L., Hurtado-Coll, A., Yamanaka, K., and Gleave, M. (2004) Cancer Res. 64, 6595-6602
8. Wu, B. J., Kingston, R. E., and Morimoto, R. I. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 629-633
9. Wu, B. J., Williams, G. T., and Morimoto, R. I. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 2203-2207
10. Morgan, W. D., Williams, G. T., Morimoto, R. I., Greene, J., Kingston, R. E., and Tjian, R. (1987) Mol. Cell. Biol. 7, 1129-1138
11. Williams, G. T., McClanahan, T. K., and Morimoto, R. I. (1989) Mol. Cell. Biol. 9, 2574-2587
12. Williams, G. T., and Morimoto, R. I. (1990) Mol. Cell. Biol. 10, 3125-3136
13. Pirkkala, L., Nykanen, P., and Sistonen, L. (2001) FASEB J. 15, 1118-1131
14. Westerheide, S. D., and Morimoto, R. I. (2005) J. Biol. Chem. 280, 33097-33100
15. Hoang, A. T., Huang, J., Rudra-Ganguly, N., Zheng, J., Powell, W. C., Rabindran, S. K., Wu, C., and Roy-Burman, P. (2000) Am. J. Pathol. 156, 857-864
16. Khaleque, M. A., Bharti, A., Sawyer, D., Gong, J., Benjamin, I. J., Stevenson, M. A., and Calderwood, S. K. (2005) Oncogene 24, 6564-6573
17. Tang, D., Khaleque, M. A., Jones, E. L., Theriault, J. R., Li, C., Wong, W. H., Stevenson, M. A., and Calderwood, S. K. (2005) Cell Stress Chaperones 10, 46-58
18. Hosokawa, N., Hirayoshi, K., Nakai, A., Hosokawa, Y., Marui, N., Yoshida, M., Sakai, T., Nishino, H., Aoike, A., Kawai, K., and Nagata, K. (1990) Cell Struct. Funct. 15, 393-401
19. Hosokawa, N., Hirayoshi, K., Kudo, H., Takechi, H., Aoike, A., Kawai, K., and Nagata, K. (1992) Mol. Cell. Biol. 12, 3490-3498
20. Nagai, N., Nakai, A., and Nagata, K. (1995) Biochem. Biophys. Res. Commun. 208, 1099-1105
21. Elia, G., Amici, C., Rossi, A., and Santoro, M. G. (1996) Cancer Res. 56, 210-217
22. Hansen, R. K., Oesterreich, S., Lemieux, P., Sarge, K. D., and Fuqua, S. A. (1997) Biochem. Biophys. Res. Commun. 239, 851-856
23. Yokota, S., Kitahara, M., and Nagata, K. (2000) Cancer Res. 60, 2942-2948
24. Lee, K. Y., Chang, W., Qiu, D., Kao, P. N., and Rosen, G. D. (1999) J. Biol. Chem. 274, 13451-13455
25. Qiu, D., Zhao, G., Aoki, Y., Shi, L., Uyei, A., Nazarian, S., Ng, J. C., and Kao, P. N. (1999) J. Biol. Chem. 274, 13443-13450
26. Jiang, X. H., Wong, B. C., Lin, M. C., Zhu, G. H., Kung, H. F., Jiang, S. H., Yang, D., and Lam, S. K. (2001) Oncogene 20, 8009-8018
27. Chang, W. T., Kang, J. J., Lee, K. Y., Wei, K., Anderson, E., Gotmare, S., Ross, J. A., and Rosen, G. D. (2001) J. Biol. Chem. 276, 2221-2227
28. Westerheide, S. D., Bosman, J. D., Mbadugha, B. N., Kawahara, T. L., Matsumoto, G., Kim, S., Gu, W., Devlin, J. P., Silverman, R. B., and Morimoto, R. I. (2004) J. Biol. Chem. 279, 56053-56060
29. Shi, Y., Kroeger, P. E., and Morimoto, R. I. (1995) Mol. Cell. Biol. 15, 4309-4318
30. Mosser, D. D., Theodorakis, N. G., and Morimoto, R. I. (1988) Mol. Cell. Biol. 8, 4736-4744
31. Sarge, K. D., Murphy, S. P., and Morimoto, R. I. (1993) Mol. Cell. Biol. 13, 1392-1407
32. Westin, G., and Schaffner, W. (1988) EMBO J. 7, 3763-3770
33. Holmberg, C. I., Tran, S. E., Eriksson, J. E., and Sistonen, L. (2002) Trends Biochem. Sci. 27, 619-627
34. Solomon, J. M., Rossi, J. M., Golic, K., McGarry, T., and Lindquist, S. (1991) New Biol. 3, 1106-1120
35. Elia, G., De Marco, A., Rossi, A., and Santoro, M. G. (1996) J. Biol. Chem. 271, 16111-16118
36. Wissing, D., and Jaattela, M. (1996) Int. J. Hyperthermia 12, 125-138
37. Mosser, D. D., Caron, A. W., Bourget, L., Denis-Larose, C., and Massie, B. (1997) Mol. Cell. Biol. 17, 5317-5327
38. McMillan, D. R., Xiao, X., Shao, L., Graves, K., and Benjamin, I. J. (1998) J. Biol. Chem. 273, 7523-7528
39. Mason, P. B., Jr., and Lis, J. T. (1997) J. Biol. Chem. 272, 33227-33233
40. Jurivich, D. A., Sistonen, L., Kroes, R. A., and Morimoto, R. I. (1992) Science 255, 1243-1245
41. Cotto, J. J., Kline, M., and Morimoto, R. I. (1996) J. Biol. Chem. 271, 3355-3358