Ribozyme approach to downregulate vascular endothelial growth factor (VEGF) 189 expression in non-small cell lung cancer (NSCLC)

European Journal of Cancer

Volumn 36, Issue 18, 2000, Pages 2390-2396

  Oshika, Y ^a,b   Nakamura, M ^a   Tokunaga, T ^a   Ohnishi, Y ^c   Abe, Y ^a   Tsuchida, T ^a   Tomii, Y ^a   Kijima, H ^a   Yamazaki, H ^a   Ozeki, Y ^b   Tamaoki, N ^c   Ueyama, Y ^a  

^a TOKAI UNIVERSITY   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^c CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

Author keywords

Isoform; Non small cell lung cancer; Ribozyme; Vascularisation; VEGF

Indexed keywords

ISOPROTEIN; MESSENGER RNA; RIBOZYME; VASCULOTROPIN;

ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOWN REGULATION; EXON; GENE REPRESSION; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE CULTURE; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR VOLUME; XENOTRANSPLANTATION;

ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; DOWN-REGULATION; ENDOTHELIAL GROWTH FACTORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LUNG NEOPLASMS; LYMPHOKINES; MICE; MICE, NUDE; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; RNA, CATALYTIC; TRANSPLANTATION, HETEROLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0033679589     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(00)00343-9     Document Type: Article

References (20)

1. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
2. Vascular endothelial growth factor expression in primary esophageal squamous cell carcinoma. Association with angiogenesis and tumour progression
3. Vascular endothelial growth factor expression in early ovarian carcinoma
4. Influence of microvessel density and vascular endothelial permiability factor/vascular endothelial growth factor expression on prognosis in vulvar cancer
5. Vascular permiability factor/vascular endothelial growth factor, microvascular hyperpermiability, and angiogenesis
6. Dual regulation of vascular endothelial growth factor bioability by genetic proteolytic mechanisms
7. The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
8. Expression of cell-associated isoform of vascular endothelial growth factor 189 and its prognostic relevance in non-small cell lung cancer
9. Vascular endothelial growth factor (VEGF) mRNA isoform expression pattern is correlated with liver metastasis and poor prognosis in colon cancer
10. Is xenotransplantability of human colon cancers in SCID mice affected by angiogenic factors?
11. Expression pattern of vascular endothelial growth factor isoform is closely correlated with tumour stage and vascularisation in renal cell carcinoma
12. In vitro splicing of the ribosomal RNA precursor of tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence
13. Ribozyme-mediated suppression of aberrant epidermal growth factor receptor gene expression inhibits tumour growth
14. Ribozymes as potential anti-HIV-1 therapeutic agents
15. Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymes
16. Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells
17. VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparin sulfates for efficient binding to the VEGF receptors of human melanoma cells
18. Normal and abnormal magnesium metabolism
19. Hammerhead ribozymes against γ-glutamylcysteine synthetase mRNA down-regulate intracellular glutathione concentrantion of mouse islet cells
20. Cell release of bioactive fibroblast growth factor 2 by exon 6-encoded sequence of vascular endothelial growth factor