메뉴 건너뛰기




Volumn 4, Issue 8, 1998, Pages 875-889

Hammerhead ribozyme kinetics

Author keywords

Catalytic RNA; RNA conformations

Indexed keywords

RIBOZYME;

EID: 0031828144     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838298980876     Document Type: Review
Times cited : (190)

References (107)
  • 1
    • 0028004021 scopus 로고
    • Global conformation of a self-cleaving hammerhead RNA
    • Amiri KMA, Hagerman PJ. 1994. Global conformation of a self-cleaving hammerhead RNA. Biochemistry 33:13172-13177.
    • (1994) Biochemistry , vol.33 , pp. 13172-13177
    • Amiri, K.M.A.1    Hagerman, P.J.2
  • 2
    • 0028007870 scopus 로고
    • Sequence-specific cleavage of HIV mRNA by a ribozyme mimic
    • Bashkin JK, Frolava EI, Sampath US. 1994. Sequence-specific cleavage of HIV mRNA by a ribozyme mimic. J Am Chem Soc 116:5981-5982.
    • (1994) J Am Chem Soc , vol.116 , pp. 5981-5982
    • Bashkin, J.K.1    Frolava, E.I.2    Sampath, U.S.3
  • 4
    • 0029903452 scopus 로고    scopus 로고
    • The ion-induced folding of the hammerhead ribozyme: Core sequence changes that perturb folding into the active conformation
    • Bassi GS, Murchie AIH, Lilley DM. 1996. The ion-induced folding of the hammerhead ribozyme: Core sequence changes that perturb folding into the active conformation. RNA 2:756-768.
    • (1996) RNA , vol.2 , pp. 756-768
    • Bassi, G.S.1    Murchie, A.I.H.2    Lilley, D.M.3
  • 5
    • 0027930184 scopus 로고
    • A kinetic mechanism for cleavage of precursor tRNA(Asp) catalyzed by the RNA component of Bacillus subtilis ribonuclease P
    • Beebe JA, Fierke CA. 1994. A kinetic mechanism for cleavage of precursor tRNA(Asp) catalyzed by the RNA component of Bacillus subtilis ribonuclease P. Biochemistry 33:10294-10304.
    • (1994) Biochemistry , vol.33 , pp. 10294-10304
    • Beebe, J.A.1    Fierke, C.A.2
  • 6
    • 0030939002 scopus 로고    scopus 로고
    • The structure, function and application of the hammerhead ribozyme
    • Birikh KR, Heaton PA, Eckstein F. 1997. The structure, function and application of the hammerhead ribozyme. Eur J Biochem 245: 1-16.
    • (1997) Eur J Biochem , vol.245 , pp. 1-16
    • Birikh, K.R.1    Heaton, P.A.2    Eckstein, F.3
  • 8
    • 0028675028 scopus 로고
    • A DNA enzyme that cleaves RNA
    • Breaker RR, Joyce GF. 1994. A DNA enzyme that cleaves RNA. Chem Biol 1:223-239.
    • (1994) Chem Biol , vol.1 , pp. 223-239
    • Breaker, R.R.1    Joyce, G.F.2
  • 9
    • 0028983570 scopus 로고
    • A DNA enzyme with Mg(2+)-dependent RNA phosphoesterase activity
    • Breaker RR, Joyce GF. 1995. A DNA enzyme with Mg(2+)-dependent RNA phosphoesterase activity. Chem Biol 2:655-660.
    • (1995) Chem Biol , vol.2 , pp. 655-660
    • Breaker, R.R.1    Joyce, G.F.2
  • 11
    • 0028881857 scopus 로고
    • An oligodeoxyribonucleotide that supports catalytic activity in the hammerhead ribozyme domain
    • Chartrand P, Harvey SC, Ferbeyre C, Usman N, Cedergren R. 1995. An oligodeoxyribonucleotide that supports catalytic activity in the hammerhead ribozyme domain. Nucleic Acids Res 23:4092-4096.
    • (1995) Nucleic Acids Res , vol.23 , pp. 4092-4096
    • Chartrand, P.1    Harvey, S.C.2    Ferbeyre, C.3    Usman, N.4    Cedergren, R.5
  • 12
    • 0030612499 scopus 로고    scopus 로고
    • 2+ binding, and functional group modification in the hammerhead ribozyme
    • 2+ binding, and functional group modification in the hammerhead ribozyme [letter]. RNA 3:692-696.
    • (1997) RNA , vol.3 , pp. 692-696
    • Chartrand, P.1    Leclerc, F.2    Cedergren, R.3
  • 13
    • 0029312926 scopus 로고
    • Branch-point attack in group II introns is a highly reversible transesterification, providing a potential proofreading mechanism for 5′-splice site selection
    • Chin K, Pyle AM. 1995. Branch-point attack in group II introns is a highly reversible transesterification, providing a potential proofreading mechanism for 5′-splice site selection. RNA 1:391-406.
    • (1995) RNA , vol.1 , pp. 391-406
    • Chin, K.1    Pyle, A.M.2
  • 14
    • 0027473887 scopus 로고
    • Ionic requirements for RNA binding, cleavage, and ligation by the hairpin ribozyme
    • Chowrira BM, Berzal HA, Burke JM. 1993. Ionic requirements for RNA binding, cleavage, and ligation by the hairpin ribozyme. Biochemistry 32:1088-1095.
    • (1993) Biochemistry , vol.32 , pp. 1088-1095
    • Chowrira, B.M.1    Berzal, H.A.2    Burke, J.M.3
  • 15
    • 0029042615 scopus 로고
    • Ribozymes as human therapeutic agents
    • Christoffersen RE, Marr JJ. 1995. Ribozymes as human therapeutic agents. J Med Chem 38:2023-2037.
    • (1995) J Med Chem , vol.38 , pp. 2023-2037
    • Christoffersen, R.E.1    Marr, J.J.2
  • 16
    • 0029853428 scopus 로고    scopus 로고
    • Kinetic characterization of two I/II format hammerhead ribozymes
    • Clouet-d'Orval B, Uhlenbeck OC. 1996. Kinetic characterization of two I/II format hammerhead ribozymes. RNA 2:483-491.
    • (1996) RNA , vol.2 , pp. 483-491
    • Clouet-D'Orval, B.1    Uhlenbeck, O.C.2
  • 17
    • 0027732494 scopus 로고
    • Evidence for the role of solvated metal hydroxide in the hammerhead cleavage mechanism
    • Dahm SC, Derrick WB, Uhlenbeck OC. 1993. Evidence for the role of solvated metal hydroxide in the hammerhead cleavage mechanism. Biochemistry 32:13040-13045.
    • (1993) Biochemistry , vol.32 , pp. 13040-13045
    • Dahm, S.C.1    Derrick, W.B.2    Uhlenbeck, O.C.3
  • 18
    • 0025998488 scopus 로고
    • Role of divalent metal ions in the hammerhead RNA cleavage reaction
    • Dahm SC, Uhlenbeck OC. 1991. Role of divalent metal ions in the hammerhead RNA cleavage reaction. Biochemistry 30:9464-9469.
    • (1991) Biochemistry , vol.30 , pp. 9464-9469
    • Dahm, S.C.1    Uhlenbeck, O.C.2
  • 19
    • 0027290463 scopus 로고
    • Cleavage of full-length BAPP mRNA by hammerhead ribozymes
    • Denman RB. 1993. Cleavage of full-length BAPP mRNA by hammerhead ribozymes. Nucleic Acids Res 21:4119-4125.
    • (1993) Nucleic Acids Res , vol.21 , pp. 4119-4125
    • Denman, R.B.1
  • 20
    • 0025265468 scopus 로고
    • Substrate sequence effects on hammerhead RNA catalytic efficiency
    • Fedor MJ, Uhlenbeck OC. 1990. Substrate sequence effects on hammerhead RNA catalytic efficiency. Proc Natl Acad Sci USA 87:1668-1672.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1668-1672
    • Fedor, M.J.1    Uhlenbeck, O.C.2
  • 21
    • 0026620322 scopus 로고
    • Kinetics of intermolecular cleavage by hammerhead ribozymes
    • Fedor MJ, Uhlenbeck OC. 1992. Kinetics of intermolecular cleavage by hammerhead ribozymes. Biochemistry 31:12042-12054.
    • (1992) Biochemistry , vol.31 , pp. 12042-12054
    • Fedor, M.J.1    Uhlenbeck, O.C.2
  • 22
    • 0032472205 scopus 로고    scopus 로고
    • Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb
    • Feig AL, Scott WG, Uhlenbeck OC. 1998. Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb. Science 279:81-84.
    • (1998) Science , vol.279 , pp. 81-84
    • Feig, A.L.1    Scott, W.G.2    Uhlenbeck, O.C.3
  • 24
    • 0023663396 scopus 로고
    • Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active site
    • Forster AC, Symons RH. 1987a. Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active site. Cell 49:211-220.
    • (1987) Cell , vol.49 , pp. 211-220
    • Forster, A.C.1    Symons, R.H.2
  • 25
    • 0023643095 scopus 로고
    • Self-cleavage of virusoid RNA is performed by the proposed 55 nucleotide active site
    • Forster AC, Symons RH. 1987b. Self-cleavage of virusoid RNA is performed by the proposed 55 nucleotide active site. Cell 50:9-16.
    • (1987) Cell , vol.50 , pp. 9-16
    • Forster, A.C.1    Symons, R.H.2
  • 26
    • 0026532114 scopus 로고
    • Importance of specific purine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme
    • Fu DJ, McLaughlin LW. 1992. Importance of specific purine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme. Proc Natl Acad Sci USA 89:3985-3989.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3985-3989
    • Fu, D.J.1    McLaughlin, L.W.2
  • 27
    • 0027971380 scopus 로고
    • Activity of the hammerhead ribozyme upon inversion of the stereocenters for the guanosine 2'-hydroxyls
    • Fu DJ, Rajur SB, McLaughlin LW. 1994. Activity of the hammerhead ribozyme upon inversion of the stereocenters for the guanosine 2'-hydroxyls. Biochemistry 33:13903-13909.
    • (1994) Biochemistry , vol.33 , pp. 13903-13909
    • Fu, D.J.1    Rajur, S.B.2    McLaughlin, L.W.3
  • 28
    • 0026664707 scopus 로고
    • Enhancement of ribozyme catalytic activity by a contiguous oligodeoxynucleotide (facilitator) and by 2′-O-methylation
    • Goodchild J. 1992. Enhancement of ribozyme catalytic activity by a contiguous oligodeoxynucleotide (facilitator) and by 2′-O-methylation. Nucleic Acids Res 20:4607-4612.
    • (1992) Nucleic Acids Res , vol.20 , pp. 4607-4612
    • Goodchild, J.1
  • 29
    • 0027432918 scopus 로고
    • The synthesis of oligoribonucleotides containing O6-methylguanosine: The role of conserved guanosine residues in hammerhead ribozyme cleavage
    • Grasby JA, Butler PJG, Gait MJ. 1993. The synthesis of oligoribonucleotides containing O6-methylguanosine: The role of conserved guanosine residues in hammerhead ribozyme cleavage. Nucleic Acids Res 21:4444-4450.
    • (1993) Nucleic Acids Res , vol.21 , pp. 4444-4450
    • Grasby, J.A.1    Butler, P.J.G.2    Gait, M.J.3
  • 30
    • 0028855671 scopus 로고
    • Efficient trans-cleavage of a stem-loop RNA substrate by a ribozyme derived from Neurospora VS RNA
    • Guo HC, Collins RA. 1995. Efficient trans-cleavage of a stem-loop RNA substrate by a ribozyme derived from Neurospora VS RNA. EMBO J 14:368-376.
    • (1995) EMBO J , vol.14 , pp. 368-376
    • Guo, H.C.1    Collins, R.A.2
  • 31
    • 0024291288 scopus 로고
    • Simple RNA enzymes with new and highly specific endoribonuclease activities
    • Haseloff J, Gerlach WL. 1988. Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature 334:585-591.
    • (1988) Nature , vol.334 , pp. 585-591
    • Haseloff, J.1    Gerlach, W.L.2
  • 32
    • 0028837570 scopus 로고
    • Kinetics and thermodynamics of intermolecular catalysis by hairpin ribozymes
    • Hegg LA, Fedor MJ. 1995. Kinetics and thermodynamics of intermolecular catalysis by hairpin ribozymes. Biochemistry 34:15813-15828.
    • (1995) Biochemistry , vol.34 , pp. 15813-15828
    • Hegg, L.A.1    Fedor, M.J.2
  • 33
    • 0026542605 scopus 로고
    • Hammerhead ribozyme-mediated cleavage of the long terminal repeat RNA of human immunodeficiency virus type 1
    • Heidenreich O, Eckstein F. 1992. Hammerhead ribozyme-mediated cleavage of the long terminal repeat RNA of human immunodeficiency virus type 1. J Biol Chem 267:1904-1909.
    • (1992) J Biol Chem , vol.267 , pp. 1904-1909
    • Heidenreich, O.1    Eckstein, F.2
  • 35
    • 0029945037 scopus 로고    scopus 로고
    • Unexpected anisotropy in substrate cleavage rates by asymmetric hammerhead ribozymes
    • Hendry P, McCall M. 1996. Unexpected anisotropy in substrate cleavage rates by asymmetric hammerhead ribozymes. Nucleic Acids Res 24:2679-2684.
    • (1996) Nucleic Acids Res , vol.24 , pp. 2679-2684
    • Hendry, P.1    McCall, M.2
  • 36
    • 0028859512 scopus 로고
    • A comparison of the in vitro activity of DNA-armed and all-RNA hammerhead ribozymes
    • Hendry P, McCall MJ. 1995. A comparison of the in vitro activity of DNA-armed and all-RNA hammerhead ribozymes. Nucleic Acids Res 23:3928-3936.
    • (1995) Nucleic Acids Res , vol.23 , pp. 3928-3936
    • Hendry, P.1    McCall, M.J.2
  • 37
    • 0026439909 scopus 로고
    • A ribozyme with DNA in the hybridizing arms displays enhanced cleavage ability
    • Hendry P, McCall MJ, Santiago FS, Jennings PA. 1992. A ribozyme with DNA in the hybridizing arms displays enhanced cleavage ability. Nucleic Acids Res 20:5737-5741.
    • (1992) Nucleic Acids Res , vol.20 , pp. 5737-5741
    • Hendry, P.1    McCall, M.J.2    Santiago, F.S.3    Jennings, P.A.4
  • 39
    • 0025850802 scopus 로고
    • Implications of ribozyme kinetics for targetting the cleavage of specific RNA molecules in vivo: More isn't always better
    • Herschlag D. 1991. Implications of ribozyme kinetics for targetting the cleavage of specific RNA molecules in vivo: More isn't always better. Proc Natl Acad Sci USA 88:6921-6925.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 6921-6925
    • Herschlag, D.1
  • 40
    • 0029163563 scopus 로고
    • RNA chaperones and the RNA folding problem
    • Herschlag D. 1995. RNA chaperones and the RNA folding problem. J Biol Chem 270:20871-20874.
    • (1995) J Biol Chem , vol.270 , pp. 20871-20874
    • Herschlag, D.1
  • 41
    • 0025085590 scopus 로고
    • Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site
    • Herschlag D, Cech T. 1990a. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site. Biochemistry 29:10159-10171.
    • (1990) Biochemistry , vol.29 , pp. 10159-10171
    • Herschlag, D.1    Cech, T.2
  • 42
    • 0025149015 scopus 로고
    • Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site
    • Herschlag D, Cech T. 1990b. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site. Biochemistry 29:10172-10180.
    • (1990) Biochemistry , vol.29 , pp. 10172-10180
    • Herschlag, D.1    Cech, T.2
  • 43
    • 0028216716 scopus 로고
    • An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis
    • Herschlag D, Khosla M, Tsuchihashi Z, Karpel RL 1994. An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis. EMBO J 13:2913-2924.
    • (1994) EMBO J , vol.13 , pp. 2913-2924
    • Herschlag, D.1    Khosla, M.2    Tsuchihashi, Z.3    Karpel, R.L.4
  • 44
    • 0028288686 scopus 로고
    • A kinetic and thermodynamic framework for the hammerhead ribozyme reaction
    • Hertel KJ, Herschlag D, Uhlenbeck OC. 1994. A kinetic and thermodynamic framework for the hammerhead ribozyme reaction. Biochemistry 33:3374-3385.
    • (1994) Biochemistry , vol.33 , pp. 3374-3385
    • Hertel, K.J.1    Herschlag, D.2    Uhlenbeck, O.C.3
  • 45
    • 0030013338 scopus 로고    scopus 로고
    • Specificity of hammerhead ribozyme cleavage
    • Hertel KJ, Herschlag D, Uhlenbeck OC. 1996. Specificity of hammerhead ribozyme cleavage. EMBO J 15:3751-3757.
    • (1996) EMBO J , vol.15 , pp. 3751-3757
    • Hertel, K.J.1    Herschlag, D.2    Uhlenbeck, O.C.3
  • 48
    • 0028906353 scopus 로고
    • The internal equilibrium of the hammerhead ribozyme reaction
    • Hertel KJ, Uhlenbeck OC. 1995. The internal equilibrium of the hammerhead ribozyme reaction. Biochemistry 34:1744-1749.
    • (1995) Biochemistry , vol.34 , pp. 1744-1749
    • Hertel, K.J.1    Uhlenbeck, O.C.2
  • 49
    • 0025217237 scopus 로고
    • Structure-activity relations in hammerhead RNA enzymes
    • Heus HA, Uhlenbeck OC, Pardi A. 1990. Structure-activity relations in hammerhead RNA enzymes. Nucleic Acids Res 18:1103-1108.
    • (1990) Nucleic Acids Res , vol.18 , pp. 1103-1108
    • Heus, H.A.1    Uhlenbeck, O.C.2    Pardi, A.3
  • 50
    • 0028234371 scopus 로고
    • Probing the hammerhead ribozyme structure with ribonucleases
    • Hodgson RAJ, Shirley NJ, Symons RH. 1994. Probing the hammerhead ribozyme structure with ribonucleases. Nucleic Acids Res 22:1620-1625.
    • (1994) Nucleic Acids Res , vol.22 , pp. 1620-1625
    • Hodgson, R.A.J.1    Shirley, N.J.2    Symons, R.H.3
  • 51
    • 0029565726 scopus 로고
    • Similar cleavage efficiencies of an oligoribonucleotide substrate and an mdr1 mRNA segment by a hammerhead ribozyme
    • Holm PS, Dietel M, Krupp G. 1995. Similar cleavage efficiencies of an oligoribonucleotide substrate and an mdr1 mRNA segment by a hammerhead ribozyme. Gene 167:221-225.
    • (1995) Gene , vol.167 , pp. 221-225
    • Holm, P.S.1    Dietel, M.2    Krupp, G.3
  • 52
    • 0027939967 scopus 로고
    • Extension of helix II of an HIV-1-directed hammerhead ribozyme with long antisense flanks does not alter kinetic parameters in vitro but causes loss of the inhibitory potential in living cells
    • Homann M, Tabler M, Tzortzakaki S, Sczakiel G. 1994. Extension of helix II of an HIV-1-directed hammerhead ribozyme with long antisense flanks does not alter kinetic parameters in vitro but causes loss of the inhibitory potential in living cells. Nucleic Acids Res 22:3951-3957.
    • (1994) Nucleic Acids Res , vol.22 , pp. 3951-3957
    • Homann, M.1    Tabler, M.2    Tzortzakaki, S.3    Sczakiel, G.4
  • 54
    • 0023047510 scopus 로고
    • Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid
    • Hutchins CJ, Rathjen PD, Forster AC, Symons RH. 1986. Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid. Nucleic Acids Res 14:3627-3640.
    • (1986) Nucleic Acids Res , vol.14 , pp. 3627-3640
    • Hutchins, C.J.1    Rathjen, P.D.2    Forster, A.C.3    Symons, R.H.4
  • 55
    • 0029868499 scopus 로고    scopus 로고
    • Oligonucleotide facilitators may inhibit or activate a hammerhead ribozyme
    • Jankowsky E, Schwenzer B. 1996. Oligonucleotide facilitators may inhibit or activate a hammerhead ribozyme. Nucleic Acids Res 24:423-429.
    • (1996) Nucleic Acids Res , vol.24 , pp. 423-429
    • Jankowsky, E.1    Schwenzer, B.2
  • 56
    • 0030804765 scopus 로고    scopus 로고
    • Peptide nucleic acid (PNA) is capable of enhancing hammerhead ribozyme activity with long but not with short RNA substrates
    • Jankowsky E, Strunk G, Schwenzer B. 1997. Peptide nucleic acid (PNA) is capable of enhancing hammerhead ribozyme activity with long but not with short RNA substrates. Nucleic Acids Res 25:2690-2693.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2690-2693
    • Jankowsky, E.1    Strunk, G.2    Schwenzer, B.3
  • 60
    • 0023788268 scopus 로고
    • Cleavage of specific sites of RNA by designed ribozymes
    • Koizumi M, Iwai S, Ohtsuka E. 1988. Cleavage of specific sites of RNA by designed ribozymes. FEBS Lett 239:285-288.
    • (1988) FEBS Lett , vol.239 , pp. 285-288
    • Koizumi, M.1    Iwai, S.2    Ohtsuka, E.3
  • 62
    • 0028842731 scopus 로고
    • Divalent metal ions and the internal equilibrium of the hammerhead ribozyme
    • Long DM, LaRiviere FJ, Uhlenbeck OC. 1995. Divalent metal ions and the internal equilibrium of the hammerhead ribozyme. Biochemistry 34:14435-14440.
    • (1995) Biochemistry , vol.34 , pp. 14435-14440
    • Long, D.M.1    Lariviere, F.J.2    Uhlenbeck, O.C.3
  • 63
    • 0027389356 scopus 로고
    • Self-cleaving catalytic RNA
    • Long DM, Uhlenbeck OC. 1993. Self-cleaving catalytic RNA. FASEB J 7:25-30.
    • (1993) FASEB J , vol.7 , pp. 25-30
    • Long, D.M.1    Uhlenbeck, O.C.2
  • 64
    • 0028339955 scopus 로고
    • Kinetic characterization of intramolecular and intermolecular hammerhead RNAs with stem II deletions
    • Long DM, Uhlenbeck OC. 1994. Kinetic characterization of intramolecular and intermolecular hammerhead RNAs with stem II deletions. Proc Natl Acad Sci USA 91:6977-6981.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6977-6981
    • Long, D.M.1    Uhlenbeck, O.C.2
  • 66
    • 0029949701 scopus 로고    scopus 로고
    • Structure and function of the hammerhead ribozyme: An unfinished story
    • McKay DB. 1996. Structure and function of the hammerhead ribozyme: An unfinished story. RNA 2:395-403.
    • (1996) RNA , vol.2 , pp. 395-403
    • McKay, D.B.1
  • 67
    • 0030448223 scopus 로고    scopus 로고
    • Mg(2+)-dependent conformational changes in the hammerhead ribozyme
    • Menger M, Tuschl T, Eckstein F, Porschke D. 1996. Mg(2+)-dependent conformational changes in the hammerhead ribozyme. Biochemistry 35:14710-14716.
    • (1996) Biochemistry , vol.35 , pp. 14710-14716
    • Menger, M.1    Tuschl, T.2    Eckstein, F.3    Porschke, D.4
  • 68
    • 0020481284 scopus 로고
    • Comparison of the kinetics of ribooligonucleotide, deoxyribooligonucleotide, and hybrid oligonucleotide double-strand formation by temperature-jump kinetics
    • Nelson JW, Tinoco I Jr. 1982. Comparison of the kinetics of ribooligonucleotide, deoxyribooligonucleotide, and hybrid oligonucleotide double-strand formation by temperature-jump kinetics. Biochemistry 1985:5289-5295.
    • (1982) Biochemistry , vol.1985 , pp. 5289-5295
    • Nelson, J.W.1    Tinoco I., Jr.2
  • 69
    • 0003156250 scopus 로고
    • Divalent metal ions in RNA folding and catalysis
    • Gesteland R, Atkins J, eds. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press
    • Pan T, Long DM, Uhlenbeck OC. 1993. Divalent metal ions in RNA folding and catalysis. In: Gesteland R, Atkins J, eds. The RNA world. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press. pp 271-302.
    • (1993) The RNA World , pp. 271-302
    • Pan, T.1    Long, D.M.2    Uhlenbeck, O.C.3
  • 70
    • 0026529507 scopus 로고
    • Nuclease resistant ribozymes with catalytic activity
    • Paolella G, Sproat BS, Lamond AI. 1992. Nuclease resistant ribozymes with catalytic activity. EMBO J 11:1913-1919.
    • (1992) EMBO J , vol.11 , pp. 1913-1919
    • Paolella, G.1    Sproat, B.S.2    Lamond, A.I.3
  • 71
    • 0030876444 scopus 로고    scopus 로고
    • Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation
    • Peracchi A, Beigelman L, Scott EC, Uhlenbeck OC, Herschlag D. 1997. Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation. J Biol Chem 272:26822-26826.
    • (1997) J Biol Chem , vol.272 , pp. 26822-26826
    • Peracchi, A.1    Beigelman, L.2    Scott, E.C.3    Uhlenbeck, O.C.4    Herschlag, D.5
  • 72
    • 0029859191 scopus 로고    scopus 로고
    • Rescue of abasic hammerhead ribozymes by exogenous addition of specific bases
    • Peracchi A, Beigelman L, Usman N, Herschlag D. 1996. Rescue of abasic hammerhead ribozymes by exogenous addition of specific bases. Proc Natl Acad Sci USA 93:11522-11527.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11522-11527
    • Peracchi, A.1    Beigelman, L.2    Usman, N.3    Herschlag, D.4
  • 73
    • 0030467890 scopus 로고    scopus 로고
    • Fluorescence resonance energy transfer analysis of ribozyme kinetics reveals the mode of action of a facilitator oligonucleotide
    • Perkins TA, Wolf DE, Goodchild J. 1996. Fluorescence resonance energy transfer analysis of ribozyme kinetics reveals the mode of action of a facilitator oligonucleotide. Biochemistry 35:16370-16377.
    • (1996) Biochemistry , vol.35 , pp. 16370-16377
    • Perkins, T.A.1    Wolf, D.E.2    Goodchild, J.3
  • 74
    • 0025762699 scopus 로고
    • Relationship between 2′-hydroxyls and Mg(II) binding in the hammerhead RNA domain: A model for ribozyme catalysis
    • Perreault JP, Labuda D, Usman N, Yang JH, Cedergren R. 1991. Relationship between 2′-hydroxyls and Mg(II) binding in the hammerhead RNA domain: A model for ribozyme catalysis. Biochemistry 30:4020-4025.
    • (1991) Biochemistry , vol.30 , pp. 4020-4025
    • Perreault, J.P.1    Labuda, D.2    Usman, N.3    Yang, J.H.4    Cedergren, R.5
  • 75
    • 0028063567 scopus 로고
    • Three-dimensional structure of a hammerhead ribozyme
    • Pley HW, Flaherty KM, McKay DB. 1994. Three-dimensional structure of a hammerhead ribozyme. Nature 372:68-74.
    • (1994) Nature , vol.372 , pp. 68-74
    • Pley, H.W.1    Flaherty, K.M.2    McKay, D.B.3
  • 76
    • 0015223587 scopus 로고
    • Co-operative non-enzymic base recognition III. Kinetics of the helix-coil transition of the oligoribouridylic · oligoriboadenylic acid system and of oligoriboadenylic acid alone at acidic pH
    • Pörschke D, Eigen M. 1971. Co-operative non-enzymic base recognition III. Kinetics of the helix-coil transition of the oligoribouridylic · oligoriboadenylic acid system and of oligoriboadenylic acid alone at acidic pH. J Mol Biol 62:361-381.
    • (1971) J Mol Biol , vol.62 , pp. 361-381
    • Pörschke, D.1    Eigen, M.2
  • 77
    • 0015846852 scopus 로고
    • Thermodynamics and kinetics of the helix-coil transition of oligomers containing GC base pairs
    • Pörschke D, Uhlenbeck OC, Martin FH. 1973. Thermodynamics and kinetics of the helix-coil transition of oligomers containing GC base pairs. Biopolymers 12:1313-1335.
    • (1973) Biopolymers , vol.12 , pp. 1313-1335
    • Pörschke, D.1    Uhlenbeck, O.C.2    Martin, F.H.3
  • 78
    • 0028351893 scopus 로고
    • Building a kinetic framework for group II intron ribozyme activity: Quantitation of interdomain binding and reaction rate
    • Pyle AM, Green JB. 1994. Building a kinetic framework for group II intron ribozyme activity: Quantitation of interdomain binding and reaction rate. Biochemistry 33:2716-2725.
    • (1994) Biochemistry , vol.33 , pp. 2716-2725
    • Pyle, A.M.1    Green, J.B.2
  • 79
    • 0029118922 scopus 로고
    • Controlled, targeted, intracellular expression of ribozymes: Progress and problems
    • Rossi JJ. 1995. Controlled, targeted, intracellular expression of ribozymes: Progress and problems. Trends Biotechnol 13:301-306.
    • (1995) Trends Biotechnol , vol.13 , pp. 301-306
    • Rossi, J.J.1
  • 80
    • 0024435363 scopus 로고
    • Studies on the hammerhead RNA self-cleaving domain
    • Ruffner DE, Dahm SC, Uhlenbeck OC. 1989. Studies on the hammerhead RNA self-cleaving domain. Gene 82:31-41.
    • (1989) Gene , vol.82 , pp. 31-41
    • Ruffner, D.E.1    Dahm, S.C.2    Uhlenbeck, O.C.3
  • 81
    • 0029168512 scopus 로고
    • Kinetic evidence based on solvent isotope effects for the nonexistence of a proton-transfer process in reactions catalyzed by a. hammerhead ribozyme: Implications to the double-metal-ion mechanism of catalysis
    • Sawata S, Komiyama M, Taira K. 1995. Kinetic evidence based on solvent isotope effects for the nonexistence of a proton-transfer process in reactions catalyzed by a. hammerhead ribozyme: Implications to the double-metal-ion mechanism of catalysis. J Am Chem Soc 117:2357-2358.
    • (1995) J Am Chem Soc , vol.117 , pp. 2357-2358
    • Sawata, S.1    Komiyama, M.2    Taira, K.3
  • 82
    • 0029073091 scopus 로고
    • The crystal structure of an all-RNA hammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage
    • Scott WG, Finch JT, Klug A. 1995. The crystal structure of an all-RNA hammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage. Cell 81:991-1002.
    • (1995) Cell , vol.81 , pp. 991-1002
    • Scott, W.G.1    Finch, J.T.2    Klug, A.3
  • 83
    • 0030476765 scopus 로고    scopus 로고
    • Capturing the structure of a catalytic RNA intermediate: The hammerhead ribozyme
    • Scott WG, Murray JB, Arnold JRP, Stoddard BL, Klug A. 1996. Capturing the structure of a catalytic RNA intermediate: The hammerhead ribozyme. Science 274:2065-2069.
    • (1996) Science , vol.274 , pp. 2065-2069
    • Scott, W.G.1    Murray, J.B.2    Arnold, J.R.P.3    Stoddard, B.L.4    Klug, A.5
  • 84
    • 0029100233 scopus 로고
    • Predicting thermodynamic properties of RNA
    • Serra MJ, Turner DH. 1995. Predicting thermodynamic properties of RNA. Methods Enzymol 259:242-261.
    • (1995) Methods Enzymol , vol.259 , pp. 242-261
    • Serra, M.J.1    Turner, D.H.2
  • 85
    • 0027227872 scopus 로고
    • Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages
    • Shimayama T, Nishikawa F, Nishikawa S, Taira K. 1993. Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages. Nucleic Acids Res 27:2605-2611.
    • (1993) Nucleic Acids Res , vol.27 , pp. 2605-2611
    • Shimayama, T.1    Nishikawa, F.2    Nishikawa, S.3    Taira, K.4
  • 86
    • 0028905538 scopus 로고
    • Generality of the NUX rule: Kinetic analysis of the results of systematic mutations in the trinucleotide at the cleavage site of the hammerhead ribozymes
    • Shimayama T, Nishikawa S, Taira K. 1995. Generality of the NUX rule: Kinetic analysis of the results of systematic mutations in the trinucleotide at the cleavage site of the hammerhead ribozymes. Biochemistry 34:3649-3654.
    • (1995) Biochemistry , vol.34 , pp. 3649-3654
    • Shimayama, T.1    Nishikawa, S.2    Taira, K.3
  • 87
    • 0029348087 scopus 로고
    • Probing RNA tertiary structure: Interhelical crosslinking of the hammerhead ribozyme
    • Sigurdsson ST, Tuschl T, Eckstein F. 1995. Probing RNA tertiary structure: Interhelical crosslinking of the hammerhead ribozyme. RNA 1:575-583.
    • (1995) RNA , vol.1 , pp. 575-583
    • Sigurdsson, S.T.1    Tuschl, T.2    Eckstein, F.3
  • 88
    • 0026102040 scopus 로고
    • Configurationally defined phosphorothiolate-containing oligoribonucleotides in the study of the mechanism of cleavage by hammerhead ribozymes
    • Slim G, Gait MJ. 1991. Configurationally defined phosphorothiolate-containing oligoribonucleotides in the study of the mechanism of cleavage by hammerhead ribozymes. Nucleic Acids Res 19:1183-1188.
    • (1991) Nucleic Acids Res , vol.19 , pp. 1183-1188
    • Slim, G.1    Gait, M.J.2
  • 89
    • 0026563846 scopus 로고
    • The role of the exocyclic amino groups of conserved purines in hammerhead ribozyme cleavage
    • Slim G, Gait MJ. 1992. The role of the exocyclic amino groups of conserved purines in hammerhead ribozyme cleavage. Biochem Biophys Res Commun 183:605-609.
    • (1992) Biochem Biophys Res Commun , vol.183 , pp. 605-609
    • Slim, G.1    Gait, M.J.2
  • 90
    • 0032580975 scopus 로고    scopus 로고
    • Circular substrates of the hammerhead ribozyme shift the internal equilibrium further towards cleavage
    • Forthcoming
    • Stage-Zimmermann T, Uhlenbeck OC. 1998. Circular substrates of the hammerhead ribozyme shift the internal equilibrium further towards cleavage. Biochemistry. Forthcoming.
    • (1998) Biochemistry
    • Stage-Zimmermann, T.1    Uhlenbeck, O.C.2
  • 91
    • 0024436928 scopus 로고
    • Self-cleavage of RNA in the replication of small pathogens of plants and animals
    • Symons RH. 1989. Self-cleavage of RNA in the replication of small pathogens of plants and animals. Trends Biochem Sci 14:445-450.
    • (1989) Trends Biochem Sci , vol.14 , pp. 445-450
    • Symons, R.H.1
  • 92
    • 0028942751 scopus 로고
    • Temperature-dependent change in the rate-determining step in a reaction catalyzed by a hammerhead ribozyme
    • Takagi Y, Taira K. 1995. Temperature-dependent change in the rate-determining step in a reaction catalyzed by a hammerhead ribozyme. FEBS Lett 361:273-276.
    • (1995) FEBS Lett , vol.361 , pp. 273-276
    • Takagi, Y.1    Taira, K.2
  • 93
    • 0026672823 scopus 로고
    • Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo
    • Taylor NR, Kaplan BE, Swiderski P, Li H, Rossi JJ. 1992. Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo. Nucleic Acids Res 20:4559-4565.
    • (1992) Nucleic Acids Res , vol.20 , pp. 4559-4565
    • Taylor, N.R.1    Kaplan, B.E.2    Swiderski, P.3    Li, H.4    Rossi, J.J.5
  • 94
    • 0027370258 scopus 로고
    • Protein enhancement of hammerhead ribozyme catalysis
    • Tsuchihashi Z, Khosla M, Herschlag D. 1993. Protein enhancement of hammerhead ribozyme catalysis. Science 262:99-102.
    • (1993) Science , vol.262 , pp. 99-102
    • Tsuchihashi, Z.1    Khosla, M.2    Herschlag, D.3
  • 96
    • 0027973506 scopus 로고
    • A three dimensional model for the hammerhead ribozyme based on fluorescence measurements
    • Tuschl T, Gohlke C, Jovin TM, Westhof E, Eckstein F. 1994. A three dimensional model for the hammerhead ribozyme based on fluorescence measurements. Science 266:785-789.
    • (1994) Science , vol.266 , pp. 785-789
    • Tuschl, T.1    Gohlke, C.2    Jovin, T.M.3    Westhof, E.4    Eckstein, F.5
  • 98
    • 0023221419 scopus 로고
    • A small catalytic oligoribonucleotide
    • Uhlenbeck OC. 1987. A small catalytic oligoribonucleotide. Nature 328:596-600.
    • (1987) Nature , vol.328 , pp. 596-600
    • Uhlenbeck, O.C.1
  • 99
    • 0029258928 scopus 로고
    • Keeping RNA happy
    • Uhlenbeck OC. 1995. Keeping RNA happy. RNA 1:4-6.
    • (1995) RNA , vol.1 , pp. 4-6
    • Uhlenbeck, O.C.1
  • 101
    • 0030696653 scopus 로고    scopus 로고
    • An ultraviolet crosslink in the hammerhead ribozyme dependent on 2-thiocytidine or 4-thiouridine substitution
    • Wang L, Ruffner DE. 1997. An ultraviolet crosslink in the hammerhead ribozyme dependent on 2-thiocytidine or 4-thiouridine substitution. Nucleic Acids Res 25:4355-4561.
    • (1997) Nucleic Acids Res , vol.25 , pp. 4355-4561
    • Wang, L.1    Ruffner, D.E.2
  • 102
    • 0029041941 scopus 로고
    • The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysis
    • Werner M, Uhlenbeck OC. 1995. The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysis. Nucleic Acids Res 23:2092-2096.
    • (1995) Nucleic Acids Res , vol.23 , pp. 2092-2096
    • Werner, M.1    Uhlenbeck, O.C.2
  • 103
    • 0024328777 scopus 로고
    • Laser temperature-jump, spectroscopic, and thermodynamic study of salt effects on duplex formation by dGCATGC
    • Williams A, Longfellow C, Freier S, Kierzek R, Turner DH. 1989. Laser temperature-jump, spectroscopic, and thermodynamic study of salt effects on duplex formation by dGCATGC. Biochemistry 28:4283-4291.
    • (1989) Biochemistry , vol.28 , pp. 4283-4291
    • Williams, A.1    Longfellow, C.2    Freier, S.3    Kierzek, R.4    Turner, D.H.5
  • 104
    • 0026558930 scopus 로고
    • Function of specific 2′-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2′ modifications
    • Williams DM, Pieken WA, Eckstein F. 1992. Function of specific 2′-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2′ modifications. Proc Natl Acad Sci USA 89:918-921.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 918-921
    • Williams, D.M.1    Pieken, W.A.2    Eckstein, F.3
  • 105
    • 0028244571 scopus 로고
    • Multiple folded conformations of a hammerhead ribozyme domain under cleavage conditions
    • Woisard A, Fourrey JL, Favre A. 1994. Multiple folded conformations of a hammerhead ribozyme domain under cleavage conditions. J Mol Biol 239:366-370.
    • (1994) J Mol Biol , vol.239 , pp. 366-370
    • Woisard, A.1    Fourrey, J.L.2    Favre, A.3
  • 106
    • 0025613003 scopus 로고
    • Mixed DNA/RNA polymers are cleaved by the hammerhead ribozyme
    • Yang J, Perreault J, Labuda D, Usman N, Cedergren R. 1990. Mixed DNA/RNA polymers are cleaved by the hammerhead ribozyme. Biochemistry 29:11156-11160.
    • (1990) Biochemistry , vol.29 , pp. 11156-11160
    • Yang, J.1    Perreault, J.2    Labuda, D.3    Usman, N.4    Cedergren, R.5
  • 107
    • 0026711027 scopus 로고
    • Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain
    • Yang J, Usman N, Chartrand P, Cedergren R. 1992. Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain. Biochemistry 31:5005-5009.
    • (1992) Biochemistry , vol.31 , pp. 5005-5009
    • Yang, J.1    Usman, N.2    Chartrand, P.3    Cedergren, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.