Therapeutic RNA and DNA enzymes

Biochemical Pharmacology

Volumn 60, Issue 8, 2000, Pages 1023-1026

  Sioud, Mouldy ^a   Leirdal, Marianne ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Angiogenesis; Apoptosis; Bcl x(L); DNA enzyme; PKC; Ribozyme; VEGF

Indexed keywords

FIBROBLAST GROWTH FACTOR; GENE PRODUCT; PROTEIN KINASE C; RIBOZYME; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL TISSUE; APOPTOSIS; CANCER CELL; CELL PROLIFERATION; CORNEA NEOVASCULARIZATION; DRUG DESIGN; GENE EXPRESSION; GENE FUNCTION; GLIOMA CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; SIGNAL TRANSDUCTION;

ANIMAL; DEOXYRIBONUCLEASES; DNA, CATALYTIC; DRUG DESIGN; HUMAN; NEOVASCULARIZATION, PATHOLOGIC; NUCLEIC ACID CONFORMATION; RIBONUCLEASES; RNA, CATALYTIC; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T;

EID: 0034668143     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00395-6     Document Type: Article

References (27)

1. Uhlenbeck O.C. A small catalytic oligonucleotide. Nature. 328:1987;596-619.
2. Haseloff J., Gerlach W.L. Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature. 334:1988;585-591.
3. Santoro S.W., Joyce G.F. A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci USA. 94:1996;4262-4266.
4. Cotten M., Birnstiel M.L. Ribozyme mediated destruction of RNA in vivo. EMBO J. 8:1989;3861-3866.
5. Sioud M., Drlica K. Prevention of HIV-1 integrase expression in E. coli by a ribozyme. Proc Natl Acad Sci USA. 88:1991;7303-7307.
6. Sioud M., Natvig J.B., Førre Ø. Preformed ribozyme destroys tumour necrosis factor mRNA in human cells. J Mol Biol. 223:1992;7303-7307.
7. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med. 3:1997;614-620.
8. Jacobson M.D., Weil M., Raff M.C. Programmed cell death in animal development. Cell. 88:1997;347-354.
9. Heidenreich O., Pieken W., Eckstein F. Chemically modified RNA. FASEB J. 7:1993;90-96.
10. Pieken W.A., Olsen D.B., Benseler F., Aurup H., Eckstein F. Kinetic characterization of ribonuclease-resistant 2′-modified hammerhead ribozymes. Science. 253:1991;314-317.
11. Heidenreich O., Benseler F., Fahrenholz A., Eckstein F. High activity and stability of hammerhead ribozymes containing 2′-modified pyrimidine nucleotides and phosphorothioates. J Biol Chem. 269:1994;2131-2138.
12. Beigelman L., McSwiggen J.A., Draper K.G., Gonzalez C., Jensen K., Karpeisky A.M., Modak A.S., Matulic-Adamic J., Direnzo A.B., Haeberli P., Sweedler D., Tracz D., Grimm S., Wincott F.E., Thackray V.G., Usman N. Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance. J Biol Chem. 270:1995;25702-25708.
13. Sioud M., Sørensen R. A nuclease-resistant protein kinase Cα ribozyme blocks glioma cell growth. Nat Biotech. 16:1998;556-561.
14. Leirdal M., Sioud M. High cleavage activity and stability of hammerhead ribozymes with a uniform 2′-amino pyrimidine modification. Biochem Biophys Res Commun. 250:1998;171-174.
15. 2+ binding and efficient cleavage by hammerhead ribozymes. Biochem Biophys Res Commun. 262:1999;461-466.
16. Sioud M., Leirdal M. Design of nuclease resistant protein kinase C α DNA enzymes with potential therapeutic application. J Mol Biol. 296:2000;937-947.
17. Newton A.C. Protein kinase C Structure, function and regulation. J Biol Chem. 270:1995;28495-28498.
18. Parker P.J., Kour G., Marais R., Mitchell F., Pears C., Stabel S., Webster C. Protein kinase C - α family affair. Mol Cell Endocrinol. 65:1989;1-11.
19. Leirdal M., Sioud M. Ribozyme inhibition of the protein kinase Cα triggers apoptosis in glioma cells. Br J Cancer. 80:1999;1558-1564.
20. Ruvolo P.P., Deng X., Carr B.K., May W.S. A functional role for mitochondrial protein kinase Cα in Bcl2 phosphorylation and suppression of apoptosis. J Biol Chem. 273:1998;25436-25442.
21. L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc Natl Acad Sci USA. 95:1998;4386-4391.
22. Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 26:1972;239-257.
23. Kartner N., Riordan J.R., Ling V. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science. 221:1983;1285-1287.
24. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1:1995;27-31.
25. Basilico C., Moscatelli D. The FGF family of growth factors and oncogenes. Adv Cancer Res. 59:1992;115-165.
26. Zetter B.R. Angiogenesis and tumor metastasis. Annu Rev Med. 49:1998;407-424.
27. Parry T.J., Cushman C., Gallegos A.M., Agrawal A.B., Richardson M., Andrews L.E., Maloney L., Mokler V.R., Wincott F.E., Pavco P.A. Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA. Nucleic Acids Res. 27:1999;2569-2777.