Divalent hammerhead ribozyme targeting template region of human telomerase RNA has potent cleavage activity, but less inhibitory activity on telomerase

Archives of Biochemistry and Biophysics

Volumn 405, Issue 1, 2002, Pages 32-37

  Yokoyama, Yasuhiro ^a   Wan, Xiaoyun ^a   Takahashi, Yuichiro ^a   Shinohara, Ariyoshi ^a   Liulin, Tang ^a   Tamaya, Teruhiko ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Catalysis; Hammerhead ribozyme; Human telomerase RNA; Telomerase; Transfection and endometrial carcinoma

Indexed keywords

RIBOZYME; RNA; TELOMERASE;

ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; ENDOMETRIUM CARCINOMA; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

BASE SEQUENCE; CELLS, CULTURED; DNA-DIRECTED RNA POLYMERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA; RNA, CATALYTIC; TELOMERASE; TIME FACTORS; TUMOR CELLS, CULTURED; VIRAL PROTEINS;

EID: 0036716950     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9861(02)00284-9     Document Type: Article

References (21)

1. Ribozymes: Principles and designs for their use as antisense and therapeutic agents