Catalytically active TYK2 is essential for interferon-β-mediated phosphorylation of STAT3 and interferon-α receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase

Journal of Biological Chemistry

Volumn 274, Issue 45, 1999, Pages 32507-32511

  Rani, M R Sandhya ^a   Leaman, Douglas W ^a   Han, Yulong ^a   Leung, Stewart ^a,c   Croze, Ed ^c   Fish, Eleanor N ^b   Wolfman, Alan ^a   Ransohoff, Richard M ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON RECEPTOR; BETA INTERFERON; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; STAT3 PROTEIN;

ARTICLE; CATALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE INDUCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CATALYSIS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; INTERFERON-BETA; MEMBRANE PROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEINS; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, INTERFERON; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; TYK2 KINASE;

EID: 0033527566     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.45.32507     Document Type: Article

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