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Volumn 177, Issue , 2007, Pages 359-389

Protein Kinases as potential targets for the treatment of pathological Pain

Author keywords

Glia; MAP kinases; Neural plasticity; Phosphorylation; Primary sensory neurons; Spinal cord

Indexed keywords

PROTEIN KINASE;

EID: 34748857186     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-540-33823-9_13     Document Type: Article
Times cited : (89)

References (119)
  • 2
    • 4344648261 scopus 로고    scopus 로고
    • Inflammation persistently enhances nocifensive behaviors mediated by spinal group i mGluRs through sustained ERK activation
    • Adwanikar H, Karim F, Gereau RW (2004) Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation. Pain 111:125-135
    • (2004) Pain , vol.111 , pp. 125-135
    • Adwanikar, H.1    Karim, F.2    Gereau, R.W.3
  • 3
    • 0033560123 scopus 로고    scopus 로고
    • Role of protein kinase A in the maintenance of inflammatory pain
    • Aley KO, Levine JD (1999) Role of protein kinase A in the maintenance of inflammatory pain. J Neurosci 19:2181-2186
    • (1999) J Neurosci , vol.19 , pp. 2181-2186
    • Aley, K.O.1    Levine, J.D.2
  • 4
    • 0032171575 scopus 로고    scopus 로고
    • Nitric oxide signaling in pain and nociceptor sensitization in the rat
    • Aley KO, McCarter G, Levine JD (1998) Nitric oxide signaling in pain and nociceptor sensitization in the rat. J Neurosci 18:7008-7014
    • (1998) J Neurosci , vol.18 , pp. 7008-7014
    • Aley, K.O.1    McCarter, G.2    Levine, J.D.3
  • 6
    • 0037381605 scopus 로고    scopus 로고
    • EphB receptors and ephrin-B ligands regulate spinal sensory connectivity andmodulate pain processing
    • Battaglia AA, SehayekK, Grist J, McMahon SB, Gavazzi I (2003) EphB receptors and ephrin-B ligands regulate spinal sensory connectivity andmodulate pain processing.NatNeurosci 6:339-340
    • (2003) Nat Neurosci , vol.6 , pp. 339-340
    • Battaglia, A.A.1    Sehayekk Grist, J.2    McMahon, S.B.3    Gavazzi, I.4
  • 7
    • 0023895875 scopus 로고
    • A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
    • Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33:87-107
    • (1988) Pain , vol.33 , pp. 87-107
    • Bennett, G.J.1    Xie, Y.K.2
  • 8
    • 18944385810 scopus 로고    scopus 로고
    • Protein kinase Adependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurones
    • Bird GC, Lash LL, Han JS, Zou X, Willis WD, Neugebauer V (2005) Protein kinase Adependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurones. J Physiol 564:907-921
    • (2005) J Physiol , vol.564 , pp. 907-921
    • Bird, G.C.1    Lash, L.L.2    Han, J.S.3    Zou, X.4    Willis, W.D.5    Neugebauer, V.6
  • 9
    • 2342573044 scopus 로고    scopus 로고
    • Use of cell-permeable peptides to prevent neuronal degeneration
    • BorselloT, BonnyC (2004) Use of cell-permeable peptides to prevent neuronal degeneration. Trends Mol Med 10:239-244
    • (2004) Trends Mol Med , vol.10 , pp. 239-244
    • Borsello, T.1    Bonny, C.2
  • 11
    • 0029942939 scopus 로고    scopus 로고
    • Characterization of a rat model of incisional pain
    • Brennan TJ, Vandermeulen EP, Gebhart GF (1996) Characterization of a rat model of incisional pain. Pain 64:493-501
    • (1996) Pain , vol.64 , pp. 493-501
    • Brennan, T.J.1    Vandermeulen, E.P.2    Gebhart, G.F.3
  • 13
    • 0026552808 scopus 로고
    • Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation
    • Chen L, Huang LY (1992) Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation. Nature 356:521-523
    • (1992) Nature , vol.356 , pp. 521-523
    • Chen, L.1    Huang, L.Y.2
  • 15
    • 0026728704 scopus 로고
    • Contribution of protein kinase C to central sensitization and persistent pain following tissue injury
    • Coderre TJ (1992) Contribution of protein kinase C to central sensitization and persistent pain following tissue injury. Neurosci Lett 140:181-184
    • (1992) Neurosci Lett , vol.140 , pp. 181-184
    • Coderre, T.J.1
  • 16
    • 0027956122 scopus 로고
    • Intracellularmessengers contributing to persistentnociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin painmodel
    • CoderreTJ, YashpalK (1994) Intracellularmessengers contributing to persistentnociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin painmodel. Eur J Neurosci 6:1328-1334
    • (1994) Eur J Neurosci , vol.6 , pp. 1328-1334
    • Coderre, T.J.1    Yashpal, K.2
  • 17
    • 0036527429 scopus 로고    scopus 로고
    • Protein kinases - The major drug targets of the twenty-first century?
    • Cohen P (2002) Protein kinases-the major drug targets of the twenty-first century? Nat Rev Drug Discov 1:309-315
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 309-315
    • Cohen, P.1
  • 18
    • 0036758662 scopus 로고    scopus 로고
    • Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization
    • DaiY, IwataK, FukuokaT, KondoE, TokunagaA, YamanakaH, TachibanaT, LiuY, NoguchiK (2002) Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization. J Neurosci 22:7737-7745
    • (2002) J Neurosci , vol.22 , pp. 7737-7745
    • Dai, Y.1    Iwata, K.2    Fukuoka, T.3    Kondo, E.4    Tokunaga, A.5    Yamanaka, H.6    Tachibana, T.7    Liu, Y.8    Noguchi, K.9
  • 19
    • 0034255439 scopus 로고    scopus 로고
    • Spared nerve injury: An animal model of persistent peripheral neuropathic pain
    • Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87:149-158
    • (2000) Pain , vol.87 , pp. 149-158
    • Decosterd, I.1    Woolf, C.J.2
  • 20
    • 0035252354 scopus 로고    scopus 로고
    • The role of neuroinflammation and neuroimmune activation in persistent pain
    • DeLeo JA, Yezierski RP (2001) The role of neuroinflammation and neuroimmune activation in persistent pain. Pain 90:1-6
    • (2001) Pain , vol.90 , pp. 1-6
    • Deleo, J.A.1    Yezierski, R.P.2
  • 21
    • 0037095759 scopus 로고    scopus 로고
    • Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization
    • Fang L, Wu J, Lin Q, Willis WD (2002) Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization. J Neurosci 22:4196-4204
    • (2002) J Neurosci , vol.22 , pp. 4196-4204
    • Fang, L.1    Wu, J.2    Lin, Q.3    Willis, W.D.4
  • 22
    • 0043021910 scopus 로고    scopus 로고
    • Extracellular signaling-regulated kinase-1 and -2 (ERK 1/2) mediate referred hyperalgesia in a murine model of visceral pain
    • Galan A, Cervero F, Laird JM (2003) Extracellular signaling-regulated kinase-1 and -2 (ERK 1/2) mediate referred hyperalgesia in a murine model of visceral pain. Brain Res Mol Brain Res 116:126-134
    • (2003) Brain Res Mol Brain Res , vol.116 , pp. 126-134
    • Galan, A.1    Cervero, F.2    Laird, J.M.3
  • 23
    • 9244250346 scopus 로고    scopus 로고
    • In vivo recruitment by painful stimuli ofAMPAreceptor subunits to the plasma membrane of spinal cord neurons
    • GalanA, Laird JM, Cervero F (2004) In vivo recruitment by painful stimuli ofAMPAreceptor subunits to the plasma membrane of spinal cord neurons. Pain 112:315-323
    • (2004) Pain , vol.112 , pp. 315-323
    • Galan, A.1    Laird, J.M.2    Cervero, F.3
  • 25
    • 0032535602 scopus 로고    scopus 로고
    • Modulation of TTX-R INa by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro
    • Gold MS, Levine JD, Correa AM (1998) Modulation of TTX-R INa by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro. J Neurosci 18:10345-10355
    • (1998) J Neurosci , vol.18 , pp. 10345-10355
    • Gold, M.S.1    Levine, J.D.2    Correa, A.M.3
  • 26
    • 3242746754 scopus 로고    scopus 로고
    • Changes in AMPA receptor phosphorylation in the rostral ventromedialmedulla after inflammatory hyperalgesia in rats
    • Guan Y, Guo W, Robbins MT, Dubner R, Ren K (2004) Changes in AMPA receptor phosphorylation in the rostral ventromedialmedulla after inflammatory hyperalgesia in rats. Neurosci Lett 366:201-205
    • (2004) Neurosci Lett , vol.366 , pp. 201-205
    • Guan, Y.1    Guo, W.2    Robbins, M.T.3    Dubner, R.4    Ren, K.5
  • 27
    • 0037101627 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia
    • Guo W, Zou S, Guan Y, Ikeda T, Tal M, Dubner R, Ren K (2002) Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia. J Neurosci 22:6208-6217
    • (2002) J Neurosci , vol.22 , pp. 6208-6217
    • Guo, W.1    Zou, S.2    Guan, Y.3    Ikeda, T.4    Tal, M.5    Dubner, R.6    Ren, K.7
  • 28
    • 0141856610 scopus 로고    scopus 로고
    • ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. I. Modulation of A-type K+ currents
    • Hu HJ, Glauner KS, Gereau RW (2003) ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. I.Modulation of A-type K+ currents. J Neurophysiol 90:1671-1679
    • (2003) J Neurophysiol , vol.90 , pp. 1671-1679
    • Hu, H.J.1    Glauner, K.S.2    Gereau, R.W.3
  • 29
    • 0034616085 scopus 로고    scopus 로고
    • Activity of p44/42 MAP kinase in the caudal subnucleus of trigeminal spinal nucleus is increased following perioral noxious stimulation in the mouse
    • Huang WJ, Wang BR, Yao LB, Huang CS, Wang X, Zhang P, Jiao XY, Duan XL, Chen BF, Ju G (2000) Activity of p44/42 MAP kinase in the caudal subnucleus of trigeminal spinal nucleus is increased following perioral noxious stimulation in the mouse. Brain Res 861:181-185
    • (2000) Brain Res , vol.861 , pp. 181-185
    • Huang, W.J.1    Wang, B.R.2    Yao, L.B.3    Huang, C.S.4    Wang, X.5    Zhang, P.6    Jiao, X.Y.7    Duan, X.L.8    Chen, B.F.9    Ju, G.10
  • 30
    • 0023277535 scopus 로고
    • Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
    • Hunt SP, Pini A, Evan G (1987) Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 328:632-634
    • (1987) Nature , vol.328 , pp. 632-634
    • Hunt, S.P.1    Pini, A.2    Evan, G.3
  • 31
    • 3142685946 scopus 로고    scopus 로고
    • Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
    • Inoue M, Rashid MH, Fujita R, Contos JJ, Chun J, Ueda H (2004) Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat Med 10:712-718
    • (2004) Nat Med , vol.10 , pp. 712-718
    • Inoue, M.1    Rashid, M.H.2    Fujita, R.3    Contos, J.J.4    Chun, J.5    Ueda, H.6
  • 32
    • 2342441834 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases as potential targets for pain killers
    • Ji RR (2004) Mitogen-activated protein kinases as potential targets for pain killers. Curr Opin Investig Drugs 5:71-75
    • (2004) Curr Opin Investig Drugs , vol.5 , pp. 71-75
    • Ji, R.R.1
  • 33
    • 7944238825 scopus 로고    scopus 로고
    • Cell signaling and the genesis of neuropathic pain
    • Ji RR, Strichartz G (2004) Cell signaling and the genesis of neuropathic pain. Sci STKE 2004:reE14
    • (2004) Sci STKE 2004:ReE14
    • Ji, R.R.1    Strichartz, G.2
  • 34
    • 0035116529 scopus 로고    scopus 로고
    • Neuronal plasticity and signal transduction in nociceptive neurons: Implications for the initiation and maintenance of pathological pain
    • Ji RR, Woolf CJ (2001) Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiol Dis 8:1-10
    • (2001) Neurobiol Dis , vol.8 , pp. 1-10
    • Ji, R.R.1    Woolf, C.J.2
  • 35
    • 0030594522 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent protein kinase type IV in dorsal root ganglion: Colocalization with peptides, axonal transport and effect of axotomy
    • Ji RR, Shi TJ, Xu ZQ, Zhang Q, Sakagami H, Tsubochi H, Kondo H, Hokfelt T (1996) Ca2+/calmodulin-dependent protein kinase type IV in dorsal root ganglion: colocalization with peptides, axonal transport and effect of axotomy. Brain Res 721:167-173
    • (1996) Brain Res , vol.721 , pp. 167-173
    • Ji, R.R.1    Shi, T.J.2    Xu, Z.Q.3    Zhang, Q.4    Sakagami, H.5    Tsubochi, H.6    Kondo, H.7    Hokfelt, T.8
  • 36
    • 0033490464 scopus 로고    scopus 로고
    • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
    • Ji RR, Baba H, Brenner GJ, Woolf CJ (1999) Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 2:1114-1119
    • (1999) Nat Neurosci , vol.2 , pp. 1114-1119
    • Ji, R.R.1    Baba, H.2    Brenner, G.J.3    Woolf, C.J.4
  • 37
    • 0037080003 scopus 로고    scopus 로고
    • ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    • Ji RR, Befort K, Brenner GJ, Woolf CJ (2002a) ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci 22:478-485
    • (2002) J Neurosci , vol.22 , pp. 478-485
    • Ji, R.R.1    Befort, K.2    Brenner, G.J.3    Woolf, C.J.4
  • 38
    • 0037179755 scopus 로고    scopus 로고
    • P38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels andmaintains heat hyperalgesia
    • Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ (2002b) p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels andmaintains heat hyperalgesia. Neuron 36:57-68
    • (2002) Neuron , vol.36 , pp. 57-68
    • Ji, R.R.1    Samad, T.A.2    Jin, S.X.3    Schmoll, R.4    Woolf, C.J.5
  • 39
    • 0242475309 scopus 로고    scopus 로고
    • Central sensitization and LTP: Do pain and memory share similar mechanisms?
    • Ji RR, Kohno T, Moore KA, Woolf CJ (2003) Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci 26:696-705
    • (2003) Trends Neurosci , vol.26 , pp. 696-705
    • Ji, R.R.1    Kohno, T.2    Moore, K.A.3    Woolf, C.J.4
  • 40
    • 0037705314 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    • Jin SX, Zhuang ZY, Woolf CJ, Ji RR (2003) p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J Neurosci 23:4017-4022
    • (2003) J Neurosci , vol.23 , pp. 4017-4022
    • Jin, S.X.1    Zhuang, Z.Y.2    Woolf, C.J.3    Ji, R.R.4
  • 41
    • 0034947242 scopus 로고    scopus 로고
    • The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex
    • Johansen JP, Fields HL, Manning BH (2001) The affective component of pain in rodents: direct evidence for a contribution of the anterior cingulate cortex. Proc Natl Acad Sci U S A 98:8077-8082
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8077-8082
    • Johansen, J.P.1    Fields, H.L.2    Manning, B.H.3
  • 42
    • 0035855860 scopus 로고    scopus 로고
    • Molecular mechanisms of nociception
    • Julius D, Basbaum AI (2001) Molecular mechanisms of nociception. Nature 413:203-210
    • (2001) Nature , vol.413 , pp. 203-210
    • Julius, D.1    Basbaum, A.I.2
  • 43
    • 0035371317 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice
    • Karim F, Wang CC, Gereau RW (2001) Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J Neurosci 21:3771-3779
    • (2001) J Neurosci , vol.21 , pp. 3771-3779
    • Karim, F.1    Wang, C.C.2    Gereau, R.W.3
  • 44
    • 4644312225 scopus 로고    scopus 로고
    • Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response elementbinding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    • Kawasaki Y, Kohno T, Zhuang ZY, Brenner GJ, Wang H, Van Der MC, Befort K, Woolf CJ, Ji RR (2004) Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response elementbinding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J Neurosci 24:8310-8321
    • (2004) J Neurosci , vol.24 , pp. 8310-8321
    • Kawasaki, Y.1    Kohno, T.2    Zhuang, Z.Y.3    Brenner, G.J.4    Wang, H.5    Van Der Befort, M.C.K.6    Woolf, C.J.7    Ji, R.R.8
  • 46
    • 0026727999 scopus 로고
    • An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
    • Kim SH, Chung JM (1992) An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50:355-363
    • (1992) Pain , vol.50 , pp. 355-363
    • Kim, S.H.1    Chung, J.M.2
  • 47
    • 0037147689 scopus 로고    scopus 로고
    • Activation of p38 MAP kinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury
    • Kim SY, Bae JC, Kim JY, Lee HL, Lee KM, Kim DS, Cho HJ (2002) Activation of p38 MAP kinase in the rat dorsal root ganglia and spinal cord following peripheral inflammation and nerve injury. Neuroreport 13:2483-2486
    • (2002) Neuroreport , vol.13 , pp. 2483-2486
    • Kim, S.Y.1    Bae, J.C.2    Kim, J.Y.3    Lee, H.L.4    Lee, K.M.5    Kim, D.S.6    Cho, H.J.7
  • 48
    • 0036847840 scopus 로고    scopus 로고
    • Role of p38 and p44/42 mitogen-activated protein kinases in microglia
    • Koistinaho M, Koistinaho J (2002) Role of p38 and p44/42 mitogen-activated protein kinases in microglia. Glia 40:175-183
    • (2002) Glia , vol.40 , pp. 175-183
    • Koistinaho, M.1    Koistinaho, J.2
  • 49
    • 0028043656 scopus 로고
    • Alpha subunit of calcium/calmodulin- dependent protein kinase enhances excitatory amino acid and synaptic responses of rat spinal dorsal horn neurons
    • KolajM, Cerne R, Cheng G, Brickey D.A., RandicM (1994) Alpha subunit of calcium/calmodulin- dependent protein kinase enhances excitatory amino acid and synaptic responses of rat spinal dorsal horn neurons. J Neurophysiol 72:2525-2531
    • (1994) J Neurophysiol , vol.72 , pp. 2525-2531
    • Kolaj, M.1    Cerne, R.2    Cheng, G.3    Brickey, D.A.4    Randic, M.5
  • 50
    • 0032479883 scopus 로고    scopus 로고
    • Nociceptive neurons in the macaque anterior cingulate activate during anticipation of pain
    • Koyama T, Tanaka YZ, Mikami A (1998) Nociceptive neurons in the macaque anterior cingulate activate during anticipation of pain. Neuroreport 9:2663-2667
    • (1998) Neuroreport , vol.9 , pp. 2663-2667
    • Koyama, T.1    Tanaka, Y.Z.2    Mikami, A.3
  • 51
    • 4544237195 scopus 로고    scopus 로고
    • NMDA receptors in the anterior cingulate cortex mediate pain-related aversion
    • Lei LG, Sun S, Gao YJ, Zhao ZQ, Zhang YQ (2004) NMDA receptors in the anterior cingulate cortex mediate pain-related aversion. Exp Neurol 189:413-421
    • (2004) Exp Neurol , vol.189 , pp. 413-421
    • Lei, L.G.1    Sun, S.2    Gao, Y.J.3    Zhao, Z.Q.4    Zhang, Y.Q.5
  • 52
    • 0142188665 scopus 로고    scopus 로고
    • The signaling components of sensory fiber transmission involved in the activation of ERK MAP kinase in the mouse dorsal horn
    • Lever IJ, Pezet S, McMahon SB, Malcangio M (2003) The signaling components of sensory fiber transmission involved in the activation of ERK MAP kinase in the mouse dorsal horn. Mol Cell Neurosci 24:259-270
    • (2003) Mol Cell Neurosci , vol.24 , pp. 259-270
    • Lever, I.J.1    Pezet, S.2    McMahon, S.B.3    Malcangio, M.4
  • 53
    • 17044405446 scopus 로고    scopus 로고
    • Spinal CK2 regulates nociceptive signaling in models of inflammatory pain
    • Li X, Shi X, Liang DY, Clark JD (2005) Spinal CK2 regulates nociceptive signaling in models of inflammatory pain. Pain 115:182-190
    • (2005) Pain , vol.115 , pp. 182-190
    • Li, X.1    Shi, X.2    Liang, D.Y.3    Clark, J.D.4
  • 54
    • 0037101970 scopus 로고    scopus 로고
    • Function and regulation of CREB family transcription factors in the nervous system
    • Lonze BE, Ginty DD (2002) Function and regulation of CREB family transcription factors in the nervous system. Neuron 35:605-623
    • (2002) Neuron , vol.35 , pp. 605-623
    • Lonze, B.E.1    Ginty, D.D.2
  • 55
    • 0036711470 scopus 로고    scopus 로고
    • Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus
    • MaW, QuirionR (2002) Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus. Pain 99:175-184
    • (2002) Pain , vol.99 , pp. 175-184
    • Ma, W.1    Quirion, R.2
  • 56
    • 0030841539 scopus 로고    scopus 로고
    • Diminished inflammation and nociceptive pain with preservation of neuropathic pain inmice with a targeted mutation of the type i regulatory subunit of cAMP-dependent protein kinase
    • Malmberg AB, Brandon EP, Idzerda RL, Liu H, McKnight GS, Basbaum AI (1997a) Diminished inflammation and nociceptive pain with preservation of neuropathic pain inmice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase. J Neurosci 17:7462-7470
    • (1997) J Neurosci , vol.17 , pp. 7462-7470
    • Malmberg, A.B.1    Brandon, E.P.2    Idzerda, R.L.3    Liu, H.4    McKnight, G.S.5    Basbaum, A.I.6
  • 57
    • 0030881680 scopus 로고    scopus 로고
    • Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma
    • Malmberg AB, Chen C, Tonegawa S, Basbaum AI (1997b) Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. Science 278:279-283
    • (1997) Science , vol.278 , pp. 279-283
    • Malmberg, A.B.1    Chen, C.2    Tonegawa, S.3    Basbaum, A.I.4
  • 62
    • 0026713777 scopus 로고
    • Pain-related increases in spinal cordmembranebound protein kinase C following peripheral nerve injury
    • Mao J, PriceDD, MayerDJ, Hayes RL (1992) Pain-related increases in spinal cordmembranebound protein kinase C following peripheral nerve injury. Brain Res 588:144-149
    • (1992) Brain Res , vol.588 , pp. 144-149
    • Mao, J.1    Price, D.D.2    Mayer, D.J.3    Hayes, R.L.4
  • 63
    • 0032890075 scopus 로고    scopus 로고
    • Inflammation-induced upregulation of protein kinase Cgamma immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing
    • Martin WJ, Liu H, Wang H, Malmberg AB, Basbaum AI (1999) Inflammation-induced upregulation of protein kinase Cgamma immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing. Neuroscience 88:1267-1274
    • (1999) Neuroscience , vol.88 , pp. 1267-1274
    • Martin, W.J.1    Liu, H.2    Wang, H.3    Malmberg, A.B.4    Basbaum, A.I.5
  • 64
    • 0029085192 scopus 로고
    • The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule
    • McMahon SB, Bennett DL, Priestley JV, Shelton DL (1995) The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule. Nat Med 1:774-780
    • (1995) Nat Med , vol.1 , pp. 774-780
    • McMahon, S.B.1    Bennett, D.L.2    Priestley, J.V.3    Shelton, D.L.4
  • 65
    • 0027502194 scopus 로고
    • Nitric oxide (NO) and nociceptive processing in the spinal cord
    • Meller ST, Gebhart GF (1993) Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain 52:127-136
    • (1993) Pain , vol.52 , pp. 127-136
    • Meller, S.T.1    Gebhart, G.F.2
  • 66
    • 0028027868 scopus 로고
    • The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat
    • Meller ST, Dykstra C, Grzybycki D, Murphy S, Gebhart GF (1994) The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat. Neuropharmacology 33:1471-1478
    • (1994) Neuropharmacology , vol.33 , pp. 1471-1478
    • Meller, S.T.1    Dykstra, C.2    Grzybycki, D.3    Murphy, S.4    Gebhart, G.F.5
  • 68
    • 18944372230 scopus 로고    scopus 로고
    • Rho kinase, a promising drug target for neurological disorders
    • Mueller BK, Mack H, Teusch N (2005) Rho kinase, a promising drug target for neurological disorders. Nat Rev Drug Discov 4:387-398
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 387-398
    • Mueller, B.K.1    Mack, H.2    Teusch, N.3
  • 70
    • 1642323740 scopus 로고    scopus 로고
    • Protein kinase inhibitors: Insights into drug design from structure
    • Noble ME, Endicott JA, Johnson LN (2004) Protein kinase inhibitors: insights into drug design from structure. Science 303:1800-1805
    • (2004) Science , vol.303 , pp. 1800-1805
    • Noble, M.E.1    Endicott, J.A.2    Johnson, L.N.3
  • 71
    • 1642357495 scopus 로고    scopus 로고
    • MAPK activation in nociceptive neurons and pain hypersensitivity
    • Obata K, Noguchi K (2004) MAPK activation in nociceptive neurons and pain hypersensitivity. Life Sci 74:2643-2653
    • (2004) Life Sci , vol.74 , pp. 2643-2653
    • Obata, K.1    Noguchi, K.2
  • 72
    • 8544239374 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation
    • ObataK, YamanakaH, Kobayashi K, DaiY, Mizushima T, KatsuraH, Fukuoka T, Tokunaga A, Noguchi K (2004) Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci 24:10211-10222
    • (2004) J Neurosci , vol.24 , pp. 10211-10222
    • Obata, K.1    Yamanaka, H.2    Kobayashi, K.3    Dai, Y.4    Mizushima, T.5    Katsura, H.6    Fukuoka, T.7    Tokunaga, A.8    Noguchi, K.9
  • 74
    • 0036603005 scopus 로고    scopus 로고
    • Chronic pain and medullary descending facilitation
    • Porreca F, Ossipov MH, Gebhart GF (2002) Chronic pain and medullary descending facilitation. Trends Neurosci 25:319-325
    • (2002) Trends Neurosci , vol.25 , pp. 319-325
    • Porreca, F.1    Ossipov, M.H.2    Gebhart, G.F.3
  • 75
    • 0025137135 scopus 로고
    • Systemic morphine suppresses noxious stimulus-evoked Fos protein-likeimmunoreactivity in the rat spinal cord
    • Presley RW, Menetrey D, Levine JD, BasbaumAI (1990) Systemic morphine suppresses noxious stimulus-evoked Fos protein-likeimmunoreactivity in the rat spinal cord. JNeurosci 10:323-335
    • (1990) JNeurosci , vol.10 , pp. 323-335
    • Presley, R.W.1    Menetrey, D.2    Levine, J.D.3    Basbaum, A.I.4
  • 76
    • 0037622717 scopus 로고    scopus 로고
    • Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a ratmodel of neuropathy
    • Raghavendra V, Tanga F, DeLeo JA (2003) Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a ratmodel of neuropathy. J Pharmacol Exp Ther 306:624-630
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 624-630
    • Raghavendra, V.1    Tanga, F.2    Deleo, J.A.3
  • 77
    • 1842731881 scopus 로고    scopus 로고
    • Src kinases: A hub for NMDA receptor regulation
    • Salter MW, Kalia LV (2004) Src kinases: a hub for NMDA receptor regulation. Nat Rev Neurosci 5:317-328
    • (2004) Nat Rev Neurosci , vol.5 , pp. 317-328
    • Salter, M.W.1    Kalia, L.V.2
  • 78
    • 0034333117 scopus 로고    scopus 로고
    • Learning and memory in pain pathways
    • Sandkuhler J (2000) Learning and memory in pain pathways. Pain 88:113-118
    • (2000) Pain , vol.88 , pp. 113-118
    • Sandkuhler, J.1
  • 79
    • 0345701254 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    • Schafers M, Svensson CI, Sommer C, Sorkin LS (2003) Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J Neurosci 23:2517-2521
    • (2003) J Neurosci , vol.23 , pp. 2517-2521
    • Schafers, M.1    Svensson, C.I.2    Sommer, C.3    Sorkin, L.S.4
  • 80
    • 0036829011 scopus 로고    scopus 로고
    • Can we conquer pain?
    • Scholz J, Woolf CJ (2002) Can we conquer pain? Nat Neurosci 5 Suppl:1062-1067
    • (2002) Nat Neurosci , vol.5 , Issue.SUPPL , pp. 1062-1067
    • Scholz, J.1    Woolf, C.J.2
  • 81
    • 10344258041 scopus 로고    scopus 로고
    • Targeting the mitogen-activated protein kinase cascade to treat cancer
    • Sebolt-Leopold JS, Herrera R (2004) Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 4:937-947
    • (2004) Nat Rev Cancer , vol.4 , pp. 937-947
    • Sebolt-Leopold, J.S.1    Herrera, R.2
  • 83
    • 0030908175 scopus 로고    scopus 로고
    • The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin
    • Sluka KA, Willis WD (1997) The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin. Pain 71:165-178
    • (1997) Pain , vol.71 , pp. 165-178
    • Sluka, K.A.1    Willis, W.D.2
  • 84
    • 0024153212 scopus 로고
    • Unilateral inflammation of the hindpaw in rats as amodel of prolonged noxious stimulation: Alterations in behavior and nociceptive thresholds
    • Stein C, MillanMJ, Herz A (1988) Unilateral inflammation of the hindpaw in rats as amodel of prolonged noxious stimulation: alterations in behavior and nociceptive thresholds. Pharmacol Biochem Behav 31:455-451
    • (1988) Pharmacol Biochem Behav , vol.31 , pp. 455-451
    • Stein, C.1    Millan, M.J.2    Herz, A.3
  • 85
    • 4444325794 scopus 로고    scopus 로고
    • A neuronal isoform of protein kinase G couples mitogen-activated protein kinase nuclear import to axotomy-induced long-term hyperexcitability in Aplysia sensory neurons
    • Sung YJ, Walters ET, Ambron RT (2004) A neuronal isoform of protein kinase G couples mitogen-activated protein kinase nuclear import to axotomy-induced long-term hyperexcitability in Aplysia sensory neurons. J Neurosci 24:7583-7595
    • (2004) J Neurosci , vol.24 , pp. 7583-7595
    • Sung, Y.J.1    Walters, E.T.2    Ambron, R.T.3
  • 86
    • 0042267829 scopus 로고    scopus 로고
    • Spinal p38MAPkinase is necessary forNMDA-induced spinal PGE (2) release and thermal hyperalgesia
    • Svensson CI, HuaXY, Protter AA, PowellHC, Yaksh TL (2003a) Spinal p38MAPkinase is necessary forNMDA-induced spinal PGE (2) release and thermal hyperalgesia. Neuroreport 14:1153-1157
    • (2003) Neuroreport , vol.14 , pp. 1153-1157
    • Svensson, C.I.1    Hua, X.Y.2    Protter, A.A.3    Powellhc Yaksh, T.L.4
  • 88
    • 19444382987 scopus 로고    scopus 로고
    • Spinal phospholipase A (2) in inflammatory hyperalgesia: Role of the small, secretory phospholipase A ( 2)
    • Svensson CI, Lucas KK, Hua XY, Powell HC, Dennis EA, Yaksh TL (2005) Spinal phospholipase A (2) in inflammatory hyperalgesia: role of the small, secretory phospholipase A (2) . Neuroscience 133:543-553
    • (2005) Neuroscience , vol.133 , pp. 543-553
    • Svensson, C.I.1    Lucas, K.K.2    Hua, X.Y.3    Powell, H.C.4    Dennis, E.A.5    Yaksh, T.L.6
  • 89
    • 0035018058 scopus 로고    scopus 로고
    • Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain
    • Sweitzer SM, Schubert P, DeLeo JA (2001) Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Ther 297:1210-1217
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 1210-1217
    • Sweitzer, S.M.1    Schubert, P.2    Deleo, J.A.3
  • 91
    • 17644414137 scopus 로고    scopus 로고
    • The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy
    • Tanga FY, Nutile-McMenemy N, DeLeo JA (2005) The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A 102:5856-5861
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 5856-5861
    • Tanga, F.Y.1    Nutile-Mcmenemy, N.2    Deleo, J.A.3
  • 92
    • 13544263311 scopus 로고    scopus 로고
    • Involvement ofRho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS)
    • Tatsumi S, Mabuchi T, Katano T, Matsumura S, Abe T, Hidaka H, Suzuki M, Sasaki Y, Minami T, Ito S (2005) Involvement ofRho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS) . Neuroscience 131:491-498
    • (2005) Neuroscience , vol.131 , pp. 491-498
    • Tatsumi, S.1    Mabuchi, T.2    Katano, T.3    Matsumura, S.4    Abe, T.5    Hidaka, H.6    Suzuki, M.7    Sasaki, Y.8    Minami, T.9    Ito, S.10
  • 95
    • 0030992837 scopus 로고    scopus 로고
    • Signalling through the lipid products of phosphoinositide-3-OH kinase
    • Toker A, Cantley LC (1997) Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387:673-676
    • (1997) Nature , vol.387 , pp. 673-676
    • Toker, A.1    Cantley, L.C.2
  • 97
    • 0346655315 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury
    • Tsuda M, Mizokoshi A, Shigemoto-Mogami Y, Koizumi S, Inoue K (2004) Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia 45:89-95
    • (2004) Glia , vol.45 , pp. 89-95
    • Tsuda, M.1    Mizokoshi, A.2    Shigemoto-Mogami, Y.3    Koizumi, S.4    Inoue, K.5
  • 98
    • 13144276331 scopus 로고    scopus 로고
    • Neuropathic pain and spinal microglia: A big problem from molecules in"small" glia
    • Tsuda M, Inoue K, SalterMW (2005) Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci 28:101-107
    • (2005) Trends Neurosci , vol.28 , pp. 101-107
    • Tsuda, M.1    Inoue, K.2    Salter, M.W.3
  • 99
  • 100
    • 4544252839 scopus 로고    scopus 로고
    • Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions
    • Verge GM, Milligan ED, Maier SF, Watkins LR, Naeve GS, Foster AC (2004) Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Eur J Neurosci 20:1150-1160
    • (2004) Eur J Neurosci , vol.20 , pp. 1150-1160
    • Verge, G.M.1    Milligan, E.D.2    Maier, S.F.3    Watkins, L.R.4    Naeve, G.S.5    Foster, A.C.6
  • 101
    • 11844303490 scopus 로고    scopus 로고
    • Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats
    • Wang CH, ChouWY, Hung KS, Jawan B, Lu CN, Liu JK, Hung YP, Lee TH (2005) Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats. Acta Pharmacol Sin 26:46-50
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 46-50
    • Wang, C.H.1    Chou, W.Y.2    Hung, K.S.3    Jawan, B.4    Lu, C.N.5    Liu, J.K.6    Hung, Y.P.7    Lee, T.H.8
  • 102
    • 0347169249 scopus 로고    scopus 로고
    • Glia: A novel drug discovery target for clinical pain
    • Watkins LR, Maier SF (2003) Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov 2:973-985
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 973-985
    • Watkins, L.R.1    Maier, S.F.2
  • 103
    • 0030840882 scopus 로고    scopus 로고
    • Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat
    • Watkins LR, Martin D, Ulrich P, Tracey KJ, Maier SF (1997) Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat. Pain 71: 225-235
    • (1997) Pain , vol.71 , pp. 225-235
    • Watkins, L.R.1    Martin, D.2    Ulrich, P.3    Tracey, K.J.4    Maier, S.F.5
  • 104
    • 0035426434 scopus 로고    scopus 로고
    • Glial activation: A driving force for pathological pain
    • Watkins LR, Milligan ED, Maier SF (2001) Glial activation: a driving force for pathological pain. Trends Neurosci 24:450-455
    • (2001) Trends Neurosci , vol.24 , pp. 450-455
    • Watkins, L.R.1    Milligan, E.D.2    Maier, S.F.3
  • 107
    • 0032928614 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
    • Widmann C, Gibson S, Jarpe MB, Johnson GL (1999) Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79:143-180
    • (1999) Physiol Rev , vol.79 , pp. 143-180
    • Widmann, C.1    Gibson, S.2    Jarpe, M.B.3    Johnson, G.L.4
  • 108
    • 0036824726 scopus 로고    scopus 로고
    • Long-term potentiation in spinothalamic neurons
    • Willis WD (2002) Long-term potentiation in spinothalamic neurons. Brain Res Brain Res Rev 40:202-214
    • (2002) Brain Res Brain Res Rev , vol.40 , pp. 202-214
    • Willis, W.D.1
  • 109
    • 0034625770 scopus 로고    scopus 로고
    • Neuronal plasticity: Increasing the gain in pain
    • Woolf CJ, Salter MW (2000) Neuronal plasticity: increasing the gain in pain. Science 288:1765-1769
    • (2000) Science , vol.288 , pp. 1765-1769
    • Woolf, C.J.1    Salter, M.W.2
  • 110
    • 23744498932 scopus 로고    scopus 로고
    • Activation of the ERK1/2 signaling cascade by excitotoxic spinal cord injury
    • Yu CG, Yezierski RP (2005) Activation of the ERK1/2 signaling cascade by excitotoxic spinal cord injury. Brain Res Mol Brain Res 138:244-255
    • (2005) Brain Res Mol Brain Res , vol.138 , pp. 244-255
    • Yu, C.G.1    Yezierski, R.P.2
  • 111
    • 18844407004 scopus 로고    scopus 로고
    • Activation of spinal extracellular signaling-regulated kinases by intraplantar melittin injection
    • Yu YQ, Chen J (2005) Activation of spinal extracellular signaling-regulated kinases by intraplantar melittin injection. Neurosci Lett 381:194-198
    • (2005) Neurosci Lett , vol.381 , pp. 194-198
    • Yu, Y.Q.1    Chen, J.2
  • 112
    • 4644248924 scopus 로고    scopus 로고
    • The contribution of autophosphorylated alpha-calcium-calmodulin kinase II to injury-induced persistent pain
    • Zeitz KP, Giese KP, Silva AJ, Basbaum AI (2004) The contribution of autophosphorylated alpha-calcium-calmodulin kinase II to injury-induced persistent pain. Neuroscience 128:889-898
    • (2004) Neuroscience , vol.128 , pp. 889-898
    • Zeitz, K.P.1    Giese, K.P.2    Silva, A.J.3    Basbaum, A.I.4
  • 113
    • 0027160873 scopus 로고
    • Nitric oxide synthase-like immunoreactivity in lumbar dorsal root ganglia and spinal cord of rat and monkey and effect of peripheral axotomy
    • Zhang X, Verge V, Wiesenfeld-Hallin Z, Ju G, Bredt D, Synder SH, Hokfelt T (1993) Nitric oxide synthase-like immunoreactivity in lumbar dorsal root ganglia and spinal cord of rat and monkey and effect of peripheral axotomy. J Comp Neurol 335:563-575
    • (1993) J Comp Neurol , vol.335 , pp. 563-575
    • Zhang, X.1    Verge, V.2    Wiesenfeld-Hallin, Z.3    Ju, G.4    Bredt, D.5    Synder, S.H.6    Hokfelt, T.7
  • 114
    • 0345167984 scopus 로고    scopus 로고
    • The effects of protein phosphatase inhibitors on nociceptive behavioral responses of rats following intradermal injection of capsaicin
    • Zhang X, Wu J, Fang L, Willis WD (2003) The effects of protein phosphatase inhibitors on nociceptive behavioral responses of rats following intradermal injection of capsaicin. Pain 106:443-451
    • (2003) Pain , vol.106 , pp. 443-451
    • Zhang, X.1    Wu, J.2    Fang, L.3    Willis, W.D.4
  • 115
    • 34447343777 scopus 로고    scopus 로고
    • Emotional distress and related memory of pain: A neurobiological review
    • Zhang YQ, Zhao ZQ, Ji RR (2005) Emotional distress and related memory of pain: a neurobiological review. Nerosci Bull 21:10-17
    • (2005) Nerosci Bull , vol.21 , pp. 10-17
    • Zhang, Y.Q.1    Zhao, Z.Q.2    Ji, R.R.3
  • 116
    • 4644250844 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization
    • Zhuang ZY, Xu H, Clapham DE, Ji RR (2004) Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci 24:8300-8309
    • (2004) J Neurosci , vol.24 , pp. 8300-8309
    • Zhuang, Z.Y.1    Xu, H.2    Clapham, D.E.3    Ji, R.R.4
  • 117
    • 14044252008 scopus 로고    scopus 로고
    • ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    • Zhuang ZY, Gerner P, Woolf CJ, Ji RR (2005) ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 114:149-159
    • (2005) Pain , vol.114 , pp. 149-159
    • Zhuang, Z.Y.1    Gerner, P.2    Woolf, C.J.3    Ji, R.R.4
  • 118
    • 33645460235 scopus 로고    scopus 로고
    • A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: Respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    • Zhuang ZY, Wen YR, Zhang DR, Borsello T, Bonny C, Strichartz GR, Decosterd I, Ji RR (2006) A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J Neurosci 26:3551-3560
    • (2006) J Neurosci , vol.26 , pp. 3551-3560
    • Zhuang, Z.Y.1    Wen, Y.R.2    Zhang, D.R.3    Borsello, T.4    Bonny, C.5    Strichartz, G.R.6    Decosterd, I.7    Ji, R.R.8
  • 119
    • 0034666110 scopus 로고    scopus 로고
    • Enhanced phosphorylation of NMDA receptor 1 subunits in spinal cord dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats
    • Zou X, Lin Q, Willis WD (2000) Enhanced phosphorylation of NMDA receptor 1 subunits in spinal cord dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats. J Neurosci 20:6989-6997
    • (2000) J Neurosci , vol.20 , pp. 6989-6997
    • Zou, X.1    Lin, Q.2    Willis, W.D.3


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