메뉴 건너뛰기




Volumn 179, Issue 11, 2007, Pages 7593-7604

Role of STAT3 in CD4+CD25+FOXP3+ regulatory lymphocyte generation: Implications in graft-versus-host disease and antitumor immunity

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; RNA; SMALL INTERFERING RNA; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; CD3 ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; MESSENGER RNA; STAT3 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

EID: 38849093957     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.11.7593     Document Type: Article
Times cited : (120)

References (64)
  • 2
    • 0036360019 scopus 로고    scopus 로고
    • The enemy within: Keeping self reactive T cells at bay in the periphery
    • Walker, L. S., and A. K. Abbas. 2002. The enemy within: keeping self reactive T cells at bay in the periphery. Nat. Rev. Immunol. 2: 11-19.
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 11-19
    • Walker, L.S.1    Abbas, A.K.2
  • 3
    • 2442484053 scopus 로고    scopus 로고
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22: 531-562.
    • (2004) Annu. Rev. Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 4
    • 0034716925 scopus 로고    scopus 로고
    • Regulatory T cells: Key controllers of immunologic selftolerance
    • Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic selftolerance. Cell 101: 455-458.
    • (2000) Cell , vol.101 , pp. 455-458
    • Sakaguchi, S.1
  • 6
    • 0034679567 scopus 로고    scopus 로고
    • + regulatory cells that control intestinal inflammation
    • + regulatory cells that control intestinal inflammation. J. Exp. Med. 192: 295-302.
    • (2000) J. Exp. Med , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 8
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 11
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou, I., A. Sarukhan, L. Klein, and H. Boehmer. 2001. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3: 756-763.
    • (2001) Nat. Immunol , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    Boehmer, H.4
  • 20
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • Tai, X., M. Cowan, L. Feigenbaum, and A. Singer. 2005. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 6: 152-162.
    • (2005) Nat. Immunol , vol.6 , pp. 152-162
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 21
    • 0037025943 scopus 로고    scopus 로고
    • + regulatory T cells suppress lethal acute graft-versushost disease after allogeneic bone marrow transplantation
    • + regulatory T cells suppress lethal acute graft-versushost disease after allogeneic bone marrow transplantation. J. Exp. Med. 196: 389-399.
    • (2002) J. Exp. Med , vol.196 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 22
    • 0037093217 scopus 로고    scopus 로고
    • + immune regulatory cells inhibits graft-versus-host disease lethality
    • + immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99: 3493-3499.
    • (2002) Blood , vol.99 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 25
    • 28544433483 scopus 로고    scopus 로고
    • Wolf, D., A. M. Wolf, H. Rumpold, H. Fiegl, A. G. Zeimet, E. Muller-Holzner, M. Deibl. M, G. Gast, E. Gunsilius, and C. Marth. 2005. The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin. Cancer Res. 11: 8326-8331.
    • Wolf, D., A. M. Wolf, H. Rumpold, H. Fiegl, A. G. Zeimet, E. Muller-Holzner, M. Deibl. M, G. Gast, E. Gunsilius, and C. Marth. 2005. The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin. Cancer Res. 11: 8326-8331.
  • 26
    • 0041386189 scopus 로고    scopus 로고
    • + regulatory T cells in patients with gastrointestinal malignancies: Possible involvement of regulatory T cells in disease progression
    • + regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression. Cancer 98: 1089-1099.
    • (2003) Cancer , vol.98 , pp. 1089-1099
    • Sasada, T.1    Kimura, M.2    Yoshida, Y.3    Kanai, M.4    Takabayashi, A.5
  • 32
    • 0033609161 scopus 로고    scopus 로고
    • The intracellular domain of interferon-α receptor 2c (IFN-αR2c) chain is responsible for Stat activation
    • Kotenko, S. V., L. S. Izotova, O. V. Mirochnitchenko, C. Lee, and S. Pestka. 1999. The intracellular domain of interferon-α receptor 2c (IFN-αR2c) chain is responsible for Stat activation. Proc. Natl. Acad. Sci. USA 96: 5007-5012.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 5007-5012
    • Kotenko, S.V.1    Izotova, L.S.2    Mirochnitchenko, O.V.3    Lee, C.4    Pestka, S.5
  • 33
    • 0033527566 scopus 로고    scopus 로고
    • Catalytically active TYK2 is essential for interferon-β-mediated phosphorylation of STAT3 and interferon-α receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase
    • Rani, M. R., D. W. Leaman, Y. Han, S. Leung, E. Croze, E. N. Fish, A. Wolfman, and R. M. Ransohoff. 1999. Catalytically active TYK2 is essential for interferon-β-mediated phosphorylation of STAT3 and interferon-α receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase. J. Biol. Chem. 274: 32507-32511.
    • (1999) J. Biol. Chem , vol.274 , pp. 32507-32511
    • Rani, M.R.1    Leaman, D.W.2    Han, Y.3    Leung, S.4    Croze, E.5    Fish, E.N.6    Wolfman, A.7    Ransohoff, R.M.8
  • 39
    • 0029909099 scopus 로고    scopus 로고
    • An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation, I: The roles of minor H antigens and endotoxin
    • Cooke, K. R., L. Kobzik, T. R. Martin, J. Brewer, J. Delmonte Jr., J. M. Crawford, and J. L. Ferrara. 1996. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation, I: the roles of minor H antigens and endotoxin. Blood 88: 3230-3239.
    • (1996) Blood , vol.88 , pp. 3230-3239
    • Cooke, K.R.1    Kobzik, L.2    Martin, T.R.3    Brewer, J.4    Delmonte Jr., J.5    Crawford, J.M.6    Ferrara, J.L.7
  • 41
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda, K., B. E. Clausen, T. Kaisho, T. Tsujimura, N. Terada, I. Forster, and S. Akira. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10: 39-49.
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3    Tsujimura, T.4    Terada, N.5    Forster, I.6    Akira, S.7
  • 42
    • 1642619154 scopus 로고    scopus 로고
    • Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis
    • Alonzi, T., I. P. Newton, P. J. Bryce, E. Di. Carlo, G. Lattanzio, M. Tripodi, P. Musiani, and V. Poli. 2004. Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine 26: 45-56.
    • (2004) Cytokine , vol.26 , pp. 45-56
    • Alonzi, T.1    Newton, I.P.2    Bryce, P.J.3    Carlo, E.D.4    Lattanzio, G.5    Tripodi, M.6    Musiani, P.7    Poli, V.8
  • 43
    • 0037452789 scopus 로고    scopus 로고
    • STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity
    • Welte, T., S. S. Zhang, T. Wang, Z. Zhang, D. G. Hesslein, Z. Yin, A. Kano, Y. Iwamoto, E. Li, J. E. Craft, et al. 2003. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc. Natl. Acad. Sci. USA 100: 1879-1884.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1879-1884
    • Welte, T.1    Zhang, S.S.2    Wang, T.3    Zhang, Z.4    Hesslein, D.G.5    Yin, Z.6    Kano, A.7    Iwamoto, Y.8    Li, E.9    Craft, J.E.10
  • 44
    • 0036195934 scopus 로고    scopus 로고
    • Regulation of Lck activity by CD4 and CD28 in the immunological synapse
    • Holdorf, A. D., K. H. Lee, W. R. Burack, P. M. Allen, and A. S. Shaw. 2002. Regulation of Lck activity by CD4 and CD28 in the immunological synapse. Nat. Immunol. 3: 259-264.
    • (2002) Nat. Immunol , vol.3 , pp. 259-264
    • Holdorf, A.D.1    Lee, K.H.2    Burack, W.R.3    Allen, P.M.4    Shaw, A.S.5
  • 45
    • 0041426730 scopus 로고    scopus 로고
    • Golubovskaya, V. M., S. Gross, A. S. Kaur, R. I. Wilson, L. H. Xu, X. H. Yang, and W. G. Cancer. 2003. Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Mol. Cancer Res. 1: 755-764.
    • Golubovskaya, V. M., S. Gross, A. S. Kaur, R. I. Wilson, L. H. Xu, X. H. Yang, and W. G. Cancer. 2003. Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Mol. Cancer Res. 1: 755-764.
  • 47
    • 0034725025 scopus 로고    scopus 로고
    • Distinct mechanisms of STAT phosphorylation via the interferon-α/β receptor: Selective inhibition of STAT3 and STAT5 by piceatannol
    • Su, L., and M. David. 2000. Distinct mechanisms of STAT phosphorylation via the interferon-α/β receptor: selective inhibition of STAT3 and STAT5 by piceatannol. J. Biol. Chem. 275: 12661-12666.
    • (2000) J. Biol. Chem , vol.275 , pp. 12661-12666
    • Su, L.1    David, M.2
  • 49
    • 16344380754 scopus 로고    scopus 로고
    • A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
    • Song, H., R. Wang, S. Wang, and J. Lin. 2005. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc. Natl. Acad. Sci. USA 102: 4700-4705.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 4700-4705
    • Song, H.1    Wang, R.2    Wang, S.3    Lin, J.4
  • 51
    • 0020038580 scopus 로고
    • An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy
    • Powell, B. R., N. R. Buist, and P. Stenzel. 1982. An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy. J. Pediatr. 100: 731-737.
    • (1982) J. Pediatr , vol.100 , pp. 731-737
    • Powell, B.R.1    Buist, N.R.2    Stenzel, P.3
  • 53
    • 0035167967 scopus 로고    scopus 로고
    • Bennett, C. L., J. Christie, F. Ramsdell, M. E. Brunkow, P. J. Ferguson, L. Whitesell, T. E. Kelly, F. T. Saulsbury, P. F. Chance, and H. D. Ochs. 2001. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27: 20-21.
    • Bennett, C. L., J. Christie, F. Ramsdell, M. E. Brunkow, P. J. Ferguson, L. Whitesell, T. E. Kelly, F. T. Saulsbury, P. F. Chance, and H. D. Ochs. 2001. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27: 20-21.
  • 56
    • 33644784733 scopus 로고    scopus 로고
    • + regulatory T cells in cancer patients
    • + regulatory T cells in cancer patients. Blood 107: 2409-2414.
    • (2006) Blood , vol.107 , pp. 2409-2414
    • Ahmadzadeh, M.1    Rosenberg, S.A.2
  • 58
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot, J. D., J. P. Rasmussen, M. A. Gavin, and A. Y. Rudensky. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6: 1142-1151.
    • (2005) Nat. Immunol , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 60
    • 33745587303 scopus 로고    scopus 로고
    • Nucleoplasmin/ anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3
    • Kasprzycka, M., M. Marzec, X. Liu, Q. Zhang, and M. A. Wasik. 2006. Nucleoplasmin/ anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3. Proc. Natl. Acad. Sci. USA 103: 9964-9969.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 9964-9969
    • Kasprzycka, M.1    Marzec, M.2    Liu, X.3    Zhang, Q.4    Wasik, M.A.5
  • 62
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan, Y. Y., and R. A. Flavell. 2007. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445: 766-770.
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 63
    • 16844368861 scopus 로고    scopus 로고
    • Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice
    • Ling, X., And R. B. Arlinghaus. 2005. Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice. Cancer Res. 65: 2532-2536.
    • (2005) Cancer Res , vol.65 , pp. 2532-2536
    • Ling, X.1    Arlinghaus, A.R.B.2
  • 64
    • 0037987977 scopus 로고    scopus 로고
    • Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo
    • Wakkach, A., N. Fournier, V. Brun, J. P. Breittmayer, F. Cottrez, and H. Groux. 2003. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 18: 605-617.
    • (2003) Immunity , vol.18 , pp. 605-617
    • Wakkach, A.1    Fournier, N.2    Brun, V.3    Breittmayer, J.P.4    Cottrez, F.5    Groux, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.