Expression of pigment epithelium-derived factor decreases liver metastasis and correlates with favorable prognosis for patients with ductal pancreatic adenocarcinoma

Cancer Research

Volumn 64, Issue 10, 2004, Pages 3533-3537

  Uehara, Hirofumi ^a   Miyamoto, Masaki ^a   Kato, Kentaro ^a   Ebihara, Yuma ^a   Kaneko, Hiroyuki ^a   Hashimoto, Hiroyuki ^a   Murakami, Yoshihiro ^a   Hase, Ryunosuke ^a   Takahashi, Ryo ^a   Mega, Seiji ^a   Shichinohe, Toshiaki ^a   Kawarada, You ^a   Itoh, Tomoo ^b   Okushiba, Shunichi ^a   Kondo, Satoshi ^a   Katoh, Hiroyuki ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PIGMENT EPITHELIUM DERIVED FACTOR;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER STAGING; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; LYMPHATIC SYSTEM; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NEOVASCULARIZATION (PATHOLOGY); PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, PANCREATIC DUCTAL; EYE PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM STAGING; NERVE GROWTH FACTORS; PANCREATIC NEOPLASMS; PROGNOSIS; PROTEIN BIOSYNTHESIS; SERPINS; SURVIVAL RATE;

EID: 2442644244     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-3725     Document Type: Article

References (33)

1. Niederhuber JE, Brennan MF, Menck HR. The National Cancer Data Base report on pancreatic cancer. Cancer (Phila) 1995;76:1671-7.
2. Yeo CJ, Cameron JL. Prognostic factors in ductal pancreatic cancer. Langenbeck's Arch Surg 1998;383:129-33.
3. Gebhardt C, Meyer W, Reichel M, Wunsch PH. Prognostic factors in the operative treatment of ductal pancreatic carcinoma. Langenbeck's Arch Surg 2000;385:14-20.
4. Yamamoto M, Ohashi O, Saitoh Y. Japan Pancreatic Cancer Registry: current status. Pancreas 1998;16:238-42.
5. Sener SF, Fremgen A, Menck HR, Winchester DP. Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985-95, using the National Cancer Database. J Am Coll Surg 1999;189:1-7.
6. Ellenrieder V, Adler G, Gress TM. Invasion and metastasis in pancreatic cancer. Ann Oncol 1999;10(Suppl 4):46-50.
7. Boehle AS, Kalthoff H. Molecular mechanisms of tumor metastasis and angiogenesis. Langenbeck's Arch Surg 1999;384:133-40.
8. Folkman J, Watson K, Ingber D, Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature (Lond) 1989;339:58-61.
9. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis; correlation in invasive breast carcinoma. N Engl J Med 1991;324:1-8.
10. Fontanini G, Bigimi D, Vignati S, et al. Microvessel count predicts metastatic disease and survival in non-small cell lung cancer. J Pathol 1995;177:57-63.
11. Hollingsworth HC, Kohn EC, Steinberg SM, Rothenberg ML, Merino MJ. Tumor angiogenesis in advanced staged ovarian carcinoma. Am J Pathol 1995;147:33-41.
12. Srivastava A, Laidler P, Davies RP, Horgan K, Hughes LE. The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. A quantitative histologic study. Am J Pathol 1988;133:419-23.
13. Guang-Wu H, Sunagawa M, Jie-En L, et al. The relationship between microvessel density, the expression of vascular endothelial growth factor (VEGF), and the extension of nasopharyngeal carcinoma. Laryngoscope 2000;110:2066-9.
14. Ohta M, Konno H, Tanaka T, et al. The significance of circulating vascular endothelial growth factor (VEGF) protein in gastric cancer. Cancer Lett 2003;192:215-25.
15. Seo Y, Baba H, Fukuda T, Takashima M, Sugimachi K. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer (Phila) 2000;88:2239-45.
16. Kayahara M, Nagakawa T, Ueno K, et al. An evaluation of radical resection for pancreatic cancer based on the mode of recurrence as determined by autopsy and diagnostic imaging. Cancer (Phila) 1993;72:2118-23.
17. Tombran-Tink J, Chader GG, Johnson LV. PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity. Exp Eye Res 1991;53:411-4.
18. Tombran-Tink J, Mazuruk K, Rodriguez IR, et al. Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin. Mol Vis 1996;2:11.
19. Cao W, Tombran-Tink J, Chen W, et al. Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death. J Neurosci Res 1999;57:789-800.
20. Dawson DW, Volpert OV, Gillis P, et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science (Wash DC) 1999;285:245-8.
21. Mori K, Duh E, Gehlbach P, et al. Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization. J Cell Physiol 2001;188:253-63.
22. Stellmach V, Crawford SE, Zhou W, Bouk N. Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. Proc Natl Acad Sci USA 2001;98:2593-7.
23. Raisler BJ, Berns KI, Grant MB, Beliaev D, Hauswirth WW. Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization. Proc Natl Acad Sci USA 2002;99:8909-14.
24. Sobin LH, Wittekind CH. UICC TNM classification of malignant tumors. 5th edition. New York: John Wiley and Sons, Inc.; 1997.
25. Hamilton SR, Aaltonen LA, editors. Pathology and genetics of tumours of the digestive system. Lyon, France: IARC Press; 2000.
26. Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst (Bethesda) 1990;82:4-6.
27. O'Reilly MS, Holmgren L, Shing Y, et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994;79:315-28.
28. Good DJ, Polverini PJ, Rastinejad F, et al. A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc Natl Acad Sci USA 1990;87:6624-8.
29. O'Reilly MS, Boehm T, Shing Y, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 1997;88:277-85.
30. Doll JA, Stellmach VM, Bouck NP, et al. Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. Nat Med 2003;9:774-80.
31. Mahtabifard A, Merritt RE, Yamada RE, Crystal RG, Korst RJ. In vivo gene transfer of pigment epithelium-derived factor inhibits tumor growth in syngeneic murine models of thoracic malignancies. J Thorac Cardiovasc Surg 2003;126:28-38.
32. Wang L, Schmitz V, Perez-Mediavilla A, et al. Suppression of angiogenesis and tumor growth by adenoviral-mediated gene transfer of pigment epithelium-derived factor. Mol Ther 2003;8:72-9.
33. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995;1:27-31.