WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac

Biochemical and Biophysical Research Communications

Volumn 293, Issue 1, 2002, Pages 93-99

  Miki, Hiroaki ^a,b   Takenawa, Tadaomi ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Arp2 3 complex; Cdc42; IRSp53; N1E 115 cells; Rac; WAVE2

Indexed keywords

BINDING PROTEIN; PROTEIN CDC42; PROTEIN IRSP53; PROTEIN WAVE2; RAC PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL LYSATE; CONTROLLED STUDY; IMMUNOPRECIPITATION; MOLECULAR INTERACTION; MOUSE; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; GLUTATHIONE TRANSFERASE; KINETICS; MICROFILAMENT PROTEINS; NERVE TISSUE PROTEINS; NEURITES; PROTEIN BINDING; RAC GTP-BINDING PROTEINS; RECOMBINANT FUSION PROTEINS; SRC HOMOLOGY DOMAINS; TRANSFECTION;

EID: 0036293357     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00218-8     Document Type: Article

References (26)

1. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome
2. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosinekinases
3. WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac
4. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
5. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex
6. WASP and WAVE family WASP proteins: Key molecules for rapid rearrangement of cortical actin filaments and cell movement
7. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
8. The interaction between N-WAS-Pand the Arp2/3 complex links Cdc42-dependent signals to actin assembly
9. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
10. Mechanismof N-WASP activation by CDC42 and phosphatidylinositol 4,5-bisphosphate
11. Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex
12. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex
13. GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex
14. A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42
15. Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway
16. Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase
17. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
18. Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kDa insulin receptor substrate to filamentous actin
19. Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex
20. Association of Ash/Grb-2 with dynamin through the Src homology 3 domain
21. The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho
22. Dentatorubral-pallidoluysian atrophy protein interacts through aproline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate
23. Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1
24. Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2
25. Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP
26. Arp2/3 complex-independent actin regulatory function of WAVE