Statistical tests of selective neutrality in the age of genomics

Heredity

Volumn 86, Issue 6, 2001, Pages 641-647

  Nielsen, R ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Darwinian selection; Neutral evolution; Nonsynonymous mutations; Statistical tests; Synonymous mutations

Indexed keywords

DNA SEQUENCE; GENETIC SELECTION; GENETIC VARIABILITY; GENOME; IDENTIFICATION; POPULATION GENETICS;

STATISTICAL ANALYSIS;

ALLELES; ANIMALS; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; GENE FREQUENCY; GENOME; GENOMICS; HUMANS; MODELS, GENETIC; SELECTION (GENETICS); STATISTICS; VARIATION (GENETICS);

EID: 0034809334     PISSN: 0018067X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2540.2001.00895.x     Document Type: Short Survey

References (39)

1. Synonymous codon usage in Drosophila melanogaster: Natural selection and translational accuracy
2. Detecting the 'footprint' of natural selection in within and between species DNA sequence data
3. Levels of naturally occurring DNA polymorphism correlate with recombination rates in D. melanogaster
4. Rapid evolution in plant chitinases: Molecular targets of selection in plant-pathogen coevolution
5. Characterization of single-nucleotide polymorphisms in coding regions of human genes
6. Evidence for adaptive evolution of the G6pd gene in the Drosophila melanogaster and Drosophila simulans lineages
7. The sampling theory of selectively neutral alleles
8. Hitchhiking under positive Darwinian selection
9. Evolutionary trees from DNA sequences: A maximum likelihood approach
10. Statistical tests of neutrality of mutations
11. Detecting bottlenecks and selective sweeps from DNA sequence polymorphism
12. The effect of purifying selection on genealogies
13. A codon-based model of nucleotide substitution for protein-coding DNA sequences
14. Gene genealogies and the coalescent process
15. A test of neutral molecular evolution based on nucleotide data
16. Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection
17. Adaptive evolution of the tumour suppressor BRCA1 in humans and chimpanzees
18. Evolutionary rate at the molecular level
19. Non-Darwinian evolution
20. Molecular evidence for natural selection
21. An examination of the constancy of the rate of molecular evolution
22. Distribution of gene frequency as a test of the theory of selective neutrality of polymorphisms
23. Adaptive protein evolution at the Adh locus in Drosophila
24. A likelihood approach for comparing synonymous and nonsynonymous nucleotide substitution rates, with application to chloroplast genome
25. The genealogy of samples in models with selection
26. The age of nonsynonymous and synonymous mutations in mtDNA and implications for the mildly deleterious theory
27. Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene
28. Remarks on the Lewontin-Krakauer test
29. Large number of replacement polymorphisms in rapidly evolving genes of Drosophila. Implications for genome-wide surveys of DNA polymorphism
30. Properties of statistical tests of neutrality for DNA polymorphism data
31. SNP frequencies in human genes an excess of rare alleles and differing modes of selection
32. Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals
33. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism
34. On the number of segregating sites in genetical models without recombination
35. Heterosis or neutrality?
36. Likelihood ratio tests for detecting positive selection and application to primate lyzosyme evolution
37. Codon-substitution models for variable selection pressure at amino acid Sites
38. Maximum-likelihood analysis of molecular adaptation in abalone sperm lysin reveals variable selective pressures among lineages and sites
39. Genealogical evidence for positive selection in the nef gene of HIV-1