Integrin signaling

Seminars in Cancer Biology

Volumn 7, Issue 3, 1996, Pages 111-118

  LaFlamme, Susan E ^a   Auer, Kelly L ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Apoptosis; Gene expression; Integrins; Proliferation; Signal transduction

Indexed keywords

CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; GROWTH FACTOR; HORMONE; INTEGRIN; LIPID; PROTEIN TYROSINE KINASE;

APOPTOSIS; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 0029980818     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.1996.0016     Document Type: Review

References (70)

1. Hynes RO (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69:11-25
2. Lo SH, Chen LB (1994) Focal adhesion as a signal transduction organelle. Cancer Metastas Rev 13:9-24
3. Schaller MD, Parsons JT (1994) Focal adhesion kinase and associated proteins. Curr Opin Cell Biol 6:705-710
4. Richardson A, Parsons JT (1995) Signal transduction through integrins: a central role for focal adhesion kinase? BioEssays 17:229-236
5. Calalb MB, Polte TR, Hanks SK (1995) Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol 15:954-963
6. Schlaepfer DD, Hanks SK, Hunter T, van der Geer P (1994) Integrin-mediated signal transduction linked to ras pathway by GRB2 binding to the focal adhesion kinase. Nature 372:786-791
7. Thorsten E, Courtneidge SA (1995) Src family protein tyrosine kinases and cellular signal transduction pathways. Curr Opin Cell Biol 7:176-182
8. Burridge K, Turner CE, Romer LH (1992) Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly. J Cell Biol 119:893-903
9. Bockholt SM, Burridge K (1993) Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin. J Biol Chem 268:14565-14567
10. Petch LA, Bockholt SM, Bouton A, Parsons JT, Burridge K (1995) Adhesion-induced tyrosine phosphorylation of the p130 SRC substrate. J Cell Sci 108:1371-1379
11. Sabe H, Hata A, Okada M, Nakagawa H, Hanafusa H (1994) Analysis of binding of the src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-src. Proc Natl Acad Sci USA 91:3984-3988
12. Chen H-C, Guan J-L (1994) Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 91:10148-10152
13. Hildebrand JD, Schaller MD, Parsons JT (1995) Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of the focal adhesion kinase. Mol Biol Cell 6:637-647
14. Chen H-C, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan J-L (1995) Interaction of focal adhesion kinase with cytoskeletal protein talin. J Biol Chem 270:16995-17016
15. Turner CE, Glenney JT, Burridge K (1990) Paxillin: a new vinculin-binding protein present in focal adhesions. J Cell Biol 111:1059-1068
16. Weng Z, Taylor JA, Turner CE, Brugge JS, Seidel-Dugan C (1993) Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/ c 3T3 cells. J Biol Chem 268:14956-14963
17. Kaplan KB, Bibbins KB, Swedlow JR, Arnaud M, Morgan DO, Varmus HE (1994) Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. EMBO J 13:4745-4556
18. Birge RB, Fajardo JE, Reichman C, Shoelson SE, Songyang Z, Cantley LC, Hanafusa H (1993) Identification and characterization of a high-affinity interaction between v-crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. Mol Cell Biol 13:4648-4656
19. Tanaka S, Morishita T, Hashimoto Y, Hattori S, Nakamura S, Shibuya M, Matuoka K, Takenawa T, Kurata T, Nagashima K, Matsuda M (1994) C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ ASH proteins. Proc Natl Acad Sci USA 91:3443-3447
20. Burgering BMT, Bos JL (1995) Regulation of Ras-mediated signalling: more than one way to skin a cat. Trends Biochem Sci 20:18-22
21. Sastry SK, Horwitz AF (1993) Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling. Curr Opin Cell Biol 5:819-831
22. Schaller MD, Otey CA, Hildebrand JD, Parsons JT (1995) Focal adhesion kinase and paxillin bind to peptides mimicking the β integrin cytoplasmic domains. J Cell Biol 130:1181-1187
23. Miyamoto S, Akiyama SK, Yamada KM (1995) Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267:883-885
24. Kanner SB, Grosmaire LS, Ledbetter JA, Damle NK (1993) β2-integrin LFA-1 signaling through phospholipase C-γ1 activation. Proc Natl Acad Sci USA 90:7099-7103
25. Daniel JL, Dangelmaier C, Smith JB (1992) Evidence for a role for tyrosine phosphorylation of phospholipase Cγ2 in collagen-induced platelet cytosolic mobilization. Biochem J 302:617-622
26. Vuori K, Ruoslahti E (1993) Activation of protein kinase C precedes α5β1 integrin-mediated cell spreading on fibronectin. J Biol Chem 268:21459-21462
27. McNamee HP, Ingber DE, Schwartz MA (1993) Adhesion of fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J Cell Biol 121:673-678
28. Chong LD, Traynor-Kaplan A, Bokoch GM, Schwartz MA (1994) The small GTP-binding protein rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 79:507-513
29. Schwartz MA (1994) Integrins as signal transducing receptors, in Integrins: Molecular and Biological Responses to the Extracellular Matrix (Cheresh DA, Mecham RP, eds) pp 33-48. Academic Press, New York
30. 2 hydrolysis and regulation of phospholipase C isozymes. Curr Opin Cell Biol 7:183-189
31. Chun J-S, Jacobson BS (1993) Requirement of diacylglycerol and protein kinase C in Hela cell-substratum adhesion and their feedback amplification of arachidonic acid production for optimum cell spreading. Mol Biol Cell 4:271-281
32. Cybulsky AV, Carbonetto S, Cyr MD, Mctavish AT, Huang Q (1993) Extracellular matrix-stimulated phospholipase activation is mediated by β1-integrin. Am J Physiol 264:C323-332
33. Auer KL, Jacobson BS (1995) β1 integrins signal lipid second messengers during cell adhesions. Mol Biol Cell 6:1305-1313
34. Guan J-L, Trevithick JE, Hynes RO (1991) Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regul 2:951-964
35. Akiyama SK, Yamada SS, Yamada KM, LaFlamme SE (1994) Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras. J Biol Chem 269:15961-15964
36. Lukashev ME, Sheppard D, Pytela R (1994) Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed β1 integrin cytoplasmic domain. J Biol Chem 269:18311-18314
37. Bauer JS, Varner J, Schreiner C, Kornberg L, Nickolas R, Juliano RL (1993) Functional role of the cytoplasmic domain of the integrin α5 subunit. J Cell Biol 122:209-221
38. Balzac F, Retta SF, Albini A, Melchiorri A, Koteliansky VE, Geuna M, Silengo L, Tarone G (1994) Expression of β1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility. J Cell Biol 127:557-565
39. LaFlamme SE, Thomas LA, Yamada SS, Yamada KM (1994) Single-subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading, and migration, and matrix assembly. J Cell Biol 126:1287-1298
40. Smilenov L, Briesewitz R, Marcantonio EE (1994) Integrin β1 cytoplasmic domain dominant negative effects revealed by lysophosphatidic acid treatment. Mol Biol Cell 5:1215-1223
41. Blystone SD, Lindberg FP, LaFlamme SE, Brown EJ (1995) Integrin β3 cytoplasmic tail is necessary and sufficient for regulation of α5β1 phagocytosis by αvβ3 and integrin-associated protein. J Cell Biol 130:745-754
42. Chan BMC, Kassner PD, Schiro JA, Byers HR, Kupper TS, Hemler ME (1992) Distinct cellular functions mediated by different VLA integrin a subunit cytoplasmic domains. Cell 68:1051-1060
43. Stoker M, O'Neill C, Berryman S, Waxman V (1968) Anchorage and growth regulation in normal and virus transformed cells. Int J Cancer 3:683-693
44. Hansen LK, Mooney DJ, Vacanti JP, Ingber DE (1994) Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth. Mol Biol Cell 5:967-975
45. Guadagno TM, Assoian RK (1991) G1/ S control of anchorage-independent growth in the fibroblast cell cycle. J Cell Biol 115:1419-1425
46. Zhu X, Assoian RK (1995) Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol Biol Cell 6:273-282
47. Davis RJ (1993) The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268:14553-14556
48. Chen Q, Kinch MS, Lin TH, Burridge K, Juliano RL (1994) Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J Biol Chem 269:26602-26605
49. Morino N, Mimura T, Hamasaki K, Tobe K, Ueki K, Kikuchi K, Takehara K, Kadowaki T, Yazaki Y, Nojima Y (1995) Matrix/ integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2. J Biol Chem 270:269-273
50. Guadagno TM, Ohtsubo M, Roberts JM, Assoian RK (1993) A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 262:1572-1575
51. Barrett JF, Lewis BC, Hoang AT, Alvarez RJ, Dang CV (1995) Cyclin A links c-Myc to adhesion-independent cell proliferation. J Biol Chem 270:15923-15925
52. Vuori K, Ruoslahti E (1994) Association of insulin receptor substrate-1 with integrins. Science 266:1576-1578
53. Pasqualini R, Hemler ME (1994) Contrasting roles for integrins β1 and β5 cytoplasmic domains in subcellular localization, cell proliferation, and cell migration. J Cell Biol 125:447-460
54. Agrez M, Chen A, Cone RI, Pytela R, Sheppard D (1994) The αvβ6 integrin promotes proliferation of colon carcinoma cells through a unique region of the β6 cytoplasmic domain. J Cell Biol 127:547-556
55. Meredith J, Takada Y, Fornaro M, Languino LR, Schwartz MA (1995) Inhibition of cell cycle progression by the alternatively spliced integrin β1C. Science 269:1570-1572
56. Steller H (1995) Mechanisms and genes of cellular suicide. Science 267:1445-1449
57. Meredith JE, Fazeli B, Schwartz MA (1993) The extracellular matrix as a cell survival factor. Mol Biol Cell 4:953-961
58. Re F, Zanetti A, Sironi M, Palentarutti N, Lanfrancone L, Dejana E, Colotta F (1994) Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J Cell Biol 127:537-546
59. Brooks PC, Montgomery AMP, Rosenfeld M, Reisfeld RA, Hu T, Klier G, Cheresh DA (1994) Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79:1157-1164
60. Frisch SM, Francis H (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124:619-626
61. Boudreau N, Sympson CJ, Werb Z, Bissell MJ (1995) Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267:891-893
62. Howlett AR, Bailey N, Damsky C, Petersen OW, Bissell MJ (1995) Cellular growth and survival are mediated by β1 integrins in normal human breast epithelium but not in breast carcinoma. J Cell Sci 108:1945-1957
63. Adams JC, Watt FM (1993) Regulation and development and differentiation by extracellular matrix. Development 117:1183-1198
64. Yirochko AD, Liu DY, Eierman D, Haskill S (1992) Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction. Proc Natl Acad Sci USA 89:9034-9038
65. Lin TH, Yurochko A, Kornberg L, Morris J, Walker JJ, Haskill S, Juliano RL (1994) The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes. J Cell Biol 126:1585-1593
66. Huhtala P, Humphries MJ, McCarthy JB, Tremble PM, Werb Z, Damsky CH (1995) Cooperative signaling by α5β1 and α4β1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J Cell Biol 129:867-879
67. Tremble P, Damsky CH, Werb Z (1995) Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals. J Cell Biol 129:1707-1720
68. Streuli CH, Bailey N, Bissell MJ (1991) Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity. J Cell Biol 115:1383-1395
69. Streuli CH, Schmidhauser C, Bailey N, Yurchenco P, Skubitz APN, Roskelley C, Bissell MJ (1995) Laminin mediates tissue-specific gene expression in mammary epithelia. J Cell Biol 129:591-603
70. Schmidhauser C, Casperson GF, Myers CA, Sanzo KT, Bolten S, Bissell MJ (1992) A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of beta-casein gene expression. Mol Biol Cell 3:699-709