Nicotine and behavioral markers of risk for schizophrenia: A double-blind, placebo-controlled, cross-over study

Neuropsychopharmacology

Volumn 27, Issue 6, 2002, Pages 1056-1070

  Dépatie, Lana ^a,b   O'Driscoll, Gillian A ^a,b   Holahan, Anne Lise V ^a   Atkinson, Victoria ^b   Thavundayil, Joseph X ^b   Kin, N Ng Ying ^b   Lal, Samarthji ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Antisaccade; Eye movements; Nicotine; Schizophrenia; Smooth pursuit; Sustained attention

Indexed keywords

NICOTINE; PLACEBO;

ADULT; ARTICLE; ATTENTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MONITORING; FEMALE; HUMAN; MALE; PERFORMANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SCHIZOPHRENIA; TRANSDERMAL PATCH;

ADULT; ANALYSIS OF VARIANCE; ATTENTION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EYE MOVEMENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; NICOTINE; PSYCHOMOTOR PERFORMANCE; RISK FACTORS; SCHIZOPHRENIA;

EID: 0036897934     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(02)00372-X     Document Type: Article

References (87)

1. Adler L.E., Hoffer L.D., Wiser A., Freedman R. Normalization of auditory physiology by cigarette smoking in schizophrenic patients. Am J Psychiatry. 150:1993;1856-1861.
2. Adler L.E., Hoffer L.J., Griffith J., Waldo M.C., Freedman R. Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics. Biol Psychiatry. 32:1992;607-616.
3. Aizawa H., Kobayashi Y., Yamamoto M., Isa T. Injection of nicotine into the superior colliculus facilitates occurrence of express saccades in monkeys. J Neurophysiol. 82:1999;1642-1646.
4. Alkondon M., Pereira E.F., Almeida L.E., Randall W.R., Albuquerque E.X. Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus. Neuropharmacology. 39:2000;2726-2739.
5. APA Diagnostic and Statistical Manual of Mental Disorders. 1994;American Psychiatric Association Press, Washington, DC.
6. Bell B.B., Abel L.A., Li W., Christian J.C., Yee R.D. Concordance of smooth pursuit and saccadic measures in normal monozygotic twin pairs. Biol Psychiatry. 36:1994;522-526.
7. Bertelsen A. Controversies and consistencies in psychiatric genetics. Acta Psychiat Scand. 319:1985;61-75.
8. Bezchlibnyk-Butler K.K., Jeffries J.J. Clinical Handbook of Psychotropic Drugs. 1998;Hogrefe & Huber, Seattle.
9. Breese C.R., Lee M.J., Adams C.E., Sullivan B., Logel J., Gillen K.M., Marks M.J., Collins A.C., Leonard S. Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia. Neuropsychopharmacology. 23:2001;351-364.
10. Brown R.M., Crane A.M., Goldman P.S. Regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey. concentrations and in vivo synthesis rates Brain Res. 168:1979;133-150.
11. Buchsbaum M.S., Haier R.J., Potkin S.G., Nuechterlein K., Bracha H.S., Katz M., Lohr J., Wu J., Lottenberg S., Jerabek P.A. Frontostriatal disorder of cerebral metabolism in never-medicated schizophrenics. Arch Gen Psychiat. 49:1992;935-942.
12. Clarke P.B., Schwartz R.D., Paul S.M., Pert C.B., Pert A. Nicotinic binding in rat brain. autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin J Neurosci. 5:1985;1307-1315.
13. Clementz B.A., McDowell J.E., Zisook S. Saccadic system functioning among schizophrenia patients and their first-degree biological relatives. J Abnorm Psychol. 103:1994;277-287.
14. Cornblatt B.A., Risch N.J., Faris G., Friedman D., Erlenmeyer-Kimling L. The Continuous Performance Test, identical pairs version (CPT- IP). I. New findings about sustained attention in normal families Psychiatry Res. 26:1988;223-238.
15. Cornblatt B.A., Keilp J.G. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull. 20:1994;31-46.
16. Coull J.T. Neural correlates of attention and arousal. insights from electrophysiology, functional neuroimaging and psychopharmacology Prog Neurobiol. 55:1998;343-361.
17. Dépatie L., O'Driscoll G.A., Wolff A.-L., Atkinson V., Thavundayil J.X., Ng Ying Kin N., Lal S. Nicotine improves attention and eye movement performance in schizophrenia. Psychophysiol. 38:2001;S36. a.
18. Dépatie L., O'Driscoll G.A., Wolff A.-L., Atkinson V., Thavundayil J.X., Ng Ying Kin N., Lal S. The effect of nicotine on attention and eye movements in schizophrenia. Schizophr Res. 49:2001;213. b.
19. Domino E.F., Ni L.S., Zhang H. Effects of tobacco smoking on human ocular smooth pursuit. Clin Pharmacol Ther. 61:1997;349-359.
20. Epstein J.N., Johnson D.E., Varia I.M., Conners C.K. Neuropsychological assessment of response inhibition in adults with ADHD. J Clin Exp Neuropsychol. 23:2001;362-371.
21. Fagerström K.O. Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. Addict Behav. 3:1978;235-241.
22. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders. 1996;New York State Psychiatric Institute, New York.
23. Frankenhaeuser M., Myrsten A.-L., Post B., Johansson G. Behavioural and physiological effects of cigarette smoking in a monotonous situation. Psychopharmacology (Berl.). 22:1971;1-7.
24. Freedman R., Coon H., Myles-Worsley M., Orr-Urtreger A., Olincy A., Davis A., Polymeropoulos M., Holik J., Hopkins J., Hoff M., Rosenthal J., Waldo M.C., Reimherr F., Wender P., Yaw J., Young D.A., Breese C.R., Adams C., Patterson D., Adler L.E., Kruglyak L., Leonard S., Byerley W. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci USA. 94:1997;587-592.
25. Freedman R., Hall M., Adler L.E., Leonard S. Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Biol Psychiatry. 38:1995;22-33.
26. Friedman L., Jesberger J.A., Malki A., Brar R., Meltzer H.Y. A methodology for the assessment of smooth pursuit dysfunction. Int J Meth Psychiatry Res. 2:1992;209-216.
27. Fukushima J., Morita N., Fukushima K., Chiba T., Tanaka S., Yamashita I. Voluntary control of saccadic eye movements in patients with schizophrenic and affective disorders. J Psychiatry Res. 24:1990;9-24.
28. Gibson J.M., Pimlott R., Kennard C. Ocular motor and manual tracking in Parkinson's disease and the effect of treatment. J Neurol Neurosurg Psychiatry. 50:1987;853-860.
29. Gorsline J., Gupta S.K., Dye D., Rolf C.N. Steady-state pharmacokinetics and dose relationship of nicotine delivered from Nicoderm (Nicotine Transdermal System). J Clin Pharmacol. 33:1993;161-168.
30. Gorsline J., Okerholm R.A., Rolf C.N., Moos C.D., Hwang S.S. Comparison of plasma nicotine concentrations after application of nicoderm (nicotine transdermal system) to different skin sites. J Clin Pharmacol. 32:1992;576-581.
31. Gottesman I.I., Bertelsen A. Confirming unexpressed genotypes for schizophrenia. Risks in the offspring of Fischer's Danish identical and fraternal discordant twins. Arch Gen Psychiatry. 46:1989;867-872.
32. Gottesman I.I., McGuffin P., Farmer A.E. Clinical genetics as clues to the "real" genetics of schizophrenia (a decade of modest gains while playing for time). Schizophr Bull. 13:1987;23-47.
33. Guitton D., Buchtel H., Douglas R.M. Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and generating goal-directed saccades. Exp Brain Res. 58:1985;455-472.
34. Hikosaka O., Wurtz R.H. Visual and oculomotor functions of monkey substantia nigra pars reticulata. IV. Relation of substantia nigra to superior colliculus. J Neurophysiol. 49:1983;1285-1301.
35. Hikosaka O., Sakamoto M., Usui S. Functional properties of monkey caudate neurons. I. Activities related to saccadic eye movements. J Neurophysiol. 4:1989;780-798.
36. Hollingshead A., Redlich F. Social Class and Mental Illness. 1958;NY, New York.
37. Holzman P.S. Behavioral markers of schizophrenia useful for genetic studies. J Psychiatr Res. 26:1992;427-445.
38. Holzman P.S., Proctor L.R., Hughes D.W. Eye-tracking patterns in schizophrenia. Science. 181:1973;179-181.
39. Hughes J.R., Hatsukami D.K., Mitchell J.E., Dahlgren L.A. Prevalence of smoking among psychiatric outpatients. Am J Psychiatry. 143:1986;993-997.
40. Iacono W.G., Lykken D.T. Eye tracking and psychophathology. New procedures applied to a sample of normal monozygotic twins. Arch Gen Psychiatry. 36:1979;1361-1370.
41. Imperato A., Mulas A., Di Chiara G. Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats. Euro J Pharmacol. 132:1986;337-338.
42. Ingvar D.H., Franzen G. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand. 50:1974;425-462.
43. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 13:1987;261-276.
44. Kendler K (1986): Genetics of schizophrenia. In Frances AJ, Hales RE (eds), Psychiatry Update: American Psychiatric Association Annual Review. Washington, DC, American Psychiatric Association Press, pp 5:25-41.
45. Kety S.S., Wender P.H., Jacobsen B., Ingraham L.J., Jansson L., Faber B., Kinney D.K. Mental illness in the biological and adoptive relatives of schizophrenic adoptees. Replication of the Copenhagen Study in the rest of Denmark. Arch Gen Psychiat. 51:1994;442-455.
46. Klein C., Andresen B. On the influence of smoking upon smooth pursuit eye movements of schizophrenics and normal controls. J Psychophysiol. 5:1991;361-369.
47. Kodaka Y., Mikami A., Kubota K. Neuronal activity in the frontal eye field of the monkey is modulated while attention is focused on to a stimulus in the peripheral visual field, irrespective of eye movement. Neurosci Res. 28:1997;291-298.
48. Kori A., Miyashita N., Kato M., Hikosaka O., Usui S., Matsumura M. Eye movements in monkeys with local dopamine depletion in the caudate nucleus. II. Deficits in voluntary saccades. J Neurosci. 15:1995;928-941.
49. Leonard S., Adams C., Breese C.R., Adler L.E., Bickford P., Byerley W., Coon H., Griffith J.M., Miller C., Myles-Worsley M., Nagamoto H.T., Rollins Y., Stevens K.E., Waldo M., Freedman R. Nicotinic receptor function in schizophrenia. Schizophr Bull. 22:1996;431-445.
50. Levin E.D., Wilson W., Rose J.E., McEvoy J. Nicotine-haloperidol interactions and cognitive performance in schizophrenics. Neuropsychopharmacology. 15:1996;429-436.
51. Levin E.D., Conners C.K., Silva D., Hinton S.C., Meck W.H., March J., Rose J.E. Transdermal nicotine effects on attention. Psychopharmacology (Berl). 140:1998;135-141.
52. Levy D.L., Holzman P.S., Matthysse S., Mendell N.R. Eye tracking dysfunction and schizophrenia. a critical perspective Schizophr Bull. 19:1993;461-536.
53. Lohr J.B., Flynn K. Smoking and schizophrenia. Schizophr Res. 8:1992;93-102.
54. Luntz-Leybman V., Bickford P.C., Freedman R. Cholinergic gating of response to auditory stimuli in rat hippocampus. Brain Res. 587:1992;130-136.
55. MacAvoy M.J., Gottlieb J.P., Bruce C.J. Smooth pursuit eye movement representation in the primate frontal eye field. Cereb Cortex. 1:1991;92-102.
56. Meltzer H.Y., Stahl S.M. The dopamine hypothesis of schizophrenia. a review Schizophr Bull. 2:1976;19-76.
57. Myles-Worsley M., Coon H., McDowell J., Brenner C., Hoff M., Lind B., Bennett P., Freedman R., Clementz B., Byerley W. Linkage of a composite inhibitory phenotype to a chromosome 22q locus in eight Utah families. Am J Med Genet. 88:1999;544-550.
58. O'Driscoll G.A., Alpert N.M., Matthysse S.W., Levy D.L., Rauch S.R., Holzman P.S. The functional neuroanatomy of antisaccade performance investigated with positron emission tomography. Proc Natl Acad Sci USA. 92:1995;925-929.
59. O'Driscoll G.A., Lenzenweger M.F., Holzman P.S. Antisaccades and smooth pursuit eye tracking and schizotypy. Arch Gen Psychiatry. 55:1998;837-843.
60. O'Driscoll G.A., Wolff A.-L., Atkinson V., Affifi T., Dépatie L., Lal S. Nicotine and behavioral markers of risk for schizophrenia. A double-blind, crossover study Schizophr Res. 36:1999;312. a.
61. O'Driscoll G.A., Benkelfat C., Florencio P.S., Wolff A.L., Joober R., Lal S., Evans A.C. Neural correlates of eye tracking deficits in first-degree relatives of schizophrenic patients. a positron emission tomography study Arch Gen Psychiatry. 56:1999;1127-1134. b.
62. Okubo Y., Suhara T., Suzuki K., Kobayashi K., Inoue O., Terasaki O., Someya Y., Sassa T., Sudo Y., Matsushima E., Iyo M., Tateno Y., Toru M. Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET. Nature. 385:1997;634-636.
63. Olincy A., Ross R.G., Young D.A., Roath M., Freedman R. Improvement in smooth pursuit eye movements after cigarette smoking in schizophrenic patients. Neuropsychopharmacology. 18:1998;175-185.
64. Orzack M.H., Kornetsky C. Attention dysfunction in chronic schizophrenia. Arch Gen Psychiatry. 14:1966;323-326.
65. Paterson D., Nordberg A. Neuronal nicotinic receptors in the human brain. Prog Neurobiol. 61:2000;75-111.
66. Paus T. Location and function of the human frontal eye-field. a selective review Neuropsychologia. 34:1996;475-483.
67. Rascol O., Clanet M., Montastruc J.L., Simonetta M., Soulier-Esteve M.J., Doyon B., Rascol A. Abnormal ocular movements in Parkinson's disease. Evidence for involvement of dopaminergic systems. Brain. 112:1989;1193-1214.
68. Roitman S.E., Cornblatt B.A., Bergman A., Obuchowski M., Mitropoulou V., Silverman J.M., Siever L.J. Attentional functioning in schizotypal personality disorder. Am J Psychiatry. 154:1997;655-660.
69. Ross D.E., Thaker G.K., Holcomb H.H., Cascella N.G., Medoff D.R., Tamminga C.A. Abnormal smooth pursuit eye movements in schizophrenic patients are associated with cerebral glucose metabolism in oculomotor regions. Psychiatry Res. 58:1995;53-67.
70. Rusted J.M., Warburton D.M. Facilitation of memory by post-trial administration of nicotine. evidence for an attentional explanation Psychopharmacology. 108:1992;452-455.
71. Sibony P.A., Evinger C., Manning K.A. The effects of tobacco smoking on smooth pursuit eye movements. Ann Neurol. 23:1988;238-241.
72. Siever L.J., Coursey R.D., Alterman I.S., Buchsbaum M.S., Murphy D.L. Impaired smooth pursuit eye movement. vulnerability marker for schizotypal personality disorder in a normal volunteer population Am J Psychiatry. 141:1984;1560-1566.
73. Stevens K.E., Freedman R., Collins A.C., Hall M., Leonard S., Marks M.J., Rose G.M. Genetic correlation of inhibitory gating of hippocampal auditory evoked response and alpha-bungarotoxin-binding nicotinic cholinergic receptors in inbred mouse strains. Neuropsychopharmacology. 15:1996;152-162.
74. Straube A., Ditterich J., Oertel W., Kupsch A. Electrical stimulation of the posteroventral pallidum influences internally guided saccades in Parkinson's disease. J Neurol. 245:1998;101-105.
75. Sweeney J.A., Clementz B.A., Haas G.L., Escobar M.D., Drake K., Frances A.J. Eye tracking dysfunction in schizophrenia. characterization of component eye movement abnormalities, diagnostic specificity, and the role of attention J Abnorm Psychol. 103:1994;222-230.
76. Swets J.A. The relative operating characteristic in psychology. Science. 182:1973;990-1000.
77. Tedeschi G., Bittencourt P.R., Smith A.T., Richens A. Effect of amphetamine on saccadic and smooth pursuit eye movements. Psychopharmacology. 79:1983;190-192.
78. Thaker G.K., Ellsberry R., Moran M., Lahti A., Tamminga C. Tobacco smoking increases square-wave jerks during pursuit eye movements. Biol Psychiatry. 29:1991;82-88.
79. Tian J.R., Lynch J.C. Subcortical input to the smooth and saccadic eye movement subregions of the frontal eye field in cebus monkey. J Neurosc. 17:1997;9233-9247.
80. Tsung C.S., Grenhoff J., Svensson T.H. Nicotine counteracts midbrain dopamine cell dysfunction induced by prefrontal cortex inactivation. Acta Physiol Scand. 138:1990;427-428.
81. Van Vunakis H., Gjika H.B., Langone J.J. Radioimmunoassay for nicotine and cotinine in environmental carcinogens methods of analysis and exposure measurement. O'Neill I.K., Brunnemann K.D., Dodet B., Hoffmann D. Environmental Carcinogens Methods of Analysis and Exposure Measurement. 1987;317-330 W.H.O. International Agency for Research on Cancer, Lyon.
82. Warburton D.M., Arnall C. Improvements in performance without nicotine withdrawal. Psychopharmacology (Berl). 115:1994;539-542.
83. Warburton D.M., Mancuso G. Evaluation of the information processing and mood effects of a transdermal nicotine patch. Psychopharmacology. 135:1998;305-310.
84. Wechsler D. Wechsler Adult Intelligence Scale - Revised. 1981;The Psychological Corporation, San Antonio, TX.
85. Weinberger D.R., Berman K.F., Zec R.F. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry. 43:1986;114-124.
86. Wonnacott S., Irons J., Rapier C., Thorne B., Lunt G.G. Presynaptic modulation of transmitter release by nicotinic receptors. Prog Brain Res. 79:1989;157-163.
87. Zhu P.J., Chiappinelli V.A. Nicotine modulates evoked GABAergic transmission in the brain. J Neurophysiol. 82:1999;3041-3045.