Hypoxia, BNip3 proteins, and the mitochondrial death pathway in cardiomyocytes

Circulation Research

Volumn 91, Issue 3, 2002, Pages 183-185

  Crow, Michael T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bcl 2 proteins; BNip3 BNip3L Nix; Hypoxia; Mitochondria permeability transition

Indexed keywords

CELL PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; PROTEIN BCL 2; PROTEIN BNIP3; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; CELL DEATH; EDITORIAL; GENE ACTIVATION; GENETIC TRANSCRIPTION; HEART MITOCHONDRION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HYPOXIA; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

ANIMALS; APOPTOSIS; CASPASES; CELL HYPOXIA; MEMBRANE PROTEINS; MITOCHONDRIA; MODELS, CARDIOVASCULAR; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0037047692     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000030195.38795.CF     Document Type: Editorial

References (19)

1. i-dependent coupling to phosphatidylinositol 3′-kinase
2. Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro
3. Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation
4. Serpin protein CrmA suppresses hypoxia-mediated apoptosis of ventricular myocytes
5. Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes
6. Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy
7. Adenovirus EIB 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins
8. BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
9. Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim, the mitochondrion
10. Adenovirus EIB-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence
11. Expression of the gene encoding the proapoptotic. Nip3 protein is induced by hypoxia
12. Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology
13. BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore
14. Hypoxia induces the expression of the pro-apoptotic gene BNIP3
15. Nip21 gene expression reduces coxsackievirus B3 replication by promoting apoptotic cell death via a mitochondria-dependent pathway
16. BNIP3 heterodimerizes with Bcl-2/Bcl-XL and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites
17. Inhibitor specificity of recombinant and endogenous caspase 9
18. The permeability transition pore complex: A target for apoptosis regulation by caspases and Bcl-2-related proteins
19. Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase 3 in human cardiomyopathy