Loss of p27(Kip1) expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma

Cancer

Volumn 85, Issue 6, 1999, Pages 1250-1260

  Lu, Cai De ^a   Morita, Shinsho ^a   Ishibashi, Takashi ^a   Hara, Hitoshi ^a   Isozaki, Hiroshi ^a   Tanigawa, Nobuhiko ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Ki 67; P27(Kip1) expression; Pancreatic adenocarcinoma; Prognosis

Indexed keywords

PROTEIN P27; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; KI 67 ANTIGEN; MICROTUBULE ASSOCIATED PROTEIN; TUMOR MARKER; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; ARTICLE; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ARTICLE; CORRELATION FUNCTION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; STATISTICAL ANALYSIS; TREATMENT OUTCOME; ADENOCARCINOMA; CELL DIVISION; CHEMISTRY; DRUG ANTAGONISM; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; PANCREAS; PANCREAS TUMOR; PATHOLOGY; SURVIVAL RATE;

ADENOCARCINOMA; ADULT; AGED; CELL CYCLE PROTEINS; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MULTIVARIATE ANALYSIS; PANCREAS; PANCREATIC NEOPLASMS; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 0033558373     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0142(19990315)85:6<1250::aid-cncr6>3.0.co;2-%23     Document Type: Article

References (22)

1. Lees E. Cyclin dependent kinase regulation. Curr Opin Cell Biol 1995;7:773-802.
2. Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclindependent kinases. Genes Dev 1995;9:1149-63.
3. Raff MC. Size control: the regulation of cell numbers in animal development. Cell 1996;86:173-5.
4. Kip1 and degree of malignancy in human breast and colorectal cancers. Proc Natl Acad Sci USA 1997;94:6380-5.
5. Kip1 protein: prognostic implications in primary breast cancer. Nature Med 1997;3:227-30.
6. Steeg PS, Abrams JS. Cancer prognostics: past, present and p27. Nature Med 1997;3:152-4.
7. Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma. Cancer Res 1998;58: 542-8.
8. Esposito V, Baldi A, Luca AD, Groger AM, Loda M, Giordano GG, et al. Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. Cancer Res 1997;57:3381-5.
9. DiMagno EP. Pancreatic adenocarcinoma. In: Yamada T, editor. Textbook of gastroenterology. 2nd edition. Philadelphia: JB Lippincott Co., 1995:2113-6.
10. Conlon KC, Klimstra DS, Brenna MF. Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathological analysis of 5-year survivors. Ann Surg 1996;223:273-9.
11. Japan Pancreas Society. General rules for the study of pancreatic cancer. 4th edition. Tokyo: Kanehara Public Co., 1993.
12. Hermanek P, Sobin LH. TNM classification of malignant tumors. 4th edition. Berlin: Springer-Verlag, 1987:65-87.
13. Lu CD, Altieri DC, Tanigawa N. Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas. Cancer Res 1998;58:1808-12.
14. Lu CD, Tanigawa N. Spontaneous apoptosis is inversely related to intratumoral microvessel density in gastric carcinoma. Cancer Res 1997;57:221-4.
15. Waf1/Cip1 expression in normal human tissues. Am J Pathol 1996;148:825-35.
16. Kip1 expression in endocrine and other tumors. Am J Pathol 1997;150:401-7.
17. Yamada M, Kozuka S, Yamao K, Nakazawa S, Naitoh Y, Tsukamoto Y. Mucin-producing tumor of the pancreas. Cancer 1991;68:159-68.
18. Kip1 is abrogated by c-Myc. EMBO J 1996;15:6595-604.
19. Fortner JG, Klimstra DS, Senie RT, Maclean BJ. Tumor size is the primary prognosticator for pancreatic cancer after regional pancreatectomy. Ann Surg 1996;223:147-53.
20. Under S, Parrado C, Falkmer UG, Blasjo M, Sundelin P, von-Rosen A. Prognostic significance of Ki-67 antigen and p53 protein expression in pancreatic duct carcinoma: a study of the monoclonal antibodies MIB-1 and DO-7 in formalin-fixed paraffin-embedded tumour material. Br J Cancer 1997;76:54-9.
21. Katayose Y, Kim M, Rakkar AN, Li Z, Cowan KH, Seth P. Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27. Cancer Res 1997;57: 5441-5.
22. Kip1 over-expression causes apoptotic death of mammalian cells. Oncogene 1997;15:2991-7.