Nicotine lowers the secretion of the Alzheimer's amyloid β-protein precursor that contains amyloid β-peptide in rat

Journal of Alzheimer's Disease

Volumn 4, Issue 5, 2002, Pages 405-415

  Utsuki, Tadanobu ^a   Shoaib, Mohammed ^b   Holloway, Harold W ^a   Ingram, Donald K ^a   Wallace, William C ^a   Haroutunian, Vahram ^c   Sambamurti, Kumar ^d   Lahiri, Debomoy K ^e   Greig, Nigel H ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d MAYO GRADUATE SCHOOL   (United States)

^e INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's dementia; Amyloid; Cholinergic system; Neuroprotection; Nicotine drug abuse; Scopolamine; Smoking; peptide

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CHLORISONDAMINE; MECAMYLAMINE; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; SCOPOLAMINE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIGARETTE SMOKING; CONTROLLED STUDY; DOSE RESPONSE; INCIDENCE; MALE; MAXIMUM TOLERATED DOSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS; RAT;

EID: 0036813113     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2002-4507     Document Type: Article

References (60)

1. J.P. Anderson, Y. Chen, K.S. Kim and N.K. Robakis, An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence, J. Neurochem. 59 (1992), 2328-2331.
2. D.J.K. Balfour, The effects of nicotine on brain neurotransmitter systems, Pharmac. Ther. 16 (1982), 269-282.
3. M.E.M. Benwell, D.J.K. Balfour and J.M. Anderson, Evidence that tobacco smoke increased the density of [3H]-nicotine binding sites in human brain, J. Neurochem. 50 (1988), 1243-1247.
4. M.P. Bowes, E. Masliah, D.A.C. Otero, J.A. Zivin and T. Saitoh, Reduction in neurologic damage by a peptide segment of amyloid protien precursor in a rabbit spinal cord ischemia model, Exp. Neurol. 129 (1994), 112-119.
5. R.D. Burgoyne, Control of exocytosis in adrenal chromaffin cells, Biochim. Biophys. Acta. 1071 (1991), 174-202.
6. J.D. Buxbaum, A.A. Ruefli, C.A. Parker, A.M. Cypress and P. Greengard, Calcium regulates processing of the Alzheimer's amyloid protein precusor in a protein kinase C-independent manner, Proc. Natl. Acad. Sci. USA 91 (1994), 4489-4493.
7. F. Checler, Processing of β-amyloid precursor protein and its regulation in Alzheimer's disease, J. Neurochem. 65 (1995), 1431-1444.
8. M. Citron, Human β-secretase and Alzheimer's disease, Exp. Opin. Ther. Target 5 (2001), 341-348.
9. P.B.S. Clarke, Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine, Br. J. Pharmacol. 83 (1984), 527-535.
10. P.B.S. Clarke and R. Kumar, Characterization of the locomotor stimulant action of nicotine in tolerant rats, Br. J. Pharmacol. 80 (1983), 587-594.
11. J. Court, C. Martin-Ruiz, M. Piggott, D. Spurden, M. Griffiths and E. Perry, Nicotinic receptor abnormalities in Alzheimer's disease, Biol. Psychiatry 49 (2001), 175-184.
12. J.A. Dani, Overview of nicotinic receptors and their roles in the central nervous system, Biol. Psychiatry 49 (2001), 166-174.
13. S. Efthimiopoulos, D. Vassilacopoulou, J.A. Ripellino, N. Tezapsidis and N. Robakis, Cholinergic agonists stimulate secretion of soluble full-length β-amyloid precursor proetin in neuroendocrine cells, Proc. Natl. Acad. Sci. USA 93 (1996), 8046-8050.
14. H. El-Bizri, M.G. Rigdon and P.B.S. Clarke, Intraneuronal accumulation and persistence of radiolabel in rat-brain following in vivo administration of [H3]-chlorisondamine, Br. J. Pharmacol. 116 (1995), 2503-2509.
15. F. Esch, P.S. Keim, E.C. Beattie, R.W. Blacher, A.R. Cullwell, T. Oltersdorf, D. McClure and P.J. Ward, Cleavage of amyloid β peptide during constitutive processing of its precursor, Science 248 (1990), 1122-1124.
16. 2 subunits and is upregulated by chronic nicotinic treatment, Mol. Pharmacol. 41 (1992), 31-37.
17. D. Games and D. Adams et al., Alzheimer-type neuropathology in transgenic mice overexpressing V717Fbeta-amyloid precursor protein, Nature 373 (1995), 523-527.
18. T.E. Golde, S. Estus, L.H. Younkin, D.J. Selkoe and S.G. Younkin, Processing of the amyloid protein precursor to potentially amyloidogenic derivatives, Science 255 (1992), 728-730.
19. C. Guela and M.M. Mesulum, The cholinergic system, in: Alzheimer's Disease, R.D. Terry, R. Katzman and K.L. Blick, eds, Raven/New York, NY, 1994, pp. 263-303.
20. C. Haass and D.J. Selkoe, Cellular processing of β-amyloid precursor protein and the genesis of β-amyloid, Cell 75 (1993), 1039-1042.
21. V. Haroutunian, N.H. Greig, X.F. Pei, T. Utsuki, K.L. Davis and W.C. Wallace, Pharmacological modulation of Alzheimer's β-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions, Mol. Brain Res. 46 (1997), 161-168.
22. J.E. Henningfield, J.M. Stapleton, N.L. Benowitz, R.F. Grayson and E.D. London, Higher levels of nicotine in arterial than in venous blood after cigarette smoking, Drug Acohol Depend. 33 (1993), 23-29.
23. K.J. Kellar, P.J. Whitehouse, A.M. Martino-Burrows, K. Marcus and D.L. Price, Muscrainic and nicotinic binding sites in Alzheimer's disease cerebral cortex, Brain Res. 436 (1987), 62-68.
24. K.J. Kellar and S. Wonnacott, Nicotine cholinergic receptors in Alzheimer's disease, in: Nicotine Psychopharmacology: Molecular Cellular and Behavioral Aspects, S. Wonnacott, S. Russel, P.A. Newhouse, T. Sunderland, P.N. Tariot, M.A. Blumhardt and I.P. Stolerman, eds, Oxford Univ. Press/Oxford, 1990, pp. 341-373.
25. S.H. Kim, Y.K. Kim, S.J. Jeong, Y.H. Kim and Y.H. Suh, Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine, Mol. Pharm. 52 (1997), 430-436.
26. W.A. Kukull, The association between smoking and Alzheimer's disease: Effects of study design and bias, Biol. Psychiatry 49 (2001), 194-199.
27. D.K. Lahiri, M.R. Farlow, J.I. Nurnberger and N.H. Greig, Effects of cholinesterases inhibitors on the secretion of betaamyloid precusor protein in cell cultures, Ann. N. Y. Acad. Sci. 826 (1997), 416-421.
28. D.K. Lahiri, S. Lewis and M.R. Farlow, Tacrine alters the secretion of beta-amyloid precursor protein in cell ines, J. Neurosci. Res. 37 (1994), 777-787.
29. P.N. Lee, Smoking and Alzheimer's disease: A review of the epidemiological evidence, Neuroepidemiol. 13 (1994), 131-144.
30. C. Leutje and J. Patrick, Both α and β subunits contribute to the agonist sensitivity of neuronal nicotinic receptors, J. Neurosci. 7 (1991), 2153-2162.
31. J. Loefler and G. Huber, Modulation of β-amyloid precusror protein secretion in differentiated and nondifferentiated cells, Biochem. Biophys. Res. Commun. 195 (1993), 97-103.
32. D.H. Malin, J.R. Lake, P. Newlin-Maultsby, L.K. Roberts, J.G. Lanier, V.A. Carter, J.S. Cunningham and O.B. Wilson, Rodent model of nicotine abstinence syndrome, Pharmacol. Biochem. Behav. 43 (1992), 779-784.
33. M.J. Marks, J.B. Burch and A.C. Collins, Effects of chronic nicotine infusion on tolerance development and nicotinic receptors, J. Pharmacol. Exp. Ther. 226 (1983), 817-826.
34. L.M. Monteggia, S.P. Americ and T. Giordano, Nicotine effects on the regulation of amyloid precursor protein splicing, neurotrophin and glucose transporter RNA levels in aged rats, Int. J. Devl. Neurosci. 12 (1994), 133-142.
35. C. Mulle, D. Choquet, H. Korn and J.P. Changeux, Calcium influx through nicotinic receptor in rat central neurons: Its relevance to cellular regulation, Neuron 8 (1992), 135-143.
36. H. Nakayama, Purification of nicotinic acetylcholine receptors from brain and ganglion, Seikagaku 63 (1991), 424-428.
37. P.A. Newhouse, T. Sunderland, P.N. Tariot, M.A. Blumhardt, H. Weingartner and W. Mellow, Intravenous nicotine in Alzheimer's disease: A pilot study, Psychopharmacol. 95 (1988), 171-175.
38. R.M. Nitsch, M.M. Deng, J.H. Growden and R.J. Wurtman, Serotonin 5HT2a and 5HT2c receptors stimulate β-amyloid precursor protein ectodomain seceretion, J. Biol. Chem. 271 (1996), 4188-4194.
39. R.M. Nitsch, J.H. Growdon, S.A. Farber, M. Deng and R.J. Wurtman, Regulation of APP processing by first messengers, in: Alzheimer Disease: Therapeutic Strategies, R. Becker and E. Giacobini, eds, Birkhäuser/Berlin, 1994, pp. 54-61.
40. R.M. Nitsch, B.E. Slack, S.A. Farber, P.R. Borghesani, J.G. Schulz, C. Kim, C.C. Felder, J.H. Growden and R.J. Wurtman, Receptor-coupled β-amyloid precusor protein processing, Ann. N.Y. Acad. Sci. 881 (1994), 122-127.
41. R.M. Nitsch, B.E. Slack, R.J. Wurtman and J.H. Growdon, Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors, Science 258 (1992), 304-307.
42. E.K. Perry, B.E. Tomlinson, G. Blessed, K. Bergman, P.H. Gibson and R.H. Perry, Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia Brit, Med. J. 2 (1978), 1457-1459.
43. E.G. Peralta, A. Ashkenazi, J.W. Winslow, J. Ramachandran and D.J. Capon, Differential regulation of PI hydrolysis and adenyl cyclase activity by muscarinic receptor subtypes, Nature 334 (1988), 434-437.
44. G. Pilleri, On the question of the relationship of the basal ganglia of Meynert (nucleus ansae lenticularis) with the temporal cortex in man, J. Hirnforsch 8 (1966), 343-358.
45. H.W. Querfurth and D.J. Selkoe, Calcium ionophore increases amyloid β peptide production by cultured cells, Biochem. 33 (1994), 4550-4561.
46. A.H. Rezvani and E.D. Levin, Cognitive effects of nicotine, Biol. Psychiatry 49 (2001), 258-267.
47. M.R. Roberson and L.E. Harrell, Cholinergic activity and amyloid precursor protein metabolism, Brain Res. Rev. 25 (1997), 50-69.
48. J.M. Roch, E. Masliah, A.C. Roch-Leveco, M.P. Sundamo, D.A.C. Otero, I. Veinbergs and T. Saitoh, Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid β/A4 protein precursor, Proc. Natll. Acad. Sci. USA 91 (1994), 7450-7454.
49. B.J. Sahakian, G.M.M. Jones, R. Levy, J.A. Grat and D.M. Warburton, The effect of nicotine on attention, information processing and short-term memory in patients with dementia of the Alzheimer's type, Br. J. Psychiatry 154 (1989), 797-800.
50. A.R. Salomon, K.J. Maccinowski, R.P. Friedland and M.G. Zagorski, Nicotine inhibits amyloid formation by the peptide, Biochem. 35 (1996), 13568-13578.
51. K. Sambamurti, N.H. Greig and D.K. Lahiri, Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease, NeuroMolecular Medicine 1 (2002), 1-20.
52. D.J. Selkoe, Alzheimer's disease: Genes, proteins and therapy, Physiol. Rev. 81 (2001), 741-766.
53. P. Seubert, T Oltersdorf, M.G. Lee, R. Barbour, C. Blomquist, D.L. Davis, K. Bryant, L.C. Fritz, D. Galasko, L.J. Thal, I. Lieberburg and D.B. Schenk, Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide, Nature 361 (1992), 260-263.
54. N.N. Sjak-Shie, E.M. Meyer and B.E. Hunter, Some novel actions of nicotine in nucleus basalis lesioned rats and in hippocampal slices, in: Cholinergic Basis for Alzheimer Therapy, R. Becker and E. Giacobini, eds, Birkhäuser/Berlin, 1991, pp. 379-385.
55. C.M. Van Dujin and A. Hofman, Relationship between nicotine intake and Alzheimer's disease, Br. Med. J. 302 (1991), 1491-1494.
56. S. Vernino, M. Amador, C.W. Leutje, J. Patrick and J.A. Dani, Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors, Neuron 8 (1992), 127-134.
57. W.C. Wallace, S.T. Ahlers, J. Gotlib, V. Bragin, J. Sugar, R. Gluck, P.A. Shea, K.L. Davis and V. Haroutunian, Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation, Proc. Natl. Acad. Sci. USA 90 (1993), 8712-8716.
58. W.C. Wallace, I. Lieberburg, D. Schenk, C. Vigo-Pelfrey, K.L. Davis and V. Haroutunian, Chronic elevation of secreted amyloid precursor protein in subcortically lesioned rats, and its exacerbation in aged rats, J. Neurosci. 15 (1995), 4896-4905.
59. S. Wonnacott, J. Irons, C. Rapier, B. Tome and C.G. Lunt, Presynaptic modulation of transmitter release by nicotinic receptors, in: Progress in Brain Research, A. Nordberg, K. Fuxe, B. Holstedt and A. Sundwall, eds, Elsevier/Amsterdam, Hooland, 1990, pp. 157-163.
60. B.A. Yankner, L.R. Dawes, S. Fisher, L. Villa-Komaroff, M. Oster-Granite and R.L. Neve, Neurotoxicity of a fragment of the amyloid percursor protein associated with Alzheimer's disease, Science 245 (1989), 417-420.