Cloning and chromosome assignment of the human CDX2 gene

Annals of Human Genetics

Volumn 61, Issue 5, 1997, Pages 393-400

  Drummond, F ^a   Putt, W ^a   Fox, M ^a   Edwards, Y H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE; COMPLEMENTARY DNA; TRANSCRIPTION FACTOR;

ADENOMATOUS POLYP; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; ASCENDING COLON; CHROMOSOME 13Q; COLORECTAL CANCER; CONTROLLED STUDY; EMBRYO SEGMENTATION; GENE EXPRESSION; GENE LOCATION; HOMEOBOX; HUMAN; HUMAN CELL; MOLECULAR CLONING; MOUSE; MOUSE MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SKELETON MALFORMATION;

AMINO ACID SEQUENCE; ANIMALS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 13; CLONING, MOLECULAR; CONSERVED SEQUENCE; CRICETINAE; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; RATS; SEQUENCE ANALYSIS, DNA; TRANS-ACTIVATORS;

EID: 0031446727     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0003480097006465     Document Type: Article

References (31)

1. BECK, F., ERLER T., RUSSELL, A. & JAMES, R. (1995). Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes. Dev. Dynam. 204, 219-227.
2. BLUMBERG, B., WRIGHT, C. V. E., DEROBERTIS, E. M. & CHO, K. W. Y. (1991). Organizer-specific homeobox genes in Xenopus laevis embryos. Science 253, 194-253.
3. BONNER, C. A., LOFTUS, S. K. & WASMUTH, J. J. (1990). Isolation, characterisation and precise physical localization of human CDX1, a caudal-type homeobox gene. Genomics 28, 206-211.
4. CHAWENGSAKSOPHAK, K. & BECK, F. (1996). Chromosomal localization of cdx2, a muring homologue of the Drosophila gene caudal, to mouse chromosome 5. Genomics 34, 270-271.
5. CHAWENGSAKSOPHAK, K., JAMES, R., HAMMOND, V. E., KONTGEN, F. & BECK, F. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 386, 94-97.
6. DRUMMOND, F., SOWDEN, J., MORRISON, K. & EDWARDS, Y. H. (1996). The caudal-type homeobox protein Cdx-2 binds to the colon promoter of the carbonic anhydrase 1 gene. Eur. J. Biochem. 236, 670-681.
7. DRUMMOND, F., SOWDEN, J., MORRISON, K. & EDWARDS, Y. H. (1997). Colon carbonic anhydrase 1: transactivation of gene expression by the homeobox protein Cdx2. (in prep).
8. DUPREY, P., CHOWDHURY, K., DRESSLER, G. R., BALLING, R., SIMON, D., GUENET, J-L. & GRUSS, P. (1988). A mouse gene homologous to the Drosophila gene caudel is expressed in epithelial cells from the embryonic intestine. Genes & Dev. 2, 1647-1654.
9. EE, H. C., ERLER, T., BHATHAL, P. S., YOUNG, G. P. & JAMES, R. J. (1995). Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma. Am-J-Pathol. Sep. 147(3), 586-592.
10. FREUND, J-N., BOUKAMEL, R. & BENAZZOUZ, A. (1992). Gradient expression of cdx along the rat intestine throughout postnatal development. FEBS Letts. 314, 163-166.
11. FRUMKIN, A., RANGINI, Z., EN-YEHUDA, A., GRUENBAUM, Y. & FAINSOD, A. (1991). A chicken caudal homologue, Chox-cad, is expressed in the epibleast with posterior localisation and in the early endodermal lineage. Development 112, 207-219.
12. GAMER, L. W. & WRIGHT, C. V. E. (1993). Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in its homeodomain sequence and early expression pattern. Mech. dev. 43, 71-81.
13. GERMAN, M. S., WANG, J., CHADWICK, R. B. & RUTTER, W. J. (1992). Synergistic activation of the insulin gene by a LIM-homeodomain protein and a basic helix-loop-helix protein: building a functional insulin mini-enhancer complex. Genes & Dev. 6, 2165-2176.
14. GERMAN, M. S., WANG, J., FERNALD, A. A., ESPINOSA III, R., LE BEAU, M. M. & BELL, G. I. (1994). Localisation of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13. Genomics 24, 403-404.
15. GREEN, F., EDWARDS, Y., HAURI, H-P., POVEY, S., HO, M. W., PINTO, M. & SWALLOW, D. (1987). Isolation of a cDNA probe for a human jejunal brush-border hydrolase, sucrase-isomaltase and assignment of the gene locus to chromosome 3. Gene 57, 101-110.
16. HORN, J. M. & ASHWORTH, A. (1995) A member of the caudal family of homeobox genes maps to the X-inactivation centre region of the mouse and human X chromosomes. Hum. Mol. Genet. 4, 1041-1047.
17. JAMES, R. & KAZENWADEL, J. (1991). Homeobox gene expression in the intestinal epithelium of adult mice. J. Biol. Chem. 266, 3246-3251.
18. JAMES, R., ERLER T. & KAZENWADEL, J. (1994). Structure of the murine homeobox gene cdx-2. J. Bio. Chem. 269, 15229-15237.
19. JOHNSON, K. R. & DAVISSON, M. T. (1992). A multipoint genetic linkage map of mouse chromosome 18. Genomics 13, 1143-1149.
20. JOLY, J-S., MAURY, M., JOLY, C., DUPREY, P., BOULEKBACHE, H. & CONDAMINE, H. (1992). Expression of a zebrafish caudal homeobox gene correlates with the establishment of posterior cell lineages at gastulation. Differentiation 50, 75-87.
21. MALLO, G. V., RECHRECHE, H., FRIGERIO, J-M., ROCHA, D., ZWEIBAUM, A., LACASA, M., JORDAN, B. R., DUSETTI, N. J., DAGORN, J-C. & IOVANNA, J. L. (1997). Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int. J. Cancer 74, 35-44.
22. MLODZIK, M., FJOSE, A. & GEHRING, W. J. (1985). Isolation of caudal, a drosophila homeo box containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage. EMBO J. 4, 2961-2969.
23. SOWDEN, J., LEIGH, S., TALBOT, I., DELHANTY, J. & EDWARDS, Y. (1993). Expression from the Proximal Promoter of the Carbonic Anhydrase I Gene as a Marker for Differentiation in Colon Epithelia. Differentiation 53, 67-74.
24. SUH, E., CHEN, L., TAYLOR, J. & TRABER, P. G. (1994). A homeodomain protein related to caudal regulates intestine-specific gene transcription. Mol. Cell. Biol. 14, 7340-7351.
25. SUH, E. & TRABER P. G. (1996). An intestine-specific homeobox gene regulates proliferation and differentiation. Mol. Cell. Biol. 16, 619-625.
26. SWENSON, E. R. (1991). Distribution of carbonic anhydrase in the gastrointestinal tract. In Carbonic Anhydrases: Cellular Physiology & Molecular Genetics (ed. S. J. Dodgson, R. E. Tashian, G. Gros & N. D. Carter), pp. 265-287. New York: Plenum Press.
27. TAYLOR, J., LEVY, T. & TRABER, P. G. (1996). The cdx2 transcription factor appears to require a tissue specific co-activator to induce transcription from enhancer elements. Gastroenterology 110, SS pA366.
28. TAYLOR, J. K., BOLL, W., LEVY, T., SUH, E-R., SIANG, S., MANTEI, N. & TRABER, P. G. (1997). Regulatory elements in a newly characterised intestinal gene suggests a common promoter structure for enterocyte-specific genes. Meeting abstract Dig. Dis. Week A-381.
29. TROELSEN, J. T., MITCHELMORE, C., SPODSBERG, N., JENSEN, A. M. NOREN, O. & SJOSTROM, H. (1997). Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homeodomain protein Cdx-2. Biochem. J. 322, 833-838.
30. VON-ENGELHARDT, W., GROS, G., BURMESTER, M., HANSEN, K., BECKER, G. & RECHKEMMER, G. (1994). Functional role of bicarbonate in propionate transport across guinea-pig isolated caecum and proximal colon. J-Physiol-Lond. Jun 1; 477 (Pt 2), 365-371.
31. WHITEHOUSE, D. B., PUTT, W., LOVEGROVE, J. U., MORRISON, K., HOLLYOAKE, M., FOX, M. F., HOPKINSON, D. A. & EDWARDS, Y. H. (1992). Phosphoglucomutase 1: complete human and rabbit mRNA sequences and direct mapping of this highly polymorphic marker on human chromosome 1. Proc. Natl. Acad. Sci. USA 89, 411-415.