Pathogenesis of glomerular damage in glomerulonephritis

Nephrology Dialysis Transplantation

Volumn 13, Issue SUPPL. 1, 1998, Pages 10-15

  Couser, William G ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BASIC FIBROBLAST GROWTH FACTOR; COMPLEMENT COMPONENT C5B; COMPLEMENT COMPONENT C9; L SELECTIN; OXIDIZING AGENT; PLATELET DERIVED GROWTH FACTOR; PROTEINASE; TRANSFORMING GROWTH FACTOR BETA;

CELL PROLIFERATION; CONFERENCE PAPER; GLOMERULONEPHRITIS; GLOMERULUS EPITHELIUM; HUMAN; INFLAMMATORY CELL; KIDNEY FAILURE; MESANGIUM CELL; NEPHROSCLEROSIS; NEPHROTIC SYNDROME; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; PROTEINURIA; THROMBOTIC THROMBOCYTOPENIC PURPURA;

EID: 0031974878     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/13.suppl_1.10     Document Type: Conference Paper

References (65)

1. Couser WG. Pathogenesis of glomerulonephritis. Kidney Int 1993; 44: S19-S26
2. Couser WG. Mediation of immune glomerular injury (review). J Am Soc Nephrol 1990; 1: 13-29
3. Causer WG. Mechanisms of glomerular injury in immune complex glomerulonephritis (Nephrology Forum). Kidney Int 1985; 28: 569-583
4. Couser WG. Research opportunities and future directions in glomerular disease. Sem Nephrol 1993; 13: 457-471
5. Couser WG, Darby C, Salant DJ, Adler S, Steele KM, Stilmant MM, Lowenstein LM. Effect of antibody to glomerular basement membrane on protein excretion in the isolated perfused rat kidney. Am J Physiol 1985; 249: F241-F250
6. Koyama A, Fujisaki M, Koboyashi M, Igarashi M, Narita M. A glomerular permeability factor produced by human T cell hybridomas. Kidney Int 1991; 40: 453-460
7. Dantal J, Bigot E, Gogers W, et al. Effect of plasma protein absorption on protein excretion in kidney transplant recipients with recurrent nephrotic syndrome. N Engl J Med 1994; 330: 7-14
8. Savin VJ, Sharma R, Sharma M, McCarthy ET, Swan SK, Ellis E, Lovell H, Waraday B, Gunwar S, Chonko AM, Artero M, Vincenti F. Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N Engl J Med 1996; 334: 878-883
9. Garin EH, Blanchard DK, Matsushima K, Djeu JY. IL-8 production by peripheral blood mononuclear cells in nephrotic patients. Kidney Int 1994; 45: 1311-1317
10. Mendrick DL, Rennke HG, I. Induction of proteinuria in the rat by a monoclonal antibody against SPG- 115-107. Kidney Int 1988; 33: 818-830
11. Assmann KJM. Van Son JPHF, Dijkman HBPM, Koene RAP. A nephritogenic rat monoclonal antibody to mouse aminopeptidase-A. Induction of massive albuminuria after a single intravenous injection. J Exp Med 1992; 175: 623-635
12. Salant DJ, Natori Y, Shimizu F. Glomerular injury due to antibody alone. (Chapter 17) In: Nielson EG, Couser WG, eds Immunologic renal diseases. Philadelphia, PA, Lippincott-Raven Publishers, 1977; 357-374
13. Cosio FG, Orosz CG. Adhesion molecules and the kidney in health and disease. J Nephrol 1993; 6: 22-32
14. Farquhar M, Saito A, Kerjaschki D, Orlando R. The Heymann nephritis antigenic complex: Megalin (gp330) and RAP. JASN 1995; 6: 35-47
15. Couser WG. Glomerular injury induced by the C5b-9 membrane attack complex of complement. In: ed. Nephrology. Springer-Verlag, Tokyo, 1991; 182-190
16. Couser WG, Pruchno CJ, Schulze M. The role of C5b-9 in experimental membranous nephropathy. Nephrol Dial Transplant 1992; 7 [Suppl 1]: 25-31
17. Couser WG, Baker PJ, Adler S. Complement and the direct mediation of immune glomerular injury (editorial review). Kidney Int 1985; 28: 879-900
18. Baker PJ, Ochi RF, Schulze M, Johnson RJ, Campbell C, Couser WG. Depletion of C-6 prevents development of proteinuria in experimental membranous nephropathy in rats. Am J Pathol 1989; 135: 185-194
19. Cybulsky A, Quigg R, Salant D. The membrane attack complex in complement-mediated glomerular epithelial cell injury: Formation and stability of C5b-9 and C5b-7 in rat membranous nephropathy. J Immunol 1986; 137: 1511-1516
20. Savin VJ, Johnson RJ, Couser WG. C5b-9 increases albumin permeability of isolated glomeruli in vitro. Kidney Int 1994; 46: 382-387
21. Leenaerts PL, Hall BM, Van Damme BJ, Daha MR, Van Renterghem YF. Active Heymann nephritis in complement component C-6 deficient rats. Kidney Int 1995; 47: 1604-1614
22. Kerjaschki D, Schulze M, Binder S, Kain R, Ojha PP, Susani M, Horvat R, Baker PJ, Couser WG. Transcellular transport and membrane insertion of the C5b-9 membrane attack complex of complement by glomerular epithelial cells in experimental membranous nephropathy. J Immunol 1989; 143: 546 552
23. Mansch GM, Schieren G, Wagner C, Schonermark M. Immune damage to the mesangium: antibody- and complement-mediated stimulation and destruction of mesangial cells. JASN 1992; 2: S139-S143
24. Neale TJ, Ullrich R, Ojha P, Poscewski H, Verhoeven AJ, Kerjaschki D. Expression of a neutrophil respiratory burst cytochrome and reactive oxygen species in kidney glomeruli in association with proteinuria in passive Heymann nephritis. Proc Natl Acad Sci USA 1993; 90: 3645-3649
25. Neale T, Ojha P, Exner M, et al. Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen. J Clin Invest 1994; 94: 1577 1584
26. McMillan JI, Riordan JW, Couser WG, Pollock AS, Lovett DH. Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase-9 with enhanced expression in a model of membranous nephropathy. J Clin Invest 1996; 97: 1094-1101
27. Shankland SJ, Pippin J, Pichler RH, Gordon KL, Gold LI, Friedman S, Johnson RJ, Couser WG. Differential expression of TG Fβ isoform and receptors in experimental membraneous nephropathy. Kidney Int 1996; 50: 118-124
28. O'Donoghue DJ, Darvill A, Ballardie W. Mesangial cell autoantigens in immunoglobulin A nephropathy and Henoch-Schönlein Purpura. J Clin Invest 1991; 88: 1522-1530
29. Tomino Y, Endoh M, Nomoto Y, Sakai H. Specificity of eluted antibody from renal tissues of patients with IgA nephropathy. Am J Kidney Dis 1982; 1: 276-280
30. Rits M, Hiemstra PS, Bazin H, Van Es LA, Voerman JP, Daha MR. Activation of rat complement by soluble and insoluble rat IgA immune complexes. Eur J Immunol 1988; 18: 1873 1880
31. Rauterberg EW, Lieberknecht HM, Wingen AM, Ritz E. Complement membrane attack (MAC) in idiopathic IgA-glomerulonephritis. Kidney Int 1987; 31: 820-829
32. Yamamoto T, Wilson CB. Quantitative and qualitative studies of antibody-induced mesangial cell damage in the rat. Kidney Int 1987; 32: 514-525
33. Brandt J, Pippin J, Schulze M, Hansche GM, Alpers CE, Johnson RJ, Gordon K, Couser WG. Role of the complement membrane attack complex (C5b-9) in mediating experimental mesangioproliferative glomerulonephritis. Kidney Int 1996; 49: 335-343
34. Wang MX, Walker RG, Kincaid-Smith P. Clinicopathologic associations of anti-endothelial cell antibodies in immunoglobulin A nephropathy and lupus nephritis. Am J Kidney Dis 1993; 22: 378-386
35. Nangaku M, Alpers CE, Pippin J, Shankland SJ, Adler S, Couser WG, Johnson RJ. A new model of renal microvascular endothelial injury. Kidney Int 1997; 52: 182-199
36. Nangaku M, Pippin J, Shankland SJ, Johnson RJ, Couser WG. Renal microvascular injury induced by antibody to glomerular endothelial cells is mediated by C5b-9. Kidney Int 1997; in press
37. Morgan BP, Meri S. Membrane proteins that protect against complement lysis. Spring Sem Immunopathol 1994; 15: 369-396
38. Nangaku M, Meek R, Pippin J, Gordon K, Morgan BP, Johnson RJ, Couser WG. Transfected CD59 protects mesangial cells from injury induced by antibody and complement. Kidney Int 1996; 50: 257-266
39. Nangaku M, Quigg Rj, Shankland SJ, Okada N, Johnson RJ, Couser WG. Overexpression of Crry protects mesangial cells from complement mediated injury. JASN 1997; in press
40. Nishikage H, Baranyi L, Okada H, Okada N, Isobe K, Nomura A. Yoshida F, Matsuo S. The role of a complement regulatory protein in rat mesangial glomerulonephritis. JASN 1995; 6: 234-242
41. Danoff TM, Nielson EG. The role of chemoattractants in renal disease (Chapter 24). In: Nielson EG, Couser WG, eds Immunologic renal diseases. Philadelphia, PA, Lippincott-Raven Publishers, 1997; 495-512
42. Brady HR. Leukocyte adhesion molecules and kidney diseases (editorial review). Kidney Int 1994; 45: 1285-1300
43. Johnson RJ, Klebanoff SJ, Couser WG. Neutrophils (Chapter 25). In: Nielson EG, Couser WG, eds Immunologic Renal Diseases. Philadelphia, PA, Lippincott-Raven Publishers, 1997; 541-512
44. Johnson RJ, Couser WG, Chi EY, Adler S, Klebanoff SJ. A new mechanisms for glomerular injury: the myeloperoxidase-hydrogen peroxide-halide system. J Clin Invest 1987; 79: 1379-1387
45. 2)-halide system in immune complex nephritis: demonstration of in vivo idodination. Kidney Int 1987; 32: 342-349
46. Johnson RJ, Alpers CE, Pritz P, Schulze M, Klebanoff SJ. The human neutrophil-dependent immune complex nephritis in the rat. J Clin Invest 1988; 82: 1225-1235
47. Johnson RJ, Couser WG, Alpers C, Vissers M, Schulze M, Klebanoff SJ. The human neutrophil serine proteinases, elastase and cathepsin G, can mediate neutrophil-dependent immune complex nephritis in the rat. J Clin Invest 1988; 82: 1225-1235
48. Nikolick-Patterson DJ, Lan HY, Atkins RC. Macrophages (Chapter 28). In: Nielson EG, Couser WG, eds Immunologic renal diseases. Philadelphia, PA, Lippincott-Raven Publishers, 1997; 567-586
49. Floege J, Rees AJ. Growth factors and cytokines (Chapter 20). In: Nielson EG, Couser WG, eds Immunologic renal diseases. Philadelphia, PA, Lippincott-Raven Publishers, 1997; 415-452
50. Johnson RJ, Floege JF, Yoshimura A, Iida H, Couser WG, Alpers CE. The activated mesangial cell: a glomerular 'myofibroblast'. J Am Soc Nephrol 1992; 2: 5190-5197
51. Couser WG, Johnson RJ. Mechanisms of progressive renal diseases in glomerulonephritis. Am J Kidney Dis 1994; 23: 193-198
52. Johnson RJ, Floege J, Couser WG, Alpers CE. Role of platelet-derived growth factor in glomerular disease. J Am Soc Nephrol 1993; 4: 119-128
53. Johnson RJ, Raines EW, Floege J, Yoshimura A, Pritzl P, Alpers C, Ross R. Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. J Exp Med 1992; 175: 1413-1416
54. Lovett DH, Johnson RJ, Marti H-P, Martin J, Davies M, Couser WG. Structural characterization of the mesangial cell type IV collagenase and enhanced expression in a model of immune complex-mediated glomerulonephritis. Am J Pathol 1992; 141: 85-98
55. Border WA, Noble NA. Transforming growth factorβ in tissue fibrosis. New Engl J Med 1994; 331: 1286-1292
56. Floege J, Alpers CE, Burns MW, Pritzl P, Gordon K, Couser WG, Johnson RJ. Glomerular cells, extracellular matrix accumulation and the development of glomerular sclerosis in the remnant kidney model. Lab Invest 1992; 66: 485-497
57. Young B, Johnson RJ, Alpers C, Engl E, Gordon K, Floege J, Couser WG. Cellular events in the evolution of experimental diabetic nephropathy. Kidney Int 1995; 47: 935-944
58. Hugo C, Pichler R, Meek R, Gordon K, Kyriakides T, Reed M, Floege J, Bornstein P, Couser WG, Johnson RJ. Thrombospondin I is expressed by proliferating mesangial cells and is regulated by PDGF and bFGF in vivo. Kidney Int 1995; 48: 1846-1856
59. Bolton WK. Mechanisms of glomerular injury: injury mediated by sensitized lymphocytes. Seminar Nephrol 1991; 11: 285-293
60. Rovin BH, Schreiner GF. Cell-mediated immunity in glomerular disease. Annu Rev Med 1991; 42: 25-33
61. Rocklin R, Lewis E, David J. In-vitro evidence for cellular hypersensitivity to glomerular basement membrane antigens in human glomerulonephritis. N Engl J Med 1970; 283: 497-501
62. Dixon FJ. What are sensitized cells doing in glomerulonephritis (editorial)? N Engt J Med 1970; 283: 536-537
63. Bolton WK, Chandra M, Tyson TM, Kirkpatrick PR, Sadovnic MJ, Sturgill BC. Transfer of experimental glomerulonephritis in chickens by mononuclear cells. Kidney Int 1988; 34: 598-610
64. Rennke HG, Klein PS, Sandstrom DJ, Mendrick DL. Cell-mediated immune injury in the kidney: acute nephritis induced in the rat by azobenzenearsonate. Kidney Int 1994; 45: 1044-1056
65. Brouwer E, Huitema MG, Klot PA, de Weerd HD, Tervaert JWC, Weening JJ, Kallenberg CGM. Anti-myeloperoxidase associated proliferative glomerulonephritis: an animal model. J Exp Med 1993; 177: 905-912