High genomic deleterious mutation rates in hominids

Nature

Volumn 397, Issue 6717, 1999, Pages 344-347

  Eyre Walker, Adam ^a   Keightley, Peter D ^b  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHIMPANZEE; DNA SEQUENCE; GENE MUTATION; GENOME; HOMINID; MATHEMATICAL ANALYSIS; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; EVOLUTION, MOLECULAR; GENE FREQUENCY; HOMINIDAE; HUMANS; MUTATION; PAN TROGLODYTES; PROTEINS; REPRODUCTION;

ANIMALIA; HOMINIDAE; PAN (APE); PAN TROGLODYTES;

EID: 0033611501     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/16915     Document Type: Article

References (30)

1. Kondrashov, A. S. Contamination of the genomes by very slightly deleterious mutations. Why have we not died 100 times over? J. Theor. Biol. 175, 583-594 (1995).
2. Crow, J. F. The high spontaneous mutation rate: is it a health risk? Proc. Natl Acad. Sci. USA 94, 8380-8386 (1997).
3. Kondrashov, A. S. & Crow, J. F. A molecular approach to estimating the human deleterious mutation rate. Hum. Mutat. 2, 229-234 (1993).
4. Kimura, M. & Maruyama, T. The mutational load with episatic gene interactions in fitness. Genetics 54, 1337-5351 (1966).
5. Muller, H. J. Our load of mutations. Am. J. Hum. Genet. 2, 111-176 (1950).
6. Lande, R. Risk of population extinction from fixation of new deleterious mutations. Evolution 48, 1460-1469 (1994).
7. Charlesworth, B., Charlesworth, D. & Morgan, M. T. Genetic loads and estimates of mutation rates in highly inbred plant populations. Nature 347, 380-382 (1990).
8. Simmons, M. I. & Crow, I. F. Mutations affecting fitness in Drosophila populations. Annu. Rev. Genet. 11, 49-78 (1977).
9. Keightley, P. D. Nature of deleterious mutation load in Drosophila. Genetics 144, 1993-1999 (1996).
10. Kimura, M. The Neutral Theory of Molecular Evolution (Cambridge Univ. Press, Cambridge, 1983).
11. Wolfe, K. H., Sharp, P. M. & Li, W.-H. Mutation rates differ among regions of the mammalian genome. Nature 337, 283-285 (1989).
12. Fields, C., Adams, M. D. & Venter, J. C. How many genes in the human genome? Nature Genet. 7, 345-346 (1994).
13. Duret, L., Mouchiroud, D. & Gouy, M. HOVERGEN - a database of homologous vertebrate genes. Nucleic Acids Res. 22, 2360-2365 (1994).
14. Goodman, M. et al. Toward a phylogenetic classification of primates based on DNA evidence complemented by fossil evidence. Mol. Phylogenet. Evol. 9, 585-598 (1998).
15. Kumar, S. & Blair Hedges, S. A molecular timescale for vertebrate evolution. Nature 392, 917-920 (1998).
16. Antequera, F. & Bird, A. Number of CpG islands and genes in human and mouse. Proc. Natl Acad. Sci. USA 90, 11995-11999 (1993).
17. Hill, K. & Hurtado, A. M. Ache Life History: The Ecology and Demography of a Foraging People (Aldone de Gruyter, New York, 1996).
18. Howell, N. Demography of the Dobe Kung (Academic, New York, 1979).
19. Melancon, T. F. Marriage and Reproduction among the Yanomamo Indians of Venezuela. Thesis, Pennsylvania State Univ. (1982).
20. Nishida, T., Takasaki, H. & Takahata, Y. in The Chimpanzees cf the Mahale Mountains (ed. Nishida, T.) 63-97 (Tokyo Univ. Press, Tokyo, 1990).
21. Ophir, R. & Graur, D. Patterns and rates of indel evolution in processed pseudogenes from humans and murids. Gene 205, 191-202 (1997).
22. Li, W.-H. Molecular Evolution (Sinauer, Sunderland, Massachusetts, 1997).
23. Ohta, T. Synonymous and nonsynonymous substitutions in mammalian genes and the nearly neutral theory. J. Mol. Evol. 40, 56-63 (1995).
24. Wolfe, K. H. & Sharp, P. M. Mammalian gene evolution - nucleotide-sequence divergence between mouse and rat. J. Mol. Evol. 37, 441-456 (1993).
25. Neel, J. V. et al. Search for mutations altering protein charge and/or function in children of atomic-bomb survivors - final report. Am. J. Hum. Genet. 42, 663-676 (1988).
26. Mohrenweiser, H. W. & Neel, J. V. Frequency of thermostability variants - estimation of total rare variant frequency in human populations. Proc. Natl Acad. Sci. USA 78, 5729-5733 (1981).
27. Drake, J. W. et al. Rates of spontaneous mutation. Genetics 148, 1667-1686 (1998).
28. Thompson, J. D. et al. The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 24, 4876-4882 (1997).
29. Ina, Y. Estimation of the transition/transversion ratio. J. Mol. Evolv. 46, 521-533 (1998).
30. Hammer, M. F. A recent common ancestry for human Y chromosomes. Nature 378, 376-378 (1985).