Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation

Current Biology

Volumn 11, Issue 5, 2001, Pages 370-374

  Weaver, Alissa M ^a   Karginov, Andrei V ^b   Kinley, Andrew W ^b   Weed, Scott A ^c   Li, Yan ^a   Parsons, J Thomas ^b   Cooper, John A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; BOS TAURUS; VESPIDAE;

EID: 0035814938     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00098-7     Document Type: Article

References (22)

1. Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex
2. Actin assembly at membranes controlled by ARF6
3. Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles
4. The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites
5. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
6. Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3
7. The interaction of Arp2/3 complex with actin-nucleation, high affinity pointed end capping, and formation of branching networks of filaments
8. Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins
9. Arp2/3 complex and actin depolymerizing factor cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia
10. Interactions of actophorin (ADF/cofilin), Arp2/3 complex, capping protein and profilin in the remodeling and disassembly of branched actin filament networks
11. Control of actin dynamics in cell motility, Role of ADF/cofilin
12. Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins
13. Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex
14. p80/85 cortactin associates with the Src SH2 domain and colocalizes with v-Src in transformed cells
15. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
16. Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape
17. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
18. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
19. Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization
20. Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex
21. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP
22. Dynamics of capping protein and actin assembly in vitro: Uncapping barbed ends by polyphosphoinositides