Retrovirus-mediated transfer of anti-MDR1 ribozymes fully restores chemosensitivity of P-glycoprotein-expressing human lymphoma cells

Human Gene Therapy

Volumn 10, Issue 7, 1999, Pages 1185-1195

  Wang, F U Sheng ^a   Kobayashi, Hiroyuki ^a,b   Liang, K E Wei ^a   Holland, James F ^a   Ohnuma, Takao ^a,c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; DNA DIRECTED RNA POLYMERASE III; DOXORUBICIN; GLYCOPROTEIN P; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; RIBOZYME; VINCRISTINE;

ARTICLE; CANCER CHEMOTHERAPY; CHEMOSENSITIVITY; CODON; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE SEQUENCE; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LYMPHOMA CELL; MOLECULAR CLONING; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN EXPRESSION; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSLATION INITIATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BASE SEQUENCE; DRUG RESISTANCE, MULTIPLE; EXONS; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; GENES, MDR; GENETIC VECTORS; HUMANS; LYMPHOMA, T-CELL; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEINS; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, CATALYTIC; RNA, MESSENGER; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 0033135323     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950018175     Document Type: Article

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