Structural and functional associations of apical junctions with cytoskeleton

Biochimica et Biophysica Acta - Biomembranes

Volumn 1778, Issue 3, 2008, Pages 670-691

  Miyoshi, Jun ^a   Takai, Yoshimi ^b  

^a OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Actin cytoskeleton; Cadherin; Epithelial cell polarity; Nectin; Small G protein

Indexed keywords

ACTIN;

APICAL MEMBRANE; CANCER INVASION; CELL ADHESION; CELL CONTACT; CELL MOTION; CELL SHAPE; CYTOSKELETON; EPITHELIUM CELL; HUMAN; IMMUNE RESPONSE; MOLECULAR DYNAMICS; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW;

ACTINS; ADHERENS JUNCTIONS; ANIMALS; CADHERINS; CELL ADHESION; CELL ADHESION MOLECULES; CELL POLARITY; CYTOSKELETON; EPITHELIAL CELLS; HUMANS; INTERCELLULAR JUNCTIONS; MICROFILAMENT PROTEINS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; SIGNAL TRANSDUCTION; TIGHT JUNCTIONS;

EID: 39849084350     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2007.12.014     Document Type: Review

References (228)

1. Van Itallie C.M., and Anderson J.M. Claudins and epithelial paracellular transport. Annu. Rev. Physiol. 68 (2006) 403-429
2. Schneeberger E.E., and Lynch R.D. The tight junction: a multifunctional complex. Am. J. Physiol. Cell Physiol. 286 (2004) C1213-C1228
3. Umeda K., Matsui T., Nakayama M., Furuse K., Sasaki H., Furuse M., and Tsukita S. Establishment and characterization of cultured epithelial cells lacking expression of ZO-1. J. Biol. Chem. 279 (2004) 44785-44794
4. Tsukita S., and Furuse M. Occludin and claudins in tight-junction strands: leading or supporting players?. Trends Cell Biol. 9 (1999) 268-273
5. Tsukita S., Furuse M., and Itoh M. Structural and signalling molecules come together at tight junctions. Curr. Opin. Cell Biol. 11 (1999) 628-633
6. Farquhar M.G., and Palade G.E. Junctional complexes in various epithelia. J. Cell Biol. 17 (1963) 375-412
7. Knust E., and Bossinger O. Composition and formation of intercellular junctions in epithelial cells. Science 298 (2002) 1955-1959
8. Tsukita S., Furuse M., and Itoh M. Multifunctional strands in tight junctions. Nat. Rev., Mol. Cell Biol. 2 (2001) 285-293
9. Yagi T., and Takeichi M. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. Genes Dev. 14 (2000) 1169-1180
10. Gumbiner B.M. Regulation of cadherin-mediated adhesion in morphogenesis. Nat. Rev., Mol. Cell Biol. 6 (2005) 622-634
11. Takai Y., and Nakanishi H. Nectin and afadin: novel organizers of intercellular junctions. J. Cell Sci. 116 (2003) 17-27
12. Takai Y., Irie K., Shimizu K., Sakisaka T., and Ikeda W. Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization. Cancer Sci. 94 (2003) 655-667
13. Boggon T.J., Murray J., Chappuis-Flament S., Wong E., Gumbiner B.M., and Shapiro L. C-Cadherin ectodomain structure and implications for cell adhesion mechanisms. Science 296 (2002) 1308-1313
14. Satoh-Horikawa K., Nakanishi H., Takahashi K., Miyahara M., Nishimura M., Tachibana K., Mizoguchi A., and Takai Y. Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J. Biol. Chem. 275 (2000) 10291-10299
15. Ikeda W., Kakunaga S., Itoh S., Shingai T., Takekuni K., Satoh K., Inoue Y., Hamaguchi A., Morimoto K., Takeuchi M., Imai T., and Takai Y. Tage4/nectin-like molecule-5 heterophilically trans-interacts with cell adhesion molecule nectin-3 and enhances cell migration. J. Biol. Chem. Jul 278 (2003) 28167-28172
16. Martinez-Rico C., Pincet F., Perez E., Thiery J.P., Shimizu K., Takai Y., and Dufour S. Separation force measurements reveal different types of modulation of E-cadherin-based adhesion by nectin-1 and -3. J. Biol. Chem. 280 (2005) 4753-4760
17. Sako Y., Nagafuchi A., Tsukita S., Takeichi M., and Kusumi A. Cytoplasmic regulation of the movement of E-cadherin on the free cell surface as studied by optical tweezers and single particle tracking: corralling and tethering by the membrane skeleton. J. Cell Biol. 140 (1998) 1227-1240
18. Chu Y.S., Thomas W.A., Eder O., Pincet F., Perez E., Thiery J.P., and Dufour S. Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42. J. Cell Biol. 167 (2004) 1183-1194
19. Nagafuchi A., Takeichi M., and Tsukita S. The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. Cell 65 (1991) 849-857
20. Mandai K., Nakanishi H., Satoh A., Obaishi H., Wada M., Nishioka H., Itoh M., Mizoguchi A., Aoki T., Fujimoto T., Matsuda Y., Tsukita S., and Takai Y. Afadin: a novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J. Cell Biol. 139 (1997) 517-528
21. Fanning A.S., Little B.P., Rahner C., Utepbergenov D., Walther Z., and Anderson J.M. The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties. Mol. Biol. Cell 18 (2007) 721-731
22. Nagafuchi A., and Takeichi M. Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO J. 7 (1988) 3679-3684
23. Vasioukhin V., Bauer C., Yin M., and Fuchs E. Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell 100 (2000) 209-219
24. Haegel H., Larue L., Ohsugi M., Fedorov L., Herrenknecht K., and Kemler R. Lack of beta-catenin affects mouse development at gastrulation. Development 121 (1995) 3529-3537
25. Ikeda W., Nakanishi H., Miyoshi J., Mandai K., Ishizaki H., Tanaka M., Togawa A., Takahashi K., Nishioka H., Yoshida H., Mizoguchi A., Nishikawa S., and Takai Y. Afadin: a key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis. J. Cell Biol. 146 (1999) 1117-1132
26. Jung A.C., Ribeiro C., Michaut L., Certa U., and Affolter M. Polychaetoid/ZO-1 is required for cell specification and rearrangement during Drosophila tracheal morphogenesis. Curr. Biol. 16 (2006) 1224-1231
27. Wei X., and Ellis H.M. Localization of the Drosophila MAGUK protein polychaetoid is controlled by alternative splicing. Mech. Dev. 100 (2001) 217-231
28. Gumbiner B.M. Regulation of cadherin adhesive activity. J. Cell Biol. 148 (2000) 399-404
29. Nagafuchi A. Molecular architecture of adherens junctions. Curr. Opin. Cell Biol. 13 (2001) 600-603
30. Perez-Moreno M., Jamora C., and Fuchs E. Sticky business: orchestrating cellular signals at adherens junctions. Cell 112 (2003) 535-548
31. Mandai K., Nakanishi H., Satoh A., Takahashi K., Satoh K., Nishioka H., Mizoguchi A., and Takai Y. Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. J. Cell Biol. 144 (1999) 1001-1017
32. Asada M., Irie K., Morimoto K., Yamada A., Ikeda W., Takeuchi M., and Takai Y. ADIP, a novel afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions. J. Biol. Chem. 278 (2003) 4103-4111
33. Ooshio T., Irie K., Morimoto K., Fukuhara A., Imai T., and Takai Y. Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells. J. Biol. Chem. 279 (2004) 31365-31373
34. Bhattacharyya R.P., Remenyi A., Yeh B.J., and Lim W.A. Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. Annu. Rev. Biochem. 75 (2006) 655-680
35. Miyatani S., Shimamura K., Hatta M., Nagafuchi A., Nose A., Matsunaga M., Hatta K., and Takeichi M. Neural cadherin: role in selective cell-cell adhesion. Science 245 (1989) 631-635
36. Hatta M., Miyatani S., Copeland N.G., Gilbert D.J., Jenkins N.A., and Takeichi M. Genomic organization and chromosomal mapping of the mouse P-cadherin gene. Nucl. Acids Res. 19 (1991) 4437-4441
37. Govindarajan R., Zhao S., Song X.H., Guo R.J., Wheelock M., Johnson K.R., and Mehta P.P. Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin. J. Biol. Chem. 277 (2002) 50087-50097
38. Taniguchi T., Miyazaki M., Miyashita Y., Arima T., and Ozawa M. Identification of regions of alpha-catenin required for desmosome organization in epithelial cells. Int. J. Mol. Med. 16 (2005) 1003-1008
39. Itoh M., Nagafuchi A., Moroi S., and Tsukita S. Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments. J. Cell Biol. Jul 138 (1997) 181-192
40. Yamamoto T., Harada N., Kano K., Taya S., Canaani E., Matsuura Y., Mizoguchi A., Ide C., and Kaibuchi K. The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells. J. Cell Biol. 139 (1997) 785-795
41. Tachibana K., Nakanishi H., Mandai K., Ozaki K., Ikeda W., Yamamoto Y., Nagafuchi A., Tsukita S., and Takai Y. Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins. J. Cell Biol. 150 (2000) 1161-1176
42. Ooshio T., Fujita N., Yamada A., Sato T., Kitagawa Y., Okamoto R., Nakata S., Miki A., Irie K., and Takai Y. Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions. J. Cell Sci. 120 (2007) 2352-2365
43. Kobielak A., and Fuchs E. Alpha-catenin: at the junction of intercellular adhesion and actin dynamics. Nat. Rev., Mol. Cell Biol. 5 (2004) 614-625
44. Ichii T., and Takeichi M. p120-catenin regulates microtubule dynamics and cell migration in a cadherin-independent manner. Genes Cells 12 (2007) 827-839
45. Giepmans B. Gap junctions and connexin-interacting proteins. Cardiovasc. Res. 62 (2004) 233-245
46. Pignatelli M. Integrins, cadherins, and catenins: molecular cross-talk in cancer cells. J. Pathol. 186 (1998) 1-2
47. Siu M.K., and Cheng C.Y. Dynamic cross-talk between cells and the extracellular matrix in the testis. Bioessays 26 (2004) 978-992
48. Keller R. Shaping the vertebrate body plan by polarized embryonic cell movements. Science 298 (2002) 1950-1954
49. Lubarsky B., and Krasnow M.A. Tube morphogenesis: making and shaping biological tubes. Cell 112 (2003) 19-28
50. Fox D.T., and Peifer M. Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 134 (2007) 567-578
51. Dawes-Hoang R.E., Parmar K.M., Christiansen A.E., Phelps C.B., Brand A.H., and Wieschaus E.F. Folded gastrulation, cell shape change and the control of myosin localization. Development 132 (2005) 4165-4178
52. Calautti E., Grossi M., Mammucari C., Aoyama Y., Pirro M., Ono Y., Li J., and Dotto G.P. Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion. J. Cell Biol. 156 (2002) 137-148
53. Honda T., Shimizu K., Fukuhara A., Irie K., and Takai Y. Regulation by nectin of the velocity of the formation of adherens junctions and tight junctions. Biochem. Biophys. Res. Commun. 306 (2003) 104-109
54. Shen L., and Turner J.R. Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Mol. Bio. Cell 16 (2005) 3919-3936
55. Yamazaki D., Oikawa T., and Takenawa T. Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion. J. Cell Sci. 120 (2007) 86-100
56. Quinlan M.P., and Hyatt J.L. Establishment of the circumferential actin filament network is a prerequisite for localization of the cadherin-catenin complex in epithelial cells. Cell Growth. Differ. 10 (1999) 839-854
57. Peifer M. The product of the Drosophila segment polarity gene armadillo is part of a multi-protein complex resembling the vertebrate adherens junction. J. Cell Sci. 105 (1993) 993-1000
58. Cox R.T., Kirkpatrick C., and Peifer M. Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis. J. Cell Biol. 134 (1996) 133-148
59. Yamada S., Pokutta S., Drees F., Weis W.I., and Nelson W.J. Deconstructing the cadherin-catenin-actin complex. Cell 123 (2005) 889-901
60. Adams C.L., Chen Y.T., Smith S.J., and Nelson W.J. Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein. J. Cell Biol. 142 (1998) 1105-1119
61. Ehrlich J.S., Hansen M.D., and Nelson W.J. Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev. Cell 3 (2002) 259-270
62. Vaezi A., Bauer C., Vasioukhin V., and Fuchs E. Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium. Dev. Cell 3 (2002) 367-381
63. Capaldo C.T., and Macara I.G. Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells. Mol. Biol. Cell 18 (2007) 189-200
64. Yamada A., Irie K., Fukuhara A., Ooshio T., and Takai Y. Requirement of the actin cytoskeleton for the association of nectins with other cell adhesion molecules at adherens and tight junctions in MDCK cells. Genes Cells 9 (2004) 843-855
65. McNeil E., Capaldo C.T., and Macara I.G. Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells. Mol. Biol. Cell 17 (2006) 1922-1932
66. Gates J., and Peifer M. Can 1000 reviews be wrong? Actin, alpha-catenin, and adherens junctions. Cell 123 (2005) 769-772
67. Burridge K. A break in the chain?. Nature 440 (2006) 38-39
68. Pollard T.D., Blanchoin L., and Mullins R.D. Actin dynamics. J. Cell Sci. 114 (2001) 3-4
69. Millard T.H., Sharp S.J., and Machesky L.M. Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex. Biochem. J. 380 (2004) 1-17
70. Schluter K., Jockusch B.M., and Rothkegel M. Profilins as regulators of actin dynamics. Biochem. Biophys. Acta 1359 (1997) 97-109
71. Pollard T.D., and Beltzner C.C. Structure and function of the Arp2/3 complex. Curr. Opin. Struct. Biol. 12 (2002) 768-774
72. Pruyne D., Evangelista M., Yang C., Bi E., Zigmond S., Bretscher A., and Boone C. Role of formins in actin assembly: nucleation and barbed-end association. Science 297 (2002) 612-615
73. Sagot I., Rodal A.A., Moseley J., Goode B.L., and Pellman D. An actin nucleation mechanism mediated by Bni1 and profiling. Nat. Cell Biol. 4 (2002) 626-631
74. Cooper J.A., and Schafer D.A. Control of actin assembly and disassembly at filament ends. Curr. Opin. Cell Biol. 12 (2000) 97-103
75. Bamburg J.R., McGough A., and Ono S. Putting a new twist on actin: ADF/cofilins modulate actin dynamics. Trends Cell Biol. 9 (1999) 364-370
76. El Sayegh T.Y., Arora P.D., Ling K., Laschinger C., Janmey P.A., Anderson R.A., and McCulloch C.A. Phosphatidylinositol-4,5 bisphosphate produced by PIP5KIgamma regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions. Mol. Biol. Cell 18 (2007) 3026-3038
77. Pollard T.D., and Borisy G.G. Cellular motility driven by assembly and disassembly of actin filaments. Cell 112 (2003) 453-465
78. Ponti A., Machacek M., Gupton S.L., Waterman-Storer C.M., and Danuser G. Two distinct actin networks drive the protrusion of migrating cells. Science 305 (2004) 1782-1786
79. Wang Y. Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmilling. J. Cell Biol. 101 (1985) 597-602
80. Zhang J., Betson M., Erasmus J., Zeikos K., Bailly M., Cramer L.P., and Braga V.M. Actin at cell-cell junctions is composed of two dynamic and functional populations. J. Cell Sci. 118 (2005) 5549-5562
81. Yamada S., and Nelson W.J. Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion. J. Cell Biol. 178 (2007) 517-527
82. Tsukasaki Y., Kitamura K., Shimizu K., Iwane A.H., Takai Y., and Yanagida T. Role of multiple bonds between the single cell adhesion molecules, nectin and cadherin, revealed by high sensitive force measurements. J. Mol. Biol. 367 (2007) 996-1006
83. Delon I., and Brown N.H. Integrins and the actin cytoskeleton. Curr. Opin. Cell Biol. 19 (2007) 43-50
84. Condeelis J. Life at the leading edge: the formation of cell protrusions. Annu. Rev. Cell Biol. 9 (1993) 411-444
85. Zigmond S.H. Signal transduction and actin filament organization. Curr. Opin. Cell Biol. 8 (1996) 66-73
86. Kiuchi T., Ohashi K., Kurita S., and Mizuno K. Cofilin promotes stimulus-induced lamellipodium formation by generating an abundant supply of actin monomers. J. Cell Biol. 177 (2007) 465-476
87. Amato P.A., and Taylor D.L. Probing the mechanism of incorporation of fluorescently labeled actin into stress fibers. J. Cell Biol. 102 (1986) 1074-1084
88. Theriot J.A., and Mitchison T.J. Actin microfilament dynamics in locomoting cells. Nature 352 (1991) 126-131
89. Mcgrath J.L., Tardy Y., Dewey Jr. C.F., Meister J.J., and Hartwig J.H. Simultaneous measurements of actin filament turnover, filament fraction, and monomer diffusion in endothelial cells. Biophys. J. 75 (1998) 2070-2078
90. Kobielak A., Pasolli H.A., and Fuchs E. Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables. Nat. Cell Biol. 6 (2004) 21-30
91. Helwani F.M., Kovacs E.M., Paterson A.D., Verma S., Ali R.G., Fanning A.S., Weed S.A., and Yap A.S. Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization. J. Cell Biol. 164 (2004) 899-910
92. Kovacs E.M., Goodwin M., Ali R.G., Paterson A.D., and Yap A.S. Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts. Curr. Biol. 12 (2002) 379-382
93. Drees F., Pokutta S., Yamada S., Nelson W.J., and Weis W.I. Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell 123 (2005) 903-915
94. Nagafuchi A., Ishihara S., and Tsukita S. The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-alpha catenin fusion molecules. J. Cell Biol. 127 (1994) 235-245
95. Siripara A.D., and Welch M.D. Actin regulators I. Cell 128 (2007) 626
96. Siripara A.D., and Welch M.D. Actin regulators II. Cell 128 (2007) 1014
97. Nakanishi H., Obaishi H., Satoh A., Wada M., Mandai K., Satoh K., Nishioka H., Matsuura Y., Mizoguchi A., and Takai Y. Neurabin: a novel neural tissue-specific actin filament-binding protein involved in neurite formation. J. Cell Biol. 139 (1997) 951-961
98. Vasioukhin V., and Fuchs E. Actin dynamics and cell-cell adhesion in epithelia. Curr. Opin. Cell Biol. 13 (2001) 76-84
99. Bretscher A., Edwards K., and Fehon R.G. ERM proteins and merlin: integrators at the cell cortex. Nat. Rev., Mol. Cell Biol. 3 (2002) 586-599
100. Steffen A., Faix J., Resch G.P., Linkner J., Wehland J., Small J.V., Rottner K., and Stradal T.E. Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes. Mol. Biol. Cell 17 (2006) 2581-2591
101. Goley E.D., and Welch M.D. The ARP2/3 complex: an actin nucleator comes of age. Nat. Rev., Mol. Cell Biol. 7 (2006) 713-726
102. Kovacs E.M., and Yap A.S. The web and the rock: cell adhesion and the ARP2/3 complex. Dev. Cell 3 (2002) 760-761
103. Wang W., Goswami S., Sahai E., Wyckoff J.B., Segall J.E., and Condeelis J.S. Tumor cells caught in the act of invading: their strategy for enhanced cell motility. Trends Cell Biol. 15 (2005) 138-145
104. Goley E.D., Rodenbusch S.E., Martin A.C., and Welch M.D. Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor. Mol. Cell 16 (2004) 269-279
105. Weaver A.M., Karginov A.V., Kinley A.W., Weed S.A., Li Y., Parsons J.T., and Cooper J.A. Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr. Biol. 11 (2001) 370-374
106. Krueger E.W., Orth J.D., Cao H., and McNiven M.A. A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells. Mol. Biol. Cell 14 (2003) 1085-1096
107. Wu H., and Parsons J.T. Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex. J. Cell Biol. 120 (1993) 1417-1426
108. Weed S.A., and Parsons J.T. Cortactin: coupling membrane dynamics to cortical actin assembly. Oncogene 20 (2001) 6418-6434
109. Weed S.A., Karginov A.V., Schafer D.A., Weaver A.M., Kinley A.W., Cooper J.A., and Parsons J.T. Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. J. Cell Biol. 151 (2000) 29-40
110. Martinez M.C., Ochiishi T., Majewski M., and Kosik K.S. Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho. J. Cell Biol. 162 (2003) 99-111
111. Uruno T., Liu J., Zhang P., Fan Yx., Egile C., Li R., Mueller S.C., and Zhan X. Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat. Cell Biol. 3 (2001) 259-266
112. Weaver A.M., Heuser J.E., Karginov A.V., Lee W.L., Parsons J.T., and Cooper J.A. Interaction of cortactin and N-WASP with Arp2/3 complex. Curr. Biol. 12 (2002) 1270-1278
113. Kinley A.W., Weed S.A., Weaver A.M., Karginov A.V., Bissonette E., Cooper J.A., and Parsons J.T. Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. Curr. Biol. 13 (2003) 384-393
114. Cory G.O., Garg R., Cramer R., and Ridley A.J. Phosphorylation of tyrosine 291 enhances the ability of WASP to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich syndrome protein. J. Biol. Chem. 277 (2002) 45115-45121
115. Torres E., and Rosen M.K. Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP. Mol. Cell 11 (2003) 1215-1227
116. Eden S., Rohatgi R., Podtelejnikov A.V., Mann M., and Kirschner M.W. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 418 (2002) 790-793
117. Suetsugu S., Kurisu S., Oikawa T., Yamazaki D., Oda A., and Takenawa T. Optimization of WAVE2-complexinduced actin polymerization by membrane-bound IRSp53, PIP3, and Rac. J. Cell Biol. 173 (2006) 571-585
118. Takenawa T., and Suetsugu S. The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat. Rev., Mol. Cell Biol. 8 (2007) 37-48
119. Schirenbeck A., Bretschneider T., Arasada R., Schleicher M., and Faix J. The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia. Nature Cell Biol. 7 (2005) 619-625
120. Goode B.L., and Eck M.J. Mechanism and function of formins in the control of actin assembly. Annu. Rev. Biochem. 76 (2007) 32.1-32.35
121. Li F., and Higgs H.N. Dissecting requirements for auto-inhibition of actin nucleation by the formin, mDia1. J. Biol. Chem. 280 (2005) 6986-6992
122. Rose R., Weyand M., Lammers M., Ishizaki T., Ahmadian M.R., and Wittinghofer A. Structural and mechanistic insights into the interaction between Rho and mammalian Dia. Nature 435 (2005) 513-518
123. Lammers M., Rose R., Scrima A., and Wittinghofer A. The regulation of mDia1 by autoinhibition and its release by Rho-GTP. EMBO J. 24 (2005) 4176-4187
124. Nezami A.G., Poy F., and Eck M.J. Structure of the autoinhibitory switch in formin mDia1. Structure 14 (2006) 257-263
125. Kovar D.R. Molecular details of formin-mediated actin assembly. Curr. Opin. Cell Biol. 18 (2006) 11-17
126. Sutherland J.D., and Way M. Looking over the edge: a new role for Ena/VASP proteins in lamellipodial dynamics. Dev. Cell 2 (2002) 692-694
127. Fradelizi J., Noireaux V., Plastino J., Menichi B., Louvard D., Sykes C., Golsteyn R.M., and Friederich E. ActA and human zyxin harbour Arp2/3-independent actin-polymerization activity. Nat. Cell Biol. 3 (2001) 699-707
128. Rottner K., Behrendt B., Small J.V., and Wehland J. VASP dynamics during lamellipodia protrusion. Nat. Cell Biol. 1 (1999) 321-322
129. Bear J.E., Svitkina T.M., Krause M., Schafer D.A., Loureiro J.J., Strasser G.A., Maly I.V., Chaga O.Y., Cooper J.A., Borisy G.G., and Gertler F.B. Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell 109 (2002) 509-521
130. Barzik M., Kotova T.I., Higgs H.N., Hazelwood L., Hanein D., Gertler F.B., and Schafer D.A. Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. J. Biol. Chem. 280 (2005) 28653-28662
131. Schirenbeck A., Arasada R., Bretschneider T., Stradal T.E., Schleicher M., and Faix J. The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 7694-7699
132. Scott J.A., Shewan A.M., den Elzen N.R., Loureiro J.J., Gertler F.B., and Yap A.S. Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts. Mol. Biol. Cell 17 (2006) 1085-1095
133. Ikari A., Ito M., Okude C., Sawada H., Harada H., Degawa M., Sakai H., Takahashi T., Sugatani J., and Miwa M. Claudin-16 is directly phosphorylated by protein kinase a independently of a vasodilator-stimulated phosphoprotein-mediated pathway. J. Cell Physiol. 214 (2007) 221-229
134. V. Niggli, J. Rossy, Ezrin/radixin/moesin: versatile controllers of signaling molecules and of the cortical cytoskeleton, Int. J. Biochem. Cell Biol. (in press).
135. Dawes-Hoang R.E., Parmar K.M., Christiansen A.E., Phelps C.B., Brand A.H., and Wieschaus E.F. Folded gastrulation, cell shape change and the control of myosin localization. Development 132 (2005) 4165-4178
136. Shewan A.M., Maddugoda M., Kraemer A., Stehbens S.J., Verma S., Kovacs E.M., and Yap A.S. Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts. Mol. Biol. Cell 16 (2005) 4531-4532
137. Tamada M., Perez T.D., Nelson W.J., and Sheetz M.P. Two distinct modes of myosin assembly and dynamics during epithelial wound closure. J. Cell Biol. 176 (2007) 27-33
138. Maddugoda M.P., Crampton M.S., Shewan A.M., and Yap A.S. Myosin VI and vinculin cooperate during the morphogenesis of cadherin cell-cell contacts in mammalian epithelial cells. J. Cell Biology 178 (2007) 529-540
139. Wallar B.J., and Alberts A.S. The formins: active scaffolds that remodel the cytoskeleton. Trends Cell Biol. 13 (2003) 435-446
140. Noren N.K., Niessen C.M., Gumbiner B.M., and Burridge K. Cadherin engagement regulates Rho family GTPases. J. Biol. Chem. 276 (2001) 33305-33308
141. Sahai E., and Marshall C.J. ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat. Cell Biol. 4 (2002) 408-415
142. Zhong C., Kinch M.S., and Burridge K. Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells. Mol. Biol. Cell 8 (1997) 2329-2344
143. Takaishi K., Sasaki T., Kotani H., Nishioka H., and Takai Y. Regulation of cell-cell adhesion by Rac and Rho small G proteins in MDCK cells. J. Cell Biol. 139 (1997) 1047-1059
144. Braga V.M., Machesky L.M., Hall A., and Hotchin N.A. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 137 (1997) 1421-1431
145. Kodama A., Takaishi K., Nakano K., Nishioka H., and Takai Y. Involvement of Cdc42 small G protein in cell-cell adhesion, migration and morphology of MDCK cells. Oncogene 18 (1999) 3996-4006
146. Bruewer M., Hopkins A.M., Hobert M.E., Nusrat A., and Madara J.L. RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin. Am. J. Physiol. Cell Physiol. 287 (2004) C327-C335
147. Tepass U., Truong K., Godt D., Ikura M., and Peifer M. Cadherins in embryonic and neural morphogenesis. Nat. Rev., Mol. Cell Biol. 1 (2000) 91-100
148. Irie K., Shimizu K., Sakisaka T., Ikeda W., and Takai Y. Roles and modes of action of nectins in cell-cell adhesion. Semin. Cell Dev. Biol. 15 (2004) 643-656
149. Yap A.S., and Kovacs E.M. Direct cadherin-activated cell signaling: a view from the plasma membrane. J. Cell Biol. 160 (2003) 11-16
150. Gavard J., Lambert M., Grosheva I., Marthiens V., Irinopoulou T., Riou J.F., Bershadsky A., and Mege R.M. Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J. Cell Sci. 117 (2004) 257-270
151. Fukuyama T., Ogita H., Kawakatsu T., Inagaki M., and Takai Y. Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway. Oncogene 25 (2006) 8-19
152. Sander E.E., van Delft S., ten Klooster J.P., Reid T., van der Kammen R.A., Michiels F., and Collard J.G. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J. Cell Biol. 143 (1998) 1385-1398
153. Perez-Moreno M., Davis M.A., Wong E., Pasolli H.A., Reynolds A.B., and Fuchs E. p120-catenin mediates inflammatory responses in the skin. Cell 124 (2006) 631-644
154. Kovacs E.M., Ali R.G., McCormack A.J., and Yap A.S. E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts. J. Biol. Chem. 277 (2002) 6708-6718
155. Machesky L.M., and Insall R.H. Signaling to actin dynamics. J. Cell Biol. 146 (1999) 267-272
156. Palovuori R., Sormunen R., and Eskelinen S. SRC-induced disintegration of adherens junctions of Madin-Darby canine kidney cells is dependent on endocytosis of cadherin and antagonized by Tiam-1. Lab. Invest. 83 (2003) 1901-1915
157. Yeatman T.J. A renaissance for SRC. Nat. Rev. Cancer 4 (2004) 470-480
158. Shimizu K., and Takai Y. Roles of the intercellular adhesion molecule nectin in intracellular signaling. J. Biochem. (Tokyo) 134 (2003) 631-636
159. Ozaki M., Ogita H., and Takai Y. Involvement of integrin-induced activation of protein kinase C in the formation of adherens junctions. Genes Cells 12 (2007) 651-662
160. Fukuyama T., Ogita H., Kawakatsu T., Fukuhara T., Yamada T., Sato T., Shimizu K., Nakamura T., Matsuda M., and Takai Y. Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions. J. Biol. Chem. 280 (2005) 815-825
161. Fukuhara T., Shimizu K., Kawakatsu T., Fukuyama T., Minami Y., Honda T., Hoshino T., Yamada T., Ogita H., Okada M., and Takai Y. Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG. J. Cell Biol. 166 (2004) 393-405
162. Kawakatsu T., Ogita H., Fukuhara T., Fukuyama T., Minami Y., Shimizu K., and Takai Y. Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac. J. Biol. Chem. 280 (2005) 4940-4947
163. Katata T., Irie K., Fukuhara A., Kawakatsu T., Yamada A., Shimizu K., and Takai Y. Involvement of nectin in the localization of IQGAP1 at the cell-cell adhesion sites through the actin cytoskeleton in Madin-Darby canine kidney cells. Oncogene 22 (2003) 2097-2109
164. Izumi G., Sakisaka T., Baba T., Tanaka S., Morimoto K., and Takai Y. Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments. J. Cell Biol. 166 (2004) 237-248
165. Boettner B., Govek E.E., Cross J., and Van Aelst L. The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profiling. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 9064-9069
166. Ebnet K., Schulz C.U., Meyer Zu Brickwedde M.K., Pendl G.G., and Vestweber D. Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1. J. Biol. Chem. 275 (2000) 27979-27988
167. Takahashi K., Nakanishi H., Miyahara M., Mandai K., Satoh K., Satoh A., Nishioka H., Aoki J., Nomoto A., Mizoguchi A., and Takai Y. Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with afadin, a PDZ domain-containing protein. J. Cell Biol. 145 (1999) 539-549
168. Davis M.A., Ireton R.C., and Reynolds A.B. A core function for p120-catenin in cadherin turnover. J. Cell Biol. 163 (2003) 525-534
169. Sato T., Fujita N., Yamada A., Ooshio T., Okamoto R., Irie K., and Takai Y. Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in Madin-Darby canine kidney cells. J. Biol. Chem. 281 (2006) 5288-5299
170. Kooistra M.R., Dube N., and Bos J.L. Rap1: a key regulator in cell-cell junction formation. J. Cell Sci. 120 (2007) 17-22
171. ctn. J. Biol. Chem. 280 (2005) 24095-24103
172. Kitayama H., Sugimoto Y., Matsuzaki T., Ikawa Y., and Noda M. A Ras-related gene with transformation suppressor activity. Cell 56 (1989) 77-84
173. Hogan C., Serpente N., Cogram P., Hosking C.R., Bialucha C.U., Feller S.M., Braga V.M., Birchmeier W., and Fujita Y. Rap1 regulates the formation of E-cadherin-based cell-cell contacts. Mol. Cell Biol. 24 (2004) 6690-6700
174. Sakurai A., Fukuhara S., Yamagishi A., Sako K., Kamioka Y., Masuda M., Nakaoka Y., and Mochizuki N. MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. Mol. Biol. Cell 17 (2006) 966-976
175. Wittchen E.S., van Buul J.D., Burridge K., and Worthylake R.A. Trading spaces: Rap, Rac, and Rho as architects of transendothelial migration. Curr. Opin. Hematol. 12 (2005) 14-21
176. Dobrosotskaya I.Y., and James G.L. MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures. Biochem. Biophys. Res. Commun. 270 (2000) 903-909
177. Mino A., Ohtsuka T., Inoue E., and Takai Y. Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions. Genes Cells 5 (2000) 1009-1016
178. Yajnik V., Paulding C., Sordella R., McClatchey A.I., Saito M., Wahrer D.C., Reynolds P., Bell D.W., Lake R., van den Heuvel S., Settleman J., and Haber D.A. DOCK4, a GTPase activator, is disrupted during tumorigenesis. Cell 112 (2003) 673-684
179. Arthur W.T., Quilliam L.A., and Cooper J.A. Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors. J. Cell Biol. 167 (2004) 111-122
180. Balzac F., Avolio M., Degani S., Kaverina I., Torti M., Silengo L., Small J.V., and Retta S.F. E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function. J. Cell Sci. 118 (2005) 4765-4783
181. Schwamborn J.C., and Puschel A.W. The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity. Nat. Neurosci. 7 (2004) 923-929
182. Suzuki A., and Ohno S. The PAR-aPKC system: lessons in polarity. J. Cell Sci. 119 (2006) 979-987
183. Kooistra M.R., Corada M., Dejana E., and Bos J.L. Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. FEBS Lett. 579 (2005) 4966-4972
184. Cullere X., Shaw S.K., Andersson L., Hirahashi J., Luscinskas F.W., and Mayadas T.N. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood 105 (2005) 1950-1955
185. Edwards D.C., Sanders L.C., Bokoch G.M., and Gill G.N. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat. Cell Biol. 1 (1999) 253-259
186. Nakagawa H., Miki H., Ito M., Ohashi K., Takenawa T., and Miyamoto S. N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia. J. Cell Sci. 114 (2001) 1555-1565
187. Braga V.M. Cell-cell adhesion and signaling. Curr. Opin. Cell Biol. 14 (2002) 546-556
188. Omelchenko T., Fetisova E., Ivanova O., Bonder E.M., Feder H., Vasiliev J.M., and Gelfand I.M. Contact interactions between epitheliocytes and fibroblasts: formation of heterotypic cadherin-containing adhesion sites is accompanied by local cytoskeletal reorganization. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 8632-8637
189. Weed S.A., Du Y., and Parsons J.T. Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. J. Cell Sci. 111 (1998) 2433-2443
190. Pinal N., Goberdhan D.C., Collinson L., Fujita Y., Cox I.M., Wilson C., and Pichaud F. Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells. Curr. Biol. 16 (2006) 140-149
191. Wells C.D., Fawcett J.P., Traweger A., Yamanaka Y., Goudreault M., Elder K., Kulkarni S., Gish G., Virag C., Lim C., Colwill K., Starostine A., Mnikov P., and Pawson T. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell 125 (2006) 535-548
192. Ohno S. Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity. Curr. Opin. Cell Biol. 13 (2001) 641-648
193. Fukuhara A., Irie K., Nakanishi H., Takekuni K., Kawakatsu T., Ikeda W., Yamada A., Katata T., Honda T., Sato T., Shimizu K., Ozaki H., Horiuchi H., Kita T., and Takai Y. Involvement of nectin in the localization of junctional adhesion molecule at tight junctions. Oncogene 21 (2002) 7642-7655
194. Fukuhara A., Irie K., Yamada A., Katata T., Honda T., Shimizu K., Nakanishi H., and Takai Y. Role of nectin in organization of tight junctions in epithelial cells. Genes Cells 7 (2002) 1059-1072
195. Mertens A.E., Rygiel T.P., Olivo C., van der Kammen R., and Collard J.G. The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex. J. Cell Biol. 170 (2005) 1029-1037
196. Kawakatsu T., Shimizu K., Honda T., Fukuhara T., Hoshino T., and Takai Y. trans-interactions of nectins induce formation of filopodia and lamellipodia through the respective activation of Cdc42 and Rac small G proteins. J. Biol. Chem. 277 (2002) 50749-50755
197. Kim S.H., Li Z., and Sacks D.B. E-cadherin-mediated cell-cell attachment activates Cdc42. J. Biol. Chem. 275 (2000) 36999-37005
198. Suzuki A., Yamanaka T., Hirose T., Manabe N., Mizuno K., Shimizu M., Akimoto K., Izumi Y., Ohnishi T., and Ohno S. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J. Cell Biol. 152 (2001) 1183-1196
199. Martin-Belmonte F., Gassama A., Datta A., Yu W., Rescher U., Gerke V., and Mostov K. PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell 128 (2007) 383-397
200. Yamada A., Irie K., Hirota T., Ooshio T., Fukuhara A., and Takai Y. Involvement of the annexin II-S100A10 complex in the formation of E-cadherin-based adherens junctions in Madin-Darby canine kidney cells. J. Biol. Chem. 280 (2005) 6016-6027
201. Vasioukhin V., Bauer C., Degenstein L., Wise B., and Fuchs E. Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell 104 (2001) 605-617
202. Bienz M. beta-Catenin: a pivot between cell adhesion and Wnt signaling. Curr. Biol. 15 (2005) R64-R67
203. Nelson W.J., and Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303 (2004) 1483-1487
204. Perrais M., Chen X., Perez-Moreno M., and Gumbiner B.M. E-Cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions. Mol. Biol. Cell 18 (2007) 2013-2025
205. Balda M.S., and Matter K. The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression. EMBO J. 19 (2000) 2024-2033
206. Balda M.S., Garrett M.D., and Matter K. The ZO-1 associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density. J. Cell Biol. 160 (2003) 423-432
207. Stevenson B.R., Siliciano J.D., Mooseker M.S., and Goodenough D.A. Identification of ZO-1, a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J. Cell Biol. 103 (1986) 755-766
208. Fanning A.S., and Anderson J.M. Protein modules as organizers of membrane structure. Curr. Opin. Cell Biol. 11 (1999) 432-439
209. Gumbiner B.M. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 84 (1996) 345-357
210. Raucher D., Stauffer T., Chen W., Shen K., Guo S., York J.D., Sheetz M.P., and Meyer T. Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell 100 (2000) 221-228
211. Tolias K.F., Hartwig J.H., Ishihara H., Shibasaki Y., Cantley L.C., and Carpenter C.L. Type I alpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr. Biol. 10 (2000) 153-156
212. Weernink P.A., Meletiadis K., Hommeltenberg S., Hinz M., Ishihara H., Schmidt M., and Jakobs K.H. Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42. J. Biol. Chem. 279 (2004) 7840-7849
213. Gilmore A.P., and Burridge K. Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4,5-bisphosphate. Nature 381 (1996) 531-535
214. He H., Watanabe T., Zhan X., Huang C., Schuuring E., Fukami K., Takenawa T., Kumar C.C., Simpson R.J., and Maruta H. Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation. Mol. Cell Biol. 18 (1998) 3829-3837
215. Rohatgi R., Ma L., Miki H., Lopez M., Kirchhausen T., Takenawa T., and Kirschner M.W. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 97 (1999) 221-231
216. Yin H.L., and Janmey P.A. Phosphoinositide regulation of the actin cytoskeleton. Annu. Rev. Physiol. 65 (2003) 761-789
217. Takenawa T., and Miki H. WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. J. Cell Sci. 114 (2001) 1801-1809
218. Egile C., Loisel T.P., Laurent V., Li R., Pantaloni D., Sansonetti P.J., and Carlier M.F. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. J. Cell Biol. 146 (1999) 1319-1332
219. Miki H., Yamaguchi H., Suetsugu S., and Takenawa T. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature 408 (2000) 732-735
220. Miki H., and Takenawa T. WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac. Biochem. Biophys. Res. Commun. 293 (2002) 93-99
221. Carramusa L., Ballestrem C., Zilberman Y., and Bershadsky A.D. Mammalian diaphanous-related formin Dia1 controls the organization of E-cadherin-mediated cell-cell junctions. J. Cell Sci. 120 (2007) 3870-3882
222. Li F., and Higgs H.N. The mouse formin mDia1 is a potent actin nucleation factor regulated by autoinhibition. Curr. Biol. 13 (2003) 1335-1340
223. Otomo T., Otomo C., Tomchick D.R., Machius M., and Rosen M.K. Structural basis of Rho GTPase-mediated activation of the formin mDia1. Mol. Cell 18 (2005) 273-281
224. Krause M., Dent E.W., Bear J.E., Loureiro J.J., and Gertler F.B. Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annu. Rev. Cell Dev. Biol. 19 (2003) 541-564
225. Pang J.H., Kraemer A., Stehbens S.J., Frame M.C., and Yap A.S. Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function. J. Biol. Chem. 280 (2005) 3043-3050
226. McLachlan R.W., Kraemer A., Helwani F.M., Kovacs E.M., and Yap A.S. E-Cadherin adhesion activates c-Src signaling at cell-cell contacts. Mol. Biol. Cell 18 (2007) 3214-3223
227. Sakamoto Y., Ogita H., Hirota T., Kawakatsu T., Fukuyama T., Yasumi M., Kanzaki N., Ozaki M., and Takai Y. Interaction of integrin alpha(v)beta3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions. J. Biol. Chem. 281 (2006) 19631-19644
228. Sakamoto Y., Ogita H., Komura H., and Takai Y. Involvement of nectin in inactivation of integrin alpha vbeta 3 after the establishment of cell-cell adhesion. J. Biol. Chem. 283 (2008) 496-505