Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans

Science

Volumn 309, Issue 5741, 2005, Pages 1717-1720

  Evans, Patrick D ^a   Gilbert, Sandra L ^a   Mekel Bobrov, Nitzan ^a   Vallender, Eric J ^a   Anderson, Jeffrey R ^a   Vaez Azizi, Leila M ^a   Tishkoff, Sarah A ^b   Hudson, Richard R ^a   Lahn, Bruce T ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b Bldg 142   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; BRAIN; PLASTICITY;

HUMAN EVOLUTIONARY LINEAGE; MICROCEPHALIN;

GENES;

MICROCEPHALIN; PROTEIN; UNCLASSIFIED DRUG;

BRAIN; GENE;

ARTICLE; BRAIN SIZE; EVOLUTION; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC DRIFT; GENETIC SELECTION; GENETIC VARIABILITY; HUMAN; MICROCEPHALIN GENE; PHENOTYPE; PRIORITY JOURNAL;

ADAPTATION, BIOLOGICAL; AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; AMINO ACID SUBSTITUTION; ASIAN CONTINENTAL ANCESTRY GROUP; BRAIN; EUROPEAN CONTINENTAL ANCESTRY GROUP; EVOLUTION; EXONS; GENE CONVERSION; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MICROCEPHALY; NERVE TISSUE PROTEINS; ORGAN SIZE; POLYMORPHISM, GENETIC; RECOMBINATION, GENETIC; SELECTION (GENETICS); SEQUENCE ANALYSIS, DNA; TIME; VARIATION (GENETICS);

EID: 24644507039     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1113722     Document Type: Article

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50. We thank the Coriell Institute for Medical Research, the Centre d'Etude du Polymorphisme Humain (CEPH), and A. Froment for human DNA samples. We thank H. M. Cann, S. Dorus, E. E. Eichler, N. M. Pearson, A. Di Rienzo, M. Kreitman, and J. K. Pritchard for technical support and/or helpful discussions. Supported in part by the Searle Scholarship and the Burroughs Wellcome Career Award (to B.T.L), and David and Lucile Packard Career Award, the Burroughs Wellcome Career Award, and NSF grant BCS-0196183 (to S.A.T).