Chimeric DNA-RNA hammerhead ribozyme to proliferating cell nuclear antigen reduces stent-induced stenosis in a porcine coronary model

Circulation

Volumn 99, Issue 5, 1999, Pages 697-703

  Frimerman, Aaron ^a   Welch, Peter J ^b   Jin, Xiaomei ^b   Eigler, Neal ^a   Yei, Soonpin ^b   Forrester, James ^a   Honda, Hidehiko ^a   Makkar, Raj ^a   Barber, Jack ^b   Litvack, Frank ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Immusol Inc   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Oligonucleotides; Restenosis; RNA, catalytic; Stents

Indexed keywords

CELL NUCLEUS ANTIGEN; OLIGONUCLEOTIDE; RIBOZYME; RNA;

ANGIOCARDIOGRAPHY; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHIMERA; CORONARY ARTERY OBSTRUCTION; CORONARY STENT; DNA RNA HYBRIDIZATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTIMA; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RESTENOSIS; SEQUENCE HOMOLOGY; SMOOTH MUSCLE FIBER; SWINE;

EID: 0033537484     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.99.5.697     Document Type: Article

References (28)

1. Rensing BJ, Hermans WRM, Beatt KJ, Laarman GJ, Surapranata H, van den Brand M, de Feyter PJ, Serruys PW. Quantitative angiographic assessment of elastic recoil after percutaneous transluminal coronary angiography. Am J Cardiol. 1990;66:1039-1044.
2. Kimura T, Kaburagi S, Tamura T, Yokoi H, Nakagawa Y, Hamasaki N, Nosaka H, Nobuyoshi M, Mintz GS, Popma JJ, Leon MB. Remodeling of human coronary arteries undergoing coronary angioplasty or atherectomy. Circulation. 1997;96:475-483.
3. Garratt K, Edwards W, Kaufmann U, Vlietstra R, Holmes D. Differential histopathology of primary atherosclerotic and restenotic lesions in coronary arteries and saphenous vein bypass grafts: analysis of tissue obtained from 73 patients by directional atherectomy. J Am Coll Cardiol. 1991; 17:442-448.
4. Schwartz RS, Huber KC, Murphy JG, Edwards WD, Camrud AR, Vlietstra RE, Holmes DR. Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model. J Am Coll Cardiol. 1992;19:267-274.
5. Fischman DL, Leon MB, Baim DS, Schatz RA, Savage MP, Penn I, Detre K, Veltri L, Ricci D, Nobuyoshi M, Cleman M, Heuser R, Almond D, Teirstein PS, Fish RD, Colombo A, Brinker J, Moses J, Shaknovich A, Hirshfeld J, Bailey S, Ellis S, Rake R, Goldberg S. A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary artery disease. N Engl J Med. 1994;331:496-501.
6. Serruys P, de Jaegere P, Kiemeneij F, Macaya C, Rutsch W, Heyndrickx G, Emanuelsson H, Marco J, Legrand V, Materne P, Belardi J, Sigwart U, Colombo A, Goy JJ, van den Heuvel P, Delcan J, Morel M. A comparison of balloon expandable stent implantation with balloon angioplasty in patients with coronary artery disease. N Engl J Med. 1994;331:489-495.
7. Forrester JS, Fishbein M, Helfant R, Fagin J. A paradigm for restenosis based on cell biology: clues for the development of new preventive therapies. J Am Coll Cardiol. 1991;17:758-769.
8. Jackson C, Schwartz S. Pharmacology of smooth muscle cell replication. Hypertension. 1992;20:713-736.
9. Libby P, Schwartz D, Brogi E, Tanaka H, Clinton S. A cascade model for restenosis. Circulation. 1992;86(suppl III):III-47-III-52.
10. Fairman MP. DNA polymerase delta/PCNA: actions and interactions. J Cell Sci. 1990;95:1-4.
11. Jaskulski D, deRiel JK, Mercer WE, Calabretta B, Baserga R. Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin. Science. 1988;240:1544-1546.
12. Liu YC, Marraccino RL, Keng PC, Bambara RA, Lord EM, Chou WG, Zain SB. Requirement for proliferating cell nuclear antigen expression during stages of the Chinese hamster ovary cell cycle. Biochemistry. 1989;28:2967-2974.
13. Xiong Y, Zhang H, Beach D. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell. 1992;71:505-514.
14. Szepesi A, Gelfand EW, Lucas JJ. Association of proliferating cell nuclear antigen with cyclin-dependent kinases and cyclins in normal and transformed human T lymphocytes. Blood. 1994;84:3413-3421.
15. Li R, Waga S, Hannon GJ, Beach D, Stillman B. Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature. 1994;371:534-537.
16. Waga S, Hannon GJ, Beach D, Stillman B. The p21 inhibitor of cyclindependent kinases control DNA replication by interaction with PCNA. Nature. 1994;369:574-578.
17. Flores-Rozas H, Kelman Z, Dean FB, Pan ZQ, Harper JW, Elledge SJ, O'Donnell M, Hurwitz J. CDK-interacting protein I directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. Proc Natl Acad Sci U S A. 1994;91:8655-8659.
18. Luo Y, Hurwitz J, Massague J. Cell-cycle inhibition by independent CDK and PCNA binding domains in p21cipl. Nature. 1995;375:159-161.
19. Wei GL, Krasinki K, Kearney M, Isner JM, Walsh K, Andres V. Temporally and spatially coordinated expression of cell cycle regulatory factors after angioplasty. Circ Res. 1997;80:418-426.
20. Speir E, Epstein SE. Inhibition of smooth muscle cell proliferation by an antisense oligodeoxynucleotide targeting the messenger RNA encoding proliferating cell nuclear antigen. Circulation. 1992;86:538-547.
21. Kaneda Y, Morishita R, Dzau VJ. Prevention of restenosis by gene therapy. Ann N Y Acad Sci. 1997;811:299-308.
22. Simons M, Edelman E, Rosenberg R. Antisense proliferating cell nuclear antigen oligonucleotides inhibit intimal hyperplasia in a rat carotid artery injury model. J Clin Invest. 1994;93:2351-2356.
23. Maeshima Y, Kashihara N, Sugiyama H, Makino H, Ota Z. Antisense oligonucleotides to proliferating cell nuclear antigen and Ki-67 inhibit human mesangial cell proliferation. J Am Soc Nephrol. 1996;7: 2219-2229.
24. Morita Y, Kashihara N, Yamamura M, Okamoto H, Harada S, Maeshima Y, Okamoto K, Makino H. Inhibition of rheumatoid synovial fibroblast proliferation by antisense oligonucleotides targeting proliferation cell nuclear antigen messenger RNA. Arthritis Rheum. 1997;40:1292-1297.
25. Sakakura C, Hagiwara A, Tsujimoto H, Ozaki K, Sakakibara T, Oyama T, Ogaki M, Takahashi T. The anti-proliferative effect of proliferating cell nuclear antigen-specific antisense oligonucleotides on human gastric cancer cell lines. Surg Today. 1995;25:184-186.
26. Karas SP, Gravanis MB, Santoian EC, Robinson KA, Anderberg KA, King SB III. Coronary intimai proliferation after balloon injury and stenting in swine: an animal model of restenosis. J Am Coll Cordial. 1992;20:467-474.
27. Taylor NR, Kaplan DE, Swidersk P, Li H, Rossi JJ. Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo. Nucleic Acids Res. 1992; 20:4559-4564.
28. Gu JL, Veerapanane D, Rossi J, Natarajan R, Thomas L, Nadler J. Ribozyme-mediated inhibition of expression of leukocyte-type 12-lipoxygenase in porcine aortic vascular smooth muscle cells. Circ Res. 1995;77:14-20.