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Volumn 11, Issue 9, 2007, Pages 1231-1249

Present and future therapeutic strategies in non-alcoholic fatty liver disease

Author keywords

Antioxidant; Aquaglyceroporin; Aquaporin; Fatty liver; Glitazone; Insulin resistance; Liver steatosis; Metabolic syndrome; Oxidative stress; Probiotic; Sibutramine

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; AQUAGLYCEROPORIN; ASPARTATE AMINOTRANSFERASE; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETAINE; BEZAFIBRATE; CLOFIBRATE; GEMFIBROZIL; INSULIN; LIPID; LOSARTAN; METFORMIN; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; OMEGA 3 FATTY ACID; PENTOXIFYLLINE; PIOGLITAZONE; PLACEBO; PRAVASTATIN; PROBIOTIC AGENT; PROBUCOL; RIMONABANT; ROSIGLITAZONE; SIBUTRAMINE; TETRAHYDROLIPSTATIN; TROGLITAZONE; UNINDEXED DRUG; URSODEOXYCHOLIC ACID;

EID: 34548819916     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.11.9.1231     Document Type: Review
Times cited : (45)

References (235)
  • 1
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis: Mayo clinic experiences with a hitherto unnamed disease
    • LUDWIG J, VIGGIANO TR, MCGILL DB, OH BJ: Nonalcoholic steatohepatitis: mayo clinic experiences with a hitherto unnamed disease. Mayo Clin. Proc. (1980) 55:434-438.
    • (1980) Mayo Clin. Proc , vol.55 , pp. 434-438
    • LUDWIG, J.1    VIGGIANO, T.R.2    MCGILL, D.B.3    OH, B.J.4
  • 3
    • 0035164629 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease in an area of southern Italy: Main clinical, histological, and pathophysiological aspects
    • LOGUERCIO C, DE GIROLAMO V, DE SIO I et al.: Non-alcoholic fatty liver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects. J. Hepatol. (2001) 35:568-574.
    • (2001) J. Hepatol , vol.35 , pp. 568-574
    • LOGUERCIO, C.1    DE GIROLAMO, V.2    DE SIO, I.3
  • 4
    • 85047691331 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: A multicentre clinical study by the Italian association for the study of the liver
    • LOGUERCIO C, DE SIMONE T, D'AURIA MV et al.: Non-alcoholic fatty liver disease: a multicentre clinical study by the Italian association for the study of the liver. Dig. Liver Dis. (2004) 36:398-405
    • (2004) Dig. Liver Dis , vol.36 , pp. 398-405
    • LOGUERCIO, C.1    DE SIMONE, T.2    D'AURIA, M.V.3
  • 5
    • 0025002079 scopus 로고
    • Liver pathology in morbidly obese patients with and without diabetes
    • SILVERMAN JF, O'BRIEN KF, LONG S et al.: Liver pathology in morbidly obese patients with and without diabetes. Am. J. Gastroenterol. (1990) 85:1349-1355.
    • (1990) Am. J. Gastroenterol , vol.85 , pp. 1349-1355
    • SILVERMAN, J.F.1    O'BRIEN, K.F.2    LONG, S.3
  • 6
    • 2342419920 scopus 로고    scopus 로고
    • Long term prognosis of fatty liver: Risk of chronic liver disease and death
    • DAM-LARSEN S, FRANZMANN M, ANDERSEN IB et al.: Long term prognosis of fatty liver: risk of chronic liver disease and death. Gut (2004) 53:750-755.
    • (2004) Gut , vol.53 , pp. 750-755
    • DAM-LARSEN, S.1    FRANZMANN, M.2    ANDERSEN, I.B.3
  • 7
    • 0242492522 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis - a long-term follow-up study: Comparison with alcoholic hepatitis in ambulatory and hospitalized patients
    • CORTEZ-PINTO H, BAPTISTA A, CAMILO ME, DE MOURA MC: Nonalcoholic steatohepatitis - a long-term follow-up study: comparison with alcoholic hepatitis in ambulatory and hospitalized patients. Dig. Dis. Sci. (2003) 48:1909-1913.
    • (2003) Dig. Dis. Sci , vol.48 , pp. 1909-1913
    • CORTEZ-PINTO, H.1    BAPTISTA, A.2    CAMILO, M.E.3    DE MOURA, M.C.4
  • 8
    • 0037126526 scopus 로고    scopus 로고
    • THIRD REPORT OF THE NATIONAL CHOLESTEROL EDUCATION PROGRAM (NCEP) EXPERT PANEL ON DETECTION EVALUATION AND TREATMENT OF HIGH BLOOD CHOLESTEROL IN ADULTS (ADULT TREATMENT PANEL III). FINAL REPORT: Circulation (2002) 106:3143-3421.
    • THIRD REPORT OF THE NATIONAL CHOLESTEROL EDUCATION PROGRAM (NCEP) EXPERT PANEL ON DETECTION EVALUATION AND TREATMENT OF HIGH BLOOD CHOLESTEROL IN ADULTS (ADULT TREATMENT PANEL III). FINAL REPORT: Circulation (2002) 106:3143-3421.
  • 9
    • 23444451889 scopus 로고    scopus 로고
    • Prevalence of and risk factors for fatty liver in a general population of Shanghai
    • FAN JG, ZHU J, LI XJ et al.: Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. J. Hepatol. (2005) 43:508-514.
    • (2005) China. J. Hepatol , vol.43 , pp. 508-514
    • FAN, J.G.1    ZHU, J.2    LI, X.J.3
  • 10
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • MARCHESINI G, BUGIANESI E, FORLANI G et al.: Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology (2003) 37:917-923.
    • (2003) Hepatology , vol.37 , pp. 917-923
    • MARCHESINI, G.1    BUGIANESI, E.2    FORLANI, G.3
  • 11
    • 23444431623 scopus 로고    scopus 로고
    • Retinoid × receptor heterodimers in the metabolic syndrome
    • SHULMAN AI, MANGELSDORF DJ: Retinoid × receptor heterodimers in the metabolic syndrome. N. Engl. J. Med. (2005) 353:604-615.
    • (2005) N. Engl. J. Med , vol.353 , pp. 604-615
    • SHULMAN, A.I.1    MANGELSDORF, D.J.2
  • 13
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • DAY CP, JAMES OF: Steatohepatitis: a tale of two "hits"? Gastroenterology (1998) 114:842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • DAY, C.P.1    JAMES, O.F.2
  • 15
    • 0032171686 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis (NASH): A disease of emerging identity and importance
    • JAMES OF, DAY CP: Non-alcoholic steatohepatitis (NASH): a disease of emerging identity and importance. J. Hepatol. (1998) 29:495-501.
    • (1998) J. Hepatol , vol.29 , pp. 495-501
    • JAMES, O.F.1    DAY, C.P.2
  • 17
    • 0033625733 scopus 로고    scopus 로고
    • Insulin resistance influence iron metabolism and hepatic steatosis in Type II diabetes
    • VIGANO M, VERGANI A, TROMBINI P, PALEARI F, PIPERNO A: Insulin resistance influence iron metabolism and hepatic steatosis in Type II diabetes. Gastroenterology (2000) 118:986-987.
    • (2000) Gastroenterology , vol.118 , pp. 986-987
    • VIGANO, M.1    VERGANI, A.2    TROMBINI, P.3    PALEARI, F.4    PIPERNO, A.5
  • 18
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
    • YANG SQ, LIN HZ, LANE MD, CLEMENS M, DIEHL AM: Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc. Natl. Acad. Sci. USA (1997) 94:2557-2562.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2557-2562
    • YANG, S.Q.1    LIN, H.Z.2    LANE, M.D.3    CLEMENS, M.4    DIEHL, A.M.5
  • 19
    • 0035572430 scopus 로고    scopus 로고
    • Liver steatosis in chronic hepatitis C: A morphological sign suggesting infection with HCV genotype 3
    • RUBBIA-BRANDT L, LEANDRO G, SPAHR L et al.: Liver steatosis in chronic hepatitis C: a morphological sign suggesting infection with HCV genotype 3. Histopathology (2001) 39:119-124.
    • (2001) Histopathology , vol.39 , pp. 119-124
    • RUBBIA-BRANDT, L.1    LEANDRO, G.2    SPAHR, L.3
  • 20
    • 0027943858 scopus 로고
    • Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis
    • SOKOL RJ, TWEDT D, MCKIM JM Jr et al.: Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis. Gastroenterology (1994) 107:1788-1798.
    • (1994) Gastroenterology , vol.107 , pp. 1788-1798
    • SOKOL, R.J.1    TWEDT, D.2    MCKIM Jr, J.M.3
  • 21
    • 0027420075 scopus 로고
    • Risk factors for primary dysfunction after liver transplantation - a multivariate analysis
    • PLOEG RJ, D'ALESSANDRO AM, KNECHTLE SJ et al.: Risk factors for primary dysfunction after liver transplantation - a multivariate analysis. Transplantation (1993) 55:807-813.
    • (1993) Transplantation , vol.55 , pp. 807-813
    • PLOEG, R.J.1    D'ALESSANDRO, A.M.2    KNECHTLE, S.J.3
  • 23
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
    • SANYAL AJ, CAMPBELL-SARGENT C, MIRSHAHI F et al.: Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology (2001) 120:1183-1192.
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • SANYAL, A.J.1    CAMPBELL-SARGENT, C.2    MIRSHAHI, F.3
  • 24
    • 0034676629 scopus 로고    scopus 로고
    • Cytokines in alcoholic and nonalcoholic steatohepatitis
    • TILG H, DIEHL AM: Cytokines in alcoholic and nonalcoholic steatohepatitis. N. Engl. J. Med. (2000) 343:1467-1476.
    • (2000) N. Engl. J. Med , vol.343 , pp. 1467-1476
    • TILG, H.1    DIEHL, A.M.2
  • 25
    • 33646014467 scopus 로고    scopus 로고
    • Serum cytokine and soluble cytokine receptor levels in patients with nonalcoholic steatohepatitis
    • ABIRU S, MIGITA K, MAEDA Y et al.: Serum cytokine and soluble cytokine receptor levels in patients with nonalcoholic steatohepatitis. Liver Int. (2006) 26: 39-45.
    • (2006) Liver Int , vol.26 , pp. 39-45
    • ABIRU, S.1    MIGITA, K.2    MAEDA, Y.3
  • 26
    • 0042265627 scopus 로고    scopus 로고
    • Cytokines and NASH: A pilot study of the effects of lifestyle modification and vitamin E
    • KUGELMAS M, HILL DB, VIVIAN B, MARSANO L, MCLAIN CJ: Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology (2003) 38:413-419.
    • (2003) Hepatology , vol.38 , pp. 413-419
    • KUGELMAS, M.1    HILL, D.B.2    VIVIAN, B.3    MARSANO, L.4    MCLAIN, C.J.5
  • 27
    • 18244370762 scopus 로고    scopus 로고
    • Inflammation, stress, and diabetes
    • WELLEN KE, HOTAMISLIGIL GS: Inflammation, stress, and diabetes. J. Clin. Invest. (2005) 115:1111-1119.
    • (2005) J. Clin. Invest , vol.115 , pp. 1111-1119
    • WELLEN, K.E.1    HOTAMISLIGIL, G.S.2
  • 28
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • SHOELSON SE, HERRERO L, NAAZ A: Obesity, inflammation, and insulin resistance. Gastroenterology (2007) 132:2169-2180.
    • (2007) Gastroenterology , vol.132 , pp. 2169-2180
    • SHOELSON, S.E.1    HERRERO, L.2    NAAZ, A.3
  • 29
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • BROWNING JD, HORTON JD: Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest. (2004) 114:147-152.
    • (2004) J. Clin. Invest , vol.114 , pp. 147-152
    • BROWNING, J.D.1    HORTON, J.D.2
  • 30
    • 1442281990 scopus 로고    scopus 로고
    • Oxidative stress as a trigger for cellular immune responses in patients with alcoholic liver disease
    • STEWART SF, VIDALI M, DAY CP, ALBANO E, JONES DE: Oxidative stress as a trigger for cellular immune responses in patients with alcoholic liver disease. Hepatology (2004) 39:197-203.
    • (2004) Hepatology , vol.39 , pp. 197-203
    • STEWART, S.F.1    VIDALI, M.2    DAY, C.P.3    ALBANO, E.4    JONES, D.E.5
  • 31
    • 33845313622 scopus 로고    scopus 로고
    • Systemic oxidative alterations are associated with visceral adiposity and liver steatosis in patients with metabolic syndrome
    • PALMIERI VO, GRATTAGLIANO I, PORTINCASA P, PALASCIANO G: Systemic oxidative alterations are associated with visceral adiposity and liver steatosis in patients with metabolic syndrome. J. Nutr. (2006) 136:3022-3026.
    • (2006) J. Nutr , vol.136 , pp. 3022-3026
    • PALMIERI, V.O.1    GRATTAGLIANO, I.2    PORTINCASA, P.3    PALASCIANO, G.4
  • 34
    • 0035196704 scopus 로고    scopus 로고
    • Non-alcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress
    • ROBERTSON G, LECLERCQ I, FARRELL GC: Non-alcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) 281:G1135-G1139.
    • (2001) Am. J. Physiol. Gastrointest. Liver Physiol , vol.281
    • ROBERTSON, G.1    LECLERCQ, I.2    FARRELL, G.C.3
  • 35
    • 0033573975 scopus 로고    scopus 로고
    • Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats
    • ENRIQUEZ A, LECLERCQ I, FARRELL GC, ROBERTSON G: Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. Biochem. Biophys. Res. Commun. (1999) 255:300-306.
    • (1999) Biochem. Biophys. Res. Commun , vol.255 , pp. 300-306
    • ENRIQUEZ, A.1    LECLERCQ, I.2    FARRELL, G.C.3    ROBERTSON, G.4
  • 37
    • 0031962151 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 is increased in patients with non-alcoholic steatohepatitis
    • WELTMAN MD, FARRELL GC, HALL P, INGELMAN-SUNDBERG M, LIDDLE C: Hepatic cytochrome P450 2E1 is increased in patients with non-alcoholic steatohepatitis. Hepatology (1998) 27:128-133.
    • (1998) Hepatology , vol.27 , pp. 128-133
    • WELTMAN, M.D.1    FARRELL, G.C.2    HALL, P.3    INGELMAN-SUNDBERG, M.4    LIDDLE, C.5
  • 38
    • 27644473284 scopus 로고    scopus 로고
    • Role of inflammation in non-alcoholic steatohepatitis
    • CHOI S, DIEHL AM: Role of inflammation in non-alcoholic steatohepatitis. Curr. Opin. Gastroenterol. (2005) 21:702-707.
    • (2005) Curr. Opin. Gastroenterol , vol.21 , pp. 702-707
    • CHOI, S.1    DIEHL, A.M.2
  • 39
    • 0035078484 scopus 로고    scopus 로고
    • Etiopathogenesis of non-alcoholic steatohepatitis
    • CHITTURI S, FARRELL GC: Etiopathogenesis of non-alcoholic steatohepatitis. Semin. Liver Dis. (2001) 21:27-41.
    • (2001) Semin. Liver Dis , vol.21 , pp. 27-41
    • CHITTURI, S.1    FARRELL, G.C.2
  • 40
    • 30044431801 scopus 로고    scopus 로고
    • From fat to inflammation
    • DAY CP: From fat to inflammation. Gastroenterology (2006) 130:207-210.
    • (2006) Gastroenterology , vol.130 , pp. 207-210
    • DAY, C.P.1
  • 41
    • 0034504237 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue: Their relation to the metabolic syndrome
    • WAJCHENBERG BL: Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr. Rev. (2000) 21:697-738.
    • (2000) Endocr. Rev , vol.21 , pp. 697-738
    • WAJCHENBERG, B.L.1
  • 42
    • 34948853969 scopus 로고    scopus 로고
    • GARRUTI G, GIUSTI V, NUSSBERGER J et al.: Expression and secretion of atrial natriuretic peptide in human adipose tissue and pre-adipocytes. Obes. Res. (2007) 15 (ahead of publication).
    • GARRUTI G, GIUSTI V, NUSSBERGER J et al.: Expression and secretion of atrial natriuretic peptide in human adipose tissue and pre-adipocytes. Obes. Res. (2007) 15 (ahead of publication).
  • 43
  • 44
    • 34247863931 scopus 로고    scopus 로고
    • Abnormal lipid and glucose metabolism in obesity: Implications for nonalcoholic fatty liver disease
    • PAREKH S, ANANIA FA: Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease. Gastroenterology (2007) 132:2191-2207.
    • (2007) Gastroenterology , vol.132 , pp. 2191-2207
    • PAREKH, S.1    ANANIA, F.A.2
  • 45
    • 14244268282 scopus 로고    scopus 로고
    • Adipose tissue in obesity - an inflammatory issue
    • TRAYHURN P: Adipose tissue in obesity - an inflammatory issue. Endocrinology (2005) 146:1003-1005.
    • (2005) Endocrinology , vol.146 , pp. 1003-1005
    • TRAYHURN, P.1
  • 46
    • 27844545767 scopus 로고    scopus 로고
    • Signalling role of adipose tissue: Adipokines and inflammation in obesity
    • TRAYHURN P, WOOD IS: Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem. Soc. Trans. (2005) 33:1078-1081.
    • (2005) Biochem. Soc. Trans , vol.33 , pp. 1078-1081
    • TRAYHURN, P.1    WOOD, I.S.2
  • 47
    • 0033849777 scopus 로고    scopus 로고
    • Obesity and insulin resistance
    • KAHN BB, FLIER JS: Obesity and insulin resistance. J. Clin. Invest. (2000) 106:473-481.
    • (2000) J. Clin. Invest , vol.106 , pp. 473-481
    • KAHN, B.B.1    FLIER, J.S.2
  • 48
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • FRIEDMAN JM, HALAAS JL: Leptin and the regulation of body weight in mammals. Nature (1998) 395:763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • FRIEDMAN, J.M.1    HALAAS, J.L.2
  • 50
    • 0035658444 scopus 로고    scopus 로고
    • Non-alcoholic steatosis and steatohepatitis. III. Peroxisomal β-oxidation, PPAR a, and steatohepatitis
    • REDDY JK: Non-alcoholic steatosis and steatohepatitis. III. Peroxisomal β-oxidation, PPAR a, and steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) 281:G1333-G1339.
    • (2001) Am. J. Physiol. Gastrointest. Liver Physiol , vol.281
    • REDDY, J.K.1
  • 51
    • 18144444592 scopus 로고    scopus 로고
    • Defective hepatic mitochondrial respiratory chain in patients with non-alcoholic steatohepatitis
    • PEREZ-CARRERAS M, DEL HOYO P, MARTIN MA et al.: Defective hepatic mitochondrial respiratory chain in patients with non-alcoholic steatohepatitis. Hepatology (2003) 38:999-1007.
    • (2003) Hepatology , vol.38 , pp. 999-1007
    • PEREZ-CARRERAS, M.1    DEL HOYO, P.2    MARTIN, M.A.3
  • 52
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • FELDSTEIN AE, CANBAY A, ANGULO P et al.: Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology (2003) 125:437-443.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • FELDSTEIN, A.E.1    CANBAY, A.2    ANGULO, P.3
  • 54
    • 0034799113 scopus 로고    scopus 로고
    • Ninety patients with non-alcoholic steatohepatitis: Insulin resistance, familial tendency, and severity of disease
    • WILLNER IR, WATERS B, PATIL SR, REUBEN A, MORELLI J, RIELY CA: Ninety patients with non-alcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease. Am. J. Gastroenterol. (2001) 96:2957-2961.
    • (2001) Am. J. Gastroenterol , vol.96 , pp. 2957-2961
    • WILLNER, I.R.1    WATERS, B.2    PATIL, S.R.3    REUBEN, A.4    MORELLI, J.5    RIELY, C.A.6
  • 55
    • 0343314903 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and cryptogenic cirrhosis within kindreds
    • STRUBEN VM, HESPENHEIDE EE, CALDWELL SH: Non-alcoholic steatohepatitis and cryptogenic cirrhosis within kindreds. Am. J. Med. (2000) 108:9-13.
    • (2000) Am. J. Med , vol.108 , pp. 9-13
    • STRUBEN, V.M.1    HESPENHEIDE, E.E.2    CALDWELL, S.H.3
  • 57
    • 34249945491 scopus 로고    scopus 로고
    • The genetics of nonalcoholic fatty liver disease
    • OSTERREICHER CH, BRENNER D: The genetics of nonalcoholic fatty liver disease. Ann. Hepatology (2007) 6:83-88.
    • (2007) Ann. Hepatology , vol.6 , pp. 83-88
    • OSTERREICHER, C.H.1    BRENNER, D.2
  • 58
    • 34948821458 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease
    • Sleisenger MH & Fordtran JS Eds, Philadelphia: WB Saunders
    • REID AE: Non-alcoholic fatty liver disease. In: Gastrointestinal Disease: Pathophysiology, Diagnosis, Management. Sleisenger MH & Fordtran JS (Eds), Philadelphia: WB Saunders (2006):1793-1805.
    • (2006) Gastrointestinal Disease: Pathophysiology, Diagnosis, Management , pp. 1793-1805
    • REID, A.E.1
  • 59
    • 18244364864 scopus 로고    scopus 로고
    • NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome
    • CHITTURI S, ABEYGUNASEKERA S, FARRELL GC et al.: NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology (2002) 35:373-379.
    • (2002) Hepatology , vol.35 , pp. 373-379
    • CHITTURI, S.1    ABEYGUNASEKERA, S.2    FARRELL, G.C.3
  • 60
    • 0025757246 scopus 로고
    • Paradoxical lack of ultrasound attenuation with gross fatty change in the liver
    • DAVIES RJ, SAVERYMUTTU SH, FALLOWFIELD M, JOSEPH AL: Paradoxical lack of ultrasound attenuation with gross fatty change in the liver. Clin. Radiol. (1991) 43:393-396.
    • (1991) Clin. Radiol , vol.43 , pp. 393-396
    • DAVIES, R.J.1    SAVERYMUTTU, S.H.2    FALLOWFIELD, M.3    JOSEPH, A.L.4
  • 61
    • 0032995108 scopus 로고    scopus 로고
    • Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis
    • AUBE C, OBERTI F, KORALI N et al.: Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis. J. Hepatol. (1999) 30:472-478.
    • (1999) J. Hepatol , vol.30 , pp. 472-478
    • AUBE, C.1    OBERTI, F.2    KORALI, N.3
  • 64
    • 34948878275 scopus 로고    scopus 로고
    • CURRY MP, AFDHAL NH: Non-invasive assessment of hepatic fibrosis. UpToDate (2007) v.15.2:1-5.
    • CURRY MP, AFDHAL NH: Non-invasive assessment of hepatic fibrosis. UpToDate (2007) v.15.2:1-5.
  • 65
    • 0042265556 scopus 로고    scopus 로고
    • A simple non-invasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
    • WAI CT, GREENSON JK, FONTANA RJ et al.: A simple non-invasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology (2003) 38:518-526.
    • (2003) Hepatology , vol.38 , pp. 518-526
    • WAI, C.T.1    GREENSON, J.K.2    FONTANA, R.J.3
  • 66
    • 0035820265 scopus 로고    scopus 로고
    • Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: A prospective study
    • IMBERT-BISMUT F, RATZIU V, PIERONI L, CHARLOTTE F, BENHAMOU Y, POYNARD T: Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Lancet (2001) 357:1069-1075.
    • (2001) Lancet , vol.357 , pp. 1069-1075
    • IMBERT-BISMUT, F.1    RATZIU, V.2    PIERONI, L.3    CHARLOTTE, F.4    BENHAMOU, Y.5    POYNARD, T.6
  • 67
    • 33846828560 scopus 로고    scopus 로고
    • Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C
    • HALFON P, BACQ Y, DE MURET A, et al.: Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C. J. Hepatol. (2007) 46:395-402.
    • (2007) J. Hepatol , vol.46 , pp. 395-402
    • HALFON, P.1    BACQ, Y.2    DE MURET, A.3
  • 68
    • 9644279531 scopus 로고    scopus 로고
    • Serum markers detect the presence of liver fibrosis: A cohort study
    • ROSENBERG WM, VOELKER M, THIEL R et al.: Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology (2004) 127:1704-1713.
    • (2004) Gastroenterology , vol.127 , pp. 1704-1713
    • ROSENBERG, W.M.1    VOELKER, M.2    THIEL, R.3
  • 69
    • 33644901827 scopus 로고    scopus 로고
    • Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C
    • SEBASTIANI G, VARIO A, GUIDO M et al.: Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C. J. Hepatol. (2006) 44:686-693.
    • (2006) J. Hepatol , vol.44 , pp. 686-693
    • SEBASTIANI, G.1    VARIO, A.2    GUIDO, M.3
  • 70
    • 32444451794 scopus 로고    scopus 로고
    • Performance of serum marker panels for liver fibrosis in chronic hepatitis C
    • PARKES J, GUHA IN, RODERICK P, ROSENBERG W: Performance of serum marker panels for liver fibrosis in chronic hepatitis C. J. Hepatol. (2006) 44:462-474.
    • (2006) J. Hepatol , vol.44 , pp. 462-474
    • PARKES, J.1    GUHA, I.N.2    RODERICK, P.3    ROSENBERG, W.4
  • 71
    • 2542560570 scopus 로고    scopus 로고
    • Prediction of liver fibrosis in patients with features of the metabolic syndrome regardless of alcohol consumption
    • LAINE F, BENDAVID C, MOIRAND R et al.: Prediction of liver fibrosis in patients with features of the metabolic syndrome regardless of alcohol consumption. Hepatology (2004) 39:1639-1646.
    • (2004) Hepatology , vol.39 , pp. 1639-1646
    • LAINE, F.1    BENDAVID, C.2    MOIRAND, R.3
  • 72
    • 34047173534 scopus 로고    scopus 로고
    • Diagnostic value of ultrasonographic examination for non-alcoholic steatohepatitis in morbidly obese patients undergoing laparoscopic bariatric surgery
    • LIANG RJ, WANG HH, LEE WJ, LIEW PL, LIN JT, WU MS: Diagnostic value of ultrasonographic examination for non-alcoholic steatohepatitis in morbidly obese patients undergoing laparoscopic bariatric surgery. Obes. Surg. (2007) 17:45-56.
    • (2007) Obes. Surg , vol.17 , pp. 45-56
    • LIANG, R.J.1    WANG, H.H.2    LEE, W.J.3    LIEW, P.L.4    LIN, J.T.5    WU, M.S.6
  • 73
    • 9144249563 scopus 로고    scopus 로고
    • Transient elastography: A new noninvasive method for assessment of hepatic fibrosis
    • SANDRIN L, FOURQUET B, HASQUENOPH JM et al.: Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med. Biol. (2003) 29:1705-1713.
    • (2003) Ultrasound Med. Biol , vol.29 , pp. 1705-1713
    • SANDRIN, L.1    FOURQUET, B.2    HASQUENOPH, J.M.3
  • 74
    • 33144485013 scopus 로고    scopus 로고
    • Diagnosis of cirrhosis by transient elastography (FibroScan): A prospective study
    • FOUCHER J, CHANTELOUP E, VERGNIOL J et al.: Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut (2006) 55:403-408.
    • (2006) Gut , vol.55 , pp. 403-408
    • FOUCHER, J.1    CHANTELOUP, E.2    VERGNIOL, J.3
  • 75
    • 33947153136 scopus 로고    scopus 로고
    • Features associated with success rate and performance of FibroScan measurements for the diagnosis of cirrhosis in HCV patients: A prospective study of 935 patients
    • KETTANEH A, MARCELLIN P, DOUVIN C et al.: Features associated with success rate and performance of FibroScan measurements for the diagnosis of cirrhosis in HCV patients: a prospective study of 935 patients. J. Hepatol. (2007) 46:628-634.
    • (2007) J. Hepatol , vol.46 , pp. 628-634
    • KETTANEH, A.1    MARCELLIN, P.2    DOUVIN, C.3
  • 76
    • 33845659921 scopus 로고    scopus 로고
    • Accuracy of liver stiffness measurement fur the diagnosis of cirrhosis in patients with chronic liver diseases
    • GANNE-CARRIE N, ZIOL M, DE LEDINGHEN V et al.: Accuracy of liver stiffness measurement fur the diagnosis of cirrhosis in patients with chronic liver diseases. Hepatology (2006)44:1511-1517.
    • (2006) Hepatology , vol.44 , pp. 1511-1517
    • GANNE-CARRIE, N.1    ZIOL, M.2    DE LEDINGHEN, V.3
  • 78
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • KLEINER DE, BRUNT EM, VAN NATTA M et al.: Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology (2005) 41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • KLEINER, D.E.1    BRUNT, E.M.2    VAN NATTA, M.3
  • 79
    • 0034116558 scopus 로고    scopus 로고
    • Liver fibrosis in overweight patients
    • RATZIU V, GIRAL P, CHARLOTTE F et al.: Liver fibrosis in overweight patients. Gastroenterology (2000) 118:1117-1123.
    • (2000) Gastroenterology , vol.118 , pp. 1117-1123
    • RATZIU, V.1    GIRAL, P.2    CHARLOTTE, F.3
  • 80
    • 11144351102 scopus 로고    scopus 로고
    • The histological course of nonalcoholic fatty liver disease: A longitudinal study of 103 patients with sequential liver biopsies
    • ADAMS LA, SANDERSON S, LINDOR KD, ANGULO P: The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J. Hepatol. (2005) 42:132-138.
    • (2005) J. Hepatol , vol.42 , pp. 132-138
    • ADAMS, L.A.1    SANDERSON, S.2    LINDOR, K.D.3    ANGULO, P.4
  • 81
    • 4644297019 scopus 로고    scopus 로고
    • Natural history of non-alcoholic steatohepatitis: A longitudinal study of repeat liver biopsies
    • FASSIO E, ALVAREZ E, DOMINGUEZ N, LANDEIRA G, LONGO C: Natural history of non-alcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology (2004) 40:820-826.
    • (2004) Hepatology , vol.40 , pp. 820-826
    • FASSIO, E.1    ALVAREZ, E.2    DOMINGUEZ, N.3    LANDEIRA, G.4    LONGO, C.5
  • 83
    • 33746429613 scopus 로고    scopus 로고
    • Does the metabolic syndrome exist?
    • GRUNDY SM: Does the metabolic syndrome exist? Diabetes Care (2006) 29:1689-1692.
    • (2006) Diabetes Care , vol.29 , pp. 1689-1692
    • GRUNDY, S.M.1
  • 86
    • 33847789529 scopus 로고    scopus 로고
    • Drugs improving insulin resistance for non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis
    • CD005166
    • ANGELICO F, BURATTIN M, ALESSANDRI C, DEL BM, LIRUSSI F: Drugs improving insulin resistance for non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis. Cochrane Database Syst. Rev. (2007):CD005166.
    • (2007) Cochrane Database Syst. Rev
    • ANGELICO, F.1    BURATTIN, M.2    ALESSANDRI, C.3    DEL BM, L.F.4
  • 88
    • 13544258741 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Recent advances from experimental models to clinical management
    • PORTINCASA P, GRATTAGLIANO I, PALMIERI VO, PALASCIANO G: Nonalcoholic steatohepatitis: recent advances from experimental models to clinical management. Clin. Biochem. (2005) 38:203-217.
    • (2005) Clin. Biochem , vol.38 , pp. 203-217
    • PORTINCASA, P.1    GRATTAGLIANO, I.2    PALMIERI, V.O.3    PALASCIANO, G.4
  • 90
    • 2542546652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss
    • DIXON JB, BHATHAL PS, HUGHES NR, O'BRIEN PE: Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology (2004) 39:1647-1654.
    • (2004) Hepatology , vol.39 , pp. 1647-1654
    • DIXON, J.B.1    BHATHAL, P.S.2    HUGHES, N.R.3    O'BRIEN, P.E.4
  • 91
    • 5044234968 scopus 로고    scopus 로고
    • Dietary composition and non-alcoholic fatty liver disease
    • SOLGA S, ALKHURAISHE AR, CLARK JM et al.: Dietary composition and non-alcoholic fatty liver disease. Dig Dis. Sci. (2004) 49:1578-1583.
    • (2004) Dig Dis. Sci , vol.49 , pp. 1578-1583
    • SOLGA, S.1    ALKHURAISHE, A.R.2    CLARK, J.M.3
  • 92
    • 0034935888 scopus 로고    scopus 로고
    • Effect of a moderately energy-restricted diet on obese patients with fatty liver
    • OKITA M, HAYASHI M, SASAGAWA T et al.: Effect of a moderately energy-restricted diet on obese patients with fatty liver. Nutrition (2001) 17:542-547.
    • (2001) Nutrition , vol.17 , pp. 542-547
    • OKITA, M.1    HAYASHI, M.2    SASAGAWA, T.3
  • 93
    • 0034746967 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: Clinical significance and pathogenesis
    • DE KNEGT RJ: Non-alcoholic steatohepatitis: clinical significance and pathogenesis. Scand. J. Gastroenterol. Suppl. (2001):88-92.
    • (2001) Scand. J. Gastroenterol. Suppl , pp. 88-92
    • DE KNEGT, R.J.1
  • 94
    • 0025959287 scopus 로고
    • Hepatic effects of dietary weight loss in morbidly obese subjects
    • ANDERSEN T, GLUUD C, FRANZMANN MB, CHRISTOFFERSEN P: Hepatic effects of dietary weight loss in morbidly obese subjects. J. Hepatol. (1991) 12:224-229.
    • (1991) J. Hepatol , vol.12 , pp. 224-229
    • ANDERSEN, T.1    GLUUD, C.2    FRANZMANN, M.B.3    CHRISTOFFERSEN, P.4
  • 95
    • 0032801516 scopus 로고    scopus 로고
    • Preparation of extremely obese patients for laparoscopic gastric banding by gastric-balloon therapy
    • WEINER R, GUTBERLET H, BOCKHORN H: Preparation of extremely obese patients for laparoscopic gastric banding by gastric-balloon therapy. Obes. Surg. (1999) 9:261-264.
    • (1999) Obes. Surg , vol.9 , pp. 261-264
    • WEINER, R.1    GUTBERLET, H.2    BOCKHORN, H.3
  • 96
    • 33646339636 scopus 로고    scopus 로고
    • Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease
    • KLEIN S, MITTENDORFER B, EAGON JC et al.: Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology (2006) 130:1564-1572.
    • (2006) Gastroenterology , vol.130 , pp. 1564-1572
    • KLEIN, S.1    MITTENDORFER, B.2    EAGON, J.C.3
  • 97
    • 2442502479 scopus 로고    scopus 로고
    • The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: One-year follow-up of a randomized trial
    • STERN L, IQBAL N, SESHADRI P et al.: The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann. Intern. Med. (2004) 140:778-785.
    • (2004) Ann. Intern. Med , vol.140 , pp. 778-785
    • STERN, L.1    IQBAL, N.2    SESHADRI, P.3
  • 98
    • 0032852016 scopus 로고    scopus 로고
    • Sibutramine: A serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity
    • LUQUE CA, REY JA: Sibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity. Ann. Pharmacother. (1999) 33:968-978.
    • (1999) Ann. Pharmacother , vol.33 , pp. 968-978
    • LUQUE, C.A.1    REY, J.A.2
  • 100
    • 15944367788 scopus 로고    scopus 로고
    • Meta-analysis: Pharmacologic treatment of obesity
    • LI Z, MAGLIONE M, TU W et al.: Meta-analysis: pharmacologic treatment of obesity Ann. Intern. Med. (2005) 142:532-546.
    • (2005) Ann. Intern. Med , vol.142 , pp. 532-546
    • LI, Z.1    MAGLIONE, M.2    TU, W.3
  • 101
    • 0141651621 scopus 로고    scopus 로고
    • Sibutramine enhances insulin sensitivity ameliorating metabolic parameters in a double-blind, randomized, placebo-controlled trial
    • TAMBASCIA MA, GELONEZE B, REPETTO EM, GELONEZE SR, PICOLO M, MAGRO DO: Sibutramine enhances insulin sensitivity ameliorating metabolic parameters in a double-blind, randomized, placebo-controlled trial. Diabetes Obes. Metab. (2003) 5:338-344.
    • (2003) Diabetes Obes. Metab , vol.5 , pp. 338-344
    • TAMBASCIA, M.A.1    GELONEZE, B.2    REPETTO, E.M.3    GELONEZE, S.R.4    PICOLO, M.5    MAGRO, D.O.6
  • 102
    • 1842479689 scopus 로고    scopus 로고
    • Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines
    • VALSAMAKIS G, MCTERNAN PG, CHETTY R et al.: Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines. Metabolism (2004) 53:430-434.
    • (2004) Metabolism , vol.53 , pp. 430-434
    • VALSAMAKIS, G.1    MCTERNAN, P.G.2    CHETTY, R.3
  • 103
    • 0141515773 scopus 로고    scopus 로고
    • The effects of sibutramine and orlistat on the ultrasonographic findings, insulin resistance and liver enzyme levels in obese patients with non-alcoholic steatohepatitis
    • SABUNCU T, NAZLIGUL Y, KARAOGLANOGLU M, UCAR E, KILIC FB: The effects of sibutramine and orlistat on the ultrasonographic findings, insulin resistance and liver enzyme levels in obese patients with non-alcoholic steatohepatitis. Rom. J. Gastroenterol. (2003) 12:189-192.
    • (2003) Rom. J. Gastroenterol , vol.12 , pp. 189-192
    • SABUNCU, T.1    NAZLIGUL, Y.2    KARAOGLANOGLU, M.3    UCAR, E.4    KILIC, F.B.5
  • 104
    • 1042303480 scopus 로고    scopus 로고
    • Xenical in the prevention of diabetes in obese subjects (XENDOS) study: A randomized study of orlistat as an adjunct to lifestyle changes for the prevention of Type 2 diabetes in obese patients
    • TORGERSON JS, HAUPTMAN J, BOLDRIN MN, SJOSTROM L: Xenical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of Type 2 diabetes in obese patients. Diabetes Care (2004) 27:155-161.
    • (2004) Diabetes Care , vol.27 , pp. 155-161
    • TORGERSON, J.S.1    HAUPTMAN, J.2    BOLDRIN, M.N.3    SJOSTROM, L.4
  • 106
    • 4344593276 scopus 로고    scopus 로고
    • Efficacy of ω-3 fatty acids, atorvastatin and orlistat in non-alcoholic fatty liver disease with dyslipidemia
    • HATZITOLIOS A, SAVOPOULOS C, LAZARAKI G et al.: Efficacy of ω-3 fatty acids, atorvastatin and orlistat in non-alcoholic fatty liver disease with dyslipidemia. Indian J. Gastroenterol. (2004) 23:131-134.
    • (2004) Indian J. Gastroenterol , vol.23 , pp. 131-134
    • HATZITOLIOS, A.1    SAVOPOULOS, C.2    LAZARAKI, G.3
  • 107
    • 0028129936 scopus 로고
    • SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
    • RINALDI-CARMONA M, BARTH F, HEAULME M et al.: SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett. (1994) 350:240-244.
    • (1994) FEBS Lett , vol.350 , pp. 240-244
    • RINALDI-CARMONA, M.1    BARTH, F.2    HEAULME, M.3
  • 108
    • 13244249625 scopus 로고    scopus 로고
    • Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice
    • LIU YL, CONNOLEY IP, WILSON CA, STOCK MJ: Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice. Int. J. Obes. (Lond.) (2005) 29:183-187.
    • (2005) Int. J. Obes. (Lond.) , vol.29 , pp. 183-187
    • LIU, Y.L.1    CONNOLEY, I.P.2    WILSON, C.A.3    STOCK, M.J.4
  • 109
    • 0037374766 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells
    • BENSAID M, GARY-BOBO M, ESCLANGON A et al.: The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Mol. Pharmacol. (2003) 63:908-914.
    • (2003) Mol. Pharmacol , vol.63 , pp. 908-914
    • BENSAID, M.1    GARY-BOBO, M.2    ESCLANGON, A.3
  • 110
    • 15444362306 scopus 로고    scopus 로고
    • Rimonabant - a selective CB1 antagonist
    • BOYD ST, FREMMING BA: Rimonabant - a selective CB1 antagonist. Ann. Pharmacother. (2005) 39:684-690.
    • (2005) Ann. Pharmacother , vol.39 , pp. 684-690
    • BOYD, S.T.1    FREMMING, B.A.2
  • 111
    • 27844463517 scopus 로고    scopus 로고
    • Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    • DESPRES JP, GOLAY A, SJOSTROM L: Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N. Engl. J. Med. (2005) 353:2121-2134.
    • (2005) N. Engl. J. Med , vol.353 , pp. 2121-2134
    • DESPRES, J.P.1    GOLAY, A.2    SJOSTROM, L.3
  • 112
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
    • VAN GAAL LF, RISSANEN AM, SCHEEN AJ, ZIEGLER O, ROSSNER S: Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet (2005) 365:1389-1397.
    • (2005) Lancet , vol.365 , pp. 1389-1397
    • VAN GAAL, L.F.1    RISSANEN, A.M.2    SCHEEN, A.J.3    ZIEGLER, O.4    ROSSNER, S.5
  • 114
    • 0029587469 scopus 로고
    • Molecular genetic aspects of human mitochondrial disorders
    • LARSSON NG, CLAYTON DA: Molecular genetic aspects of human mitochondrial disorders. Annu. Rev. Genet. (1995) 29:151-178.
    • (1995) Annu. Rev. Genet , vol.29 , pp. 151-178
    • LARSSON, N.G.1    CLAYTON, D.A.2
  • 116
    • 0024382876 scopus 로고
    • Myoclonic epilepsy and ragged-red fibers with cytochrome oxidase deficiency: Neuropathology biochemistry, and molecular genetics
    • LOMBES A, MENDELL JR, NAKASE H et al.: Myoclonic epilepsy and ragged-red fibers with cytochrome oxidase deficiency: neuropathology biochemistry, and molecular genetics. Ann. Neurol. (1989) 26:20-33.
    • (1989) Ann. Neurol , vol.26 , pp. 20-33
    • LOMBES, A.1    MENDELL, J.R.2    NAKASE, H.3
  • 117
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    • BUGIANESI E, GENTILCORE E, MANINI R et al.: A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am. J. Gastroenterol. (2005) 100:1082-1090.
    • (2005) Am. J. Gastroenterol , vol.100 , pp. 1082-1090
    • BUGIANESI, E.1    GENTILCORE, E.2    MANINI, R.3
  • 118
    • 1642296465 scopus 로고    scopus 로고
    • Metformin in the treatment of patients with non-alcoholic steatohepatitis
    • UYGUN A, KADAYIFCI A, ISIK AT et al.: Metformin in the treatment of patients with non-alcoholic steatohepatitis. Aliment. Pharmacol. Ther. (2004) 19:537-544.
    • (2004) Aliment. Pharmacol. Ther , vol.19 , pp. 537-544
    • UYGUN, A.1    KADAYIFCI, A.2    ISIK, A.T.3
  • 119
    • 14944359845 scopus 로고    scopus 로고
    • A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis
    • SANYAL AJ, MOFRAD PS, CONTOS MJ et al.: A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis. Clin. Gastroenterol. Hepatol. (2004) 2:1107-1115.
    • (2004) Clin. Gastroenterol. Hepatol , vol.2 , pp. 1107-1115
    • SANYAL, A.J.1    MOFRAD, P.S.2    CONTOS, M.J.3
  • 120
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • BELFORT R, HARRISON SA, BROWN K et al.: A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N. Engl. J. Med. (2006) 355:2297-2307.
    • (2006) N. Engl. J. Med , vol.355 , pp. 2297-2307
    • BELFORT, R.1    HARRISON, S.A.2    BROWN, K.3
  • 124
    • 34250865768 scopus 로고    scopus 로고
    • Rosiglitazone evaluated for cardiovascular outcomes-an interim analysis
    • HOME PD, POCOCK SJ, BECK-NIELSEN H et al.: Rosiglitazone evaluated for cardiovascular outcomes-an interim analysis. N. Engl. J. Med. (2007) 357:28-38.
    • (2007) N. Engl. J. Med , vol.357 , pp. 28-38
    • HOME, P.D.1    POCOCK, S.J.2    BECK-NIELSEN, H.3
  • 125
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • NISSEN SE, WOLSKI K: Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med. (2007) 356:2457-2471.
    • (2007) N. Engl. J. Med , vol.356 , pp. 2457-2471
    • NISSEN, S.E.1    WOLSKI, K.2
  • 126
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone
    • NEUSCHWANDER-TETRI BA, BRUNT EM, WEHMEIER KR, OLIVER D, BACON BR: Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone. Hepatology (2003) 38:1008-1017.
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • NEUSCHWANDER-TETRI, B.A.1    BRUNT, E.M.2    WEHMEIER, K.R.3    OLIVER, D.4    BACON, B.R.5
  • 127
    • 1442355447 scopus 로고    scopus 로고
    • A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
    • PROMRAT K, LUTCHMAN G, UWAIFO GI et al.: A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis. Hepatology (2004) 39:188-196.
    • (2004) Hepatology , vol.39 , pp. 188-196
    • PROMRAT, K.1    LUTCHMAN, G.2    UWAIFO, G.I.3
  • 128
    • 2942655390 scopus 로고    scopus 로고
    • Evidence for a potent antiinflammatory effect of rosiglitazone
    • MOHANTY P, ALJADA A, GHANIM H et al.: Evidence for a potent antiinflammatory effect of rosiglitazone. J. Clin. Endocrinol. Metab. (2004) 89:2728-2735.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , pp. 2728-2735
    • MOHANTY, P.1    ALJADA, A.2    GHANIM, H.3
  • 129
    • 0026448725 scopus 로고
    • The discovery and development of HMG-CoA reductase inhibitors
    • ENDO A: The discovery and development of HMG-CoA reductase inhibitors. J. Lipid Res. (1992) 33:1569-1582.
    • (1992) J. Lipid Res , vol.33 , pp. 1569-1582
    • ENDO, A.1
  • 130
    • 0347917155 scopus 로고    scopus 로고
    • Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis
    • KIYICI M, GULTEN M, GUREL S et al.: Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis. Can. J. Gastroenterol. (2003) 17:713-718.
    • (2003) Can. J. Gastroenterol , vol.17 , pp. 713-718
    • KIYICI, M.1    GULTEN, M.2    GUREL, S.3
  • 131
    • 34047271926 scopus 로고    scopus 로고
    • Therapeutic options in non-alcoholic steatohepatitis (NASH). Are all Agents Alike? results of a preliminary study
    • GEORGESCU EF, GEORGESCU M: Therapeutic options in non-alcoholic steatohepatitis (NASH). Are all Agents Alike? results of a preliminary study. J. Gastrointestin. Liver Dis. (2007) 16:39-46.
    • (2007) J. Gastrointestin. Liver Dis , vol.16 , pp. 39-46
    • GEORGESCU, E.F.1    GEORGESCU, M.2
  • 132
    • 2342456307 scopus 로고    scopus 로고
    • Pravastatin in patients with nonalcoholic steatohepatitis: Results of a pilot study
    • RALLIDIS LS, DRAKOULIS CK, PARASI AS: Pravastatin in patients with nonalcoholic steatohepatitis: results of a pilot study. Atherosclerosis (2004) 174: 193-196.
    • (2004) Atherosclerosis , vol.174 , pp. 193-196
    • RALLIDIS, L.S.1    DRAKOULIS, C.K.2    PARASI, A.S.3
  • 133
    • 16244384606 scopus 로고    scopus 로고
    • Statins and hepatotoxicity: Focus on patients with fatty liver
    • CHALASANI N: Statins and hepatotoxicity: focus on patients with fatty liver. Hepatology (2005) 41:690-695.
    • (2005) Hepatology , vol.41 , pp. 690-695
    • CHALASANI, N.1
  • 134
    • 84933047295 scopus 로고    scopus 로고
    • Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: A pilot study
    • LAURIN J, LINDOR KD, CRIPPIN JS et al.: Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study. Hepatology (1996) 23:1464-1467.
    • (1996) Hepatology , vol.23 , pp. 1464-1467
    • LAURIN, J.1    LINDOR, K.D.2    CRIPPIN, J.S.3
  • 135
    • 0032776856 scopus 로고    scopus 로고
    • A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis
    • BASARANOGLU M, ACBAY O, SONSUZ A: A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis. J. Hepatol. (1999) 31:384.
    • (1999) J. Hepatol , vol.31 , pp. 384
    • BASARANOGLU, M.1    ACBAY, O.2    SONSUZ, A.3
  • 136
    • 0033594768 scopus 로고    scopus 로고
    • Bezafibrate for tamoxifen-induced non-alcoholic steatohepatitis
    • SAIBARA T, ONISHI S, OGAWA Y, YOSHIDA S, ENZAN H: Bezafibrate for tamoxifen-induced non-alcoholic steatohepatitis. Lancet (1999) 353:1802.
    • (1999) Lancet , vol.353 , pp. 1802
    • SAIBARA, T.1    ONISHI, S.2    OGAWA, Y.3    YOSHIDA, S.4    ENZAN, H.5
  • 137
    • 0035984958 scopus 로고    scopus 로고
    • Prevention/reversal of choline deficiency-induced steatohepatitis by a peroxisome proliferator-activated receptor α ligand in rats
    • RAO MS, PAPREDDY K, MUSUNURI S, OKONKWO A: Prevention/reversal of choline deficiency-induced steatohepatitis by a peroxisome proliferator-activated receptor α ligand in rats. In vivo (2002) 16:145-152.
    • (2002) In vivo , vol.16 , pp. 145-152
    • RAO, M.S.1    PAPREDDY, K.2    MUSUNURI, S.3    OKONKWO, A.4
  • 138
    • 33645891166 scopus 로고    scopus 로고
    • Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARδ agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet
    • NAGASAWA T, INADA Y, NAKANO S et al.: Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARδ agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet. Eur. J. Pharmacol. (2006) 536:182-191.
    • (2006) Eur. J. Pharmacol , vol.536 , pp. 182-191
    • NAGASAWA, T.1    INADA, Y.2    NAKANO, S.3
  • 139
    • 20244370723 scopus 로고    scopus 로고
    • Systemic markers of lipid peroxidation and antioxidants in patients with nonalcoholic fatty liver disease
    • YESILOVA Z, YAMAN H, OKTENLI C et al.: Systemic markers of lipid peroxidation and antioxidants in patients with nonalcoholic fatty liver disease. Am. J. Gastroenterol. (2005) 100:850-855.
    • (2005) Am. J. Gastroenterol , vol.100 , pp. 850-855
    • YESILOVA, Z.1    YAMAN, H.2    OKTENLI, C.3
  • 140
    • 0033851609 scopus 로고    scopus 로고
    • Starvation impairs antioxidant defense in fatty livers of rats fed a choline-deficient diet
    • GRATTAGLIANO I, VENDEMIALE G, CARACENI P et al.: Starvation impairs antioxidant defense in fatty livers of rats fed a choline-deficient diet. J. Nutr. (2000) 130:2131-2136.
    • (2000) J. Nutr , vol.130 , pp. 2131-2136
    • GRATTAGLIANO, I.1    VENDEMIALE, G.2    CARACENI, P.3
  • 141
    • 0034799895 scopus 로고    scopus 로고
    • Plasma transforming growth factor-β1 level and efficacy of α-tocopherol in patients with non-alcoholic steatohepatitis: A pilot study
    • HASEGAWA T, YONEDA M, NAKAMURA K, MAKINO I, TERANO A: Plasma transforming growth factor-β1 level and efficacy of α-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study. Aliment Pharmacol. Ther. (2001) 15:1667-1672.
    • (2001) Aliment Pharmacol. Ther , vol.15 , pp. 1667-1672
    • HASEGAWA, T.1    YONEDA, M.2    NAKAMURA, K.3    MAKINO, I.4    TERANO, A.5
  • 142
    • 0034126755 scopus 로고    scopus 로고
    • Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study
    • LAVINE JE: Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study. J. Pediatr. (2000) 136:734-738.
    • (2000) J. Pediatr , vol.136 , pp. 734-738
    • LAVINE, J.E.1
  • 143
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis
    • HARRISON SA, TORGERSON S, HAYASHI P, WARD J, SCHENKER S: Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am. J. Gastroenterol. (2003) 98:2485-2490.
    • (2003) Am. J. Gastroenterol , vol.98 , pp. 2485-2490
    • HARRISON, S.A.1    TORGERSON, S.2    HAYASHI, P.3    WARD, J.4    SCHENKER, S.5
  • 144
    • 22244466105 scopus 로고    scopus 로고
    • An editorial update: Annus horribilis for vitamin E
    • GUALLAR E, HANLEY DF, MILLER ER III: An editorial update: annus horribilis for vitamin E. Ann. Intern. Med. (2005) 143:143-145.
    • (2005) Ann. Intern. Med , vol.143 , pp. 143-145
    • GUALLAR, E.1    HANLEY, D.F.2    MILLER III, E.R.3
  • 145
    • 0242487635 scopus 로고    scopus 로고
    • N-acetylcysteine in the treatment of non-alcoholic steatohepatitis
    • PAMUK GE, SONSUZ A: N-acetylcysteine in the treatment of non-alcoholic steatohepatitis. J. Gastroenterol. Hepatol. (2003) 18: 1220-1221.
    • (2003) J. Gastroenterol. Hepatol , vol.18 , pp. 1220-1221
    • PAMUK, G.E.1    SONSUZ, A.2
  • 146
    • 6844254540 scopus 로고    scopus 로고
    • Augmentation of mitochondrial reduced glutathione by S-adenosyl-L-methionine administration in ischemia-reperfusion injury of the rat steatotic liver induced by choline-methionine-deficient diet
    • KANESHIRO Y, NAKANO H, KUMADA K et al.: Augmentation of mitochondrial reduced glutathione by S-adenosyl-L-methionine administration in ischemia-reperfusion injury of the rat steatotic liver induced by choline-methionine-deficient diet. Eur. Surg. Res. (1998) 30:34-42.
    • (1998) Eur. Surg. Res , vol.30 , pp. 34-42
    • KANESHIRO, Y.1    NAKANO, H.2    KUMADA, K.3
  • 147
    • 0027497354 scopus 로고
    • Review article: S-adenosyl-L-methionine - a new therapeutic agent in liver disease?
    • OSMAN E, OWEN JS, BURROUGHS AK: Review article: S-adenosyl-L-methionine - a new therapeutic agent in liver disease? Aliment. Pharmacol. Ther. (1993) 7:21-28.
    • (1993) Aliment. Pharmacol. Ther , vol.7 , pp. 21-28
    • OSMAN, E.1    OWEN, J.S.2    BURROUGHS, A.K.3
  • 148
    • 0033884107 scopus 로고    scopus 로고
    • Efficacy and safety of oral betaine glucuronate in non-alcoholic steatohepatitis. A double-blind, randomized, parallel-group, placebo-controlled prospective clinical study
    • MIGLIO F, ROVATI LC, SANTORO A, SETNIKAR I: Efficacy and safety of oral betaine glucuronate in non-alcoholic steatohepatitis. A double-blind, randomized, parallel-group, placebo-controlled prospective clinical study. Arzneimittelforschung (2000) 50:722-727.
    • (2000) Arzneimittelforschung , vol.50 , pp. 722-727
    • MIGLIO, F.1    ROVATI, L.C.2    SANTORO, A.3    SETNIKAR, I.4
  • 149
    • 0034834208 scopus 로고    scopus 로고
    • Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: Results of a pilot study
    • ABDELMALEK MF, ANGULO P, JORGENSEN RA, SYLVESTRE PB, LINDOR KD: Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am. J. Gastroenterol. (2001) 96:2711-2717.
    • (2001) Am. J. Gastroenterol , vol.96 , pp. 2711-2717
    • ABDELMALEK, M.F.1    ANGULO, P.2    JORGENSEN, R.A.3    SYLVESTRE, P.B.4    LINDOR, K.D.5
  • 150
    • 33644875895 scopus 로고    scopus 로고
    • Hepatoprotective and antifibrotic effect of a new silybin-phosphatidylcholine-Vitamin E complex in rats
    • DI SARIO A, BENDIA E, TAFFETANI S et al.: Hepatoprotective and antifibrotic effect of a new silybin-phosphatidylcholine-Vitamin E complex in rats. Dig. Liver Dis. (2005) 37:869-876.
    • (2005) Dig. Liver Dis , vol.37 , pp. 869-876
    • DI SARIO, A.1    BENDIA, E.2    TAFFETANI, S.3
  • 151
    • 33646770979 scopus 로고    scopus 로고
    • A new silybin-vitamin E-phospholipid complex improves insulin resistance and liver damage in patients with non-alcoholic fatty liver disease: Preliminary observations
    • FEDERICO A, TRAPPOLIERE M, TUCCILLO C et al.: A new silybin-vitamin E-phospholipid complex improves insulin resistance and liver damage in patients with non-alcoholic fatty liver disease: preliminary observations. Gut (2006) 55:901-902.
    • (2006) Gut , vol.55 , pp. 901-902
    • FEDERICO, A.1    TRAPPOLIERE, M.2    TUCCILLO, C.3
  • 152
    • 34547839674 scopus 로고    scopus 로고
    • The effect of a silybin-vitamin E-phospholipid complex on nonalcoholic fatty liver disease: A Pilot study
    • LOGUERCIO C, FEDERICO A, TRAPPOLIERE M et al.: The effect of a silybin-vitamin E-phospholipid complex on nonalcoholic fatty liver disease: a Pilot study. Dig. Dis. Sci. (2007).
    • (2007) Dig. Dis. Sci
    • LOGUERCIO, C.1    FEDERICO, A.2    TRAPPOLIERE, M.3
  • 153
    • 0027944823 scopus 로고
    • Pentoxifylline in vivo down-regulates the release of IL-1 β, IL-6, IL-8 and tumour necrosis factor-α by human peripheral blood mononuclear cells
    • NEUNER P, KLOSNER G, SCHAUER E et al.: Pentoxifylline in vivo down-regulates the release of IL-1 β, IL-6, IL-8 and tumour necrosis factor-α by human peripheral blood mononuclear cells. Immunology (1994) 83:262-267.
    • (1994) Immunology , vol.83 , pp. 262-267
    • NEUNER, P.1    KLOSNER, G.2    SCHAUER, E.3
  • 154
    • 0035125052 scopus 로고    scopus 로고
    • The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor a in the pathogenesis of non-alcoholic steatohepatitis
    • WIGG AJ, ROBERTS-THOMSON IC, DYMOCK RB, MCCARTHY PJ, GROSE RH, CUMMINS AG: The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor a in the pathogenesis of non-alcoholic steatohepatitis. Gut (2001) 48:206-211.
    • (2001) Gut , vol.48 , pp. 206-211
    • WIGG, A.J.1    ROBERTS-THOMSON, I.C.2    DYMOCK, R.B.3    MCCARTHY, P.J.4    GROSE, R.H.5    CUMMINS, A.G.6
  • 155
    • 11144249271 scopus 로고    scopus 로고
    • A pilot trial of pentoxifylline in nonalcoholic steatohepatitis
    • ADAMS LA, ZEIN CO, ANGULO P, LINDOR KD: A pilot trial of pentoxifylline in nonalcoholic steatohepatitis. Am. J. Gastroenterol. (2004) 99:2365-2368.
    • (2004) Am. J. Gastroenterol , vol.99 , pp. 2365-2368
    • ADAMS, L.A.1    ZEIN, C.O.2    ANGULO, P.3    LINDOR, K.D.4
  • 156
    • 0344826103 scopus 로고    scopus 로고
    • Systematic review: Ursodeoxycholic acid - adverse effects and drug interactions
    • HEMPFLING W, DILGER K, BEUERS U: Systematic review: ursodeoxycholic acid - adverse effects and drug interactions. Aliment. Pharmacol. Ther. (2003) 18:963-972.
    • (2003) Aliment. Pharmacol. Ther , vol.18 , pp. 963-972
    • HEMPFLING, W.1    DILGER, K.2    BEUERS, U.3
  • 157
    • 11844300314 scopus 로고    scopus 로고
    • Primary sclerosing cholangitis: Updates in diagnosis and therapy
    • PORTINCASA P, VACCA M, MOSCHETTA A et al.: Primary sclerosing cholangitis: updates in diagnosis and therapy. World J. Gastroenterol. (2005) 11:7-16.
    • (2005) World J. Gastroenterol , vol.11 , pp. 7-16
    • PORTINCASA, P.1    VACCA, M.2    MOSCHETTA, A.3
  • 160
    • 0042768056 scopus 로고    scopus 로고
    • Pathways of cholesterol crystallization in model bile and native bile
    • PORTINCASA P, MOSCHETTA A, VAN ERPECUM KJ et al.: Pathways of cholesterol crystallization in model bile and native bile. Dig. Liver Dis. (2003) 35:118-126.
    • (2003) Dig. Liver Dis , vol.35 , pp. 118-126
    • PORTINCASA, P.1    MOSCHETTA, A.2    VAN ERPECUM, K.J.3
  • 161
    • 0036844111 scopus 로고    scopus 로고
    • Effect of ursodeoxycholic acid on hepatic steatosis in rats
    • OKAN A, ASTARCIOGLU H, TANKURT E et al.: Effect of ursodeoxycholic acid on hepatic steatosis in rats. Dig. Dis. Sci. (2002) 47:2389-2397.
    • (2002) Dig. Dis. Sci , vol.47 , pp. 2389-2397
    • OKAN, A.1    ASTARCIOGLU, H.2    TANKURT, E.3
  • 162
    • 0038446882 scopus 로고    scopus 로고
    • A randomized double-blind study of the short-time treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic acid
    • SANTOS VN, LANZONI VP, SZEJNFELD J, SHIGUEOKA D, PARISE ER: A randomized double-blind study of the short-time treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic acid. Braz. J. Med. Biol. Res. (2003) 36:723-729.
    • (2003) Braz. J. Med. Biol. Res , vol.36 , pp. 723-729
    • SANTOS, V.N.1    LANZONI, V.P.2    SZEJNFELD, J.3    SHIGUEOKA, D.4    PARISE, E.R.5
  • 163
    • 21644475309 scopus 로고    scopus 로고
    • Weight reduction and ursodeoxycholic acid in subjects with nonalcoholic fatty liver disease. A double-blind, placebo-controlled trial
    • MENDEZ-SANCHEZ N, GONZALEZ V, CHAVEZ-TAPIA N, RAMOS MH, URIBE M: Weight reduction and ursodeoxycholic acid in subjects with nonalcoholic fatty liver disease. A double-blind, placebo-controlled trial. Ann. Hepatol. (2004) 3:108-112.
    • (2004) Ann. Hepatol , vol.3 , pp. 108-112
    • MENDEZ-SANCHEZ, N.1    GONZALEZ, V.2    CHAVEZ-TAPIA, N.3    RAMOS, M.H.4    URIBE, M.5
  • 164
    • 1542515099 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial
    • LINDOR KD, KOWDLEY KV, HEATHCOTE EJ et al.: Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial. Hepatology (2004) 39:770-778.
    • (2004) Hepatology , vol.39 , pp. 770-778
    • LINDOR, K.D.1    KOWDLEY, K.V.2    HEATHCOTE, E.J.3
  • 165
    • 33845326443 scopus 로고    scopus 로고
    • Management of fatty liver disease with vitamin E and C compared to ursodeoxycholic acid treatment
    • ERSOZ G, GUNSAR F, KARASU Z, AKAY S, BATUR Y, AKARCA US: Management of fatty liver disease with vitamin E and C compared to ursodeoxycholic acid treatment. Turk. J. Gastroenterol. (2005) 16:124-128.
    • (2005) Turk. J. Gastroenterol , vol.16 , pp. 124-128
    • ERSOZ, G.1    GUNSAR, F.2    KARASU, Z.3    AKAY, S.4    BATUR, Y.5    AKARCA, U.S.6
  • 166
    • 33845336554 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin e in nonalcoholic steatohepatitis
    • DUFOUR JF, ONETA CM, GONVERS JJ et al.: Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin e in nonalcoholic steatohepatitis. Clin. Gastroenterol. Hepatol. (2006) 4:1537-1543.
    • (2006) Clin. Gastroenterol. Hepatol , vol.4 , pp. 1537-1543
    • DUFOUR, J.F.1    ONETA, C.M.2    GONVERS, J.J.3
  • 167
    • 26944449731 scopus 로고    scopus 로고
    • Metabolic effect of telmisartan and losartan in hypertensive patients with metabolic syndrome
    • VITALE C, MERCURO G, CASTIGLIONI C et al.: Metabolic effect of telmisartan and losartan in hypertensive patients with metabolic syndrome. Cardiovasc. Diabetol. (2005) 4:6.
    • (2005) Cardiovasc. Diabetol , vol.4 , pp. 6
    • VITALE, C.1    MERCURO, G.2    CASTIGLIONI, C.3
  • 168
    • 0347986777 scopus 로고    scopus 로고
    • NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis
    • BATALLER R, SCHWABE RF, CHOI YH et al.: NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J. Clin. Invest. (2003) 112:1383-1394.
    • (2003) J. Clin. Invest , vol.112 , pp. 1383-1394
    • BATALLER, R.1    SCHWABE, R.F.2    CHOI, Y.H.3
  • 169
    • 0034802566 scopus 로고    scopus 로고
    • Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats
    • YOSHIJI H, KURIYAMA S, YOSHII J et al.: Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats. Hepatology (2001) 34:745-750.
    • (2001) Hepatology , vol.34 , pp. 745-750
    • YOSHIJI, H.1    KURIYAMA, S.2    YOSHII, J.3
  • 170
    • 0036827163 scopus 로고    scopus 로고
    • Effect of losartan, an angiotensin II antagonist, on secondary biliary cirrhosis
    • RAMALHO LN, RAMALHO FS, ZUCOLOTO S et al.: Effect of losartan, an angiotensin II antagonist, on secondary biliary cirrhosis. Hepatogastroenterology (2002) 49:1499-1502.
    • (2002) Hepatogastroenterology , vol.49 , pp. 1499-1502
    • RAMALHO, L.N.1    RAMALHO, F.S.2    ZUCOLOTO, S.3
  • 171
    • 0035991447 scopus 로고    scopus 로고
    • Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats
    • YOSHIJI H, YOSHII J, IKENAKA Y et al.: Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. J. Hepatol. (2002) 37:22-30.
    • (2002) J. Hepatol , vol.37 , pp. 22-30
    • YOSHIJI, H.1    YOSHII, J.2    IKENAKA, Y.3
  • 172
    • 18744383954 scopus 로고    scopus 로고
    • Treating the metabolic syndrome: Telmisartan as a peroxisome proliferator-activated receptor-γ activator
    • KURTZ TW: Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-γ activator. Acta Diabetol. (2005) 42(Suppl. 1):S9-S16.
    • (2005) Acta Diabetol , vol.42 , Issue.SUPPL. 1
    • KURTZ, T.W.1
  • 173
    • 7044222556 scopus 로고    scopus 로고
    • Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis
    • YOKOHAMA S, YONEDA M, HANEDA M et al.: Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. Hepatology (2004) 40:1222-1225.
    • (2004) Hepatology , vol.40 , pp. 1222-1225
    • YOKOHAMA, S.1    YONEDA, M.2    HANEDA, M.3
  • 174
  • 175
    • 0034320252 scopus 로고    scopus 로고
    • Increased gastrointestinal ethanol production in obese mice: Implications for fatty liver disease pathogenesis
    • COPE K, RISBY T, DIEHL AM: Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis. Gastroenterology (2000) 119:1340-1347.
    • (2000) Gastroenterology , vol.119 , pp. 1340-1347
    • COPE, K.1    RISBY, T.2    DIEHL, A.M.3
  • 176
    • 0035045382 scopus 로고    scopus 로고
    • Obesity and female gender increase breath ethanol concentration: Potential implications for the pathogenesis of nonalcoholic steatohepatitis
    • NAIR S, COPE K, RISBY TH, DIEHL AM: Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis. Am. J. Gastroenterol. (2001) 96:1200-1204.
    • (2001) Am. J. Gastroenterol , vol.96 , pp. 1200-1204
    • NAIR, S.1    COPE, K.2    RISBY, T.H.3    DIEHL, A.M.4
  • 177
    • 0037879075 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: Lumen-liver interactions and possible role for probiotics
    • SOLGA SF, DIEHL AM: Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics. J. Hepatol. (2003) 38:681-687.
    • (2003) J. Hepatol , vol.38 , pp. 681-687
    • SOLGA, S.F.1    DIEHL, A.M.2
  • 178
    • 0036677340 scopus 로고    scopus 로고
    • Gut-liver axis: A new point of attack to treat chronic liver damage?
    • LOGUERCIO C, DE SIMONE T, FEDERICO A et al.: Gut-liver axis: a new point of attack to treat chronic liver damage? Am. J. Gastroenterol. (2002) 97:2144-2146.
    • (2002) Am. J. Gastroenterol , vol.97 , pp. 2144-2146
    • LOGUERCIO, C.1    DE SIMONE, T.2    FEDERICO, A.3
  • 179
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • LI Z, YANG S, LIN H et al.: Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology (2003) 37:343-350.
    • (2003) Hepatology , vol.37 , pp. 343-350
    • LI, Z.1    YANG, S.2    LIN, H.3
  • 180
    • 20844440555 scopus 로고    scopus 로고
    • Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases
    • LOGUERCIO C, FEDERICO A, TUCCILLO C et al.: Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases. J. Clin. Gastroenterol. (2005) 39:540-543.
    • (2005) J. Clin. Gastroenterol , vol.39 , pp. 540-543
    • LOGUERCIO, C.1    FEDERICO, A.2    TUCCILLO, C.3
  • 181
    • 20844434973 scopus 로고    scopus 로고
    • Increased orocecal transit time in patients with nonalcoholic fatty liver disease
    • SOZA A, RIQUELME A, GONZALEZ R et al.: Increased orocecal transit time in patients with nonalcoholic fatty liver disease. Dig. Dis. Sci. (2005) 50:1136-1140.
    • (2005) Dig. Dis. Sci , vol.50 , pp. 1136-1140
    • SOZA, A.1    RIQUELME, A.2    GONZALEZ, R.3
  • 182
    • 1542410333 scopus 로고    scopus 로고
    • Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats
    • LEVY JR, CLORE JN, STEVENS W: Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats. Hepatology (2004) 39:608-616.
    • (2004) Hepatology , vol.39 , pp. 608-616
    • LEVY, J.R.1    CLORE, J.N.2    STEVENS, W.3
  • 183
    • 18044368848 scopus 로고    scopus 로고
    • Supplementation with α-linolenic acid-rich diacylglycerol suppresses fatty liver formation accompanied by an up-regulation of β-oxidation in Zucker fatty rats
    • MURASE T, AOKI M, TOKIMITSU I: Supplementation with α-linolenic acid-rich diacylglycerol suppresses fatty liver formation accompanied by an up-regulation of β-oxidation in Zucker fatty rats. Biochim. Biophys. Acta (2005) 1733:224-231.
    • (2005) Biochim. Biophys. Acta , vol.1733 , pp. 224-231
    • MURASE, T.1    AOKI, M.2    TOKIMITSU, I.3
  • 184
    • 14944342635 scopus 로고    scopus 로고
    • ω-3 fatty acids improve hepatic steatosis in a murine model: Potential implications for the marginal steatotic liver donor
    • ALWAYN IP, ANDERSSON C, ZAUSCHER B, GURA K, NOSE V, PUDER M: ω-3 fatty acids improve hepatic steatosis in a murine model: potential implications for the marginal steatotic liver donor. Transplantation (2005) 79:606-608.
    • (2005) Transplantation , vol.79 , pp. 606-608
    • ALWAYN, I.P.1    ANDERSSON, C.2    ZAUSCHER, B.3    GURA, K.4    NOSE, V.5    PUDER, M.6
  • 185
    • 20044376106 scopus 로고    scopus 로고
    • ω-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease
    • ALWAYN IP, GURA K, NOSE V et al.: ω-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease. Pediatr. Res. (2005) 57:445-452.
    • (2005) Pediatr. Res , vol.57 , pp. 445-452
    • ALWAYN, I.P.1    GURA, K.2    NOSE, V.3
  • 187
    • 6344265885 scopus 로고    scopus 로고
    • Development of alcoholic fatty liver and fibrosis in rhesus monkeys fed a low n-3 fatty acid diet
    • PAWLOSKY RJ, SALEM N Jr: Development of alcoholic fatty liver and fibrosis in rhesus monkeys fed a low n-3 fatty acid diet. Alcohol Clin. Exp. Res. (2004) 28:1569-1576.
    • (2004) Alcohol Clin. Exp. Res , vol.28 , pp. 1569-1576
    • PAWLOSKY, R.J.1    SALEM Jr, N.2
  • 188
    • 33646882162 scopus 로고    scopus 로고
    • Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: A pilot study
    • CAPANNI M, CALELLA F, BIAGINI MR et al.: Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. Aliment. Pharmacol. Ther. (2006) 23:1143-1151.
    • (2006) Aliment. Pharmacol. Ther , vol.23 , pp. 1143-1151
    • CAPANNI, M.1    CALELLA, F.2    BIAGINI, M.R.3
  • 189
    • 0037372390 scopus 로고    scopus 로고
    • Probucol in the treatment of nonalcoholic steatohepatitis: An open-labeled study
    • MERAT S, MALEKZADEH R, SOHRABI MR et al.: Probucol in the treatment of nonalcoholic steatohepatitis: an open-labeled study. J. Clin. Gastroenterol. (2003) 36:266-268.
    • (2003) J. Clin. Gastroenterol , vol.36 , pp. 266-268
    • MERAT, S.1    MALEKZADEH, R.2    SOHRABI, M.R.3
  • 190
    • 0037383865 scopus 로고    scopus 로고
    • Probucol in the treatment of non-alcoholic steatohepatitis: A double-blind randomized controlled study
    • MERAT S, MALEKZADEH R, SOHRABI MR et al.: Probucol in the treatment of non-alcoholic steatohepatitis: a double-blind randomized controlled study. J. Hepatol. (2003) 38:414-418.
    • (2003) J. Hepatol , vol.38 , pp. 414-418
    • MERAT, S.1    MALEKZADEH, R.2    SOHRABI, M.R.3
  • 191
    • 0035052345 scopus 로고    scopus 로고
    • Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis
    • CONTOS MJ, CALES W, STERLING RK et al.: Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis. Liver Transpl. (2001) 7:363-373.
    • (2001) Liver Transpl , vol.7 , pp. 363-373
    • CONTOS, M.J.1    CALES, W.2    STERLING, R.K.3
  • 192
    • 28844459409 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: From cell biology to clinical practice
    • CORTEZ-PINTO H, DE MOURA MC, DAY CP: Non-alcoholic steatohepatitis: from cell biology to clinical practice. J. Hepatol. (2006) 44:197-208.
    • (2006) J. Hepatol , vol.44 , pp. 197-208
    • CORTEZ-PINTO, H.1    DE MOURA, M.C.2    DAY, C.P.3
  • 193
    • 0031926753 scopus 로고    scopus 로고
    • Donor liver selection. The South-Eastern organ procurement foundation liver committee
    • BROUGHAN TA, DOUZDJIAN V: Donor liver selection. The South-Eastern organ procurement foundation liver committee. Am. Surg. (1998) 64:785-790.
    • (1998) Am. Surg , vol.64 , pp. 785-790
    • BROUGHAN, T.A.1    DOUZDJIAN, V.2
  • 194
    • 34948823513 scopus 로고    scopus 로고
    • FRIEDMAN SL: Emerging therapies for hepatic fibrosis. UpToDate (2007) v.15.2:1-5.
    • FRIEDMAN SL: Emerging therapies for hepatic fibrosis. UpToDate (2007) v.15.2:1-5.
  • 195
    • 0036191894 scopus 로고    scopus 로고
    • Dissolution of cholesterol gallstones in mice by the oral administration of a fatty acid bile acid conjugate
    • GILAT T, LEIKIN-FRENKEL A, GOLDINER I, HALPERN Z, KONIKOFF FM: Dissolution of cholesterol gallstones in mice by the oral administration of a fatty acid bile acid conjugate. Hepatology (2002) 35:597-600.
    • (2002) Hepatology , vol.35 , pp. 597-600
    • GILAT, T.1    LEIKIN-FRENKEL, A.2    GOLDINER, I.3    HALPERN, Z.4    KONIKOFF, F.M.5
  • 196
    • 0041764976 scopus 로고    scopus 로고
    • Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC)
    • GILAT T, LEIKIN-FRENKEL A, GOLDINER I et al.: Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC). Hepatology (2003) 38:436-442.
    • (2003) Hepatology , vol.38 , pp. 436-442
    • GILAT, T.1    LEIKIN-FRENKEL, A.2    GOLDINER, I.3
  • 197
    • 33745292751 scopus 로고    scopus 로고
    • Physiological roles of glycerol-transporting aquaporins: The aquaglyceroporins
    • HARA-CHIKUMA M, VERKMAN AS: Physiological roles of glycerol-transporting aquaporins: the aquaglyceroporins. Cell Mol. Life Sci. (2006) 63:1386-1392.
    • (2006) Cell Mol. Life Sci , vol.63 , pp. 1386-1392
    • HARA-CHIKUMA, M.1    VERKMAN, A.S.2
  • 199
    • 30944453514 scopus 로고    scopus 로고
    • Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray
    • CHIAPPINI F, BARRIER A, SAFFROY R et al.: Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray. Lab. Invest. (2006) 86:154-165.
    • (2006) Lab. Invest , vol.86 , pp. 154-165
    • CHIAPPINI, F.1    BARRIER, A.2    SAFFROY, R.3
  • 200
    • 0035965246 scopus 로고    scopus 로고
    • Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel
    • KISHIDA K, SHIMOMURA I, KONDO H et al.: Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel. J. Biol. Chem. (2001) 276:36251-36260.
    • (2001) J. Biol. Chem , vol.276 , pp. 36251-36260
    • KISHIDA, K.1    SHIMOMURA, I.2    KONDO, H.3
  • 201
    • 19944403543 scopus 로고    scopus 로고
    • MAEDAN, FUNAHASHI T, HIBUSE T et al.: Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue. Proc. Natl. Acad. Sci. USA (2004) 101:17801-17806.
    • MAEDAN, FUNAHASHI T, HIBUSE T et al.: Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue. Proc. Natl. Acad. Sci. USA (2004) 101:17801-17806.
  • 202
    • 18144401213 scopus 로고    scopus 로고
    • Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: Adipocyte glycerol permeability as a novel regulator of fat accumulation
    • HARA-CHIKUMA M, SOHARA E, RAI T et al.: Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation. J. Biol. Chem. (2005) 280:15493-15496.
    • (2005) J. Biol. Chem , vol.280 , pp. 15493-15496
    • HARA-CHIKUMA, M.1    SOHARA, E.2    RAI, T.3
  • 203
    • 23344437899 scopus 로고    scopus 로고
    • Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase
    • HIBUSE T, MAEDA N, FUNAHASHI T et al.: Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. Proc. Natl. Acad. Sci. USA (2005) 102:10993-10998.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 10993-10998
    • HIBUSE, T.1    MAEDA, N.2    FUNAHASHI, T.3
  • 205
    • 34548243166 scopus 로고    scopus 로고
    • Aquaporin 7 is a {β} cell protein and regulator of intra-islet glycerol content and glycerol kinase activity, {β} cell mass, and insulin production and secretion
    • MATSUMURA K, CHANG BH, FUJIMYA M et al.: Aquaporin 7 is a {β} cell protein and regulator of intra-islet glycerol content and glycerol kinase activity, {β} cell mass, and insulin production and secretion. Mol. Cell Biol. (2007).
    • (2007) Mol. Cell Biol
    • MATSUMURA, K.1    CHANG, B.H.2    FUJIMYA, M.3
  • 206
    • 0037418313 scopus 로고    scopus 로고
    • Aquaglyceroporin AQP9: Solute permeation and metabolic control of expression in liver
    • CARBREY JM, GORELICK-FELDMAN DA, KOZONO D et al.: Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. Proc. Natl. Acad. Sci. USA (2003) 100:2945-2950.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2945-2950
    • CARBREY, J.M.1    GORELICK-FELDMAN, D.A.2    KOZONO, D.3
  • 207
  • 209
    • 0035930502 scopus 로고    scopus 로고
    • Enhancement of the aquaporin adipose gene expression by a peroxisome proliferator-activated receptor ω
    • KISHIDA K, SHIMOMURA I, NISHIZAWA H et al.: Enhancement of the aquaporin adipose gene expression by a peroxisome proliferator-activated receptor ω. J. Biol. Chem. (2001) 276:48572-48579.
    • (2001) J. Biol. Chem , vol.276 , pp. 48572-48579
    • KISHIDA, K.1    SHIMOMURA, I.2    NISHIZAWA, H.3
  • 210
    • 0036787385 scopus 로고    scopus 로고
    • Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9
    • KURIYAMA H, SHIMOMURA I, KISHIDA K et al.: Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9. Diabetes (2002) 51:2915-2921.
    • (2002) Diabetes , vol.51 , pp. 2915-2921
    • KURIYAMA, H.1    SHIMOMURA, I.2    KISHIDA, K.3
  • 212
    • 0033052521 scopus 로고    scopus 로고
    • The mammalian aquaporin water channel family: A promising new drug target
    • BEITZ E, SCHULTZ JE: The mammalian aquaporin water channel family: a promising new drug target. Curr. Med. Chem. (1999) 6:457-467.
    • (1999) Curr. Med. Chem , vol.6 , pp. 457-467
    • BEITZ, E.1    SCHULTZ, J.E.2
  • 213
    • 10944255127 scopus 로고    scopus 로고
    • Molecular mechanisms and drug development in aquaporin water channel diseases: Aquaporin superfamily (superaquaporins): expansion of aquaporins restricted to multicellular organisms
    • MORISHITA Y, SAKUBE Y, SASAKI S, ISHIBASHI K: Molecular mechanisms and drug development in aquaporin water channel diseases: aquaporin superfamily (superaquaporins): expansion of aquaporins restricted to multicellular organisms. J. Pharmacol. Sci. (2004) 96:276-279.
    • (2004) J. Pharmacol. Sci , vol.96 , pp. 276-279
    • MORISHITA, Y.1    SAKUBE, Y.2    SASAKI, S.3    ISHIBASHI, K.4
  • 215
    • 24344497831 scopus 로고    scopus 로고
    • More than just water channels: Unexpected cellular roles of aquaporins
    • VERKMAN AS: More than just water channels: unexpected cellular roles of aquaporins. J. Cell Sci. (2005) 118:3225-3232.
    • (2005) J. Cell Sci , vol.118 , pp. 3225-3232
    • VERKMAN, A.S.1
  • 216
    • 0037561528 scopus 로고    scopus 로고
    • Suppression of aquaporin adipose gene expression by isoproterenol, TNF-α, and dexamethasone
    • FASSHAUER M, KLEIN J, LOSSNER U, KLIER M, KRALISCH S, PASCHKE R: Suppression of aquaporin adipose gene expression by isoproterenol, TNF-α, and dexamethasone. Horm. Metab. Res. (2003) 35:222-227.
    • (2003) Horm. Metab. Res , vol.35 , pp. 222-227
    • FASSHAUER, M.1    KLEIN, J.2    LOSSNER, U.3    KLIER, M.4    KRALISCH, S.5    PASCHKE, R.6
  • 218
    • 0037040994 scopus 로고    scopus 로고
    • Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities
    • RAZANI B, COMBS TP, WANG XB et al.: Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J. Biol. Chem. (2002) 277:8635-8647.
    • (2002) J. Biol. Chem , vol.277 , pp. 8635-8647
    • RAZANI, B.1    COMBS, T.P.2    WANG, X.B.3
  • 219
    • 33748773325 scopus 로고    scopus 로고
    • Caveolin-1 is essential for liver regeneration
    • FERNANDEZ MA, ALBOR C, INGELMO-TORRES M et al.: Caveolin-1 is essential for liver regeneration. Science (2006) 313:1628-1632.
    • (2006) Science , vol.313 , pp. 1628-1632
    • FERNANDEZ, M.A.1    ALBOR, C.2    INGELMO-TORRES, M.3
  • 221
    • 33846918919 scopus 로고    scopus 로고
    • Caveolin-1 and liver regeneration: Role in proliferation and lipogenesis
    • FRANK PG, LISANTI MP: Caveolin-1 and liver regeneration: role in proliferation and lipogenesis. Cell Cycle (2007) 6:115-116.
    • (2007) Cell Cycle , vol.6 , pp. 115-116
    • FRANK, P.G.1    LISANTI, M.P.2
  • 222
    • 26844431513 scopus 로고    scopus 로고
    • Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: The bezafibrate lessons
    • TENENBAUM A, MOTRO M, FISMAN EZ: Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons. Cardiovasc. Diabetol. (2005) 4:14.
    • (2005) Cardiovasc. Diabetol , vol.4 , pp. 14
    • TENENBAUM, A.1    MOTRO, M.2    FISMAN, E.Z.3
  • 223
    • 34248136952 scopus 로고    scopus 로고
    • A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities
    • PRUDENTE S, FLEX E, MORINI E et al.: A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities. Diabetes (2007) 56:1468-1474.
    • (2007) Diabetes , vol.56 , pp. 1468-1474
    • PRUDENTE, S.1    FLEX, E.2    MORINI, E.3
  • 224
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
    • CAI D, YUAN M, FRANTZ DF et al.: Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nat. Med. (2005) 11:183-190.
    • (2005) Nat. Med , vol.11 , pp. 183-190
    • CAI, D.1    YUAN, M.2    FRANTZ, D.F.3
  • 225
    • 22344452893 scopus 로고    scopus 로고
    • The natural histoty of nonalcoholic fatty liver disease: A population-based cohort study
    • ADAMS LA, LYMP JF, ST SAUVER J, et al.: The natural histoty of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology (2005) 129:113-121.
    • (2005) Gastroenterology , vol.129 , pp. 113-121
    • ADAMS, L.A.1    LYMP, J.F.2    ST SAUVER, J.3
  • 226
    • 4344706012 scopus 로고    scopus 로고
    • Clinical proteomics: Revolutionizing disease detection and patient tailoring therapy
    • PETRICOIN E, WULFKUHLE J, ESPINA V, LIOTTA LA: Clinical proteomics: revolutionizing disease detection and patient tailoring therapy. J. Proteome Res. (2004) 3:209-217.
    • (2004) J. Proteome Res , vol.3 , pp. 209-217
    • PETRICOIN, E.1    WULFKUHLE, J.2    ESPINA, V.3    LIOTTA, L.A.4
  • 227
    • 1942454310 scopus 로고    scopus 로고
    • Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics
    • CALLEWAERT N, VAN VH, VAN HA, LAROY W, DELANGHE J, CONTRERAS R: Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics. Nat. Med. (2004) 10:429-434.
    • (2004) Nat. Med , vol.10 , pp. 429-434
    • CALLEWAERT, N.1    VAN VH, V.H.2    LAROY, W.3    DELANGHE, J.4    CONTRERAS, R.5
  • 228
    • 33645983221 scopus 로고    scopus 로고
    • LXRS and FXR: The yin and yang of cholesterol and fat metabolism
    • KALAANY NY, MANGELSDORF DJ: LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu. Rev. Physiol. (2006) 68:159-191.
    • (2006) Annu. Rev. Physiol , vol.68 , pp. 159-191
    • KALAANY, N.Y.1    MANGELSDORF, D.J.2
  • 229
    • 33749344968 scopus 로고    scopus 로고
    • Nuclear bile acid receptor FXR as pharmacological target: Are we there yet?
    • MODICA S, MOSCHETTA A: Nuclear bile acid receptor FXR as pharmacological target: are we there yet? FEBS Lett. (2006) 580:5492-5499.
    • (2006) FEBS Lett , vol.580 , pp. 5492-5499
    • MODICA, S.1    MOSCHETTA, A.2
  • 230
    • 33747154772 scopus 로고    scopus 로고
    • Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
    • BOOKOUT AL, JEONG Y, DOWNES M, YU RT, EVANS RM, MANGELSDORF DJ: Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell (2006) 126:789-799.
    • (2006) Cell , vol.126 , pp. 789-799
    • BOOKOUT, A.L.1    JEONG, Y.2    DOWNES, M.3    YU, R.T.4    EVANS, R.M.5    MANGELSDORF, D.J.6
  • 231
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • YKI-JARVINEN H: Thiazolidinediones. N. Engl. J. Med. (2004) 351:1106-1118.
    • (2004) N. Engl. J. Med , vol.351 , pp. 1106-1118
    • YKI-JARVINEN, H.1
  • 232
    • 0141998792 scopus 로고    scopus 로고
    • Polycystic ovary syndrome: Syndrome XX?
    • SAM S, DUNAIF A: Polycystic ovary syndrome: syndrome XX? Trends Endocrinol. Metab. (2003) 14:365-370.
    • (2003) Trends Endocrinol. Metab , vol.14 , pp. 365-370
    • SAM, S.1    DUNAIF, A.2
  • 233
    • 3042702620 scopus 로고    scopus 로고
    • Cholesterol gallstones: A fellow traveler with metabolic syndrome?
    • GRUNDY SM: Cholesterol gallstones: a fellow traveler with metabolic syndrome? Am. J. Clin. Nutr. (2004) 80:1-2.
    • (2004) Am. J. Clin. Nutr , vol.80 , pp. 1-2
    • GRUNDY, S.M.1
  • 234
    • 33947400987 scopus 로고    scopus 로고
    • Effects of vitamin E treatment on peroxisome proliferator-activated receptor-α expression and insulin resistance in patients with non-alcoholic steatohepatitis: Results of a pilot study
    • YAKARYILMAZ F, GULITER S, SAVAS B et al.: Effects of vitamin E treatment on peroxisome proliferator-activated receptor-α expression and insulin resistance in patients with non-alcoholic steatohepatitis: results of a pilot study. Intern. Med J. (2007) 37:229-235.
    • (2007) Intern. Med J , vol.37 , pp. 229-235
    • YAKARYILMAZ, F.1    GULITER, S.2    SAVAS, B.3
  • 235
    • 23144446413 scopus 로고    scopus 로고
    • The nutritional status modulates preservation-reperfusion injury in rat fatty liver
    • CARACENI P, DOMENICALI M, MARIA PERTOSA A et al.: The nutritional status modulates preservation-reperfusion injury in rat fatty liver. J. Surg. Res. (2005) 127:190-196.
    • (2005) J. Surg. Res , vol.127 , pp. 190-196
    • CARACENI, P.1    DOMENICALI, M.2    MARIA PERTOSA, A.3


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