Prognostic significance of angiogenesis in human pancreatic cancer

British Journal of Cancer

Volumn 79, Issue 9-10, 1999, Pages 1553-1563

  Ikeda, N ^a,b   Adachi, M ^a   Taki, T ^a   Huang, C ^a   Hashida, H ^a   Takabayashi, A ^a   Sho, M ^b   Nakajima, Y ^b   Kanehiro, H ^b   Hisanaga, M ^b   Nakano, H ^b   Miyake, M ^a  

^a Kitano Hospital   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Pancreatic cancer; PD ECGF; Prognosis and intratumoral microvessel density (IMD); VEGF

Indexed keywords

PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER SURVIVAL; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL TIME;

EID: 0032976338     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690248     Document Type: Article

References (45)

1. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE, Nguyen HV, Aiello LM, Ferrara N and King GL (1994) Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331: 1480-1487
2. Barton CM, Hall PA, Hughes CM, Gullick WJ and Lemoine NR (1991) Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer. J Pathol 163: 111-116
3. Bramhall SR, Allum WH, Jones AG, Allwood A, Cummins C and Neoptolemos JP (1995) Treatment and survival in 13 560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: an epidemiological study. Br J Surg 82: 111-115
4. Brogi E, Schatteman G, Wu T, Kim EA, Varticovski L, Keyt B and Isner JM (1996) Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression. J Clin Invest 97: 469-476
5. Chomczynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159
6. Cox DR (1972) Regression models and life-tables. J R Stat Soc B 34: 187-220
7. Detmar M, Brown LF, Claffey KB, Yeo KT, Kocher O, Jackman RW, Berse B and Dvorak HF (1994) Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med 180: 1141-1146
8. Dvorak HF, Brown LF, Detmar M and Dvorak AM (1995) Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146: 1029-1039
9. Fava RA, Olsen NJ, Spencer-Green G, Yeo KT, Yeo TK, Berse B, Jackman RW, Senger DR, Dvorak HF and Brown LF (1994) Vascular permeability factor/endothelial growth factor (VPF/NEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med 180: 341-346
10. Fidler IJ and Ellis LM (1994) The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 79: 185-188
11. Folkman J (1995a) Clinical applications of research on angiogenesis. N Engl J Med 333: 1757-1763
12. Folkman J (1995b) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med 1: 27-31
13. Friess H, Yamanaka Y, Büchler M, Ebert M, Beger HG, Gold LI and Korc M (1993) Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival. Gastroenterology 105: 1846-1856
14. Furukawa T, Yoshimura A, Sumizawa T, Haraguchi M and Akiyama S (1992) Angiogenic factor. Nature (Lond) 356: 668
15. Gastrointestinal Tumor Study Group (1987) Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer (Phila.) 59: 2006-2010
16. Hanahan D and Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364
17. Houck KA, Lcung DW, Rowland AM, Winer J and Ferrara N (1992) Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 267: 26031-26037
18. Ishikawa F, Miyazono K, Hellman U, Drexler H, Wernstedt C, Hagiwara K, Usuki K, Takaku F, Risau W and Heldin CH (1989) Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature (Lond.) 338: 557-562
19. Itakura J, Ishiwata T, Friess H, Fujii H, Matsumoto, Büchler MW and Kore M (1997) Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression. Clin Cancer Res 3: 1309-1316.
20. Kamthan AG, Morris JC, Dalton J, Mandeli JP, Chesser MR, Leben D, Cooperman A and Bruckner HW (1997) Combined modality therapy for stage II and stage III pancreatic carcinoma. J Clin Oncol 15: 2920-2927
21. Kaplan EL and Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53: 457-481
22. Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS and Ferrara N (1993) Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 362: 841-844
23. Mantel N (1966) Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50: 163-170
24. McCulloch P, Choy A and Martin L (1995) Association between tumor angiogenesis and tumor cell shedding into effluent venous blood during breast cancer surgery. Lancet 346: 1334-1335
25. Millauer B, Shawver LK, Plate KH, Risau W and Ullrich A (1994) Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature. 367: 576-579
26. Minari Y, Nio Y, Sato Y, Omori H, Takeda H, Hirahara N, Sumi S and Tamura K (1997) The clinicopathological significance of thymidine phosphorylase in human pancreatic cancer: Its different distribution between the primary and the metastatic lesions. J Jpn Soc Cancer Ther 32: 315-325
27. Nakajima-Iijima S, Hamada H, Reddy P and Kakunaga T (1985) Molecular structure of the human cytoplasmic β-actin gene: interspecies homology of sequences in the introns. Proc Natl Acad Sci USA 82: 6133-6137
28. Nitecki SS, Michael GS, Colby TV and van Heerden JA (1995) Long-term survival after resection for ductal adenocacinoma of the pancreas. Is it really improving? Ann Surg 221: 59-66
29. Ozaki H, Kinoshita T, Kosuge T, Yamamoto J, Shimada K, Inoue K, Koyama Y and Mukai K (1996) An aggressive therapeutic approach to carcinoma of the body and tail of the pancreas. Cancer 77: 2240-2245
30. Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirasawa S, Sasazuki T and Kerbel RS (1995) Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res 55: 4575-4580
31. Ramakrishnan S, Olson TA, Bautch VL and Mohanraj D (1996) Vascular endothelial growth factor-toxin conjugate specifically inhibits KDR/flk-1-positive endothelial cell proliferation in vitro and angiogenesis in vivo. Cancer Res 56: 1324-1330
32. Schnall SF and Macdonald JS (1996) Chemotherapy of adenocarcinoma of the pancreas. Seminars in Oncol 23: 220-228
33. Shimoyama S, Gansauge F, Gansauge S, Negri G, Oohara T and Beger HG (1996) Increased angiogenin expression in pancreatic cancer is related to cancer aggressiveness. Cancer Res 56: 2703-2706
34. Sobin LH and Wittekind CH (1997) TNM classification of malignant tumors. In International Union Against Cancer (UICC), 5th ed. pp 87-90. John Wiley New York
35. Takahashi Y, Bucana CD, Liu W, Yoneda I, Kitadai Y, Cleary KR and Ellis LM (1996) Platelet-derived endothelial cell growth factor in human colon cancer angiogenesis: Role of infiltrating cells. J Natl Cancer Inst 88: 1146-1151
36. Takahashi Y, Bucana CD, Akagi Y, Liu W, Cleary KR, Mai M and Ellis LM (1998) Significance of platelet-derived endothelial cell growth factor in the angiogenesis of human gastric cancer. Clin Cancer Res 4: 429-434
37. Takebayashi Y, Akiyama S, Akiba S, Yamada K, Miyadera K, Sumizawa T, Yamada Y, Murata F and Aikou T (1996) Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma. J Natl Cancer Inst 88: 1110-1117
38. Tandon AK, Clark GM, Chamness GC, Chirgwin JM and McGuire WL (1990) Cathepsin D and prognosis in breast cancer. N Engl J Med 322: 297-302
39. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC and Abraham JA (1991) The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266: 11947-11954
40. Tsurumi Y, Murohara T, Krasinski K, Chen D, Witzenbichler B, Kearney M, Couffinhal T and Isner JM (1997) Reciprocal relation between VEGF and NO in the regulation of endothelial integrity. Nature Med: 879-886
41. Usuki K, Saras J and Waltenberger J (1992) Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. Biochem Biophys Res Commun 184: 1311-1316
42. Weidner N and Folkman J (1996) Tumoral vascularity as a prognostic factor in cancer. In Important Advances in Oncology 1996, DeVita VT Jr, Hellman S and Rosenberg SA (eds) pp 167-190. Lippincott-Raven: Philadelphia
43. Yamamoto Y, Toi M, Kondo S, Matsumoto T, Suzuki H, Kitamura M, Tsuruta K, Taniguchi T, Okamoto A, Mori T, Yoshida M, Ikeda T and Tominaga T (1996) Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients. Clin Cancer Res 2: 821-826
44. Yamanaka Y, Friess H, Buchler M, Beger HG, Uchida E, Onda M, Kobrin MS and Korc M (1993) Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage. Cancer Res 53: 5289-5296
45. Yoshiji H, Gomez DE, Shibuya M and Thorgeirsson UP (1996) Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer. Cancer Res 56: 2013-2016