Therapeutic potential of hammerhead ribozymes in the treatment of hyper-proliferative diseases

Current Pharmaceutical Biotechnology

Volumn 5, Issue 4, 2004, Pages 369-386

  Grassi, G ^a,b   Dawson, P ^c   Guarnieri, G ^a   Kandolf, R ^b   Grassi, M ^d  

^a UNIVERSITY HOSPITAL OF TRIESTE   (Italy)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Hammerhead ribozyme; Hyper proliferative diseases

Indexed keywords

ADENOVIRUS VECTOR; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; BINDING PROTEIN; CHITOSAN; CYCLINE; CYTOKINE; FIBROBLAST GROWTH FACTOR; LENTIVIRUS VECTOR; LIPOSOME; LIPOXYGENASE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; NANOPARTICLE; ONCOPROTEIN; PARVOVIRUS VECTOR; PLATELET DERIVED GROWTH FACTOR A; PLEIOTROPHIN; POLYETHYLENEIMINE; POLYMER; PROTEIN BCL 2; PROTEIN C FOS; RETROVIRUS VECTOR; RIBOZYME; RNA; SCATTER FACTOR; SURVIVIN; TELOMERASE; TRANSCRIPTION FACTOR E2F1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VIRUS VECTOR;

APOPTOSIS; ATHEROSCLEROSIS; BACULOVIRUS; BREAST CANCER; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CELL METABOLISM; CELL PROLIFERATION; CHEMOSENSITIVITY; CLINICAL PRACTICE; COLON CANCER; COLON CARCINOMA; CYTOLOGY; DRUG EFFICACY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME STRUCTURE; ERYTHROLEUKEMIA CELL; EYE DISEASE; GENETIC ENGINEERING; GLIOBLASTOMA; GLIOMA; GLOMERULONEPHRITIS; GROWTH INHIBITION; HUMAN; INHIBITION KINETICS; LEUKEMIA; LEWIS CARCINOMA; LIVER CELL CARCINOMA; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; LYMPHOMA; MELANOMA; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OVARY CARCINOMA; PANCREAS CANCER; PARAINFLUENZA VIRUS 1; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PREDICTION; PROSTATE CARCINOMA; RABBIT; RADIOSENSITIVITY; RAT; RESTENOSIS; REVIEW; RHEUMATOID ARTHRITIS; RNA CLEAVAGE; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; STENT; TREATMENT OUTCOME; TUMOR VASCULARIZATION; VIRAL GENE DELIVERY SYSTEM; VITREORETINOPATHY;

ANIMALS; ARTHRITIS, RHEUMATOID; CORONARY RESTENOSIS; DRUG DELIVERY SYSTEMS; GENE SILENCING; GENE THERAPY; GLOMERULONEPHRITIS; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; RNA, CATALYTIC; SEVERITY OF ILLNESS INDEX; VITREORETINOPATHY, PROLIFERATIVE;

EID: 4344664697     PISSN: 13892010     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389201043376760     Document Type: Review

References (198)

1. Scherr, M., Morgan, M. A. and Eder, M. (2003) Curr. Med. Chem. 10(3) 245-256
2. Hutvagner, G. and Zamore, P. D. (2002) Science 297(5589) 2056-2060
3. Kruger, K., Grabowski, P. J., Zaug, A. J., Sands, J., Gottschling, D. E. and Cech, T. R. (1982) Cell 31(1) 147-157
4. Puerta-Fernandez, E., Romero-Lopez, C., Barroso-del Jesus, A. and Berzal-Herranz, A. (2003) FEMS Microbiol. Rev. 27(1) 75-97
5. Grassi, G. and Marini, J. C. (1996) Ann. Med. 28(6) 499-510
6. Uhlenbeck, O. C. (1987) Nature 328(6131) 596-600
7. Haseloff, J. and Gerlach, W. L. (1988) Nature 334(6183) 585-591
8. Birikh, K. R., Heaton, P. A. and Eckstein, F. (1997) Eur. J. Biochem. 245(1) 1-16
9. Symons, R. H. (1992) Annu. Rev. Biochem. 61 641-671
10. Vaish, N. K., Heaton, P. A., Fedorova, O. and Eckstein, F. (1998) Proc. Natl. Acad. Sci. USA 95(5) 2158-2162
11. Dahm, S. C. and Uhlenbeck, O. C. (1991) Biochemistry 30(39) 9464-9469
12. Stage-Zimmermann, T. K. and Uhlenbeck, O. C. (1998) RNA. 4(8) 875-889
13. Zuker, M. and Jacobson, A. B. (1998) RNA 4(6) 669-679
14. Scherr, M., Rossi, J. J., Sczakiel, G. and Patzel, V. (2000) Nucleic Acids Res. 28(13) 2455-2461
15. Amarzguioui, M., Brede, G., Babaie, E., Grotli, M., Sproat, B. and Prydz, H. (2000) Nucleic Acids Res. 28(21) 4113-4124
16. Mercatanti, A., Rainaldi, G., Mariani, L., Marangoni, R. and Citti, L. (2002) J. Comput. Biol. 9(4) 641-653
17. Grassi, G., Grassi, M., Platz, J., Bauriedel, G., Kandolf, R. and Kuhn, A. (2001) Antisense Nucleic Acid Drug Dev. 11(5) 271-287
18. Birikh, K. R., Berlin, Y. A., Soreq, H. and Eckstein, F. (1997) RNA 3(4) 429-437
19. Cairns, M. J., Hopkins, T. M., Witherington, C., Wang, L. and Sun, L. Q. (1999) Nat. Biotechnol. 17(5) 480-486
20. Lima, W. F., Brown-Driver, V., Fox, M., Hanecak, R. and Bruice, T. W. (1997) J. Biol. Chem. 272(1) 626-638
21. Pan, W. H., Xin, P., Bui, V. and Clawson, G. A. (2003) Mol. Ther. 7(1) 129-139
22. Zu, P. J., Yu, Q., Burke, J. M. and Wands, J. R. (1999) J. Virol. 73(7) 5381-5387
23. Jarvis, T. C., Wincott, F. E., Alby, L. J., McSwiggen, .J. A., Beigelman, L., Gustofson, J., DiRenzo, A., Levy, K., Arthur, M., Matulic-Adamic, J., Karpeisky, A., Gonzalez, C., Woolf, T. M., Usman, N. and Stinchcomb, D. T. (1996) J. Biol. Chem. 271(46) 29107-29112
24. Lieber, A. and Strauss, M. (1995) Mol. Cell Biol. 15(1) 540-551
25. Pierce, M. L. and Ruffner, D. E. (1998) Nucleic Acids Res. 26(22) 5093-5101
26. Bramlage, B., Luzi, E. and Eckstein, F. (2000) Nucleic Acids Res. 28(21) 4059-4067
27. Warashina, M., Kuwabara, T., Kato, Y., Sano, M. and Taira, K. (2001) Proc. Natl. Acad. Sci. USA 98(10) 5572-5577
28. Heidenreich, O., Benseler, F., Fahrenholz, A. and Eckstein, F. (1994) J. Biol. Chem. 269(3) 2131-2138
29. Gavin, D. K. and Gupta, K. C. (1997) J. Biol. Chem. 272(3) 1461-1472
30. Grassi, G., Grassi, M., Kuhn, A. and Kandolf, R. (2002) J. Math. Biol. 45(3) 261-277
31. Balicki, D. and Beutler, E. (2002) Medicine (Baltimore) 81(1) 69-86
32. Kurreck, J. (2003) Eur. J. Biochem. 270(8) 1628-1644
33. Eckstein, F. (2000) Antisense Nucleic Acid Drug Dev. 10(2) 117-121
34. Godbey, W. T., Wu, K. K. and Mikos, A. G. (1999) J. Control Release 60(2-3) 149-160
35. Koping-Hoggard, M., Tubulekas, I., Guan, H., Edwards, K., Nilsson, M., Varum, K. M. and Artursson, P. (2001) Gene Ther. 8(14) 1108-1421
36. Borchard, G. (2001) Adv. Drug Deliv. Rev. 52(2) 145-150
37. Liang, L., Liu, D. P. and Liang, C. C. (2002) Eur. J. Biochem. 269(23) 5753-5758
38. Chorny, M., Fishbein, I. and Golomb, G. (2000) Crit. Rev. Ther. Drug Carrier Syst. 17(3) 249-284
39. Ghosh, S., Parvez, M. K., Banerjee, K., Sarin, S. K. and Hasnain, S. E. (2002) Mol. Ther. 6(1) 5-11
40. Hofmann, C., Sandig, V., Jennings, G., Rudolph, M., Schlag, P. and Strauss, M. (1995) Proc. Natl. Acad. Sci. USA 92(22) 10099-10103
41. Sarkis, C., Serguera, C., Petres, S., Buchet, D., Ridet, J. L., Edelman, L. and Mallet, J. (2000) Proc. Natl. Acad. Sci. USA 97(26) 14638-14643
42. Rossi, J. J. (1995) Trends Biotechnol. 13(8) 301-306
43. Bertrand, E., Castanotto, D., Zhou, C., Carbonnelle, C., Lee, N. S,, Good, P., Chatterjee, S., Grange, T., Pictet, R., Kohn, D., Engelke, D. and Rossi, J. J. (1997) RNA. 3(1) 75-88
44. Grassi, G., Maccaroni, P., Meyer, R., Kaiser, H., D'Ambrosio, E., Pascale, E., Grassi, M., Kuhn, A., Di Nardo, P., Kandolf R. and Kupper, J. H. (2003) Carcinogenesis 24(10) 1625-1635
45. Robertson, K. D. (2001) Oncogene 20(24) 3139-3155
46. Marks, P., Rifkind, R. A., Richon, V. M., Breslow, R., Miller, T. and Kelly, W. K. (2001) Nat. Rev. Cancer 1(3) 194-202
47. Duggan, D. J., Bittner, M., Chen, Y., Meltzer, P. and Trent, J. M. (1999) Nat. Genet. 21(1 Suppl.) 10-14
48. Lipshutz, R. J., Fodor, S. P., Gingeras, T. R. and Lockhart, D. J. (1999) Nat. Genet. 21(1 Suppl.) 20-24
49. Kotani, M., Fukuda, N., Ando, H., Hu, W. Y., Kunimoto, S., Saito, S. and Kanmatsuse, K. (2003) Cardiovasc. Res. 57(1) 265-276
50. Edwin Bierman (1994) Atherosclerosis and other forms of arteriosclerosis. In Kurt Isselbacher, Eugene Braunwald, Jean Wilson, Joseph Martin, Anthony Fauci, and Dennis Kasper, editors. Principle of Internal Medcine, McGraw-Hill, New York
51. Ross, R. (1999) N. Engl. J. Med. 340(2) 115-126
52. Califf, R. M. (1995) Am. Heart J 130(3 Pt 2) 680-684
53. Fischman, D. L., Leon, M. B., Baim, D. S., Schatz, R. A., Savage, M. P., Penn, I., Detre, K., Veltri, L., Ricci, D., Nobuyoshi, M. and . (1994) N. Engl. J. Med. 331(8) 496-501
54. Serruys, P. W., de Jaegere, P., Kiemeneij, F., Macaya, C., Rutsch, W., Heyndrickx, G., Emanuelsson. H., Marco, J., Legrand, V., Materne, P. and .(1994) N. Engl. J. Med. 331(8) 489-495
55. Versaci, F., Gaspardone, A., Tomai, F., Crea, F., Chiariello, L. and Gioffre, P. A. (1997) N. Engl. J. Med. 336(12) 817-822
56. Lane, D. M. (1999) Am. J. Cardiol. 84(9) 1141
57. Labinaz, M., Pels, K., Hoffert, C., Aggarwal, S. and O'Brien, E. R. (1999) Cardiovasc. Res. 41(1) 255-266
58. Wijns, W. (1995) Eur. Heart J. 16(10) 1307-1308
59. Edelman, E. R. and Rogers, C. (1998) Am. J. Cardiol. 81(7A) 4E-6E
60. Kearney, M., Pieczek, A., Haley, L., Losordo, D. W., Andres, V., Schainfeld, R., Rosenfield, K. and Isner, J. M. (1997) Circulation 95(8) 1998-2002
61. Bauriedel, G., Schluckebier, S., Hutter, R., Welsch, U., Kandolf, R., Luderitz, B. and Prescott, M. F. (1998) Arterioscler. Thromb. Vasc. Biol. 18(7) 1132-1139
62. Bennett, M. R. (1999) Cardiovasc. Res. 41(2) 361-368
63. Ross, R. (1993) Nature 362(6423) 801-809
64. Landau, C., Lange, R. A. and Hillis, L. D. (1994) N. Engl. J. Med. 330(14) 981-993
65. Herrman, J. P., Hermans, W. R., Vos, J. and Serruys, P. W. (1993) Drugs 46(1) 18-52
66. Hart, C. E., Forstrom, J. W., Kelly, J. D., Seifert, R. A., Smith, R. A., Ross, R., Murray, M. J. and Bowen-Pope, D. F. (1988) Science 240(4858) 1529-1531
67. Nilsson, J., Sjolund, M., Palmberg, L., Thyberg, J. and Heldin, C. H. (1985) Proc. Natl. Acad. Sci. USA 82(13) 4418-4422
68. Yamamoto, K., Morishita, R., Tomita, N., Shimozato, T., Nakagami, H, Kikuchi, A., Aoki, M., Higaki, J., Kaneda, Y. and Ogihara, T. (2000) Circulation 102(11) 1308-1314
69. Nikol, S., Isner, J. M., Pickering, J. G., Kearney, M., Leclerc, G. and Weir, L. (1992) J. Clin. Invest 90(4) 1582-1592
70. Hu, W. Y., Fukuda, N., Kishioka, H., Nakayama, M., Satoh, C. and Kanmatsuse, K. (2001) Atherosclerosis 158(2) 321-329
71. Frimerman, A., Welch, P. J., Jin, X., Eigler, N., Yei, S., Forrester, J., Honda, H., Makkar, R., Barber, J. and Litvack, F. (1999) Circulation 99(5) 697-703
72. Fairman, M. P. (1990) J. Cell Sci. 95(Pt1) 1-4
73. Jarvis, T. C., Alby, L. J., Beaudry, A. A., Wincott, F. E., Beigelman, L., McSwiggen, J. A., Usman, N. and Stinchcomb, D. T. (1996) RNA. 2(5) 419-428
74. Alitalo, K., Winqvist, R., Lin, C. C., de la, C. A., Schwab, M. and Bishop, J. M. (1984) Proc. Natl. Acad. Sci. USA 81(14) 4534-4538
75. Macejak, D. G., Lin, H., Webb, S., Chase, J., Jensen, K., Jarvis, T. C., Leiden, J. M. and Couture, L. (1999) J. Virol. 73(9) 7745-7751
76. Dyson, N. (1998) Genes Dev. 12(15) 2245-2262
77. Ohtsubo, M., Theodoras, A. M., Schumacher, J., Roberts, J. M. and Pagano, M. (1995) Mol. Cell Biol. 15(5) 2612-2624
78. Geng, Y., Eaton, E. N., Picon, M., Roberts, J. M., Lundberg, A. S., Gifford, A., Sardet, C. and Weinberg, R. A. (1996) Oncogene 12(6) 1173-1180
79. Perlman, H., Sata, M., Krasinski, K., Dorai, T., Buttyan, R. and Walsh, K. (2000) Cardiovasc. Res. 45(3) 570-578
80. Gu, J. L., Veerapanane, D., Rossi, J., Natarajan, R., Thomas, L. and Nadler, J. (1995) Circ. Res. 77(1) 14-20
81. Gu, J. L., Pei, H., Thomas, L., Nadler, J. L., Rossi, J. J., Lanting, L. and Natarajan, R. (2001) Circulation 103(10) 1446-1452
82. Pabst, R. and Sterzel, R. B. (1983) Kidney Int. 24(5) 626-631
83. Couser, W. G. (1998) Nephrol. Dial. Transplant. 13 Suppl 1 10-15
84. Kurogi, Y. (2003) Med. Res. Rev. 23(1) 15-31
85. Floege, J., Alpers, C. E., Burns, M. W., Pritzl, P., Gordon, K., Couser, W. G. and Johnson, R. J. (1992) Lab. Invest 66(4) 485-497
86. Lovett, D. H., Johnson, R. J., Marti, H. P., Martin, J., Davies, M. and Couser, W. G. (1992) Am. J. Pathol. 141(1) 85-98
87. Turck, J., Pollock, A. S., Lee, L. K., Marti, H. P. and Lovett, D. H. (1996) J. Biol. Chem. 271(25) 15074-15083
88. Maeshima, Y., Kashihara, N., Yasuda, T., Sugiyama, H, Sekikawa, T., Okamoto, K., Kanao, K., Watanabe, Y., Kanwar, Y. S. and Makino, H. (1998) J. Clin. Invest 101(11) 2589-2597
89. Haas, C. S., Schocklmann, H.O, Lang, S., Kralewski, M. and Sterzel, R. B. (1999) J. Nephrol. 12(6) 405-415
90. Maeshima, Y., Kashihara, N., Sugiyama, H., Makino, H. and Ota, Z. (1996) J. Am. Soc. Nephrol. 7(10) 2219-2229
91. Woessner, J. F., Jr. (1991) FASEB J. 5(8) 2145-2154
92. Marti, H. P., Lee, L., Kashgarian, M. and Lovett, D. H. (1994) Am. J. Pathol. 144(1) 82-94
93. Pope, RM. and Perlman, H. (2000) Rheumatoid Arthritis. In Tsokas, G. and Totowa, editors. Principles of Molecular Rheumatology, Humana Press, New Jersey
94. Pope, R. M. (2002) Nat. Rev. Immunol. 2(7) 527-535
95. Liu, H. and Pope, R. M. (2003) Curr. Opin. Pharmacol. 3(3) 317-322
96. Sugiyama, M., Tsukazaki, T., Yonekura, A., Matsuzaki, S., Yamashita, S. and Iwasaki, K. (1996) Ann. Rheum. Dis. 55(7) 442-449
97. Perlman, H., Georganas, C., Pagliari, L. J., Koch, A. E., Haines, K., III, and Pope, R. M. (2000) J. Immunol. 164(10) 5227-5235
98. (1983) Ophthalmology 90(2) 121-125
99. Frenzel, E. M., Neely, K. A., Walsh, A. W., Cameron, J. D. and Gregerson, D. S. (1998) Invest. Ophthalmol. Vis. Sci. 39(11) 2157-2164
100. Chaum, E. (1995) Int. Ophthalmol. Clin. 35(1) 163-173
101. Glaser, B. and Lemor, M. (1994) Pathobiology of Proliferative Vitreoretinopathy, CV Mosby, St.Louis
102. Glaser, B. and Lemor, M. (1998) In Ryan, S., editor. Retina, Mosby, St. Louis
103. Mandava, N., Blackburn, P., Paul, D. B., Wilson, M. W., Read, S. B., Alspaugh, E., Tritz, R., Barber, J. R., Robbins, J. M. and Kruse, C. A. (2002) Invest. Ophthalmol. Vis. Sci. 43(10) 3338-3348
104. Klein, R., Klein, B. E., Moss, S. E., Davis, M. D. and DeMets, D. L. (1984) Arch. Ophthalmol. 102(4) 520-526
105. (1991) Arch. Ophthalmol. 109(8) 1109-1114
106. Campochiaro, P. A. (2002) Expert. Opin. Biol. Ther. 2(5) 537-544
107. Papetti, M. and Herman, I. M. (2002) Am. J. Physiol. Cell Physiol. 282(5) C947-C970
108. Munnerlyn, C. R., Koons, S. J. and Marshall, J. (1988) J. Cataract. Refract. Surg. 14(1) 46-52
109. Seiler, T. and McDonnell, P. J. (1995) Surv. Ophthalmol. 40(2) 89-118
110. Wilson, S. E. (1991) J. Refract. Surg. 13(2) 171-175
111. Apple, D. J., Solomon, K. D., Tetz, M. R., Assia, E. I., Holland, E. Y., Legler, U. F., Tsai, J. C., Castaneda, V. E., Hoggatt, J. P. and Kostick, A. M. (1992) Surv. Ophthalmol. 37(2) 73-116
112. Kampmeier, J., Behrens, A., Wang, Y., Yee, A., Anderson, W. F., Hall, F. L., Gordon, E. M. and McDonnell, P. J. (2000) Hum. Gene Ther. 11(1) 1-8
113. Scanlon, K. J., Jiao, L., Funato, T., Wang, W., Tone, T., Rossi, J. J. and Kashani-Sabet, M. (1991) Proc. Natl. Acad. Sci. USA 88(23) 10591-10595
114. Weidner, K. M., Arakaki, N., Hartmann, G., Vandekerckhove, J., Weingart, S., Rieder, H., Fonatsch, C., Tsubouchi, H., Hishida, T., Daikuhara, Y. and . (1991) Proc. Natl. Acad. Sci. USA 88(16) 7001-7005
115. Samoto, K., Ikezaki, K., Ono, M., Shono, T., Kohno, K., Kuwano, M. and Fukui, M. (1995) Cancer Res. 55(5) 1189-1193
116. Morino, F., Tokunaga, T., Tsuchida, T., Handa, A., Nagata, J., Tomii, Y., Kijima, H., Yamazaki, H., Watanabe, N.,Matsuzaki, S., Ueyama, Y. and Nakamura, M. (2000) Int. J. Oncol. 17(3) 495-499
117. Kamochi, J., Tokunaga, T., Morino, F., Nagata, J., Tomii, Y., Abe, Y., Hatanaka, H., Kijima, H., Yamazaki, H., Watanabe, N., Matsuzaki, S., Ueyama, Y. and Nakamura, M. (2002) Int. J. Oncol. 21(1) 81-84
118. Ke, L. D., Fueyo, J., Chen, X., Steck, P. A., Shi, Y. X, Im, S. A. and Yung, W. K. (1998) Int. J. Oncol. 12(6) 1391-1396
119. Sioud, M. and Leirdal, M. (2000) Biochem. Pharmacol. 60(8) 1023-1026
120. Oshika, Y., Nakamura, M., Tokunaga, T., Ohnishi, Y., Abe, Y., Tsuchida, T., Tomii, Y., Kijima, H, Yamazaki, H., Ozeki, Y., Tamaoki, N. and Ueyama, Y. (2000) Eur. J. Cancer 36(18) 2390-2396
121. Tokunaga, T., Abe, Y., Tsuchida, T., Hatanaka, H., Oshika, Y., Tomisawa, M., Yoshimura, M., Ohnishi, Y., Kijima, H., Yamazaki, H., Ueyama. Y. and Nakamura, M. (2002) Int. J. Oncol. 21(5) 1027-1032
122. Parry, T. J., Cushman, C., Gallegos, A. M., Agrawal, A. B., Richardson, M., Andrews, L. E., Maloney, L., Mokler, V. R., Wincott, F. E. and Pavco, P. A. (1999) Nucleic Acids Res. 27(13) 2569-2577
123. Pavco, P. A., Bouhana, K. S., Gallegos, A. M., Agrawal, A., Blanchard, K. S., Grimm, S. L., Jensen, K. L., Andrews, L. E., Wincott, F. E., Pitot, P. A., Tressler, R. J., Cushman, C., Reynolds, M. A. and Parry, T. J. (2000) Clin. Cancer Res. 6(5) 2094-2103
124. Weng, D. E. and Usman, N. (2001) Curr. Oncol. Rep. 3(2) 141-146
125. Sandberg, J. A., Bouhana, K. S., Gallegos, A. M., Agrawal, A. B., Grimm, S. L., Wincott, F. E., Reynolds, M. A., Pavco, P. A. and Parry, T. J. (1999) Antisense Nucleic Acid Drug Dev. 9(3) 271-277
126. Sandberg, J. A., Sproul, C. D., Blanchard, K. S., Bellon, L., Sweedler, D., Powell, J. A., Caputo, F. A., Kornbrust, D. J., Parker, V. P., Parry, T. J. and Blatt, L. M. (2000) Antisense Nucleic Acid Drug Dev. 10(3) 153-162
127. Sandberg, J. A., Parker, V. P., Blanchard, K. S., Sweedler, D., Powell, J. A., Kachensky, A., Bellon, L., Usman, N., Rossing, T., Borden, E. and Blatt, L. M. (2000) J. Clin. Pharmacol. 40(12 Pt 2) 1462-1469
128. Sullenger, B. A. and Gilboa, E. (2002) Nature 418(6894) 252-258
129. Souttou, B., Juhl, H.,Hackenbruck, J., Rockseisen, M., Klomp, H. J., Raulais, D., Vigny, M. and Wellstein, A. (1998) J. Natl. Cancer Inst. 90(19) 1468-1473
130. Czubayko, F., Schulte, A. M., Berchem, G. J. and Wellstein, A. (1996) Proc. Natl. Acad. Sci. USA 93(25) 14753-14758
131. Czubayko, F., Riegel, A. T. and Wellstein, A. (1994) J. Biol. Chem. 269(33) 21358-21363
132. Czubayko, F., Downing, S. G., Hsieh, S. S., Goldstein, D. J., Lu, P. Y., Trapnell, B. C. and Wellstein, A. (1997) Gene Ther. 4(9) 943-949
133. Weber, D., Klomp, H. J., Czubayko, F., Wellstein, A. and Juhl, H. (2000) Cancer Res. 60(18) 5284-5288
134. Aigner, A., Fischer, D., Merdan, T., Brus, C., Kissel, T. and Czubayko, F. (2002) Gene Ther. 9(24) 1700-1707
135. Ohnuma, T., Wang, F., Halatsch, M. and Hollonad, J. F. (2000) Cancer Detection and Prevention 24(Supplement 1)
136. Jiang, W. G., Grimshaw, D., Martin, T. A., Davies, G., Parr, C., Watkins, G., Lane, J., Abounader, R., Laterra, J. and Manse], R. E. (2003) Clin. Cancer Res. 9(11) 4274-4281
137. Lamszus, K., Laterra, J., Westphal, M. and Rosen, E. M. (1999) Int. J. Dev. Neurosci. 17(5-6) 517-530
138. Abounader, R., Ranganathan, S., Lal, B., Fielding, K., Book, A., Dietz, H, Burger, P. and Laterra, J. (1999) J. Natl. Cancer Inst, 91(18) 1548-1556
139. Abounader, R., Lal, B., Luddy, C., Koe, G., Davidson, B., Rosen, E. M. and Laterra, J. (2002) FASEB J. 16(1) 108-110
140. Jiang, W. G., Grimshaw, D., Lane, J., Martin, T. A., Abounader, R., Laterra, J., Mansel, R. E. and Abounder, R. (2001) Clin. Cancer Res. 7(8) 2555-2562
141. Herynk, M. H., Stoeltzing, O., Reinmuth, N., Parikh, N. U., Abounader, R., Laterra, J., Radinsky, R.., Ellis, L. M. and Gallick, G. E. (2003) Cancer Res. 63(11) 2990-2996
142. Liu, C., Sun, L. Q. and Tien, P. (2000) Cancer Gene Ther. 7(5) 671-675
143. Hatley, M. E., Srinivasan, S., Reilly, K. B., Bolick, D. T. and Hedrick, C. C. (2003) J. Biol. Chem. 278(28) 25369-25375
144. Czubayko, F., Liaudet-Coopman, E. D., Aigner, A., Tuveson, A. T., Berchem, G. J. and Wellstein, A. (1997) Nat. Med. 3(10) 1137-1140
145. Aigner, A., Renneberg, H., Bojunga, J., Apel, J., Nelson, P. S. and Czubayko, F. (2002) Oncogene 21(37) 5733-5742
146. Dorai, T., Olsson, C. A., Katz, A. E. and Buttyan, R. (1997) Prostate 32(4) 246-258
147. Dorai, T., Perlman, H., Walsh, K., Shabsigh, A., Goluboff, E. T., Olsson, C. A. and Buttyan, R. (1999) Int. J. Cancer 82(6) 846-852
148. Dorai, T., Goluboff, E. T., Olsson, C. A. and Buttyan, R. (1997) Anticancer Res. 17(5A) 3307-3312
149. Pennati, M,, Binda, M., Colella, G., Folini, M., Citti, L., Villa, R., Daidone, M. G. and Zaffaroni, N. (2003) J. Invest. Dermatol. 120(4) 648-654
150. Grossman, D., McNiff, J. M., Li, F. and Altieri, D. C. (1999) J. Invest. Dermatol. 113(6) 1076-1081
151. Scanlon, K. J., Ishida, H. and Kashani-Sabet, M. (1994) Proc. Natl. Acad. Sci. USA 91(23) 11123-11127
152. Funato, T., Ishii, T., Kanbe, M., Scanlon, K. J. and Sasaki, T. (1997) In Vivo 11(3) 217-220
153. Daly, C., Coyle, S., McBride, S., O'Driscoll, L., Daly, N., Scanlon, K. and Clynes, M. (1996) Cytotechnology, 19(3) 199-205
154. Kobayashi, H., Dorai, T., Holland, J. F. and Ohnuma, T. (1994) Cancer Res. 54(5) 1271-1275
155. Masuda, Y., Kobayashi, H., Holland, J. F. and Ohnuma, T. (1998) Cancer Chemother. Pharmacol. 42(1) 9-16
156. Nagata, J., Kijima, H., Hatanaka, H., Asai, S., Miyachi, H., Abe, Y., Yamazaki, H., Nakamura, M., Watanabe, N., Mine, T., Kondo, T., Scanlon, K. J. and Ueyama, Y. (2002) Int. J. Oncol. 21(5) 1021-1026
157. Osada, H., Tokunaga, T., Abe, Y., Asai, S., Miyachi, H., Hatanaka, H., Tsugu, A., Kijima, H., Yamazaki, H., Shima, K., Ueyama, Y., Osamura, Y. and Nakamura, M. (2003) Int. J. Oncol. 22(4) 823-827
158. Wang, F. S., Kobayashi, H., Liang, K. W., Holland, J. F. and Ohnuma, T. (1999) Hum. Gene Ther. 1O(7) 1185-1195
159. Hatanaka, H., Abe, Y., Naruke, M., Asai, S., Miyachi, H., Kawakami, T., Nagata, J., Kamochi, J., Kijima, H., Yamazaki, H., Scanlon, K. J,, Ueyama, Y. and Nakamura, M. (2001) Anticancer Res. 21(2A) 879-885
160. Shay, J. W. and Wright, W. E. (2002) Cancer Cell 2(4) 257-265
161. White, L. K., Wright, W. E. and Shay. J. W. (2001) Trends Biotechnol. 19(3) 114-120
162. Folini, M., Pennati, M. and Zaffaroni, N. (2002) Curr. Med. Chem. Anti. -Canc. Agents 2(5) 605-612
163. Zaffaroni, N., Villa, R., Pennati, M. and Folini, M. (2003) Mini. Rev. Med. Chem. 3(1) 51-60
164. Kanazawa, Y., Ohkawa, K., Ueda, K., Mita, E., Takehara, T., Sasaki, Y., Kasahara, A. and Hayashi, N. (1996) Biochem. Biophys. Res. Commun. 225(2) 570-576
165. Wan, M. S., Fell, P. L. and Akhtar, S. (1998) Antisense Nucleic Acid Drug Dev. 8(4) 309-317
166. Yokoyama, Y., Takahashi, Y., Shinohara, A., Lian, Z., Wan, X., Niwa, K. and Tamaya, T. (1998) Cancer Res. 58(23) 5406-5410
167. Yokoyama, Y., Wan, X., Shinohara, A., Takahashi, Y. and Tamaya, T. (2001) Hum. Cell 14(3) 223-231
168. Yokoyama, Y., Wan, X., Takahashi, Y., Shinohara, A., Liulin, T. and Tamaya, T. (2002) Arch. Biochem. Biophys. 405(1) 32-37
169. Folini, M., Colella, G., Villa, R., Lualdi, S., Daidone, M. G. and Zaffaroni, N.(2000) J. Invest. Dermatol. 114(2) 259-267
170. Folini, M., De Marco, C., Orlandi, L., Daidone, M. G. and Zaffaroni, N. (2000) Eur. J. Cancer 36(16) 2137-2145
171. Villa, R., Folini, M., Porta, C. D., Valentini, A., Pennati, M., Daidone, M. G. and Zaffaroni, N. (2003) Carcinogenesis 24(5) 851-859
172. Yokoyama, Y., Takahashi, Y., Shinohara, A., Wan, X., Takahashi, S., Niwa, K. and Tamaya, T. (2000) Biochem. Biophys. Res. Commun. 273(1) 316-321
173. Hao, Z. M., Luo, J. Y., Cheng, J., Wang, Q. Y. and Yang, G. X. (2003) World J. Gastroenterol. 9(1) 104-107
174. Ludwig, A., Saretzki, G., Holm, P. S., Tiemann, F., Lorenz, M., Emrich, T., Harley, C. B. and von Zglinicki, T. (2001) Cancer Res. 61(7) 3053-3061
175. Saretzki, G., Ludwig, A., von Zglinicki, T. and Runnebaum, I. B. (2001) Cancer Gene Ther. 8(10) 827-834
176. Shore, S. K., Nabissa, P. M. and Reddy, E. P. (1993) Oncogene 8(11) 3183-3188
177. Leopold, L. H., Shore, S. K., Newkirk, T. A., Reddy, R. M. and Reddy, E. P. (1995) Blood 85(8) 2162-2170
178. Snyder, D. S., Wu, Y., Wang, J. L., Rossi, J. J., Swiderski, P., Kaplan, B. E. and Forman, S. J. (1993) Blood 82(2) 600-605
179. Kato, Y., Kuwabara, T., Toda, H., Warashina, M. and Taira, K. (2000) Nucleic Acids Symp. Ser. (44) 283-284
180. Scherr, M., Grez, M., Ganser, A. and Engels, J. W. (1997) J. Biol. Chem. 272(22) 14304-14313
181. Wiechen, K., Zimmer, C. and Dietel, M. (1998) Cancer Gene Ther. 5(1) 45-51
182. Funato, T., Ishii, T., Kambe, M., Scanlon, K. .J. and Sasaki, T. (2000) Cancer Gene Ther. 7(3) 495-500
183. Cheng, J., Luo, J., Zhang, X, Hu, J., Hui, H., Wang, C. and Stern, A. (2000) Cancer Gene Ther. 7(3) 407-412
184. Scherr, M., Maurer, A. B., Klein, S., Ganser, A., Engels, J. W. and Grez, M. (1998) Gene Ther. 5(9) 1227-1234
185. Tokunaga, T., Tsuchida, T., Kijima, H., Okamoto, K., Oshika, Y., Sawa, N., Ohnishi, Y., Yamazaki, H., Miura, S., Ueyama, Y. and Nakamura, M. (2000) Br. J. Cancer 83(6) 833-839
186. Tsuchida, T., Kijima, H., Oshika, Y., Tokunaga, T., Abe, Y., Yamazaki, H., Tamaoki, N., Ueyama, Y., Scanlon, K. J. and Nakamura, M. (1998) Biochem. Biophys. Res. Commun. 253(2) 368-373
187. Kashani-Sabet, M., Funato, T., Florenes, V. A., Fodstad, O. and Scanlon, K. J. (1998) Cancer Res. 54(4) 900-902
188. Ohta, Y., Kijima, H., Kashani-Sabet, M. and Scanlon, K. J. (1996) J. Invest. Dermatol. 106(2) 275-280
189. Irie, A., Anderegg, B., Kashani-Sabet, M., Ohkawa, T., Suzuki, T., Halks-Miller, M., Curiel, D. T. and Scanlon, K. J. (1999) Antisense Nucleic Acid Drug Dev. 9(4) 341-349
190. Wang, C. H., Tsai, L. J., Tsao, Y. P., Hsieh, J. T., Chien, W. W., Liao, C. L., Wang, H. W., Liu, H. S. and Chen, S. L. (2002) Biochem. Biophys. Res. Commun. 298(5) 805-814
191. Suzuki, T., Anderegg, B., Ohkawa, T., Irie, A., Engebraaten, O., Halks-Miller, M., Holm, P. S., Curie], D. T., Kashani-Sabet, M. and Scanlon, K. J. (2000) Gene Ther. 7(3) 241-248
192. Luo, X., Gong, X. and Tang, C. K. (2003) Int. J. Cancer 104(6) 716-721
193. Yamazaki, H., Kijima, H., Ohnishi, Y., Abe, Y., Cshika, Y., Tsuchida, T., Tokunaga, T., Tsugu, A., Ueyama, Y., Tamaoki, N. and Nakamura, M. (1998) J. Natl. Cancer Inst. 90(8) 581-587
194. Dancey, J. E. and Schoenfeldt, M. (2003) Oncology (Huntingt) 17(6) 819, 826-4
195. Hubinger, G., Wehnes, E., Xue, L., Morris, S. W. and Maurer, U. (2003) Exp. Hematol. 31(3) 226-233
196. Guo, N., Ye, J. J., Liang, S. J., Mineo, R., Li, S. L., Giannini, S., Plymate, S. R., Sikes, R. A. and Fujita-Yamaguchi, Y. (2003) Growth Horm. IGF. Res. 13(1) 44-53
197. Kashani-Sabet, M., Liu, Y., Fong, S., Desprez, P. Y., Liu, S., Tu, G., Nosrati, M., Handumrongkul, C., Liggitt, D., Thor, A. D. and Debs, R. J. (2002) Proc. Natl. Acad. Sci. USA 99(6) 3878-3883
198. Ivorra, C., Samyn, H., Edo, M. D., Castro, C., Sanz-Gonzalez, S. M., Deez-Juan, A. and Andres, V. (2003) Curr. Pharm. Biotechnol. 4(1) 21-37