Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion

Developmental Cell

Volumn 3, Issue 2, 2002, Pages 259-270

  Ehrlich, Jason S ^a   Hansen, Marc D H ^a   Nelson, W James ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; RAC1 PROTEIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL CONTACT; CELL KINETICS; CELL MEMBRANE; CELL STRAIN; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM CELL; IMAGE ANALYSIS; LAMELLIPODIUM; MICROSCOPY; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; TIME;

ANIMALIA;

EID: 0036696823     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(02)00216-2     Document Type: Article

References (47)

1. Adams, C.L., and Nelson, W.J. (1998). Cytomechanics of cadherin-mediated cell-cell adhesion. Curr. Opin. Cell Biol. 10, 572-577.
2. Adams, C.L., Chen, Y.T., Smith, S.J., and Nelson, W.J. (1998). Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein. J. Cell Biol. 142, 1105-1119.
3. Ahmari, S.E., Buchanan, J., and Smith, S.J. (2000). Assembly of presynaptic active zones from cytoplasmic transport packets. Nat. Neurosci. 3, 445-451.
4. Akhtar, N., and Hotchin, N.A. (2001). RAC1 regulates adherens junctions through endocytosis of E-cadherin. Mol. Biol. Cell 12, 847-862.
5. Akhtar, N., Hudson, K.R., and Hotchin, N.A. (2000). Co-localization of Rac1 and E-cadherin in human epidermal keratinocytes. Cell Adhes. Commun. 7, 465-476.
6. Allen, W.E., Jones, G.E., Pollard, J.W., and Ridley, A.J. (1997). Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages. J. Cell Sci. 110, 707-720.
7. Bishop, A.L., and Hall, A. (2000). Rho GTPases and their effector proteins. Biochem. J. 348, 241-255.
8. Braga, V.M., Machesky, L.M., Hall, A., and Hotchin, N.A. (1997). The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 137, 1421-1431.
9. Braga, V.M., Betson, M., Li, X., and Lamarche-Vane, N. (2000). Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes. Mol. Biol. Cell 11, 3703-3721.
10. Chamberlain, C.E., Kraynov, V.S., and Hahn, K.M. (2000). Imaging spatiotemporal dynamics of Rac activation in vivo with FLAIR. Methods Enzymol. 325, 389-400.
11. Espada, J., Perez-Moreno, M., Braga, V.M., Rodriguez-Viciana, P., and Cano, A. (1999). H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of β-catenin in epidermal keratinocytes. J. Cell Biol. 146, 967-980.
12. Farnsworth, C.L., and Feig, L.A. (1991). Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP. Mol. Cell. Biol. 11, 4822-4829.
13. Fukata, M., and Kaibuchi, K. (2001). Rho-family GTPases in cadherin-mediated cell-cell adhesion. Nat. Rev. Mol. Cell Biol. 2, 887-897.
14. Fukata, M., Kuroda, S., Nakagawa, M., Kawajiri, A., Itoh, N., Shoji, I., Matsuura, Y., Yonehara, S., Fujisawa, H., Kikuchi, A., and Kaibuchi, K. (1999). Cdc42 and Rac1 regulate the interaction of IQGAP1 with β-catenin. J. Biol. Chem. 274, 26044-26050.
15. Gumbiner, B.M. (2000). Regulation of cadherin adhesive activity. J. Cell Biol. 148, 399-404.
16. Hansen, M.D., and Nelson, W.J. (2001). Serum-activated assembly and membrane translocation of an endogenous Rac1:effector complex. Curr. Biol. 11, 356-360.
17. Haugh, J.M., Codazzi, F., Teruel, M., and Meyer, T. (2000). Spatial sensing in fibroblasts mediated by 3′ phosphoinositides. J. Cell Biol. 151, 1269-1280.
18. Hordijk, P.L., ten Klooster, J.P., van der Kammen, R.A., Michiels, F., Oomen, L.C., and Collard, J.G. (1997). Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science 278, 1464-1466.
19. Jacinto, A., Wood, W., Balayo, T., Turmaine, M., Martinez-Arias, A., and Martin, P. (2000). Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closure. Curr. Biol. 10, 1420-1426.
20. Jou, T.S., and Nelson, W.J. (1998). Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J. Cell Biol. 142, 85-100.
21. Jou, T.S., Schneeberger, E.E., and Nelson, W.J. (1998). Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J. Cell Biol. 142, 101-115.
22. Kim, J.B., Islam, S., Kim, Y.J., Prudoff, R.S., Sass, K.M., Wheelock, M.J., and Johnson, K.R. (2000a). N-Cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility. J. Cell Biol. 151, 1193-1206.
23. Kim, S.H., Li, Z., and Sacks, D.B. (2000b). E-cadherin-mediated cell-cell attachment activates Cdc42. J. Biol. Chem. 275, 36999-37005.
24. Kovacs, E.M., Ali, R.G., McCormack, A.J., and Yap, A.S. (2002). E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts. J. Biol. Chem. 277, 6708-6718.
25. Kraynov, V.S., Chamberlain, C., Bokoch, G.M., Schwartz, M.A., Slabaugh, S., and Hahn, K.M. (2000). Localized Rac activation dynamics visualized in living cells. Science 290, 333-337.
26. Krendel, M.F., and Bonder, E.M. (1999). Analysis of actin filament bundle dynamics during contact formation in live epithelial cells. Cell Motil. Cytoskeleton 43, 296-309.
27. Kuroda, S., Fukata, M., Nakagawa, M., Fujii, K., Nakamura, T., Ookubo, T., Izawa, I., Nagase, T., Nomura, N., Tani, H., et al. (1998). Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion. Science 281, 832-835.
28. Marshall, J.G., Booth, J.W., Stambolic, V., Mak, T., Balla, T., Schreiber, A.D., Meyer, T., and Grinstein, S. (2001). Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc γ receptor-mediated phagocytosis. J. Cell Biol. 153, 1369-1380.
29. Mochizuki, N., Yamashita, S., Kurokawa, K., Ohba, Y., Nagai, T., Miyawaki, A., and Matsuda, M. (2001). Spatio-temporal images of growth-factor-induced activation of Ras and Rap1. Nature 411, 1065-1068.
30. Nakagawa, M., Fukata, M., Yamaga, M., Itoh, N., and Kaibuchi, K. (2001). Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J. Cell Sci. 114, 1829-1838.
31. Nobes, C.D., and Hall, A. (1995). Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.
32. Nobes, C.D., and Hall, A. (1999). Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 144, 1235-1244.
33. Noren, N.K., Niessen, C.M., Gumbiner, B.M., and Burridge, K. (2001). Cadherin engagement regulates Rho family GTPases. J. Biol. Chem. 276, 33305-33308.
34. Pece, S., Chiariello, M., Murga, C., and Gutkind, J.S. (1999). Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. J. Biol. Chem. 274, 19347-19351.
35. Ridley, A.J., and Hall, A. (1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
36. Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D., and Hall, A. (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.
37. Sander, E.E., van Delft, S., ten Klooster, J.P., Reid, T., van der Kammen, R.A., Michiels, F., and Collard, J.G. (1998). Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J. Cell Biol. 143, 1385-1398.
38. Spaargaren, M., and Bos, J.L. (1999). Rab5 induces Rac-independent lamellipodia formation and cell migration. Mol. Biol. Cell 10, 3239-3250.
39. Stacey, D.W., Feig, L.A., and Gibbs, J.B. (1991). Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras. Mol. Cell. Biol. 11, 4053-4064.
40. Subauste, M.C., Von Herrath, M., Benard, V., Chamberlain, C.E., Chuang, T.H., Chu, K., Bokoch, G.M., and Hahn, K.M. (2000). Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. J. Biol. Chem. 275, 9725-9733.
41. Takaishi, K., Sasaki, T., Kotani, H., Nishioka, H., and Takai, Y. (1997). Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J. Cell Biol. 139, 1047-1059.
42. Vasioukhin, V., and Fuchs, E. (2001). Actin dynamics and cell-cell adhesion in epithelia. Curr. Opin. Cell Biol. 13, 76-84.
43. Vasioukhin, V., Bauer, C., Yin, M., and Fuchs, E. (2000). Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell 100, 209-219.
44. Watton, S.J., and Downward, J. (1999). Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction. Curr. Biol. 9, 433-436.
45. West, M.A., Prescott, A.R., Eskelinen, E.L., Ridley, A.J., and Watts, C. (2000). Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation. Curr. Biol. 10, 839-848.
46. Woodfield, R.J., Hodgkin, M.N., Akhtar, N., Morse, M.A., Fuller, K.J., Saqib, K., Thompson, N.T., and Wakelam, M.J. (2001). The p85 subunit of phosphoinositide 3-kinase is associated with β-catenin in the cadherin-based adhesion complex. Biochem. J. 360, 335-344.
47. Yonemura, S., Itoh, M., Nagafuchi, A., and Tsukita, S. (1995). Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cells. J. Cell Sci. 108, 127-142.