The transcriptional coactivator Peroxisome Proliferator-Activated Receptor (PPAR)γ coactivator-1α and the nuclear receptor PPARα control the expression of glycerol kinase and metabolism genes independently of PPARγ activation in human white adipocytes

Diabetes

Volumn 56, Issue 10, 2007, Pages 2467-2475

  Mazzucotelli, Anne ^a,b   Viguerie, Nathalie ^a,b,c   Tiraby, Claire ^a,b   Annicotte, Jean Sébastien ^a   Mairal, Aline ^a,b   Klimcakova, Eva ^a,b,c   Lepin, Emmanuelle ^a,b   Delmar, Paul ^d   Dejean, Sébastien ^e   Tavernier, Geneviève ^a,b   Lefort, Corinne ^a,b   Hidalgo, Juan ^f   Pineau, Thierry ^g   Fajas, Lluis ^a   Clément, Karine ^h   Langin, Dominique ^a,b,c,i  

^a INSERM   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c Inserm   (Czech Republic)

^d ECOLE CENTRALE PARIS   (France)

^e CNRS   (France)

^f INSTITUT DE NEUROCIÈNCIES   (Spain)

^g CEMAGREF   (France)

^h CENTRE DE RECHERCHE DES CORDELIERS   (France)

ⁱ TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; GLYCEROL KINASE; LIPID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRIACYLGLYCEROL;

ADIPOCYTE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROLYSIS KINETICS; IN VIVO STUDY; LIPID METABOLISM; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; RECEPTOR UPREGULATION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILD TYPE;

ADIPOCYTES; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCEROL KINASE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PPAR ALPHA; PPAR GAMMA;

EID: 34948899219     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-1465     Document Type: Article

References (38)

1. Crowley VE, Yeo GS, O'Rahilly S: Obesity therapy: altering the energy intake-and-expenditure balance sheet. Nat Rev Drug Discov 1:276-286, 2002
2. Astrup A, Bulow J, Madsen J, Christensen NJ: Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man. Am J Physiol 248:E507-E515, 1985
3. Oberkofler H, Dallinger G, Liu YM, Hell E, Krempler F, Patsch W: Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans. J Lipid Res 38:2125-2133, 1997
4. Tiraby C, Langin D: Conversion from white to brown adipocytes: a strategy for the control of fat mass? Trends Endocrinol Metab 14:439-441, 2003
5. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM: A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839, 1998
6. Lin J, Handschin C, Spiegelman BM: Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1:361-370, 2005
7. Finck BN, Kelly DP: PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 116:615-622, 2006
8. Vega RB, Huss JM, Kelly DP: The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol 20:1868-1876, 2000
9. Schreiber SN, Emter R, Hock MB, Knutti D, Cardenas J, Podvinec M, Oakeley EJ, Kralli A: The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. Proc Natl Acad Sci U S A 101:6472-6477, 2004
10. Larrouy D, Vidal H, Andreelli F, Laville M, Langin D: Cloning and mRNA tissue distribution of human PPARgamma coactivator-1. Int J Obes 23:1327-1332, 1999
11. Tiraby C, Tavernier G, Lefort C, Larrouy D, Bouillaud F, Ricquier D, Langin D: Acquirement of brown fat cell features by human white adipocytes. J Biol Chem 278:33370-33376, 2003
12. Guan HP, Li Y, Jensen MV, Newgard CB, Steppan CM, Lazar MA: A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat Med: 1122-1128, 2002
13. Smih F, Rouet P, Lucas S, Mairal A, Sengenes C, Lafontan M, Vaulont S, Casado M, Langin D: Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose. Diabetes 51:293-300, 2002
14. Moro C, Klimcakova E, Lolmede K, Berlan M, Lafontan M, Stich V, Bouloumie A, Galitzky J, Arner P, Langin D: Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue. Diabetologia 50:1038-1047, 2007
15. Viguerie N, Clement K, Barbe P, Courtine M, Benis A, Larrouy D, Hanczar B, Pelloux V, Poitou C, Khalfallah Y, Barsh GS, Thalamas C, Zucker JD, Langin D: In vivo epinephrine-mediated regulation of gene expression in human skeletal muscle. J Clin Endocrinol Metab 89:2000-2014, 2004
16. Delmar P, Robin S, Daudin JJ: VarMixt: efficient variance modelling for the differential analysis of replicated gene expression data. Bioinformatics 21:502-508, 2005
17. Gasull T, Rebollo DV, Romero B, Hidalgo J: Development of a competitive double antibody radioimmunoassay for rat metallothionein. J Immunoassay 14:209-225, 1993
18. Noel RJ, Antinozzi PA, McGarry JD, Newgard CB: Engineering of glycerol-stimulated insulin secretion in islet beta cells: differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling. J Biol Chem 272:18621-18627, 1997
19. Annicotte JS, Chavey C, Servant N, Teyssier J, Bardin A, Licznar A, Badia E, Pujol P, Vignon F, Maudelonde T, Lazennec G, Cavailles V, Fajas L: The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene. Oncogene 24:8167-8175, 2005
20. Guan HP, Ishizuka T, Chui PC, Lehrke M, Lazar MA: Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev 19:453-461, 2005
21. Li P, Zhu Z, Lu Y, Granneman JG: Metabolic and cellular plasticity in white adipose tissue II: role of peroxisome proliferator-activated receptor-alpha. Am J Physiol Endocrinol Metab 289:E617-E626, 2005
22. Lowell BB, Shulman GI: Mitochondrial dysfunction and type 2 diabetes. Science 307:384-387, 2005
23. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34:267-273, 2003
24. Beattie JH, Wood AM, Trayhurn P, Jasani B, Vincent A, McCormack G, West AK: Metallothionein is expressed in adipocytes of brown fat and is induced by catecholamines and zinc. Am J Physiol Regul Integr Comp Physiol 278:R1082-R1089, 2000
25. Iszard MB, Liu J, Klaassen CD: Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats. Toxicology 104:25-33, 1995
26. Houstis N, Rosen ED, Lander ES: Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440:944-948, 2006
27. Beattie JH, Wood AM, Newman AM, Bremner I, Choo KH, Michalska AE, Duncan JS, Trayhurn P: Obesity and hyperleptinemia in metallothionein (-I and -II) null mice. Proc Natl Acad Sci U S A 95:358-363, 1998
28. Ryall RL, Goldrick RB: Glycerokinase in human adipose tissue. Lipids 12:272-277, 1977
29. Newsholme EA, Parry-Billings M: Some evidence for the existence of substrate cycles and their utility in vivo. Biochem J 285:340-341, 1992
30. Cadoudal T, Blouin JM, Collinet M, Fouque F, Tan GD, Loizon E, Beale EG, Frayn KN, Karpe F, Vidal H, Benelli C, Forest C: Acute and selective regulation of glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase in adipose tissue by thiazolidinediones in type 2 diabetes. Diabetologia 50:666-675, 2007
31. Tan G, Debard C, Tiraby C, Humphreys S, Frayn KNF, Langin D, Vidal H, Karpe D: A "futile cycle" induced by thiazolidinediones in adipose tissue? Nat Med 9:811-812, 2003
32. Bogacka I, Xie H, Bray GA, Smith SR: The effect of pioglitazone on peroxisome proliferator-activated receptor-gamma target genes related to lipid storage in vivo. Diabetes Care 27:1660-1667, 2004
33. Chen JL, Peacock E, Samady W, Turner SM, Neese RA, Hellerstein MK, Murphy EJ: Physiologic and pharmacologic factors influencing glyceroneogenic contribution to triacylglyceride glycerol measured by mass isotopomer distribution analysis. J Biol Chem 280:25396 -25402, 2005
34. Bogacka I, Ukropcova B, McNeil M, Gimble JM, Smith SR: Structural and functional consequences of mitochondrial biogenesis in human adipocytes in vitro. J Clin Endocrinol Metab 90:6650-6656, 2005
35. Islam KK, Knight BL, Frayn KN, Patel DD, Gibbons GF: Deficiency of PPARalpha disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue. Biochim Biophys Acta 1734:259-268, 2005
36. Tsuchida A, Yamauchi T, Takekawa S, Hada Y, Ito Y, Maki T, Kadowaki T: Peroxisome proliferator-activated receptor (PPARα) activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARα, PPARγ, and their combination. Diabetes 54:3358-3370, 2005
37. Lee Y, Yu X, Gonzales F, Mangelsdorf DJ, Wang M-Y, Richardson C, Witters LA, Unger RH: PPARalpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue. Proc Natl Acad Sci U S A 99:11848-11853, 2002
38. Langin D: Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol Res 53:482-491, 2006