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Volumn 11, Issue 12, 2007, Pages 1553-1569

Molecular prognostic factors in patients with pancreatic cancer

Author keywords

Genes; Outcome; Pancreatic cancer; Prognosis; Protein; Survival

Indexed keywords

ADAM PROTEIN; ADAM PROTEIN 9; BEVACIZUMAB; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DYSADHERIN; ERLOTINIB; GEMCITABINE; GROWTH FACTOR; K RAS PROTEIN; MARIMASTAT; MATRILYSIN; MATRIX METALLOPROTEINASE; MICROSOMAL AMINOPEPTIDASE; MUCIN 4; PIGMENT EPITHELIUM DERIVED FACTOR; PLACEBO; PROTEIN BCL 2; PROTEIN BNIP3; PROTEIN P16; PROTEIN P53; SMAD4 PROTEIN; SURVIVIN; SYNDECAN 1; THROMBOPLASTIN; THROMBOSPONDIN 1; TIPIFARNIB; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

EID: 37349008544     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.11.12.1553     Document Type: Review
Times cited : (26)

References (165)
  • 1
    • 0034767957 scopus 로고    scopus 로고
    • Cancer burden in the year 2000. The global picture
    • PARKIN DM, BRAY FI, DEVESA SS: Cancer burden in the year 2000. The global picture. Eur. J. Cancer (2001) 37:4-66.
    • (2001) Eur. J. Cancer , vol.37 , pp. 4-66
    • PARKIN, D.M.1    BRAY, F.I.2    DEVESA, S.S.3
  • 3
    • 0032985541 scopus 로고    scopus 로고
    • Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National cancer database
    • SENER S, FRENGEN A, MENCK HR, WINCHESTER DP: Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National cancer database. J. Am. Coll. Surg. (1999) 189:1-7.
    • (1999) J. Am. Coll. Surg , vol.189 , pp. 1-7
    • SENER, S.1    FRENGEN, A.2    MENCK, H.R.3    WINCHESTER, D.P.4
  • 4
    • 0024399684 scopus 로고
    • Oncogenes, antioncogenes and the molecular basis of multistep carcinogenesis
    • WEINBERG RA: Oncogenes, antioncogenes and the molecular basis of multistep carcinogenesis. Cancer Res. (1989) 49:3713-3719.
    • (1989) Cancer Res , vol.49 , pp. 3713-3719
    • WEINBERG, R.A.1
  • 5
    • 0026491965 scopus 로고
    • Oncogenes and oncoproteins as tumor markers
    • PILLAI R: Oncogenes and oncoproteins as tumor markers. Eur. J. Surg. Oncol. (1992) 18:417-424.
    • (1992) Eur. J. Surg. Oncol , vol.18 , pp. 417-424
    • PILLAI, R.1
  • 6
    • 0026337295 scopus 로고
    • Tumor suppressor genes
    • WEINBERG RA: Tumor suppressor genes. Science (1991) 254:1138-1142.
    • (1991) Science , vol.254 , pp. 1138-1142
    • WEINBERG, R.A.1
  • 7
    • 0028988396 scopus 로고
    • Tumor suppressor genes in disease and therapy
    • SKUSE GR, LUDLOW JW: Tumor suppressor genes in disease and therapy. Lancet (1995) 345:902-906.
    • (1995) Lancet , vol.345 , pp. 902-906
    • SKUSE, G.R.1    LUDLOW, J.W.2
  • 8
    • 0031717905 scopus 로고    scopus 로고
    • Tumor-suppressor p53: Implications for tumor development and prognosis
    • KIRSCH DG, KASTAN MB: Tumor-suppressor p53: implications for tumor development and prognosis. J. Clin. Oncol. (1998) 16:3158-3168.
    • (1998) J. Clin. Oncol , vol.16 , pp. 3158-3168
    • KIRSCH, D.G.1    KASTAN, M.B.2
  • 9
    • 0029097316 scopus 로고
    • Molecular controls of growth arrest and apoptosis: P53-dependent and independent markers
    • LIEBERMANN DA, HOFFMAN B, STEINMAN RA: Molecular controls of growth arrest and apoptosis: p53-dependent and independent markers. Oncogene (1995) 11:199-210.
    • (1995) Oncogene , vol.11 , pp. 199-210
    • LIEBERMANN, D.A.1    HOFFMAN, B.2    STEINMAN, R.A.3
  • 10
    • 37649026089 scopus 로고    scopus 로고
    • Mutant p53: "gain of function" through perturbation of nuclear structure and function?
    • DEPPERT W, GOHLER T, KOGA H, KIM E: Mutant p53: "gain of function" through perturbation of nuclear structure and function? J. Cell Biochem. Suppl. (2000) 35:115-122.
    • (2000) J. Cell Biochem. Suppl , vol.35 , pp. 115-122
    • DEPPERT, W.1    GOHLER, T.2    KOGA, H.3    KIM, E.4
  • 11
    • 0035207991 scopus 로고    scopus 로고
    • Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/ Smad4
    • MOORE PS, SIPOS B, ORLANDINI S et al.: Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/ Smad4. Virc. Arch. (2001) 439:798-802.
    • (2001) Virc. Arch , vol.439 , pp. 798-802
    • MOORE, P.S.1    SIPOS, B.2    ORLANDINI, S.3
  • 12
    • 0031594279 scopus 로고    scopus 로고
    • NAKA, KOBAYASHI M, ASHIDA K et al.: Aberrant p16INK4 expression related to clinical stage and prognosis in patients with pancreatic cancer. Int. J. Oncol. (1998) 125:1111-1116.
    • NAKA, KOBAYASHI M, ASHIDA K et al.: Aberrant p16INK4 expression related to clinical stage and prognosis in patients with pancreatic cancer. Int. J. Oncol. (1998) 125:1111-1116.
  • 13
    • 0032902994 scopus 로고    scopus 로고
    • Comparative significance of p53 and WAF/1-p21 expression on the efficacy of adjuvant chemotherapy for resectable invasive ductal carcinoma of the pancreas
    • NIO Y, DONG M, UEGAKI K et al.: Comparative significance of p53 and WAF/1-p21 expression on the efficacy of adjuvant chemotherapy for resectable invasive ductal carcinoma of the pancreas. Pancreas (1999) 18(2):117-126.
    • (1999) Pancreas , vol.18 , Issue.2 , pp. 117-126
    • NIO, Y.1    DONG, M.2    UEGAKI, K.3
  • 14
    • 0028305095 scopus 로고
    • Overexpression of p53 protein in adenocarcinoma of the pancreas
    • DIGIUSEPPE A, HRUBAN RH, GOODMAN SN et al.: Overexpression of p53 protein in adenocarcinoma of the pancreas. Am. J. Clin. Pathol. (1994) 101:684-688.
    • (1994) Am. J. Clin. Pathol , vol.101 , pp. 684-688
    • DIGIUSEPPE, A.1    HRUBAN, R.H.2    GOODMAN, S.N.3
  • 15
    • 0031899556 scopus 로고    scopus 로고
    • Clinical contribution of bcl-2, p53 and Ki-67 proteins in pancreatic ductal adenocarcinoma
    • MAKINEN K, HAKALA T, LIPPONEN P et al.: Clinical contribution of bcl-2, p53 and Ki-67 proteins in pancreatic ductal adenocarcinoma. Anticancer Res. (1998) 18:615-618.
    • (1998) Anticancer Res , vol.18 , pp. 615-618
    • MAKINEN, K.1    HAKALA, T.2    LIPPONEN, P.3
  • 16
    • 0035085625 scopus 로고    scopus 로고
    • Expression of Bcl-2 and p53 protein in resectable invasive ductal carcinoma of the pancreas: Effects on clinical outcome and efficacy of adjuvant chemotherapy
    • NIO Y, DONG M, IGUCHI C et al.: Expression of Bcl-2 and p53 protein in resectable invasive ductal carcinoma of the pancreas: effects on clinical outcome and efficacy of adjuvant chemotherapy. J. Surg. Oncol. (2001) 76:188-196.
    • (2001) J. Surg. Oncol , vol.76 , pp. 188-196
    • NIO, Y.1    DONG, M.2    IGUCHI, C.3
  • 17
    • 0030999374 scopus 로고    scopus 로고
    • Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma
    • DERGHAM T, DUGAN MC, KUCWAY R et al.: Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma. Int. J. Pancreatol. (1997) 21(2):127-143.
    • (1997) Int. J. Pancreatol , vol.21 , Issue.2 , pp. 127-143
    • DERGHAM, T.1    DUGAN, M.C.2    KUCWAY, R.3
  • 18
    • 0034693635 scopus 로고    scopus 로고
    • K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma
    • KAWESHA A, GHANEH P, ANDREN-SANDBERG A et al.: K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma. Int. J. Cancer (2000) 89(6):469-474.
    • (2000) Int. J. Cancer , vol.89 , Issue.6 , pp. 469-474
    • KAWESHA, A.1    GHANEH, P.2    ANDREN-SANDBERG, A.3
  • 19
    • 0033050187 scopus 로고    scopus 로고
    • p53 overexpression in lymph node metastases predicts clinical outcome in ductal pancreatic cancer
    • CAMPANI D, BOGGI U, CECCHETTI D et al.: p53 overexpression in lymph node metastases predicts clinical outcome in ductal pancreatic cancer. Pancreas (1999) 19:26-32.
    • (1999) Pancreas , vol.19 , pp. 26-32
    • CAMPANI, D.1    BOGGI, U.2    CECCHETTI, D.3
  • 20
    • 0028670932 scopus 로고    scopus 로고
    • YOKOYAMA M, YAMANAKA Y, FRIESS H et al.: p53 expression in human pancreatic cancer correlates with enhanced biological aggressiveness. Anticancer Res. (1994) 14(6B):2477-2483.
    • YOKOYAMA M, YAMANAKA Y, FRIESS H et al.: p53 expression in human pancreatic cancer correlates with enhanced biological aggressiveness. Anticancer Res. (1994) 14(6B):2477-2483.
  • 21
    • 0032957020 scopus 로고    scopus 로고
    • Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma
    • HU YX, WATANABE H, OHTSUBO K et al.: Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma. Br. J. Cancer (1999) 80:1075-1079.
    • (1999) Br. J. Cancer , vol.80 , pp. 1075-1079
    • HU, Y.X.1    WATANABE, H.2    OHTSUBO, K.3
  • 22
    • 0027957431 scopus 로고
    • Immunohistochemical analysis of p53 expression in human pancreatic carcinomas
    • ZHANG Y, RUGGERI B, AGARWAL P et al.: Immunohistochemical analysis of p53 expression in human pancreatic carcinomas. Arch. Pathol. Lab. Med. (1994) 1182:150-154.
    • (1994) Arch. Pathol. Lab. Med , vol.1182 , pp. 150-154
    • ZHANG, Y.1    RUGGERI, B.2    AGARWAL, P.3
  • 23
    • 0034102707 scopus 로고    scopus 로고
    • Ki-ras point mutation and p53 expression in human pancreatic cancer: A comparative study among Chinese, Japanese and Western patients
    • DONG M, NIO Y, TAMURA K et al.: Ki-ras point mutation and p53 expression in human pancreatic cancer: a comparative study among Chinese, Japanese and Western patients. Cancer Epidemiol. Biomark. Prev. (2000) 9:279-284.
    • (2000) Cancer Epidemiol. Biomark. Prev , vol.9 , pp. 279-284
    • DONG, M.1    NIO, Y.2    TAMURA, K.3
  • 24
    • 0037311096 scopus 로고    scopus 로고
    • p53 alteration is not an independent prognostic indicator, but affects the efficacy of adjuvant chemotherapy in human pancreatic cancer
    • DONG M, NIO Y, YAMASAWA K et al.: p53 alteration is not an independent prognostic indicator, but affects the efficacy of adjuvant chemotherapy in human pancreatic cancer. J. Surg. Oncol. (2003) 82:111-120.
    • (2003) J. Surg. Oncol , vol.82 , pp. 111-120
    • DONG, M.1    NIO, Y.2    YAMASAWA, K.3
  • 25
    • 0031047115 scopus 로고    scopus 로고
    • Molecular pathology of primary and metastatic ductal pancreatic lesions: Analyses of mutations and expression of the p53, mdm-2, and p21/WAF-1 genes in sporadic and familial lesions
    • RUGGERI BA, HUANG L, BERGER D et al.: Molecular pathology of primary and metastatic ductal pancreatic lesions: analyses of mutations and expression of the p53, mdm-2, and p21/WAF-1 genes in sporadic and familial lesions. Cancer (1997) 79(4):700-716.
    • (1997) Cancer , vol.79 , Issue.4 , pp. 700-716
    • RUGGERI, B.A.1    HUANG, L.2    BERGER, D.3
  • 26
    • 0030443653 scopus 로고    scopus 로고
    • Bcl-2 and p53 expression in resectable pancreatic adenocarcinomas: Association with clinical outcome
    • SINICROPE FA, EVANS DB, LEACH SD et al.: Bcl-2 and p53 expression in resectable pancreatic adenocarcinomas: association with clinical outcome. Clin. Cancer Res. (1996) 2(12):2015-2022.
    • (1996) Clin. Cancer Res , vol.2 , Issue.12 , pp. 2015-2022
    • SINICROPE, F.A.1    EVANS, D.B.2    LEACH, S.D.3
  • 27
    • 0028922149 scopus 로고
    • Association of p53 gene mutations with short survival in pancreatic adenocarcinoma
    • NAKAMORI S, YASHIMA K, MURAKAMI Y et al.: Association of p53 gene mutations with short survival in pancreatic adenocarcinoma. Jpn J. Cancer Res. (1995) 86(2):174-181.
    • (1995) Jpn J. Cancer Res , vol.86 , Issue.2 , pp. 174-181
    • NAKAMORI, S.1    YASHIMA, K.2    MURAKAMI, Y.3
  • 28
    • 0029917644 scopus 로고    scopus 로고
    • Prognostic value of immunohistochemical expression of p53 in patients with pancreatic cancer
    • LUNDIN J, NORDLING S, VON BOGUSLAWSKY K et al.: Prognostic value of immunohistochemical expression of p53 in patients with pancreatic cancer. Oncology (1996) 52(2):104-111.
    • (1996) Oncology , vol.52 , Issue.2 , pp. 104-111
    • LUNDIN, J.1    NORDLING, S.2    VON BOGUSLAWSKY, K.3
  • 29
    • 0344301900 scopus 로고    scopus 로고
    • Role of the p16 tumour suppressor gene in cancer
    • LIGGETT WH, SIDRANSKY D: Role of the p16 tumour suppressor gene in cancer. J. Clin. Oncol. (1998) 16:1197-1203.
    • (1998) J. Clin. Oncol , vol.16 , pp. 1197-1203
    • LIGGETT, W.H.1    SIDRANSKY, D.2
  • 30
    • 14444284330 scopus 로고    scopus 로고
    • Tumor-suppressive pathways in pancreatic carcinoma
    • ROZENBLUM E, SCHUTTE M, GOGGINS M et al.: Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res. (1997) 57:1731-1734.
    • (1997) Cancer Res , vol.57 , pp. 1731-1734
    • ROZENBLUM, E.1    SCHUTTE, M.2    GOGGINS, M.3
  • 31
    • 0036006684 scopus 로고    scopus 로고
    • p16INK4a is a prognostic marker in resected ductal pancreatic cancer: An analysis of p16INK4a, p53, MDM2, an Rb
    • GERDES B, RAMASWAMY A, ZIEGLER A et al.: p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb. Ann. Surg. (2002) 235(1):51-59.
    • (2002) Ann. Surg , vol.235 , Issue.1 , pp. 51-59
    • GERDES, B.1    RAMASWAMY, A.2    ZIEGLER, A.3
  • 32
    • 0036894028 scopus 로고    scopus 로고
    • DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma
    • BLANKIN AV, MOREY AL, LEE C et al.: DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma. J. Clin. Oncol. (2002) 20:4531-4542.
    • (2002) J. Clin. Oncol , vol.20 , pp. 4531-4542
    • BLANKIN, A.V.1    MOREY, A.L.2    LEE, C.3
  • 33
    • 0030795157 scopus 로고    scopus 로고
    • Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma
    • HU YX, WATANABE H, OHTSUBO K et al.: Frequent loss of p16 expression and its correlation with clinicopathological parameters in pancreatic carcinoma. Clin. Cancer Res. (1997) 3(9):1473-1477.
    • (1997) Clin. Cancer Res , vol.3 , Issue.9 , pp. 1473-1477
    • HU, Y.X.1    WATANABE, H.2    OHTSUBO, K.3
  • 34
    • 0041561141 scopus 로고    scopus 로고
    • Abnormalities of tumor suppressor gene p16 in pancreatic carcinoma immunohistochemical and genetic findings compared with clinicopathological parameters
    • OHTSUBO K, WATANABE H, YAMAGUCHI Y et al.: Abnormalities of tumor suppressor gene p16 in pancreatic carcinoma immunohistochemical and genetic findings compared with clinicopathological parameters. J. Gastroenterol. (2003) 38(7):663-671.
    • (2003) J. Gastroenterol , vol.38 , Issue.7 , pp. 663-671
    • OHTSUBO, K.1    WATANABE, H.2    YAMAGUCHI, Y.3
  • 35
    • 24644494649 scopus 로고    scopus 로고
    • Clinical significance of p16 protein expression loss and aberrant p53 protein expression in pancreatic cancer
    • JEONG J, PARK YN, PARK JS, YOON DS, CHI HS, KIM BR: Clinical significance of p16 protein expression loss and aberrant p53 protein expression in pancreatic cancer. Yonsei Med. J. (2005) 46(4):519-525.
    • (2005) Yonsei Med. J , vol.46 , Issue.4 , pp. 519-525
    • JEONG, J.1    PARK, Y.N.2    PARK, J.S.3    YOON, D.S.4    CHI, H.S.5    KIM, B.R.6
  • 36
    • 0034644472 scopus 로고    scopus 로고
    • TGF-β signalling in growth control, cancer, and heritable disorders
    • MASSAGUE J, BLAIN SW, LO RS: TGF-β signalling in growth control, cancer, and heritable disorders. Cell (2000) 103:295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • MASSAGUE, J.1    BLAIN, S.W.2    LO, R.S.3
  • 37
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • HAHN SA, SCHUTTE M, HOQUE AT et al.: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science (1996) 271(5247):350-353.
    • (1996) Science , vol.271 , Issue.5247 , pp. 350-353
    • HAHN, S.A.1    SCHUTTE, M.2    HOQUE, A.T.3
  • 38
    • 0037867947 scopus 로고    scopus 로고
    • The relationship between loss expression of DPC4/Smad4 gene and carcinogenesis of pancreatobiliary carcinoma
    • TANG H, ZOU SQ, HAO YH et al.: The relationship between loss expression of DPC4/Smad4 gene and carcinogenesis of pancreatobiliary carcinoma. Hepatobiliary Pancreat. Dis. Int. (2002) 1(4):624-629.
    • (2002) Hepatobiliary Pancreat. Dis. Int , vol.1 , Issue.4 , pp. 624-629
    • TANG, H.1    ZOU, S.Q.2    HAO, Y.H.3
  • 39
    • 0348227997 scopus 로고    scopus 로고
    • Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma
    • HUA Z, ZHANG YC, HU XM, JIA ZG: Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma. World J. Gastroenterol. (2003) 9:2764-2767.
    • (2003) World J. Gastroenterol , vol.9 , pp. 2764-2767
    • HUA, Z.1    ZHANG, Y.C.2    HU, X.M.3    JIA, Z.G.4
  • 40
    • 0035671396 scopus 로고    scopus 로고
    • The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma
    • TASCILAR M, SKINNER HG, ROSTY C et al.: The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. Clin. Cancer Res. (2001) 7:4115-4121.
    • (2001) Clin. Cancer Res , vol.7 , pp. 4115-4121
    • TASCILAR, M.1    SKINNER, H.G.2    ROSTY, C.3
  • 42
    • 0034660892 scopus 로고    scopus 로고
    • The Pezcoller lecture: Cancer cell cycles revisited
    • SHERR CJ: The Pezcoller lecture: cancer cell cycles revisited. Cancer Res. (2000) 60(14):3689-3695.
    • (2000) Cancer Res , vol.60 , Issue.14 , pp. 3689-3695
    • SHERR, C.J.1
  • 43
    • 0024333967 scopus 로고
    • High frequency of Ki-ras codon 12 mutations in pancreatic adenocarcinomas
    • GRUNEWALD K LYONS J, FROHLICH A et al.: High frequency of Ki-ras codon 12 mutations in pancreatic adenocarcinomas. Int. J. Cancer (1989) 43:1037-1041.
    • (1989) Int. J. Cancer , vol.43 , pp. 1037-1041
    • GRUNEWALD, K.1    LYONS, J.2    FROHLICH, A.3
  • 44
    • 0030999374 scopus 로고    scopus 로고
    • Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma
    • DERGHAM ST, DUGAN MC, KUCWAY R et al.: Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma. Int. J. Pancreatol. (1997) 21(2):127-143.
    • (1997) Int. J. Pancreatol , vol.21 , Issue.2 , pp. 127-143
    • DERGHAM, S.T.1    DUGAN, M.C.2    KUCWAY, R.3
  • 45
    • 0033696309 scopus 로고    scopus 로고
    • Comparison of K-ras mutation at codon 12 and p21 expression in pancreatic cancer between Japanese and Chinese patients
    • SONG MM, NIO Y, DONG M et al.: Comparison of K-ras mutation at codon 12 and p21 expression in pancreatic cancer between Japanese and Chinese patients. J. Surg. Oncol. (2000) 75:176-185.
    • (2000) J. Surg. Oncol , vol.75 , pp. 176-185
    • SONG, M.M.1    NIO, Y.2    DONG, M.3
  • 46
    • 0029775661 scopus 로고    scopus 로고
    • Clinicopathological significance of K-ras point mutation and expression in benign and malignant exocrine turnouts of the human pancreas
    • SONG MM, NIO Y, SATO Y et al.: Clinicopathological significance of K-ras point mutation and expression in benign and malignant exocrine turnouts of the human pancreas. Int. J. Pancreatol. (1996) 20:85-93.
    • (1996) Int. J. Pancreatol , vol.20 , pp. 85-93
    • SONG, M.M.1    NIO, Y.2    SATO, Y.3
  • 47
    • 0031918491 scopus 로고    scopus 로고
    • DNA content and other factors associated with 10-year survival after resection of pancreatic carcinoma
    • ALLISON DC, PIANTADOSI S, HRUBAN RH et al.: DNA content and other factors associated with 10-year survival after resection of pancreatic carcinoma. J. Surg. Oncol. (1998) 6:151-159.
    • (1998) J. Surg. Oncol , vol.6 , pp. 151-159
    • ALLISON, D.C.1    PIANTADOSI, S.2    HRUBAN, R.H.3
  • 48
    • 2342544035 scopus 로고    scopus 로고
    • Comparison of K-ras mutation distributions in intraductal papillary mucinous turnouts and ductal adenocarcinoma of the pancreas
    • KITAGO M, UEDA M, AIRURA K et al.: Comparison of K-ras mutation distributions in intraductal papillary mucinous turnouts and ductal adenocarcinoma of the pancreas. Intl. J. Cancer (2004) 10:177-182.
    • (2004) Intl. J. Cancer , vol.10 , pp. 177-182
    • KITAGO, M.1    UEDA, M.2    AIRURA, K.3
  • 49
    • 0025720078 scopus 로고
    • Mutations in the Kirsten-ras oncogene are common but lack correlation with prognosis and tumour stage in human pancreatic carcinoma
    • MOTOJIMA K, URANO T, NAGATA Y et al.: Mutations in the Kirsten-ras oncogene are common but lack correlation with prognosis and tumour stage in human pancreatic carcinoma. Am. J. Gastroenterol. (1991) 86:1784-1788.
    • (1991) Am. J. Gastroenterol , vol.86 , pp. 1784-1788
    • MOTOJIMA, K.1    URANO, T.2    NAGATA, Y.3
  • 50
    • 0028351157 scopus 로고
    • K-ras-2 topographic genotyping of pancreatic adenocarcinoma
    • FINKELSTEIN SD, PRZYGODZKI RM, PRICOLO VE et al.: K-ras-2 topographic genotyping of pancreatic adenocarcinoma. Arch. Surg. (1994) 129:367-372.
    • (1994) Arch. Surg , vol.129 , pp. 367-372
    • FINKELSTEIN, S.D.1    PRZYGODZKI, R.M.2    PRICOLO, V.E.3
  • 51
    • 0027733796 scopus 로고
    • K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant enriched chain reaction analysis and allele specific oligonucleotide hybridization
    • HRUBAN RH, VAN MANSFIELD AD, OFFERHAUS G et al.: K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant enriched chain reaction analysis and allele specific oligonucleotide hybridization. Am. J. Pathol. (1993) 143:545-554.
    • (1993) Am. J. Pathol , vol.143 , pp. 545-554
    • HRUBAN, R.H.1    VAN MANSFIELD, A.D.2    OFFERHAUS, G.3
  • 52
    • 0346689073 scopus 로고    scopus 로고
    • Loss of p27 expression is associated with poor prognosis in stage I-II pancreatic cancer
    • JUUTI A, NORDLING S, LOUHIMO J et al.: Loss of p27 expression is associated with poor prognosis in stage I-II pancreatic cancer. Oncology (2003) 65:371-377.
    • (2003) Oncology , vol.65 , pp. 371-377
    • JUUTI, A.1    NORDLING, S.2    LOUHIMO, J.3
  • 53
    • 0033558373 scopus 로고    scopus 로고
    • Loss of p27-kip1 expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma
    • LU CD, MORITA S, ISHIBASHI T et al.: Loss of p27-kip1 expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma. Cancer (1999) 85:1250-1260.
    • (1999) Cancer , vol.85 , pp. 1250-1260
    • LU, C.D.1    MORITA, S.2    ISHIBASHI, T.3
  • 54
    • 9444236895 scopus 로고    scopus 로고
    • Minireview cyclin D1: Normal and abnormal functions
    • FU M, WANG C, LI Z, SAKAMAKI T, PESTELL RG: Minireview cyclin D1: normal and abnormal functions. Endocrinology (2004) 145(12):5439-5447.
    • (2004) Endocrinology , vol.145 , Issue.12 , pp. 5439-5447
    • FU, M.1    WANG, C.2    LI, Z.3    SAKAMAKI, T.4    PESTELL, R.G.5
  • 55
    • 0642367570 scopus 로고    scopus 로고
    • Relationship between the expression of β-catenin, cyclin D1 and myc and the occurrence and biological behaviour of pancreatic cancer
    • LI YJ, JI XR: Relationship between the expression of β-catenin, cyclin D1 and myc and the occurrence and biological behaviour of pancreatic cancer. Zhonghua Bing Li Xue Za Zhi (2003) 32:238-241.
    • (2003) Zhonghua Bing Li Xue Za Zhi , vol.32 , pp. 238-241
    • LI, Y.J.1    JI, X.R.2
  • 56
    • 0035918538 scopus 로고    scopus 로고
    • Reduced membranous and ectopic cytoplasmic expression of β-catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer
    • QIAO Q, RAMADANI M, GANSAUGE S et al.: Reduced membranous and ectopic cytoplasmic expression of β-catenin correlate with cyclin D1 overexpression and poor prognosis in pancreatic cancer. Int. J. Cancer (2001) 95:194-197.
    • (2001) Int. J. Cancer , vol.95 , pp. 194-197
    • QIAO, Q.1    RAMADANI, M.2    GANSAUGE, S.3
  • 57
    • 0031713061 scopus 로고    scopus 로고
    • Prognostic significance of molecular alterations in human pancreatic carcinoma an immunological study
    • GANSAUGE F, GANSAUGE S, SCHMIDT E et al.: Prognostic significance of molecular alterations in human pancreatic carcinoma an immunological study. Langebecks Arch. Surg. (1998) 383:152-155.
    • (1998) Langebecks Arch. Surg , vol.383 , pp. 152-155
    • GANSAUGE, F.1    GANSAUGE, S.2    SCHMIDT, E.3
  • 58
    • 0034693635 scopus 로고    scopus 로고
    • K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma
    • KAWESHA A, GHANEH P, ANDREN-SANDBERG A et al.: K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma. Int. J. Cancer (2000) 89(6):469-474.
    • (2000) Int. J. Cancer , vol.89 , Issue.6 , pp. 469-474
    • KAWESHA, A.1    GHANEH, P.2    ANDREN-SANDBERG, A.3
  • 59
    • 0031812131 scopus 로고    scopus 로고
    • KORNMANN M, ISHIWATA T, ITAKURA J et al.: Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival. Oncology (1998) 55(4):363-369.
    • KORNMANN M, ISHIWATA T, ITAKURA J et al.: Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival. Oncology (1998) 55(4):363-369.
  • 60
    • 0030969478 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis
    • GANSAUGE S, GANSUAGE F, RAMADANI M et al.: Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis. Cancer Res. (1997) 57:1634-1637.
    • (1997) Cancer Res , vol.57 , pp. 1634-1637
    • GANSAUGE, S.1    GANSUAGE, F.2    RAMADANI, M.3
  • 61
    • 0030947095 scopus 로고    scopus 로고
    • Programmed cell death in animal development
    • JACOBSON MD, WEIL M, RAFF MC: Programmed cell death in animal development. Cell (1997) 88:347-354.
    • (1997) Cell , vol.88 , pp. 347-354
    • JACOBSON, M.D.1    WEIL, M.2    RAFF, M.C.3
  • 62
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • ASHKENAZI A, DIXIT VM: Death receptors: signaling and modulation. Science (1998) 281:1305-1308.
    • (1998) Science , vol.281 , pp. 1305-1308
    • ASHKENAZI, A.1    DIXIT, V.M.2
  • 63
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • GREEN DR, REED JC: Mitochondria and apoptosis. Science (1998) 281:1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • GREEN, D.R.1    REED, J.C.2
  • 64
    • 0242522206 scopus 로고    scopus 로고
    • Regulation of apoptosis by Bcl-2 family proteins
    • BURLACU A: Regulation of apoptosis by Bcl-2 family proteins. J. Cell Mol. Med. (2003) 7(3):249-257.
    • (2003) J. Cell Mol. Med , vol.7 , Issue.3 , pp. 249-257
    • BURLACU, A.1
  • 65
    • 0037530398 scopus 로고    scopus 로고
    • Expression of the bcl-2 gene and its significance in human pancreatic cancer
    • SUN CY, WANG BL, HU CQ et al.: Expression of the bcl-2 gene and its significance in human pancreatic cancer. Hepatobiliary Pancreat. Dis. Int. (2002) 1:306-308.
    • (2002) Hepatobiliary Pancreat. Dis. Int , vol.1 , pp. 306-308
    • SUN, C.Y.1    WANG, B.L.2    HU, C.Q.3
  • 66
    • 0035087309 scopus 로고    scopus 로고
    • Apoptosis and expression of Bcl-2 and Bax proteins in invasive ductal carcinoma of the pancreas
    • NIO Y, IGUCHI C, YAMASAWA K et al.: Apoptosis and expression of Bcl-2 and Bax proteins in invasive ductal carcinoma of the pancreas. Pancreas (2001) 22:230-239.
    • (2001) Pancreas , vol.22 , pp. 230-239
    • NIO, Y.1    IGUCHI, C.2    YAMASAWA, K.3
  • 67
    • 0035085625 scopus 로고    scopus 로고
    • Expression of Bcl-2 and p53 protein in resectable invasive ductal carcinoma of the pancreas: Effects on clinical outcome and efficacy of adjuvant chemotherapy
    • NIO Y, DONG M, IGUCHI C et al.: Expression of Bcl-2 and p53 protein in resectable invasive ductal carcinoma of the pancreas: effects on clinical outcome and efficacy of adjuvant chemotherapy. J. Surg. Oncol. (2001) 76:188-196.
    • (2001) J. Surg. Oncol , vol.76 , pp. 188-196
    • NIO, Y.1    DONG, M.2    IGUCHI, C.3
  • 68
    • 0035554145 scopus 로고    scopus 로고
    • Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas
    • EVANS JD, CORNFORD PA, DODSON A et al.: Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas. Pancreatology (2001) 1:254-262.
    • (2001) Pancreatology , vol.1 , pp. 254-262
    • EVANS, J.D.1    CORNFORD, P.A.2    DODSON, A.3
  • 69
    • 0032957020 scopus 로고    scopus 로고
    • Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma
    • HU YX, WATANABE H, OHTSUBO K et al.: Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma. Br. J. Cancer (1999) 80:1075-1079.
    • (1999) Br. J. Cancer , vol.80 , pp. 1075-1079
    • HU, Y.X.1    WATANABE, H.2    OHTSUBO, K.3
  • 70
    • 0031715838 scopus 로고    scopus 로고
    • Bax, but not bcl-2, influences the prognosis of human pancreatic cancer
    • FRIESS H, LU Z, GRABER HU et al.: Bax, but not bcl-2, influences the prognosis of human pancreatic cancer. Gut (1998) 43:414-421.
    • (1998) Gut , vol.43 , pp. 414-421
    • FRIESS, H.1    LU, Z.2    GRABER, H.U.3
  • 71
    • 0032471711 scopus 로고    scopus 로고
    • Moderate activation of the apoptosis inhibitor bcl-xL worsens prognosis in pancreatic cancer
    • FRIESS H, LU Z, ANDREN-SANDBERG A et al.: Moderate activation of the apoptosis inhibitor bcl-xL worsens prognosis in pancreatic cancer. Ann. Surg. (1998) 228:780-787.
    • (1998) Ann. Surg , vol.228 , pp. 780-787
    • FRIESS, H.1    LU, Z.2    ANDREN-SANDBERG, A.3
  • 72
    • 0031863603 scopus 로고    scopus 로고
    • An immunohistochemical study of blc-2 and p53 protein expression in pancreatic carcinomas
    • OHSHIO G, SUWA H, IMMAMURA T et al.: An immunohistochemical study of blc-2 and p53 protein expression in pancreatic carcinomas. Scand. J. Gastroenterol. (1998) 33:535-539.
    • (1998) Scand. J. Gastroenterol , vol.33 , pp. 535-539
    • OHSHIO, G.1    SUWA, H.2    IMMAMURA, T.3
  • 73
    • 0031899556 scopus 로고    scopus 로고
    • Clinical contribution of bcl-2, p53 and Ki-67 proteins in pancreatic ductal adenocarcinoma
    • MAKINEN K, HAKALA T, LIPPONEN P et al.: Clinical contribution of bcl-2, p53 and Ki-67 proteins in pancreatic ductal adenocarcinoma. Anticancer Res. (1998) 18:615-618.
    • (1998) Anticancer Res , vol.18 , pp. 615-618
    • MAKINEN, K.1    HAKALA, T.2    LIPPONEN, P.3
  • 74
    • 0030443653 scopus 로고    scopus 로고
    • Bcl-2 and p53 expression in resectable pancreatic adenocarcinomas: Association with clinical outcome
    • SINICROPE FA, EVANS DB, LEACH SD et al.: Bcl-2 and p53 expression in resectable pancreatic adenocarcinomas: association with clinical outcome. Clin. Cancer Res. (1996) 2(12):2015-2022.
    • (1996) Clin. Cancer Res , vol.2 , Issue.12 , pp. 2015-2022
    • SINICROPE, F.A.1    EVANS, D.B.2    LEACH, S.D.3
  • 75
    • 18944399531 scopus 로고    scopus 로고
    • Clinicopathological significance of Bcl-2 and Bax protein expression in human pancreatic cancer
    • DONG M, ZHOU JP, ZHANG H, GUO KJ, TIAN YL, DONG YT: Clinicopathological significance of Bcl-2 and Bax protein expression in human pancreatic cancer. World J. Gastroenterol. (2005) 11(18):2744-2747.
    • (2005) World J. Gastroenterol , vol.11 , Issue.18 , pp. 2744-2747
    • DONG, M.1    ZHOU, J.P.2    ZHANG, H.3    GUO, K.J.4    TIAN, Y.L.5    DONG, Y.T.6
  • 76
    • 30044445726 scopus 로고    scopus 로고
    • Apoptotic index or a combination of Bax/Bcl-2 expression correlate with survival after resection of pancreatic adenocarcinoma
    • MAGISTRELLI P, COPPOLA R, TONINI G et al.: Apoptotic index or a combination of Bax/Bcl-2 expression correlate with survival after resection of pancreatic adenocarcinoma. J. Cell Biochem. (2006) 97(1):98-108.
    • (2006) J. Cell Biochem , vol.97 , Issue.1 , pp. 98-108
    • MAGISTRELLI, P.1    COPPOLA, R.2    TONINI, G.3
  • 77
    • 0037047692 scopus 로고    scopus 로고
    • Hypoxia. BNip3 proteins, and the mitochondrialdeath pathway in cardiomyocytes
    • CROW MT: Hypoxia. BNip3 proteins, and the mitochondrialdeath pathway in cardiomyocytes. Circ. Res. (2002) 91:183-185.
    • (2002) Circ. Res , vol.91 , pp. 183-185
    • CROW, M.T.1
  • 78
    • 21744434389 scopus 로고    scopus 로고
    • Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis
    • ERKAN M, KLEEFF J, ESPOSITO I et al.: Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene (2005) 24(27):4421-4432.
    • (2005) Oncogene , vol.24 , Issue.27 , pp. 4421-4432
    • ERKAN, M.1    KLEEFF, J.2    ESPOSITO, I.3
  • 79
    • 0032410818 scopus 로고    scopus 로고
    • The inhibitors of apoptosis (IAPs) and their emerging role in cancer
    • LACASSE EC, BAIRD S, KORNELUK RG, MACKENZIE AE: The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene (1998) 17:3247-3259.
    • (1998) Oncogene , vol.17 , pp. 3247-3259
    • LACASSE, E.C.1    BAIRD, S.2    KORNELUK, R.G.3    MACKENZIE, A.E.4
  • 80
    • 3843099444 scopus 로고    scopus 로고
    • Survivin expression is a prognostic marker in pancreatic cancer patients
    • KAMI K, DOI R, KOIZUMA M et al.: Survivin expression is a prognostic marker in pancreatic cancer patients. Surgery (2004) 136:443-448.
    • (2004) Surgery , vol.136 , pp. 443-448
    • KAMI, K.1    DOI, R.2    KOIZUMA, M.3
  • 81
    • 22044440609 scopus 로고    scopus 로고
    • Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients
    • TONINI G, VINCENZI B, SANTINI D et al.: Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients. Br. J. Cancer (2005) 92(12):2225-2232.
    • (2005) Br. J. Cancer , vol.92 , Issue.12 , pp. 2225-2232
    • TONINI, G.1    VINCENZI, B.2    SANTINI, D.3
  • 82
    • 0021079540 scopus 로고
    • Tumor invasion and the extracellular matrix
    • LIOTTA LA, RAO CN, BARSKY SH: Tumor invasion and the extracellular matrix. Lab. Invest. (1983) 49:636-649.
    • (1983) Lab. Invest , vol.49 , pp. 636-649
    • LIOTTA, L.A.1    RAO, C.N.2    BARSKY, S.H.3
  • 85
    • 33744455223 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their inhibitors in bone: An overview of regulation and functions
    • VARGHESE S: Matrix metalloproteinases and their inhibitors in bone: an overview of regulation and functions. Front. Biosci. (2006) 11:2949-2966.
    • (2006) Front. Biosci , vol.11 , pp. 2949-2966
    • VARGHESE, S.1
  • 86
    • 10744232549 scopus 로고    scopus 로고
    • Evaluation of urinary plasminogen activator, its receptor matrix metalloproteinase-9 and von Willebrand factor in pancreatic cancer
    • HARVEY SR, HURD TC, MARKUS G et al.: Evaluation of urinary plasminogen activator, its receptor matrix metalloproteinase-9 and von Willebrand factor in pancreatic cancer. Clin. Cancer Res. (2003) 9(13):4935-4943.
    • (2003) Clin. Cancer Res , vol.9 , Issue.13 , pp. 4935-4943
    • HARVEY, S.R.1    HURD, T.C.2    MARKUS, G.3
  • 87
    • 18544413108 scopus 로고    scopus 로고
    • Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma
    • NAKAMURA H, HORITA S, SENMARU N et al.: Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma. Oncol. Rep. (2002) 9:751-755.
    • (2002) Oncol. Rep , vol.9 , pp. 751-755
    • NAKAMURA, H.1    HORITA, S.2    SENMARU, N.3
  • 88
    • 0035865438 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: Clinicopathologic and prognostic significance of matrilysin expression
    • YAMMAMOTO H, ITAH F, IKU S et al.: Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression. J. Clin. Oncol. (2001) 19:1118-1127.
    • (2001) J. Clin. Oncol , vol.19 , pp. 1118-1127
    • YAMMAMOTO, H.1    ITAH, F.2    IKU, S.3
  • 89
    • 0033910993 scopus 로고    scopus 로고
    • Differential expression of matrix metalloproteinase (MMP)-2 and 9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: Implications for tumour progression and clinical prognosis
    • MAATA M, SOINI Y, LIAKKA A et al.: Differential expression of matrix metalloproteinase (MMP)-2 and 9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumour progression and clinical prognosis. Clin. Cancer Res. (2000) 6:2726-2734.
    • (2000) Clin. Cancer Res , vol.6 , pp. 2726-2734
    • MAATA, M.1    SOINI, Y.2    LIAKKA, A.3
  • 90
    • 0033999274 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases and the tissue inhibitors of metalloproteinases and their local invasiveness and metastasis in Chinese human pancreatic cancer
    • GONG YL, XU GM, HUANG WD et al.: Expression of matrix metalloproteinases and the tissue inhibitors of metalloproteinases and their local invasiveness and metastasis in Chinese human pancreatic cancer. J. Surg. Oncol. (2000) 73:95-99.
    • (2000) J. Surg. Oncol , vol.73 , pp. 95-99
    • GONG, Y.L.1    XU, G.M.2    HUANG, W.D.3
  • 91
    • 0032817034 scopus 로고    scopus 로고
    • Expression of MMP-1 in human pancreatic carcinoma: Relationship with prognostic factors
    • ITO T, ITO M, SHIOZAWA J et al.: Expression of MMP-1 in human pancreatic carcinoma: relationship with prognostic factors. Mod. Pathol. (1999) 12:669-674.
    • (1999) Mod. Pathol , vol.12 , pp. 669-674
    • ITO, T.1    ITO, M.2    SHIOZAWA, J.3
  • 92
    • 0032519608 scopus 로고    scopus 로고
    • Involvement of matrix metalloproteinase-2 activity in invasion and metastasis of pancreatic carcinoma
    • KOSHIBA T, HOSOTANI R, WADA M et al.: Involvement of matrix metalloproteinase-2 activity in invasion and metastasis of pancreatic carcinoma. Cancer (1998) 82:642-650.
    • (1998) Cancer , vol.82 , pp. 642-650
    • KOSHIBA, T.1    HOSOTANI, R.2    WADA, M.3
  • 93
    • 1942438135 scopus 로고    scopus 로고
    • Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer increased expression of matrix metalloproteinase-7 predicts poor survival
    • JONES LE, HUMPHREYS MJ, CAMPBELL F, NEOPTOLEMOS JP, BOYD MT: Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer increased expression of matrix metalloproteinase-7 predicts poor survival. Clin. Cancer Res. (2004) 10(8):2832-2845.
    • (2004) Clin. Cancer Res , vol.10 , Issue.8 , pp. 2832-2845
    • JONES, L.E.1    HUMPHREYS, M.J.2    CAMPBELL, F.3    NEOPTOLEMOS, J.P.4    BOYD, M.T.5
  • 94
    • 11144356553 scopus 로고    scopus 로고
    • ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma
    • GRUTZMANN R, LUTTGES J, SIPOS B et al.: ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma. Br. J. Cancer (2004) 90(5):1053-1058.
    • (2004) Br. J. Cancer , vol.90 , Issue.5 , pp. 1053-1058
    • GRUTZMANN, R.1    LUTTGES, J.2    SIPOS, B.3
  • 95
    • 0037389803 scopus 로고    scopus 로고
    • Clinical significance of aminopeptidase N/CD13 expression in human pancreatic carcinoma
    • IKEDA N, NAKAJIMA Y, TOKUHARA T et al.: Clinical significance of aminopeptidase N/CD13 expression in human pancreatic carcinoma. Clin. Cancer Res. (2003) 9(4):1503-1508.
    • (2003) Clin. Cancer Res , vol.9 , Issue.4 , pp. 1503-1508
    • IKEDA, N.1    NAKAJIMA, Y.2    TOKUHARA, T.3
  • 96
    • 0037441643 scopus 로고    scopus 로고
    • Dysadherin overexpression in pancreatic ductal adenocarcinoma reflects tumor aggressiveness: Relationship to E-cadherin expression
    • SHIMAMURA T, SAKAMOTO M: Dysadherin overexpression in pancreatic ductal adenocarcinoma reflects tumor aggressiveness: relationship to E-cadherin expression. J. Clin. Oncol. (2003) 21(4):659-667.
    • (2003) J. Clin. Oncol , vol.21 , Issue.4 , pp. 659-667
    • SHIMAMURA, T.1    SAKAMOTO, M.2
  • 98
    • 23844491522 scopus 로고    scopus 로고
    • Syndecan-1 expression - a novel prognostic marker in pancreatic cancer
    • JUUTI A, NORDLING S, LUNDIN J, LOUHIMO J, HAGLUND C: Syndecan-1 expression - a novel prognostic marker in pancreatic cancer. Oncology (2005) 68(2-3):97-106.
    • (2005) Oncology , vol.68 , Issue.2-3 , pp. 97-106
    • JUUTI, A.1    NORDLING, S.2    LUNDIN, J.3    LOUHIMO, J.4    HAGLUND, C.5
  • 99
    • 11844298904 scopus 로고    scopus 로고
    • The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury
    • BORNSTEIN P, AGAH A, KYRIAKIDES TR: The role of thrombospondins 1 and 2 in the regulation of cell-matrix interactions, collagen fibril formation, and the response to injury. Int. J. Biochem. Cell Biol. (2004) 36(6):1115-1125.
    • (2004) Int. J. Biochem. Cell Biol , vol.36 , Issue.6 , pp. 1115-1125
    • BORNSTEIN, P.1    AGAH, A.2    KYRIAKIDES, T.R.3
  • 100
    • 0347982180 scopus 로고    scopus 로고
    • Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma
    • TOBITA K, KIJIMA H, DOWAKI S et al.: Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. Int. J. Oncol. (2002) 21(6)1189-1195.
    • (2002) Int. J. Oncol , vol.21 , Issue.6 , pp. 1189-1195
    • TOBITA, K.1    KIJIMA, H.2    DOWAKI, S.3
  • 101
    • 23444448425 scopus 로고    scopus 로고
    • MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas
    • SAITOU M, GOTO M, HORINOUCHI M et al.: MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. J. Clin. Pathol. (2005) 58(8):845-852.
    • (2005) J. Clin. Pathol , vol.58 , Issue.8 , pp. 845-852
    • SAITOU, M.1    GOTO, M.2    HORINOUCHI, M.3
  • 102
    • 0037652135 scopus 로고    scopus 로고
    • RECK expression in pancreatic cancer: Its correlation with lower invasiveness and better prognosis
    • MASUI T, DOI R, KOSHIBA T et al.: RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis. Clin. Cancer Res. (2003) 9(5):1779-1784.
    • (2003) Clin. Cancer Res , vol.9 , Issue.5 , pp. 1779-1784
    • MASUI, T.1    DOI, R.2    KOSHIBA, T.3
  • 103
    • 2442644244 scopus 로고    scopus 로고
    • Expression of pigment epithelium-derived factor decreases liver metastasis and correlates with favorable prognosis for patients with ductal pancreatic adenocarcinoma
    • UEHARA H, MIYAMOTO M, KATO K et al.: Expression of pigment epithelium-derived factor decreases liver metastasis and correlates with favorable prognosis for patients with ductal pancreatic adenocarcinoma. Cancer Res. (2004) 64:3533-3537.
    • (2004) Cancer Res , vol.64 , pp. 3533-3537
    • UEHARA, H.1    MIYAMOTO, M.2    KATO, K.3
  • 104
    • 20244366228 scopus 로고    scopus 로고
    • Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma
    • NITORI N, INO Y: Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. Clin. Cancer Res. (2005) 11:2531-2539.
    • (2005) Clin. Cancer Res , vol.11 , pp. 2531-2539
    • NITORI, N.1    INO, Y.2
  • 105
    • 0036023418 scopus 로고    scopus 로고
    • Clinicopathological significance of galectin-3 expression in ductal adenocarcinoma of the pancreas
    • SHIMAMURA T, SAKAMOTO M: Clinicopathological significance of galectin-3 expression in ductal adenocarcinoma of the pancreas. Clin. Cancer Res. (2002) 8:2570-2575.
    • (2002) Clin. Cancer Res , vol.8 , pp. 2570-2575
    • SHIMAMURA, T.1    SAKAMOTO, M.2
  • 106
    • 0028000213 scopus 로고
    • The mitogen activated protein kinase signal transduction pathway: From the cell surface to the nucleus
    • GUAN UL: The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus. Cell Signal. (1994) 6:581-589.
    • (1994) Cell Signal , vol.6 , pp. 581-589
    • GUAN, U.L.1
  • 107
    • 0028897113 scopus 로고
    • Transcriptional regulation by extracellular signals: Mechanisms and specificity
    • HILL CS, TREISMAN R: Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell (1995) 80:199-211.
    • (1995) Cell , vol.80 , pp. 199-211
    • HILL, C.S.1    TREISMAN, R.2
  • 108
    • 0034533657 scopus 로고    scopus 로고
    • Signaling of transforming growth factor-β family members through Smad proteins
    • ITOH S, ITOH F, GOUMANS MJ, TEN DIJKE P: Signaling of transforming growth factor-β family members through Smad proteins. Eur. J. Biochem. (2000) 267(24):6954-6967.
    • (2000) Eur. J. Biochem , vol.267 , Issue.24 , pp. 6954-6967
    • ITOH, S.1    ITOH, F.2    GOUMANS, M.J.3    TEN DIJKE, P.4
  • 109
    • 0030024411 scopus 로고    scopus 로고
    • Pancreatic cancer: The potential clinical relevance of alterations in growth factors and their receptors
    • FRIESS H, BERBERAT P, SCHILLING M, KUNZ J, KORC M, BUCHLER MW: Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors. J. Mol. Med. (1996) 74:35-42.
    • (1996) J. Mol. Med , vol.74 , pp. 35-42
    • FRIESS, H.1    BERBERAT, P.2    SCHILLING, M.3    KUNZ, J.4    KORC, M.5    BUCHLER, M.W.6
  • 110
    • 0029788089 scopus 로고    scopus 로고
    • Expression of epidermal and transforming growth factors in pancreatic cancer
    • LAKSHMIKESARI A, RADHAKRISHNA R, BRANUMATHI A et al.: Expression of epidermal and transforming growth factors in pancreatic cancer. Oncol. Rep. (1996) 3:963-966.
    • (1996) Oncol. Rep , vol.3 , pp. 963-966
    • LAKSHMIKESARI, A.1    RADHAKRISHNA, R.2    BRANUMATHI, A.3
  • 111
    • 0034744458 scopus 로고    scopus 로고
    • Correlation between TGF-β1 and p21 (WAFI/CIP1) expression and prognosis in resectable invasive ductal carcinoma of the pancreas
    • HASHIMOTO Y, NIO Y, SUMI S et al.: Correlation between TGF-β1 and p21 (WAFI/CIP1) expression and prognosis in resectable invasive ductal carcinoma of the pancreas. Pancreas (2001) 22:341-371.
    • (2001) Pancreas , vol.22 , pp. 341-371
    • HASHIMOTO, Y.1    NIO, Y.2    SUMI, S.3
  • 112
    • 0032711157 scopus 로고    scopus 로고
    • Enhanced expression of the type II TGF-β1 receptor is associated with decreased survival in human pancreatic cancer
    • WAGNER M, KLEEFF J, FRIESS H et al.: Enhanced expression of the type II TGF-β1 receptor is associated with decreased survival in human pancreatic cancer. Pancreas (1999) 19:370-376.
    • (1999) Pancreas , vol.19 , pp. 370-376
    • WAGNER, M.1    KLEEFF, J.2    FRIESS, H.3
  • 113
    • 0031595728 scopus 로고    scopus 로고
    • Analysis of p53, p21WAF1, and TGF-β1 in human ductal adenocarcinoma of the pancreas: TGF-β1 protein expression predicts longer survival
    • COPPOLA D, LU L, FREHAUF JP et al.: Analysis of p53, p21WAF1, and TGF-β1 in human ductal adenocarcinoma of the pancreas: TGF-β1 protein expression predicts longer survival. Am. J. Clin. Pathol. (1998) 110:16-23.
    • (1998) Am. J. Clin. Pathol , vol.110 , pp. 16-23
    • COPPOLA, D.1    LU, L.2    FREHAUF, J.P.3
  • 114
    • 0027131252 scopus 로고
    • Enhanced expression of TGF-β isoform-2 in pancreatic cancer correlates with decreased survival
    • FRIESS H, YAMANAKA Y, BUCHLER M et al.: Enhanced expression of TGF-β isoform-2 in pancreatic cancer correlates with decreased survival. Gastroenterology (1993) 105:1846-1856.
    • (1993) Gastroenterology , vol.105 , pp. 1846-1856
    • FRIESS, H.1    YAMANAKA, Y.2    BUCHLER, M.3
  • 116
    • 0027293748 scopus 로고
    • Co-expression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumour aggressiveness
    • YAMANAKA Y, FRIESS H, KOBRIN MS et al.: Co-expression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumour aggressiveness. Anticancer Res. (1993) 13:565-570.
    • (1993) Anticancer Res , vol.13 , pp. 565-570
    • YAMANAKA, Y.1    FRIESS, H.2    KOBRIN, M.S.3
  • 117
    • 0031452314 scopus 로고    scopus 로고
    • Clinicopathological significance of epidermal growth factor and receptor in human pancreatic cancer
    • UEGAKI K, NIO Y, INOUE S et al.: Clinicopathological significance of epidermal growth factor and receptor in human pancreatic cancer. Anticancer Res. (1997) 17:3841-3847.
    • (1997) Anticancer Res , vol.17 , pp. 3841-3847
    • UEGAKI, K.1    NIO, Y.2    INOUE, S.3
  • 118
    • 0026813448 scopus 로고
    • The immunohistochemical expressions of epidermal growth factor, epidermal growth factor receptors and c-erbB2 oncoprotein in human pancreatic cancer
    • YAMANAKA Y: The immunohistochemical expressions of epidermal growth factor, epidermal growth factor receptors and c-erbB2 oncoprotein in human pancreatic cancer. Nippon Ika Daigaku Zasshi (1992) 59:51-61.
    • (1992) Nippon Ika Daigaku Zasshi , vol.59 , pp. 51-61
    • YAMANAKA, Y.1
  • 119
    • 0027293748 scopus 로고
    • Co-expression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumour aggressiveness
    • YAMANAKA Y, FRIESS H, KOBRIN MS et al.: Co-expression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumour aggressiveness. Anticancer Res. (1993) 13:565-570.
    • (1993) Anticancer Res , vol.13 , pp. 565-570
    • YAMANAKA, Y.1    FRIESS, H.2    KOBRIN, M.S.3
  • 120
    • 6044241807 scopus 로고    scopus 로고
    • The correlation between cytoplasmic overexpression of epidermal growth factor and tumour aggressiveness: Poor prognosis in patients with pancreatic ductal adenocarcinoma
    • UEDA M, OGATA S, TSUDA H et al.: The correlation between cytoplasmic overexpression of epidermal growth factor and tumour aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas (2004) 29:1-8.
    • (2004) Pancreas , vol.29 , pp. 1-8
    • UEDA, M.1    OGATA, S.2    TSUDA, H.3
  • 121
    • 1842431104 scopus 로고    scopus 로고
    • Correlation of immunohistochemically detected HER-2/neu (erbB-2) with histological stage and perineural invasion in pancreatic cancer
    • TAMIOLAKIS D, VENIZELOS I, SIMOPOULOS C et al.: Correlation of immunohistochemically detected HER-2/neu (erbB-2) with histological stage and perineural invasion in pancreatic cancer. Hepatogastroenterology (2004) 51:334-337.
    • (2004) Hepatogastroenterology , vol.51 , pp. 334-337
    • TAMIOLAKIS, D.1    VENIZELOS, I.2    SIMOPOULOS, C.3
  • 122
    • 4143128359 scopus 로고    scopus 로고
    • Epidermal growth factor expression in human pancreatic carcinoma significance for liver metastasis
    • TOBITA K, KIJIMA H, DOWAKI S et al.: Epidermal growth factor expression in human pancreatic carcinoma significance for liver metastasis. Int. J. Mol. Med. (2003) 11:305-309.
    • (2003) Int. J. Mol. Med , vol.11 , pp. 305-309
    • TOBITA, K.1    KIJIMA, H.2    DOWAKI, S.3
  • 123
    • 0038205584 scopus 로고    scopus 로고
    • Expression of c-erbB2 oncogene protein, epidermal growth factor receptor and TGF-β1 in human pancreatic ductal adenocarcinoma
    • ZHANG H, YUAN SZ: Expression of c-erbB2 oncogene protein, epidermal growth factor receptor and TGF-β1 in human pancreatic ductal adenocarcinoma. Hepatobiliary Pancreat. Dis. Int. (2002) 1:620-623.
    • (2002) Hepatobiliary Pancreat. Dis. Int , vol.1 , pp. 620-623
    • ZHANG, H.1    YUAN, S.Z.2
  • 124
    • 0036324918 scopus 로고    scopus 로고
    • Role of immunohistochemical identification of Her-2/neu and detection of variability in overexpression of pancreatic carcinoma
    • KOKA V, POTTI A, KOCH M et al.: Role of immunohistochemical identification of Her-2/neu and detection of variability in overexpression of pancreatic carcinoma. Anticancer Res. (2002) 22:1593-1597.
    • (2002) Anticancer Res , vol.22 , pp. 1593-1597
    • KOKA, V.1    POTTI, A.2    KOCH, M.3
  • 125
    • 0004345993 scopus 로고    scopus 로고
    • Comparative analysis of the EGF-receptor family in pancreatic cancer: Expression of HER-4 correlates with a favourable tumour stage
    • THYBUSCH-BERNHARDT, BECKMANN S, JUHL H: Comparative analysis of the EGF-receptor family in pancreatic cancer: expression of HER-4 correlates with a favourable tumour stage. Int. J. Surg. Invest. (2001) 2:393-400.
    • (2001) Int. J. Surg. Invest , vol.2 , pp. 393-400
    • THYBUSCH-BERNHARDT, B.S.1    JUHL, H.2
  • 126
    • 0034793404 scopus 로고    scopus 로고
    • Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma
    • SAFRAN H, STEINHOFF M, MANGRAY S et al.: Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am. J. Clin. Oncol. (2001) 24:496-499.
    • (2001) Am. J. Clin. Oncol , vol.24 , pp. 496-499
    • SAFRAN, H.1    STEINHOFF, M.2    MANGRAY, S.3
  • 127
    • 0034918559 scopus 로고    scopus 로고
    • Prognostic significance of c-erbB-2 gene expression in pancreatic cancer patients
    • NOVOTNY J, PETRUZELKA L, VEDRALOVA J et al.: Prognostic significance of c-erbB-2 gene expression in pancreatic cancer patients. Neoplasma (2001) 48:188-191.
    • (2001) Neoplasma , vol.48 , pp. 188-191
    • NOVOTNY, J.1    PETRUZELKA, L.2    VEDRALOVA, J.3
  • 128
    • 0032942803 scopus 로고    scopus 로고
    • ErbB-4 mRNA expression is decreased in non-metastatic pancreatic cancer
    • GRABER HU, FRIESS H, KAUFMANN B et al.: ErbB-4 mRNA expression is decreased in non-metastatic pancreatic cancer. Int. J. Cancer (1999) 84:24-27.
    • (1999) Int. J. Cancer , vol.84 , pp. 24-27
    • GRABER, H.U.1    FRIESS, H.2    KAUFMANN, B.3
  • 129
    • 0030936660 scopus 로고    scopus 로고
    • HER-2/neu expression in pancreatic adenocarcinoma: Relationship to tumour differentiation and survival
    • DUGAN MC, DERGHAM ST, KUCWAY R et al.: HER-2/neu expression in pancreatic adenocarcinoma: relationship to tumour differentiation and survival. Pancreas (1997) 14:229-236.
    • (1997) Pancreas , vol.14 , pp. 229-236
    • DUGAN, M.C.1    DERGHAM, S.T.2    KUCWAY, R.3
  • 130
    • 0029144897 scopus 로고
    • Elevated serum c-erbB-2 protein levels in patients with pancreatic cancer: Correlation to metastasis and shorter survival
    • OKADA N, OHSHIO G, YAMAKI K et al.: Elevated serum c-erbB-2 protein levels in patients with pancreatic cancer: correlation to metastasis and shorter survival. Oncology (1995) 52(5):392-396.
    • (1995) Oncology , vol.52 , Issue.5 , pp. 392-396
    • OKADA, N.1    OHSHIO, G.2    YAMAKI, K.3
  • 131
    • 0028912856 scopus 로고
    • Overexpression of HER2/neu oncogene in pancreatic cancer correlates with shortened survival
    • LEI S, APPERT HE, NAKATA B et al.: Overexpression of HER2/neu oncogene in pancreatic cancer correlates with shortened survival. Int. J. Pancreatol. (1995) 17:15-21.
    • (1995) Int. J. Pancreatol , vol.17 , pp. 15-21
    • LEI, S.1    APPERT, H.E.2    NAKATA, B.3
  • 132
    • 30944440262 scopus 로고    scopus 로고
    • Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF)
    • BYRNE AM, BOUCHIER-HAYES DJ, HARMEY JH: Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J. Cell Mol. Med. (2005) 9(4):777-794.
    • (2005) J. Cell Mol. Med , vol.9 , Issue.4 , pp. 777-794
    • BYRNE, A.M.1    BOUCHIER-HAYES, D.J.2    HARMEY, J.H.3
  • 133
    • 11144234518 scopus 로고    scopus 로고
    • Impact of vascular endothelial growth factor-C and -D expression in human pancreatic cancer: Its relationship to lymph node metastasis
    • KURAHARA H, TAKAO S, MAEMURA K, SHINCHI H, NATSUGOE S, AIKOU T: Impact of vascular endothelial growth factor-C and -D expression in human pancreatic cancer: its relationship to lymph node metastasis. Clin. Cancer Res. (2004) 10(24):8413-8412.
    • (2004) Clin. Cancer Res , vol.10 , Issue.24 , pp. 8413-8412
    • KURAHARA, H.1    TAKAO, S.2    MAEMURA, K.3    SHINCHI, H.4    NATSUGOE, S.5    AIKOU, T.6
  • 134
    • 0036894180 scopus 로고    scopus 로고
    • VEGF-RII influences the prognosis of pancreatic cancer
    • BUCHLER P, REBER HA, BUCHLER MW et al.: VEGF-RII influences the prognosis of pancreatic cancer. Ann. Surg. (2002) 236:738-749.
    • (2002) Ann. Surg , vol.236 , pp. 738-749
    • BUCHLER, P.1    REBER, H.A.2    BUCHLER, M.W.3
  • 135
    • 0036311535 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor predicting early recurrence and poor prognosis after curative resection of ductal adenocarcinoma of the pancreas
    • NIEDERGETHMANN M, HILDENBRAND R, WOSTBROCK B et al.: High expression of vascular endothelial growth factor predicting early recurrence and poor prognosis after curative resection of ductal adenocarcinoma of the pancreas. Pancreas (2002) 25:122-129.
    • (2002) Pancreas , vol.25 , pp. 122-129
    • NIEDERGETHMANN, M.1    HILDENBRAND, R.2    WOSTBROCK, B.3
  • 136
    • 0034657029 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor is associated with liver metastasis and poor prognosis for patients with ductal adenocarcinoma
    • SEO Y, BABA H, FUKUDA T et al.: High expression of vascular endothelial growth factor is associated with liver metastasis and poor prognosis for patients with ductal adenocarcinoma. Cancer (2000) 88:2239-2245.
    • (2000) Cancer , vol.88 , pp. 2239-2245
    • SEO, Y.1    BABA, H.2    FUKUDA, T.3
  • 137
    • 0032976338 scopus 로고    scopus 로고
    • Prognostic significance of angiogenesis in human pancreatic cancer
    • IKEDA N, ADACHI M, TAKI T et al.: Prognostic significance of angiogenesis in human pancreatic cancer. Br. J. Cancer (1999) 79:1553-1563.
    • (1999) Br. J. Cancer , vol.79 , pp. 1553-1563
    • IKEDA, N.1    ADACHI, M.2    TAKI, T.3
  • 138
    • 0023032871 scopus 로고
    • A molecular gradient in early Drosophila embryos and its role in specifying the body pattern
    • MACDONALD PM, STRUHL G: A molecular gradient in early Drosophila embryos and its role in specifying the body pattern. Nature (1986) 324:537-545.
    • (1986) Nature , vol.324 , pp. 537-545
    • MACDONALD, P.M.1    STRUHL, G.2
  • 139
    • 0028080881 scopus 로고
    • A homeodomain protein related to caudal regulates intestine-specific gene transcription
    • SUH E, CHEN L, TAYLOR J, TRABER PG: A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol. Cell Biol. (1994) 14:7340-7351.
    • (1994) Mol. Cell Biol , vol.14 , pp. 7340-7351
    • SUH, E.1    CHEN, L.2    TAYLOR, J.3    TRABER, P.G.4
  • 140
    • 0031446727 scopus 로고    scopus 로고
    • Cloning and chromosome assignment of the human CDX2 gene
    • DRUMMOND F, PUTT W, FOX M, EDWARDS YH: Cloning and chromosome assignment of the human CDX2 gene. Ann. Hum. Genet. (1997) 61(5):393-400.
    • (1997) Ann. Hum. Genet , vol.61 , Issue.5 , pp. 393-400
    • DRUMMOND, F.1    PUTT, W.2    FOX, M.3    EDWARDS, Y.H.4
  • 141
    • 16644389487 scopus 로고    scopus 로고
    • Cdx2 expression in pancreatic tumors: Relationship with prognosis of invasiveductal carcinomas
    • MATSUMOTO K, MIZOSHITA T, TSUKAMOTO T: Cdx2 expression in pancreatic tumors: relationship with prognosis of invasiveductal carcinomas. Oncol. Rep. (2004) 12(6):1239-1243.
    • (2004) Oncol. Rep , vol.12 , Issue.6 , pp. 1239-1243
    • MATSUMOTO, K.1    MIZOSHITA, T.2    TSUKAMOTO, T.3
  • 142
    • 33645662710 scopus 로고    scopus 로고
    • The clinical significance of MAGEA3 expression in pancreatic cancer
    • KIM J, REBER HA, HINES OJ et al.: The clinical significance of MAGEA3 expression in pancreatic cancer. Int. J. Cancer (2006) 118(9):2269-2275.
    • (2006) Int. J. Cancer , vol.118 , Issue.9 , pp. 2269-2275
    • KIM, J.1    REBER, H.A.2    HINES, O.J.3
  • 143
    • 27744439823 scopus 로고    scopus 로고
    • Significance of RCAS1 antigen in hepatocellular, cholangiocellular and pancreatic carcinomas
    • ENJOJI M, NAKASHIMA M, YAMAGUCHI K, KOTOH K, NAKAMUTA M: Significance of RCAS1 antigen in hepatocellular, cholangiocellular and pancreatic carcinomas. J. Gastroenterol. Hepatol. (2005) (8):1143-1148.
    • (2005) J. Gastroenterol. Hepatol , vol.8 , pp. 1143-1148
    • ENJOJI, M.1    NAKASHIMA, M.2    YAMAGUCHI, K.3    KOTOH, K.4    NAKAMUTA, M.5
  • 144
    • 0037140959 scopus 로고    scopus 로고
    • High expression of tumor-associated antigen RCAS1 in pancreatic ductaladenocarcinoma is an unfavorable prognostic marker
    • HIRAOKA K, HIDA Y, MIYAMOTO M et al.: High expression of tumor-associated antigen RCAS1 in pancreatic ductaladenocarcinoma is an unfavorable prognostic marker. Int. J. Cancer (2002) 99(3):418-423.
    • (2002) Int. J. Cancer , vol.99 , Issue.3 , pp. 418-423
    • HIRAOKA, K.1    HIDA, Y.2    MIYAMOTO, M.3
  • 145
    • 33747670837 scopus 로고    scopus 로고
    • SKP2 contains a novel cyclin a binding domain that directly protects cyclin A from inhibition by p27Kip1
    • JI P, GOLDIN L, REN H et al.: SKP2 contains a novel cyclin a binding domain that directly protects cyclin A from inhibition by p27Kip1. J. Biol. Chem. (2006) 281(33):24058-24069.
    • (2006) J. Biol. Chem , vol.281 , Issue.33 , pp. 24058-24069
    • JI, P.1    GOLDIN, L.2    REN, H.3
  • 146
    • 33646843794 scopus 로고    scopus 로고
    • High-level Skp2 expression in pancreatic ductal adenocarcinoma correlationwith the extent of lymph node metastasis, higher histological grade, and poorer patient outcome
    • EINAMA T, KAGATA Y, TSUDA H et al.: High-level Skp2 expression in pancreatic ductal adenocarcinoma correlationwith the extent of lymph node metastasis, higher histological grade, and poorer patient outcome. Pancreas (2006) 32(4):376-381.
    • (2006) Pancreas , vol.32 , Issue.4 , pp. 376-381
    • EINAMA, T.1    KAGATA, Y.2    TSUDA, H.3
  • 147
    • 0842333201 scopus 로고    scopus 로고
    • Prognostic significance of HIF-1α overexpression in human pancreaticcancer, 6C:4721-4727
    • SHIBAJI T, NAGAO M, IKEDA N et al.: Prognostic significance of HIF-1α overexpression in human pancreaticcancer. Anticancer Res. (2003) 23(6C):4721-4727.
    • (2003) Anticancer Res , vol.23
    • SHIBAJI, T.1    NAGAO, M.2    IKEDA, N.3
  • 148
    • 0034489892 scopus 로고    scopus 로고
    • PGP9.5 as a prognostic factor in pancreatic cancer
    • TEZEL E, HIBI K, NAGASAKA T, NAKAO A: PGP9.5 as a prognostic factor in pancreatic cancer. Clin. Cancer Res. (2000) 6(12):4764-4767.
    • (2000) Clin. Cancer Res , vol.6 , Issue.12 , pp. 4764-4767
    • TEZEL, E.1    HIBI, K.2    NAGASAKA, T.3    NAKAO, A.4
  • 149
    • 20244385466 scopus 로고    scopus 로고
    • High nuclear S100A6 (calcyclin) is significantly associated with poor survivalin pancreatic cancer patients
    • VIMALACHANDRAN D, GREENHALF W, THOMPSON C et al.: High nuclear S100A6 (calcyclin) is significantly associated with poor survivalin pancreatic cancer patients. Cancer Res. (2005) 65(8):3218-3225.
    • (2005) Cancer Res , vol.65 , Issue.8 , pp. 3218-3225
    • VIMALACHANDRAN, D.1    GREENHALF, W.2    THOMPSON, C.3
  • 150
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • SONG G, OUYANG G, BAO S: The activation of Akt/PKB signaling pathway and cell survival. J. Cell Mol. Med. (2005) 9(1):59-71.
    • (2005) J. Cell Mol. Med , vol.9 , Issue.1 , pp. 59-71
    • SONG, G.1    OUYANG, G.2    BAO, S.3
  • 151
    • 11144354317 scopus 로고    scopus 로고
    • Prognostic significance of activated Akt expression in pancreatic ductaladenocarcinoma
    • YAMAMOTO S, TOMITA Y, HOSHIDA Y et al.: Prognostic significance of activated Akt expression in pancreatic ductaladenocarcinoma. Clin. Cancer Res. (2004) 10(8):2846-2850.
    • (2004) Clin. Cancer Res , vol.10 , Issue.8 , pp. 2846-2850
    • YAMAMOTO, S.1    TOMITA, Y.2    HOSHIDA, Y.3
  • 152
    • 18744386654 scopus 로고    scopus 로고
    • Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma
    • SUZUOKI M, MIYAMOTO M, KATO K et al.: Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma. Br. J. Cancer (2002) 87(10):1140-1144.
    • (2002) Br. J. Cancer , vol.87 , Issue.10 , pp. 1140-1144
    • SUZUOKI, M.1    MIYAMOTO, M.2    KATO, K.3
  • 153
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Rote of ATP-dependent transporters
    • GOTTESMAN MM, FOJO T, BATES SE: Multidrug resistance in cancer: rote of ATP-dependent transporters. Nat. Rev. Cancer (2002) 2:48-58.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • GOTTESMAN, M.M.1    FOJO, T.2    BATES, S.E.3
  • 154
    • 0033803167 scopus 로고    scopus 로고
    • Expression of the multidrug-resistance 1 (MDR1) gene and prognosis in human pancreatic cancer
    • LU Z, KLEEFF J, SHRIKHANDE S et al.: Expression of the multidrug-resistance 1 (MDR1) gene and prognosis in human pancreatic cancer. Pancreas (2000) 21(3):240-247.
    • (2000) Pancreas , vol.21 , Issue.3 , pp. 240-247
    • LU, Z.1    KLEEFF, J.2    SHRIKHANDE, S.3
  • 155
    • 0029665330 scopus 로고    scopus 로고
    • Immunohistochemical localization of P-glycoprotein and expression of the multidrug resistance-1 gene in human pancreatic cancer: Relevance to indicator of better prognosis
    • SUWA H, OHSHIO G, ARAO S et al.: Immunohistochemical localization of P-glycoprotein and expression of the multidrug resistance-1 gene in human pancreatic cancer: relevance to indicator of better prognosis. Jpn J. Cancer Res. (1996) 87(6):641-649.
    • (1996) Jpn J. Cancer Res , vol.87 , Issue.6 , pp. 641-649
    • SUWA, H.1    OHSHIO, G.2    ARAO, S.3
  • 156
    • 23844517889 scopus 로고    scopus 로고
    • A Phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: A Southwest oncology group (SWOG 9924) study
    • MACDONALD JS, MCCOY S, WHITEHEAD RP et al.: A Phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: a Southwest oncology group (SWOG 9924) study. Invest. New Drugs (2005) 23:485-487.
    • (2005) Invest. New Drugs , vol.23 , pp. 485-487
    • MACDONALD, J.S.1    MCCOY, S.2    WHITEHEAD, R.P.3
  • 158
    • 8744248268 scopus 로고    scopus 로고
    • Molecular targeting therapy for pancreatic cancer
    • XIONG HQ: Molecular targeting therapy for pancreatic cancer. Cancer Chemother. Pharmacol. (2004) 54(Suppl. 1):S69-S77.
    • (2004) Cancer Chemother. Pharmacol , vol.54 , Issue.SUPPL. 1
    • XIONG, H.Q.1
  • 159
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat as first-line therapy for patients with unresectable pancreatic cancer; a randomized trial
    • BRAMHALL SR, ROSEMURGY A, BROWN PD et al.: Marimastat as first-line therapy for patients with unresectable pancreatic cancer; a randomized trial. J. Clin. Oncol. (2001) 19:3447-3455.
    • (2001) J. Clin. Oncol , vol.19 , pp. 3447-3455
    • BRAMHALL, S.R.1    ROSEMURGY, A.2    BROWN, P.D.3
  • 160
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomized study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • BRAMHALL SR, SCHULZ J, NEMUNAITIS J et al.: A double-blind placebo-controlled, randomized study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br. J. Cancer (2002) 87:161-167.
    • (2002) Br. J. Cancer , vol.87 , pp. 161-167
    • BRAMHALL, S.R.1    SCHULZ, J.2    NEMUNAITIS, J.3
  • 161
    • 29044439943 scopus 로고    scopus 로고
    • Erlotinib improves survival when added to gemcitabine in patients with advanced pancreatic cancer: A Phase III trial of the National cancer institute of Canada Clinical trials group (NCIC-CTG)
    • 27-29 January, Hollywood, Florida, USA , Abstract 77
    • MOORE MJ, GOLDSTEIN D, HAMM J et al.: Erlotinib improves survival when added to gemcitabine in patients with advanced pancreatic cancer: a Phase III trial of the National cancer institute of Canada Clinical trials group (NCIC-CTG). Program and Abstracts of the 2005 American Society of Clinical Oncology Gastrointestinal Cancers Symposium (27-29 January 2005), Hollywood, Florida, USA (2005):(Abstract 77).
    • (2005) Program and Abstracts of the 2005 American Society of Clinical Oncology Gastrointestinal Cancers Symposium
    • MOORE, M.J.1    GOLDSTEIN, D.2    HAMM, J.3
  • 162
    • 34447129570 scopus 로고    scopus 로고
    • Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large Phase III studies
    • WACKER B, NAGRANI T, WEINBERG J, WITT K, CLARK G, CAGNONI PJ: Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large Phase III studies. Clin. Cancer Res. (2007) 13(13):3913-3921.
    • (2007) Clin. Cancer Res , vol.13 , Issue.13 , pp. 3913-3921
    • WACKER, B.1    NAGRANI, T.2    WEINBERG, J.3    WITT, K.4    CLARK, G.5    CAGNONI, P.J.6
  • 163
    • 1642475141 scopus 로고    scopus 로고
    • Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis
    • SINGH A, MONIAUX, N, CHAUHAN S et al.: Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res. (2004) 64:622-630.
    • (2004) Cancer Res , vol.64 , pp. 622-630
    • SINGH, A.1    MONIAUX, N.2    CHAUHAN, S.3
  • 164
    • 33846658776 scopus 로고    scopus 로고
    • Emerging roles of MUC4 in cancer: A novel target for diagnosis and therapy
    • SINGH AP, CHATURVEDI P, BATRA SK: Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy. Cancer Res. (2007) 67:433-436.
    • (2007) Cancer Res , vol.67 , pp. 433-436
    • SINGH, A.P.1    CHATURVEDI, P.2    BATRA, S.K.3
  • 165
    • 37349034578 scopus 로고    scopus 로고
    • KINDLER HL, NIEDZWIECKI D, HOLLIS D et al.: A double-blind, placebo-controlled, randomized Phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): a preliminary analysis of cancer and leukemia group B (CALGB) 80303. Program and Abstracts of the 2007 American Society of Clinical Oncology Gastrointestinal Cancers Symsposium (17-21 January 2007), Orlando, Florida, USA (2007):(Abstract 108).
    • KINDLER HL, NIEDZWIECKI D, HOLLIS D et al.: A double-blind, placebo-controlled, randomized Phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): a preliminary analysis of cancer and leukemia group B (CALGB) 80303. Program and Abstracts of the 2007 American Society of Clinical Oncology Gastrointestinal Cancers Symsposium (17-21 January 2007), Orlando, Florida, USA (2007):(Abstract 108).


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