Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration

Neuroscience and Biobehavioral Reviews

Volumn 32, Issue 4, 2008, Pages 693-706

  Conejero Goldberg, Concepcion ^a   Davies, Peter ^a,b   Ulloa, Luis ^c  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

Acetylcholine; Alpha7nicotinic receptors; Alzheimer's disease; Beta amyloid; Inflammation; Microglia; Neurodegeneration; Nicotinic receptors; Tau

Indexed keywords

1,4 DIAZABICYCLO[3.2.2]NONANE 4 CARBOXYLIC ACID 4 BROMOPHENYL ESTER; 3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; 3 (4 HYDROXY 2 METHOXYBENZYLIDENE)ANABASEINE; 3 METHYL 5 (1 METHYL 2 PYRROLIDINYL)ISOXAZOLE; ANTIINFLAMMATORY AGENT; BUNGAROTOXIN RECEPTOR; CHOLINERGIC RECEPTOR; GALANTAMINE; IBUPROFEN; INDOMETACIN; MEM 3454; N (1 AZABICYCLO[2.2.2]OCT 3 YL) 4 CHLOROBENZAMIDE; N (1 AZABICYCLO[2.2.2]OCT 3 YL) 7 [2 (METHOXY)PHENYL] 1 BENZOFURAN 2 CARBOXAMIDE; N (1 AZABICYCLO[2.2.2]OCT 3 YL)FURO[2,3 C]PYRIDINE 5 CARBOXAMIDE; NAPROXEN; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NONSTEROID ANTIINFLAMMATORY AGENT; PHA 543613; PHYSOSTIGMINE; PNU 120596; PNU 282987; PREDNISONE; ROFECOXIB; SEROTONIN ANTAGONIST; SSR 180711; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; CLINICAL TRIAL; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG MECHANISM; GLIA CELL; HUMAN; IMMUNE RESPONSE; INFLAMMATION; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SCHIZOPHRENIA; UNSPECIFIED SIDE EFFECT;

EID: 40149104224     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2007.10.007     Document Type: Review

References (154)

1. L.E. Adler L.D. Hoffer A. Wiser R. Freedman Normalization of auditory physiology by cigarette smoking in schizophrenic patients American Journal of Psychiatry 150 1993 1856 1861
2. L.E. Adler A. Olincy M. Waldo J.G. Harris J. Griffith K. Stevens K. Flach H. Nagamoto P. Bickford S. Leonard R. Freedman Schizophrenia, sensory gating, and nicotinic receptors Schizophrenia Bulletin 24 1998 189 202
3. P.S. Aisen K.L. Davis J.D. Berg K. Schafer K. Campbell R.G. Thomas M.F. Weiner M.R. Farlow M. Sano M. Grundman L.J. Thal A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study [see comment] Neurology 54 2000 588 593
4. P.S. Aisen K.A. Schafer M. Grundman E. Pfeiffer M. Sano K.L. Davis M.R. Farlow S. Jin R.G. Thomas L.J. Thal A.S.D.C. Study. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial Journal of the American Medical Association 289 2003 2819 2826
5. H. Akiyama T. Arai H. Kondo E. Tanno C. Haga K. Ikeda Cell mediators of inflammation in the Alzheimer disease brain Alzheimer Disease and Associated Disorders 14 Suppl. 1 2000 S47 S53
6. G. Akk J.H. Steinbach Galantamine activates muscle-type nicotinic acetylcholine receptors without binding to the acetylcholine-binding site Journal of Neuroscience 25 2005 1992 2001
7. M. Alkondon E.X. Albuquerque Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes Journal of Pharmacology and Experimental Therapeutics 265 1993 1455 1473
8. D.K. Berg W.G. Conroy Nicotinic alpha 7 receptors: synaptic options and downstream signaling in neurons Journal of Neurobiology 53 2002 512 523
9. B. Biton O.E. Bergis F. Galli A. Nedelec A.W. Lochead S. Jegham D. Godet C. Lanneau R. Santamaria F. Chesney J. Leonardon P. Granger M.W. Debono G.A. Bohme F. Sgard F. Besnard D. Graham A. Coste A. Oblin O. Curet X. Vige C. Voltz L. Rouquier J. Souilhac V. Santucci C. Gueudet D. Francon R. Steinberg G. Griebel F. Oury-Donat P. George P. Avenet B. Scatton SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (1) binding and functional profile Neuropsychopharmacology 32 2007 1 16
10. A.L. Bodnar L.A. Cortes-Burgos K.K. Cook D.M. Dinh V.E. Groppi M. Hajos N.R. Higdon W.E. Hoffmann R.S. Hurst J.K. Myers B.N. Rogers T.M. Wall M.L. Wolfe E. Wong Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors Journal of Medicinal Chemistry 48 2005 905 908
11. F.G. Boess J. De Vry C. Erb T. Flessner M. Hendrix J. Luithle C. Methfessel B. Riedl K. Schnizler F.J. van der Staay M. van Kampen W.B. Wiese G. Koenig The novel alpha7 nicotinic acetylcholine receptor agonist N -[(3R)-1-azabicyclo[2.2.2]oct-3- yl ]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodents Journal of Pharmacology and Experimental Therapeutics 321 2007 716 725
12. C.R. Breese C. Adams J. Logel C. Drebing Y. Rollins M. Barnhart B. Sullivan B.K. Demasters R. Freedman S. Leonard Comparison of the regional expression of nicotinic acetylcholine receptor alpha7 mRNA and [125I]-alpha-bungarotoxin binding in human postmortem brain Journal of Comparative Neurology 387 1997 385 398
13. M.H. Bridge E. Williams M.E. Lyons K.F. Tipton W. Linert Electrochemical investigation into the redox activity of Fe(II)/Fe(III) in the presence of nicotine and possible relations to neurodegenerative diseases Biochimica et Biophysica Acta 1690 2004 77 84
14. L.M. Broad R. Zwart K.H. Pearson M. Lee L. Wallace G.I. McPhie R. Emkey S.P. Hollinshead C.P. Dell S.R. Baker E. Sher Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators Journal of Pharmacology and Experimental Therapeutics 318 2006 1108 1117
15. V. Buee-Scherrer M. Goedert Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases in intact cells FEBS Letters 515 2002 151 154
16. L. Burghaus U. Schutz U. Krempel R.A. de Vos E.N. Jansen Steur A. Wevers J. Lindstrom H. Schroder Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients. Brain Research Molecular Brain Research 76 2000 385 388
17. P.M. Callahan S. Wang W. Xie S. Dragan S. Sun T. Michael B. Herbert W. Rowe A. Tehim D. Lowe J.E. Barret Pharmacological characterization of MEM 3454, a novel nicotinic alpha7 receptor partial agonist: theurapeutic potential for the cognitive deficits associated with Alzheimer's disease and schizophrenia Neuropsychopharmacology 31 2006 198
18. P.B. Clarke The fall and rise of neuronal alpha-bungarotoxin binding proteins Trends in Pharmacological Sciences 13 1992 407 413
19. J.P. Cleary D.M. Walsh J.J. Hofmeister G.M. Shankar M.A. Kuskowski D.J. Selkoe K.H. Ashe Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function Nature Neuroscience 8 2005 79 84
20. J.C. Cooper O. Gutbrod V. Witzemann C. Methfessel Pharmacology of the nicotinic acetylcholine receptor from fetal rat muscle expressed in Xenopus oocytes European Journal of Pharmacology 309 1996 287 298
21. J.A. Court S. Lloyd M. Johnson M. Griffiths N.J. Birdsall M.A. Piggott A.E. Oakley P.G. Ince E.K. Perry R.H. Perry Nicotinic and muscarinic cholinergic receptor binding in the human hippocampal formation during development and aging Developmental Brain Research 101 1997 93 105
22. J.A. Court C. Martin-Ruiz A. Graham E. Perry Nicotinic receptors in human brain: topography and pathology Journal of Chemical Neuroanatomy 20 2000 281 298
23. + stores Journal of Neurochemistry 81 2002 606 614
24. F.A. Dajas-Bailador L. Soliakov S. Wonnacott Nicotine activates the extracellular signal-regulated kinase 1/2 via the alpha7 nicotinic acetylcholine receptor and protein kinase A, in SH-SY5Y cells and hippocampal neurones Journal of Neurochemistry 80 2002 520 530
25. P. Davies S. Feisullin Postmortem stability of alpha-bungarotoxin binding sites in mouse and human brain Brain Research 216 1981 449 454
26. A.J. de Craen J. Gussekloo B. Vrijsen R.G. Westendorp Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia American Journal of Epidemiology 161 2005 114 120
27. M.J. De Rosa C. Esandi Mdel A. Garelli D. Rayes C. Bouzat Relationship between alpha 7nAChR and apoptosis in human lymphocytes Journal of Neuroimmunology 160 2005 154 161
28. S.T. DeKosky S.W. Scheff Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity Annals of Neurology 27 1990 457 464
29. L. Depatie G.A. O’Driscoll A.L. Holahan V. Atkinson J.X. Thavundayil N.N. Kin S. Lal Nicotine and behavioral markers of risk for schizophrenia: a double-blind, placebo-controlled, cross-over study Neuropsychopharmacology 27 2002 1056 1070
30. R.C. Drisdel W.N. Green Neuronal alpha-bungarotoxin receptors are alpha7 subunit homomers Journal of Neuroscience 20 2000 133 139
31. M.R. D’Andrea R.G. Nagele H.Y. Wang P.A. Peterson D.H. Lee Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease Histopathology 38 2001 120 134
32. Engidawork, E., Gulesserian, T., Balic, N., Cairns, N., Lubec, G., 2001. Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease. Journal of Neural Transmission Supplementum, 211–222.
33. D. Fayuk J.L. Yakel Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons Molecular Pharmacology 66 2004 658 666
34. C. Fernandes E. Hoyle E. Dempster L.C. Schalkwyk D.A. Collier Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory Genes, Brain, and Behavior 5 2006 433 440
35. I. Ferrer M. Barrachina B. Puig M. Martinez de Lagran E. Marti J. Avila M. Dierssen Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models Neurobiology of Disease 20 2005 392 400
36. L. Fratiglioni H.X. Wang Smoking and Parkinson's and Alzheimer's disease: review of the epidemiological studies Behavioural Brain Research 113 2000 117 120
37. S.A. Frautschy G.M. Cole A. Baird Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid American Journal of Pathology 140 1992 1389 1399
38. R. Freedman S. Leonard M. Waldo J. Gault A. Olincy L.E. Adler Characterization of allelic variants at chromosome 15q14 in schizophrenia Genes, Brain, and Behavior 5 Suppl. 1 2006 14 22
39. V. Gerzanich X. Peng F. Wang G. Wells R. Anand S. Fletcher J. Lindstrom Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors Molecular Pharmacology 48 1995 774 782
40. M. Goedert M. Hasegawa R. Jakes S. Lawler A. Cuenda P. Cohen Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases FEBS Letters 409 1997 57 62
41. A.J. Graham C.M. Martin-Ruiz T. Teaktong M.A. Ray J.A. Court Human brain nicotinic receptors, their distribution and participation in neuropsychiatric disorders Current Drug Targets—CNS and Neurological Disorders 1 2002 387 397
42. A.J. Graham M.A. Ray E.K. Perry E. Jaros R.H. Perry S.G. Volsen S. Bose N. Evans J. Lindstrom J.A. Court Differential nicotinic acetylcholine receptor subunit expression in the human hippocampus Journal of Chemical Neuroanatomy 25 2003 97 113
43. Z.Z. Guan X. Zhang R. Ravid A. Nordberg Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease Journal of Neurochemistry 74 2000 237 243
44. K.A. Gyure R. Durham W.F. Stewart J.E. Smialek J.C. Troncoso Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome Archives of Pathology and Laboratory Medicine 125 2001 489 492
45. M. Hamada J.P. Hendrick G.R. Ryan M. Kuroiwa H. Higashi M. Tanaka A.C. Nairn P. Greengard A. Nishi Nicotine regulates DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of 32 kDa) phosphorylation at multiple sites in neostriatal neurons Journal of Pharmacology and Experimental Therapeutics 315 2005 872 878
46. J.G. Harris S. Kongs D. Allensworth L. Martin J. Tregellas B. Sullivan G. Zerbe R. Freedman Effects of nicotine on cognitive deficits in schizophrenia Neuropsychopharmacology 29 2004 1378 1385
47. E. Hellstrom-Lindahl M. Mousavi X. Zhang R. Ravid A. Nordberg Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain Brain Research. Molecular Brain Research 66 1999 94 103
48. E. Hellstrom-Lindahl J. Court J. Keverne M. Svedberg M. Lee A. Marutle A. Thomas E. Perry I. Bednar A. Nordberg Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice European Journal of Neuroscience 19 2004 2703 2710
49. E. Hellstrom-Lindahl M. Mousavi R. Ravid A. Nordberg Reduced levels of Abeta 40 and Abeta 42 in brains of smoking controls and Alzheimer's patients Neurobiology of Disease 15 2004 351 360
50. E. Hoyle R.F. Genn C. Fernandes I.P. Stolerman Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task Psychopharmacology 189 2006 211 223
51. M. Hu Q.S. Liu K.T. Chang D.K. Berg Nicotinic regulation of CREB activation in hippocampal neurons by glutamatergic and nonglutamatergic pathways Molecular and Cellular Neurosciences 21 2002 616 625
52. S. Humbert R. Dhavan L. Tsai p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton Journal of Cell Science 113 2000 975 983
53. R.S. Hurst M. Hajos M. Raggenbass T.M. Wall N.R. Higdon J.A. Lawson K.L. Rutherford-Root M.B. Berkenpas W.E. Hoffmann D.W. Piotrowski V.E. Groppi G. Allaman R. Ogier S. Bertrand D. Bertrand S.P. Arneric A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization Journal of Neuroscience 25 2005 4396 4405
54. J.M. Huston M. Ochani M. Rosas-Ballina H. Liao K. Ochani V.A. Pavlov M. Gallowitsch-Puerta M. Ashok C.J. Czura B. Foxwell K.J. Tracey L. Ulloa Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis Journal of Experimental Medicine 203 2006 1623 1628
55. V. Itier D. Bertrand Neuronal nicotinic receptors: from protein structure to function FEBS Letters 504 2001 118 125
56. W.R. Kem V.M. Mahnir L. Prokai R.L. Papke X. Cao S. LeFrancois K. Wildeboer K. Prokai-Tatrai J. Porter-Papke F. Soti Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration Molecular Pharmacology 65 2004 56 67
57. T. Kihara S. Shimohama H. Sawada K. Honda T. Nakamizo H. Shibasaki T. Kume A. Akaike Alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity Journal of Biological Chemistry 276 2001 13541 13546
58. H. Kitagawa T. Takenouchi R. Azuma K.A. Wesnes W.G. Kramer D.E. Clody A.L. Burnett Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers Neuropsychopharmacology 28 2003 542 551
59. M. Kitazawa S. Oddo T.R. Yamasaki K.N. Green F.M. LaFerla Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease Journal of Neuroscience 25 2005 8843 8853
60. A. Klegeris P.L. McGeer Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity Neurobiology of Aging 23 2002 787 794
61. K.S. Kosik C.L. Joachim D.J. Selkoe Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease Proceedings of the National Academy of Sciences of the United States of America 83 1986 4044 4048
62. M.S. Lee L.H. Tsai Cdk5: one of the links between senile plaques and neurofibrillary tangles? Journal of Alzheimer's Disease 5 2003 127 137
63. M.S. Lee Y.T. Kwon M. Li J. Peng R.M. Friedlander L.H. Tsai Neurotoxicity induces cleavage of p35 to p25 by calpain Nature 405 2000 360 364
64. F.M. Leonik R.L. Papke H. NA Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors Bioorganic & Medicinal Chemistry Letters 17 2007 1520 1522
65. S. Leuchtenberger D. Beher S. Weggen Selective modulation of Abeta42 production in Alzheimer's disease: non-steroidal anti-inflammatory drugs and beyond Current Pharmaceutical Design 12 2006 4337 4355
66. E.D. Levin Nicotinic receptor subtypes and cognitive function Journal of Neurobiology 53 2002 633 640
67. E.D. Levin F.J. McClernon A.H. Rezvani Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization Psychopharmacology 184 2006 523 539
68. Y. Li L. Liu S.W. Barger W.S. Griffin Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway Journal of Neuroscience 23 2003 1605 1611
69. W. Linert M.H. Bridge M. Huber K.B. Bjugstad S. Grossman G.W. Arendash In vitro and in vivo studies investigating possible antioxidant actions of nicotine: relevance to Parkinson's and Alzheimer's diseases Biochimica et Biophysica Acta 1454 1999 143 152
70. Q. Liu B. Zhao Nicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures British Journal of Pharmacology 141 2004 746 754
71. Q. Liu Y. Tao B. Zhao ESR study on scavenging effect of nicotine on free radicals Applied Magnetic Resonance 24 2003 105 112
72. Q. Liu J. Zhang H. Zhu C. Qin Q. Chen B. Zhao Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model FASEB Journal 21 2007 61 73
73. R.J. Lukas J.P. Changeux N. Le Novere E.X. Albuquerque D.J. Balfour D.K. Berg D. Bertrand V.A. Chiappinelli P.B. Clarke A.C. Collins J.A. Dani S.R. Grady K.J. Kellar J.M. Lindstrom M.J. Marks M. Quik P.W. Taylor S. Wonnacott International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits Pharmacological Reviews 51 1999 397 401
74. V. Luntz-Leybman P.C. Bickford R. Freedman Cholinergic gating of response to auditory stimuli in rat hippocampus Brain Research 587 1992 130 136
75. M.A. Lynch Long-term potentiation and memory Physiological Reviews 84 2004 87 136
76. T.K. Machu M.E. Hamilton T.F. Frye C.L. Shanklin M.C. Harris H. Sun T.E. Tenner Jr. F.S. Soti W.R. Kem Benzylidene analogs of anabaseine display partial agonist and antagonist properties at the mouse 5-hydroxytryptamine(3A) receptor Journal of Pharmacology and Experimental Therapeutics 299 2001 1112 1119
77. L. Maggi E. Sher E. Cherubini Regulation of GABA release by nicotinic acetylcholine receptors in the neonatal rat hippocampus Journal of Physiology 536 2001 89 100
78. M.J. Marks A.C. Collins Characterization of nicotine binding in mouse brain and comparison with the binding of alpha-bungarotoxin and quinuclidinyl benzilate Molecular Pharmacology 22 1982 554 564
79. M.B. Marrero R.L. Papke B.S. Bhatti S. Shaw M. Bencherif The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase Journal of Pharmacology and Experimental Therapeutics 309 2004 16 27
80. L.F. Martin W.R. Kem R. Freedman Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia Psychopharmacology 174 2004 54 64
81. C.M. Martin-Ruiz J.A. Court E. Molnar M. Lee C. Gotti A. Mamalaki T. Tsouloufis S. Tzartos C. Ballard R.H. Perry E.K. Perry Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease Journal of Neurochemistry 73 1999 1635 1640
82. E.M. Meyer A. Kuryatov V. Gerzanich J. Lindstrom R.L. Papke Analysis of 3-(4-hydroxy, 2-methoxybenzylidene)anabaseine selectivity and activity at human and rat alpha-7 nicotinic receptors Journal of Pharmacology and Experimental Therapeutics 287 1998 918 925
83. C.S. Myers O. Robles A.N. Kakoyannis J.D. Sherr M.T. Avila T.A. Blaxton G.K. Thaker Nicotine improves delayed recognition in schizophrenic patients Psychopharmacology 174 2004 334 340
84. W. Noble V. Olm K. Takata E. Casey O. Mary J. Meyerson K. Gaynor J. LaFrancois L. Wang T. Kondo P. Davies M. Burns Veeranna R. Nixon D. Dickson Y. Matsuoka M. Ahlijanian L.F. Lau K. Duff Cdk5 is a key factor in tau aggregation and tangle formation in vivo Neuron 38 2003 555 565
85. A. Nordberg Human nicotinic receptors—their role in aging and dementia Neurochemistry International 25 1994 93 97
86. A. Nordberg Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications Biological Psychiatry 49 2001 200 210
87. A. Nordberg B. Winblad Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains Neuroscience Letters 72 1986 115 119
88. A. Nordberg E. Hellstrom-Lindahl M. Lee M. Johnson M. Mousavi R. Hall E. Perry I. Bednar J. Court Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw) Journal of Neurochemistry 81 2002 655 658
89. A. Olincy J.G. Harris L.L. Johnson V. Pender S. Kongs D. Allensworth J. Ellis G.O. Zerbe S. Leonard K.E. Stevens J.O. Stevens L. Martin L.E. Adler F. Soti W.R. Kem R. Freedman Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia Archives of General Psychiatry 63 2006 630 638
90. K. Ono K. Hasegawa M. Yamada H. Naiki Nicotine breaks down preformed Alzheimer's beta-amyloid fibrils in vitro Biological Psychiatry 52 2002 880 886
91. G. Ophir N. Amariglio J. Jacob-Hirsch R. Elkon G. Rechavi D.M. Michaelson Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade Neurobiology of Disease 20 2005 709 718
92. G.N. Patrick L. Zukerberg M. Nikolic S. de la Monte P. Dikkes L.H. Tsai Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration [see comment] Nature 402 1999 615 622
93. J.J. Pei E. Braak H. Braak I. Grundke-Iqbal K. Iqbal B. Winblad C. RF Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration Journal of Alzheimer's Disease 3 2001 41 48
94. E.F. Pereira C. Hilmas M.D. Santos M. Alkondon A. Maelicke E.X. Albuquerque Unconventional ligands and modulators of nicotinic receptors Journal of Neurobiology 53 2002 479 500
95. A. Potter J. Corwin J. Lang M. Piasecki R. Lenox P.A. Newhouse Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease Psychopharmacology 142 1999 334 342
96. D. Potter A. Summerfelt J. Gold R.W. Buchanan Review of clinical correlates of P50 sensory gating abnormalities in patients with schizophrenia Schizophrenia Bulletin 32 2006 692 700
97. K.A. Radcliffe J.A. Dani Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission Journal of Neuroscience 18 1998 7075 7083
98. F. Rangwala R.C. Drisdel S. Rakhilin E. Ko P. Atluri A.B. Harkins A.P. Fox S.S. Salman W.N. Green Neuronal alpha-bungarotoxin receptors differ structurally from other nicotinic acetylcholine receptors Journal of Neuroscience 17 1997 8201 8212
99. S.A. Reines G.A. Block J.C. Morris G. Liu M.L. Nessly C.R. Lines B.A. Norman C.C. Baranak G. Rofecoxib Protocol 091 Study Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study Neurology 62 2004 66 71
100. K. Ren J. Thinschmidt J. Liu L. Ai R.L. Papke M.A. King J.A. Hughes E.M. Meyer Alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation Neuroscience 145 2007 314 322
101. J. Rogers L.C. Kirby S.R. Hempelman D.L. Berry P.L. McGeer A.W. Kaszniak J. Zalinski M. Cofield L. Mansukhani P. Willson Clinical trial of indomethacin in Alzheimer's disease Neurology 43 1993 1609 1611
102. J. Rogers R. Strohmeyer C.J. Kovelowski R. Li Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide Glia 40 2002 260 269
103. F. Rubboli J.A. Court C. Sala C. Morris B. Chini E. Perry F. Clementi Distribution of nicotinic receptors in the human hippocampus and thalamus European Journal of Neuroscience 6 1994 1596 1604
104. A. Rubio M. Perez J. Avila Acetylcholine receptors and tau phosphorylation Current Molecular Medicine 6 2006 423 428
105. D.J. Selkoe The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease Trends in Cell Biology 8 1998 447 453
106. A. Sengupta Q. Wu I. Grundke-Iqbal K. Iqbal T.J. Singh Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5 Molecular and Cellular Biochemistry 167 1997 99 105
107. G. Sharma S. Vijayaraghavan Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores [see comment] Proceedings of the National Academy of Sciences of the United States of America 98 2001 4148 4153
108. S. Shaw M. Bencherif M.B. Marrero Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid Journal of Biological Chemistry 277 2002 44920 44924
109. S. Shaw M. Bencherif M.B. Marrero Angiotensin II blocks nicotine-mediated neuroprotection against beta-amyloid (1-42) via activation of the tyrosine phosphatase SHP-1 Journal of Neuroscience 23 2003 11224 11228
110. F.S. Shie R.C. LeBoeuf L.W. Jin Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice [erratum appears in Neuroreport. 2004 Aug 26;15(12):1993 Note: LeBoeur, Renee C [corrected to LeBoeuf, Renee C]] Neuroreport 14 2003 123 129
111. R.D. Shytle T. Mori K. Townsend M. Vendrame N. Sun J. Zeng J. Ehrhart A.A. Silver P.R. Sanberg J. Tan Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors Journal of Neurochemistry 89 2004 337 343
112. A.J. Silva J.H. Kogan P.W. Frankland S. Kida CREB and memory Annual Review of Neuroscience 21 1998 127 148
113. E.J. Slow R.K. Graham M.R. Hayden To be or not to be toxic: aggregations in Huntington and Alzheimer disease Trends in Genetics 22 2006 408 411
114. M.A. Smith Alzheimer disease International Review of Neurobiology 42 1998 1 54
115. R.C. Smith A. Singh M. Infante A. Khandat A. Kloos Effects of cigarette smoking and nicotine nasal spray on psychiatric symptoms and cognition in schizophrenia Neuropsychopharmacology 27 2002 479 497
116. R.C. Smith J. Warner-Cohen M. Matute E. Butler E. Kelly S. Vaidhyanathaswamy A. Khan Effects of nicotine nasal spray on cognitive function in schizophrenia Neuropsychopharmacology 31 2006 637 643
117. J. Snaedal T. Johannesson J.E. Jonsson G. Gylfadottir The effects of nicotine in dermal plaster on cognitive functions in patients with Alzheimer's disease Dementia 7 1996 47 52
118. D.P. Spurden J.A. Court S. Lloyd A. Oakley R. Perry C. Pearson R.G. Pullen E.K. Perry Nicotinic receptor distribution in the human thalamus: autoradiographical localization of [3H]nicotine and [125I] alpha-bungarotoxin binding Journal of Chemical Neuroanatomy 13 1997 105 113
119. C. Stokes J.K. Papke N.A. Horenstein W.R. Kem T.J. McCormack R.L. Papke The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors Molecular Pharmacology 66 2004 14 24
120. W.J. Streit Microglia as neuroprotective, immunocompetent cells of the CNS Glia 40 2002 133 139
121. S.N. Sudweeks J.L. Yakel Functional and molecular characterization of neuronal nicotinic ACh receptors in rat CA1 hippocampal neurons Journal of Physiology 527 Part 3 2000 515 528
122. K. Sugaya E. Giacobini V.A. Chiappinelli Nicotinic acetylcholine receptor subtypes in human frontal cortex: changes in Alzheimer's disease Journal of Neuroscience Research 27 1990 349 359
123. T. Suzuki I. Hide A. Matsubara C. Hama K. Harada K. Miyano M. Andra H. Matsubayashi N. Sakai S. Kohsaka K. Inoue Y. Nakata Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotective role Journal of Neuroscience Research 83 2006 1461 1470
124. T. Teaktong A. Graham J. Court R. Perry E. Jaros M. Johnson R. Hall E. Perry Alzheimer's disease is associated with a selective increase in alpha7 nicotinic acetylcholine receptor immunoreactivity in astrocytes Glia 41 2003 207 211
125. R.D. Terry E. Masliah D.P. Salmon N. Butters R. DeTeresa R. Hill L.A. Hansen R. Katzman Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment Annals of Neurology 30 1991 572 580
126. M. Tolnay A. Probst REVIEW: tau protein pathology in Alzheimer's disease and related disorders Neuropathology and Applied Neurobiology 25 1999 171 187
127. S. Ueno J. Bracamontes C. Zorumski D.S. Weiss J.H. Steinbach Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor Journal of Neuroscience 17 1997 625 634
128. L. Ulloa The vagus nerve and the nicotinic anti-inflammatory pathway Nature Reviews Drug Discovery 4 2005 673 684
129. V.V. Uteshev E.M. Meyer R.L. Papke Regulation of neuronal function by choline and 4OH-GTS-21 through alpha 7 nicotinic receptors Journal of Neurophysiology 89 2003 1797 1806
130. K. Utsugisawa Y. Nagane H. Tohgi M. Yoshimura H. Ohba Y. Genda Changes with aging and ischemia in nicotinic acetylcholine receptor subunit alpha7 mRNA expression in postmortem human frontal cortex and putamen Neuroscience Letters 270 1999 145 148
131. T. Utsuki M. Shoaib H.W. Holloway D.K. Ingram W.C. Wallace V. Haroutunian K. Sambamurti D.K. Lahiri N.H. Greig Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat Journal of Alzheimer's Disease 4 2002 405 415
132. D.P. Walker D.G. Wishka D.W. Piotrowski S. Jia S.C. Reitz K.M. Yates J.K. Myers T.N. Vetman B.J. Margolis E.J. Jacobsen B.A. Acker V.E. Groppi M.L. Wolfe B.A. Thornburgh P.M. Tinholt L.A. Cortes-Burgos R.R. Walters M.R. Hester E.P. Seest L.A. Dolak F. Han B.A. Olson L. Fitzgerald B.A. Staton T.J. Raub M. Hajos W.E. Hoffmann K.S. Li N.R. Higdon T.M. Wall R.S. Hurst E.H. Wong B.N. Rogers Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists Bioorganic and Medicinal Chemistry 14 2006 8219 8248
133. H.Y. Wang D.H. Lee M.R. D’Andrea P.A. Peterson R.P. Shank A.B. Reitz Beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology Journal of Biological Chemistry 275 2000 5626 5632
134. H.Y. Wang D.H. Lee C.B. Davis R.P. Shank Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors Journal of Neurochemistry 75 2000 1155 1161
135. H. Wang M. Yu M. Ochani C.A. Amella M. Tanovic S. Susarla J.H. Li H. Wang H. Yang L. Ulloa Y. Al-Abed C.J. Czura K.J. Tracey Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation [see comment] Nature 421 2003 384 388
136. H.Y. Wang W. Li N.J. Benedetti D.H. Lee Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation Journal of Biological Chemistry 278 2003 31547 31553
137. H. Wang H.Y. Liao M. Ochani M. Justiniani X. Lin L. Yang Y. Al-Abed H. Wang C. Metz E.J. Miller K.J. Tracey L. Ulloa Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis [see comment] Nature Medicine 10 2004 1216 1221
138. S. Weggen J.L. Eriksen P. Das S.A. Sagi R. Wang C.U. Pietrzik K.A. Findlay T.E. Smith M.P. Murphy T. Bulter D.E. Kang N. Marquez-Sterling T.E. Golde E.H. Koo A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity [see comment] Nature 414 2001 212 216
139. J.H. Weishaupt L. Kussmaul P. Grotsch A. Heckel G. Rohde H. Romig M. Bahr F. Gillardon Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction Molecular and Cellular Neurosciences 24 2003 489 502
140. M.A. Westerman D. Cooper-Blacketer A. Mariash L. Kotilinek T. Kawarabayashi L.H. Younkin G.A. Carlson S.G. Younkin K.H. Ashe The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease Journal of Neuroscience 22 2002 1858 1867
141. A. Wevers A. Jeske C. Lobron C. Birtsch S. Heinemann A. Maelicke R. Schroder H. Schroder Cellular distribution of nicotinic acetylcholine receptor subunit mRNAs in the human cerebral cortex as revealed by non-isotopic in situ hybridization. Brain Research Molecular Brain Research 25 1994 122 128
142. A. Wevers L. Burghaus N. Moser B. Witter O.K. Steinlein U. Schutz B. Achnitz U. Krempel S. Nowacki K. Pilz J. Stoodt J. Lindstrom R.A. De Vos E.N. Jansen Steur H. Schroder Expression of nicotinic acetylcholine receptors in Alzheimer's disease: postmortem investigations and experimental approaches Behavioural Brain Research 113 2000 207 215
143. H.K. White E.D. Levin Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease Psychopharmacology 143 1999 158 165
144. H.K. White E.D. Levin Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment Psychopharmacology 171 2004 465 471
145. P.J. Whitehouse R.N. Kalaria Nicotinic receptors and neurodegenerative dementing diseases: basic research and clinical implications Alzheimer Disease and Associated Disorders 9 Suppl 2 1995 3 5
146. A.L. Wilson L.K. Langley J. Monley T. Bauer S. Rottunda E. McFalls C. Kovera J.R. McCarten Nicotine patches in Alzheimer's disease: pilot study on learning, memory, and safety Pharmacology, Biochemistry and Behavior 51 1995 509 514
147. C.A. Wilson R.W. Doms V.M. Lee Intracellular APP processing and A beta production in Alzheimer disease Journal of Neuropathology and Experimental Neurology 58 1999 787 794
148. O. Wirths G. Multhaup C. Czech V. Blanchard S. Moussaoui G. Tremp L. Pradier K. Beyreuther T.A. Bayer Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice Neuroscience Letters 306 2001 116 120
149. D.G. Wishka D.P. Walker K.M. Yates S.C. Reitz S. Jia J.K. Myers K.L. Olson E.J. Jacobsen M.L. Wolfe V.E. Groppi A.J. Hanchar B.A. Thornburgh L.A. Cortes-Burgos E.H. Wong B.A. Staton T.J. Raub N.R. Higdon T.M. Wall R.S. Hurst R.R. Walters W.E. Hoffmann M. Hajos S. Franklin G. Carey L.H. Gold K.K. Cook S.B. Sands S.X. Zhao J.R. Soglia A.S. Kalgutkar S.P. Arneric B.N. Rogers Discovery of N -[(3R)-1-azabicyclo[2.2.2]oct-3- yl ]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure–activity relationship Journal of Medicinal Chemistry 49 2006 4425 4436
150. B.L. Wolozin A. Pruchnicki D.W. Dickson P. Davies A neuronal antigen in the brains of Alzheimer patients Science 232 1986 648 650
151. Y. Yoshiyama M. Higuchi B. Zhang S.M. Huang N. Iwata T.C. Saido J. Maeda T. Suhara J.Q. Trojanowski L. VM Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model Neuron 53 2007 337 351
152. J.W. Young N. Crawford J.S. Kelly L.E. Kerr H.M. Marston C. Spratt K. Finlayson J. Sharkey Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice European Neuropsychopharmacology 17 2007 145 155
153. J. Zhang Q. Liu Q. Chen N.Q. Liu F.L. Li Z.B. Lu C. Qin H. Zhu Y.Y. Huang W. He B.L. Zhao Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis FASEB Journal 20 2006 1212 1214
154. X. Zhang Y. Chen C.L.Y.H. Wang Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia Proceedings of the National Academy of Sciences of the United States of America 104 2007 9864 9869