Direct cadherin-activated cell signaling: A view from the plasma membrane

Journal of Cell Biology

Volumn 160, Issue 1, 2003, Pages 11-16

  Yap, Alpha S ^a   Kovacs, Eva M ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b NONE

Author keywords

Actin cytoskeleton; Cadherin; PI3 kinase; Rac; Rho GTPase

Indexed keywords

CADHERIN; CELL ADHESION MOLECULE; RAC PROTEIN;

CELL ADHESION; CELL FUNCTION; CELL INTERACTION; CELL MEMBRANE; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 0037421188     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200208156     Document Type: Short Survey

References (48)

1. Adams, C.L., Y.-T. Chen, S.J. Smith, and W.J. Nelson. 1998. Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein. J. Cell Biol. 142:1105-1119.
2. Adams, C.L., and W.J. Nelson. 1998. Cytomechanics of cadherin-mediated cell-cell adhesion. Curr. Opin. Cell Biol. 10:572-577.
3. Anastasiadis, P.Z., S.Y. Moon, M.A. Thoreson, D.J. Mariner, H.C. Crawford, Y. Zheng, and A.B. Reynolds. 2000. Inhibition of RhoA by p120 catenin. Nat. Cell Biol. 2:637-644.
4. Braga, V. 2000. Epithelial cell shape: cadherins and small GTPases. Exp. Cell Res. 261:83-90.
5. Braga, V.M., A. Del Maschio, L. Machesky, and E. Dejana. 1999. Regulation of cadherin function by Rho and Rac: modulation of junction maturation and cellular context. Mol. Biol. Cell. 10:9-22.
6. Brieher, W.M., and B.M. Gumbiner. 1994. Regulation of cadherin function during activin induced morphogenesis of Xenopus animal caps. J. Cell Biol. 126:519-527.
7. Brieher, W.M., A.S. Yap, and B.M. Gumbiner. 1996. Lateral dimerization is required for the homophilic binding activity of C-cadherin. J. Cell Biol. 135:487-489.
8. Carmeliet, P., M.G. Lampugnani, L. Moons, F. Breviario, V. Compernolle, F. Bono, G. Balconi, R. Spagnuolo, B. Oostuyse, M. Dewerchin, et al. 1999. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 98:147-157.
9. Charrasse, S., M. Meriane, F. Comunale, A. Blangy, and C. Gauthier-Rouviere. 2002. N-cadherin-dependent cell-cell contact regulates Rho GTPases and β-catenin localization in mouse C2C12 myoblasts. J. Cell Biol. 158:953-965.
10. Coniglio, S.J., T.-S. Jou, and M. Symons. 2001. Rac1 protects epithelial cells against anoikis. J. Biol. Chem. 276:28113-28120.
11. Ehrlich, J.S., M.D.H. Hansen, and W.J. Nelson. 2002. Spatio-temporal regulation of Rac1 localization and lamelliodia dynamics during epithelial cell-cell adhesion. Dev. Cell. 3:259-270.
12. Godt, D., and U. Tepass. 1998. Drosophila oocyte localization is mediated by differential cadherin-based adhesion. Nature. 395:387-391.
13. Grevengoed, E.E., J.J. Loureiro, T.L. Jesse, and M. Peifer. 2001. Abelson kinase regulates epithelial morphogenesis in Drosophila. J. Cell Biol. 155:1185-1198.
14. Hall, A. 1998. Rho GTPases and the actin cytoskeleton. Science. 279:509-514.
15. Hansen, M.D., J.S. Ehrlich, and W.J. Nelson. 2002. Molecular mechanism for orienting membrane and actin dynamics to nascent cell-cell contacts in epithelial cells. J Biol Chem. 277:45371-45376.
16. Hawkins, P.T., A. Eguinoa, R.-G. Qiu, D. Stokoe, F.T. Cooke, R. Walters, S. Wennstrom, L. Claesson-Welsh, T. Evans, M. Symons, and L. Stephens. 1995. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curt. Biol. 5:393-403.
17. Heasman, J., A. Crawford, K. Goldstone, P. Garnet-Hamrick, B. Gumbiner, P. McCrea, C. Kintner, C. Yoshida Noro, and C. Wylie. 1994. Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell. 79:791-803.
18. Hordijk, P.L., J.P. ten Klooster, R.A. van der Kammen, F. Michiels, L.C. Oomen, and J.G. Collard. 1997. Inhibition of invasion of epithelial cells by Tiam 1-Rac signaling. Science. 278:1464-1466.
19. Jou, T.-S., and W.J. Nelson. 1998. Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epitehlial (MDCK) cell polarity. J. Cell Biol. 142:85-100.
20. Kim, S.H., Z. Li, and D.B. Sacks. 2000. E-cadherin-mediated cell-cell attachment activates Cdc42. J. Biol. Chem. 275:36999-37005.
21. Kovacs, E.M., R.G. Ali, A.J. McCormack, and A.S. Yap. 2002a. E-cadherin homophilic ligation directly signals through Rac and PI3-kinase to regulate adhesive contacts. J. Biol. Chem. 277:6708-6718.
22. Kovacs, E.M., M. Goodwin, R.G. Ali, A.D. Paterson, and A.S. Yap. 2002b. Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts. Curr. Biol. 12:379-382.
23. Kuroda, S., M. Fukata, K. Fujii, T. Nakamura, I. Izawa, and K. Kaibuchi. 1997. Regulation of cell-cell adhesion of MDCK cells by Cdc42 and Rac1 small GTPases. Biochem. Biophys. Res. Commun. 240:430-435.
24. Lambert, M., D. Choquet, and P.M. Mege. 2002. Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton. J. Cell Biol. 157:469-479.
25. Lampugnani, M.G., A. Zanetti, F. Breviario, G. Balconi, F. Orsenigo, M. Corada, R. Spagnuolo, M. Betson, V. Braga, and E. Dejana. 2002. VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. Mol. Biol. Cell. 13:1175-1189.
26. Magic, C.R., D. Pinto-Santini, and S.M. Parkhurst. 2002. Rho1 interacts with p120ctn and α-catenin, and regulates cadherin-based adherens junctions in Drosophila. Development. 129:3771-3782.
27. Meigs, T.E., T.A. Fields, D.D. McKee, and P.J. Casey. 2001. Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta-catenin release. Proc. Natl. Acad. Sci. USA. 98:519-524.
28. Nakagawa, M., M. Fukata, M. Yamagawa, M. Itoh, and K. Kaibuchi. 2001. Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J. Cell Sci. 114:1829-1838.
29. Niessen, C.M., and B.M. Gumbiner. 2002. Cadherin-mediated cell sorting not determined by binding or adhesion specificity. J. Cell Biol. 156:389-400.
30. Noren, N.K., B.P. Liu, K. Burridge, and B. Kreft. 2000. p120 catenin regulates the actin cytoskeleton via rho family GTPases. J. Cell Biol. 150:567-579.
31. Noren, N.K., C.M. Niessen, B.M. Gumbiner, and K. Burridge. 2001. Cadherin engagement regulates Rho family GTPases. J. Biol. Chem. 276:33305-33308.
32. Pece, S., M. Chiariello, C. Murga, and J.S. Gutkind. 1999. Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated call-cell junctions. J. Biol. Chem. 274:19347-19351.
33. Pece, S., and J.S. Gutkind. 2000. Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation. J. Biol. Chem. 275:41227-41233.
34. Pollard, T.D., L. Blanchoin, and R.D. Mullins. 2000. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu. Rev. Biophys. Biomol. Struct. 29:545-576.
35. Raich, W.B., C. Agbunag, and J. Hardin. 1999. Rapid epithelial sheet sealing in the Caenorhabditis elegans embryo requires cadherin-dependent filopodial priming. Curr. Biol. 9:1139-1146.
36. Rottner, K., A. Hall, and J.V. Small. 1999. Interplay between Rac and Rho in the control of substrate contact dynamics. Curr. Biol. 9:640-648.
37. Schmidt, A., and A. Hall. 2002. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev. 16:1587-1609.
38. Semb, H., and G. Christofori. 1998. The tumor-suppressor function of E-cadherin. Am. J. Hum. Genet. 63:1588-1593.
39. Steinberg, M.S., and P.M. McNutt. 1999. Cadherins and their connections: adhesion junctions have broader functions. Curr. Opin. Cell Biol. 11:554-560.
40. Symons, M., and J. Settleman. 2000. Rho family GTPases: more than simple switches. Trends Cell Biol. 10:415-419.
41. Takaishi, K., T. Sasaki, H. Kotani, H. Nishioka, and Y. Takai. 1997. Regulation of cell-cell adhesion by Rac and Rho small G proteins in MDCK cells. J. Cell Biol. 139:1047-1059.
42. Togashi, H., K. Abe, A. Mizoguchi, K. Takaoka, O. Chisaka, and M. Takeichi. 2002. Cadherin regulates dendritic spine morphogenesis. Neuron. 35:77-89.
43. Vaezi, A., C. Bauet, V. Vasioukhin, and E. Fuchs. 2002. Actin cable dynamics and rho/rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium. Dev. Cell. 3:367-381.
44. Vasioukhin, V., C. Bauer, M. Yin, and E. Fuchs. 2000. Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell. 100:209-219.
45. Vleminckx, K., and R. Kemler. 1999. Cadherins and tissue formation: integrating adhesion and signaling. Bioessays. 21:211-220.
46. Watton, S.J., and J. Downward. 1999. Akt/PKB localisation and 3′-phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction. Curr. Biol. 9:433-436.
47. Xu, Y., D.-F. Guo, M. Davidson, T. Inagami, and G. Carpenter. 1997. Interaction of the adaptor protein Shc and the adhesion molecule cadherin. J. Biol. Chem. 272:13463-13466.
48. Yap, A.S., W.M. Brieher, M. Pruschy, and B.M. Gumbiner. 1997. Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function. Curr. Biol. 7:308-315.