Interaction of cortactin and N-WASp with Arp2/3 complex

Current Biology

Volumn 12, Issue 15, 2002, Pages 1270-1278

  Weaver, Alissa M ^a   Heuser, John E ^a   Karginov, Andrei V ^a   Lee, Wei lih ^a   Parsons, J Thomas ^a   Cooper, John A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINS; AMINO ACID SEQUENCE; ANIMAL; BINDING SITES; BRAIN; CATTLE; CHICKENS; CYTOSKELETAL PROTEINS; KINETICS; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THYMUS GLAND; TRYPTOPHAN; WISKOTT-ALDRICH SYNDROME; ACTIN-RELATED PROTEIN 2; ACTIN-RELATED PROTEIN 3; ANIMALS; CORTACTIN; WISKOTT-ALDRICH SYNDROME PROTEIN, NEURONAL;

VESPIDAE;

ACTIN; ACTIN BINDING PROTEIN; ACTIN RELATED PROTEIN 2; ACTIN RELATED PROTEIN 3; CORTACTIN; CYTOSKELETON PROTEIN; HYBRID PROTEIN; NERVE PROTEIN; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; TRYPTOPHAN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BINDING SITE; BRAIN; CATTLE; CHEMISTRY; CHICKEN; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; THYMUS; WISKOTT ALDRICH SYNDROME;

EID: 0037031144     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)01035-7     Document Type: Article

References (41)

1. Actin machinery: Pushing the envelope
2. Regulation of actin filament network formation through Atp2/3 complex: Activation by a diverse array of proteins
3. The interaction of Atp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments
4. Structure of Arp2/3 complex in its activated state and in actin filament branch junctions
5. Crystal structure of Arp2/3 complex
6. Activation of the Atp2/3 complex by the Listeria Acta protein: Acta binds two actin monomers and three subunits of the Arp2/3 complex
7. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
8. Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization
9. The F-actin side binding activity of the Arp2/3 complex is essential for actin nucleation and lamellipod extension
10. Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation
11. Activation of Arp2/3 complex-mediated actin polymerization by cortactin
12. Activation of the Arp2/3 complex by the actin filament binding protein Abp1p
13. Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex
14. The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites
15. Cortactin potentiates bone metastasis of breast cancer cells
16. Overexpreseion of EMS1/cortactin in NIH3T3 fibroblasts causes increased cell motility and invasion in vitro
17. Cortactin: Coupling membrane dynamics to cortical actin assembly
18. Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Atp2/3 complex
19. Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles
20. Actin assembly at membranes controlled by ARF6
21. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP
22. Identification and characterization of a novel cytoskeleton-associated pp60src substrate
23. Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts
24. Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals
25. Cortactin is necessary for F-actin accumulation in pedestal structures induced by enteropathogenic Escherichia coli infection
26. Down-regulation of the filamentous actin crosslinking activity of cortactin by Src-mediated tyrosine phosphorylation
27. Procedure for freeze-drying molecules adsorbed to mica flakes
28. Protocol for 3-D visualization of molecules on mica via the quick-freeze, deepetch technique
29. Fission yeast myosin-I, Myo1p, stimulates actin assembly by Arp2/3 complex and shares functions with WASp
30. New tricks for an old dog?
31. p80/85 cortactin associates with the Src SH2 domain and colocalizes with v-Src in transformed cells
32. A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway
33. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility
34. The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Atp2/3 complex
35. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly
36. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity
37. The regulation of rabbit skeletal muscle contraction
38. Rate constants for the reactions of ATP-and ADP-actin with the ends of actin filaments
39. Pyrene actin: Documentation of the validity of a sensitive assay for actin polymerization
40. Cleavage of structural proteins during the assembly of the head of bacteriophage T4