메뉴 건너뛰기




Volumn 4, Issue 12, 2006, Pages 1537-1543

Randomized Placebo-Controlled Trial of Ursodeoxycholic Acid With Vitamin E in Nonalcoholic Steatohepatitis

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; URSODEOXYCHOLIC ACID;

EID: 33845336554     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2006.09.025     Document Type: Article
Times cited : (307)

References (29)
  • 1
    • 0033019013 scopus 로고    scopus 로고
    • Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease
    • Caldwell S.H., Oelsner D.H., Iezzoni J.C., et al. Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. Hepatology 29 (1999) 664-669
    • (1999) Hepatology , vol.29 , pp. 664-669
    • Caldwell, S.H.1    Oelsner, D.H.2    Iezzoni, J.C.3
  • 2
    • 0033038672 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity
    • Matteoni C.A., Younossi Z.M., Gramlich T., et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 116 (1999) 1413-1419
    • (1999) Gastroenterology , vol.116 , pp. 1413-1419
    • Matteoni, C.A.1    Younossi, Z.M.2    Gramlich, T.3
  • 3
    • 0037037292 scopus 로고    scopus 로고
    • Treatment options in non-alcoholic steatohepatitis according to pathogenic considerations
    • Oneta C., and Dufour J.-F. Treatment options in non-alcoholic steatohepatitis according to pathogenic considerations. Swiss Med Wkly 132 (2002) 493-505
    • (2002) Swiss Med Wkly , vol.132 , pp. 493-505
    • Oneta, C.1    Dufour, J.-F.2
  • 4
    • 1642338852 scopus 로고    scopus 로고
    • Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease
    • vi
    • Paumgartner G., and Beuers U. Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease. Clin Liver Dis 8 (2004) 67-81 vi
    • (2004) Clin Liver Dis , vol.8 , pp. 67-81
    • Paumgartner, G.1    Beuers, U.2
  • 5
    • 84933047295 scopus 로고    scopus 로고
    • Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study
    • Laurin J., Lindor K.D., Crippin J.S., et al. Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study. Hepatology 23 (1996) 1464-1467
    • (1996) Hepatology , vol.23 , pp. 1464-1467
    • Laurin, J.1    Lindor, K.D.2    Crippin, J.S.3
  • 6
    • 1542515099 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial
    • Lindor K.D., Kowdley K.V., Heathcote E.J., et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial. Hepatology 39 (2004) 770-778
    • (2004) Hepatology , vol.39 , pp. 770-778
    • Lindor, K.D.1    Kowdley, K.V.2    Heathcote, E.J.3
  • 7
    • 0033025969 scopus 로고    scopus 로고
    • Comparison of serum concentrations of alpha-tocopherol and beta-carotene in a cross-sectional sample of obese and nonobese children (NHANES III)
    • Strauss R. Comparison of serum concentrations of alpha-tocopherol and beta-carotene in a cross-sectional sample of obese and nonobese children (NHANES III). J Pediatr 134 (1999) 160-165
    • (1999) J Pediatr , vol.134 , pp. 160-165
    • Strauss, R.1
  • 8
    • 0034799895 scopus 로고    scopus 로고
    • Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study
    • Hasegawa T., Yoneda M., Nakamura K., et al. Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study. Aliment Pharmacol Ther 15 (2001) 1667-1672
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1667-1672
    • Hasegawa, T.1    Yoneda, M.2    Nakamura, K.3
  • 9
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis
    • Harrison S.A., Torgerson S., Hayashi P., et al. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 98 (2003) 2485-2490
    • (2003) Am J Gastroenterol , vol.98 , pp. 2485-2490
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3
  • 10
    • 1442355447 scopus 로고    scopus 로고
    • A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
    • Promrat K., Lutchman G., Uwaifo G.I., et al. A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis. Hepatology 39 (2004) 188-196
    • (2004) Hepatology , vol.39 , pp. 188-196
    • Promrat, K.1    Lutchman, G.2    Uwaifo, G.I.3
  • 11
    • 0030740659 scopus 로고    scopus 로고
    • Therapeutic effects of restricted diet and exercise in obese patients with fatty liver
    • Ueno T., Sugawara H., Sujaku K., et al. Therapeutic effects of restricted diet and exercise in obese patients with fatty liver. J Hepatol 27 (1997) 103-107
    • (1997) J Hepatol , vol.27 , pp. 103-107
    • Ueno, T.1    Sugawara, H.2    Sujaku, K.3
  • 12
    • 27744490794 scopus 로고    scopus 로고
    • Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease
    • Suzuki A., Lindor K., St Saver J., et al. Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol 43 (2005) 1060-1066
    • (2005) J Hepatol , vol.43 , pp. 1060-1066
    • Suzuki, A.1    Lindor, K.2    St Saver, J.3
  • 13
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    • Bugianesi E., Gentilcore E., Manini R., et al. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol 100 (2005) 1082-1090
    • (2005) Am J Gastroenterol , vol.100 , pp. 1082-1090
    • Bugianesi, E.1    Gentilcore, E.2    Manini, R.3
  • 14
    • 14944359845 scopus 로고    scopus 로고
    • A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis
    • Sanyal A.J., Mofrad P.S., Contos M.J., et al. A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2 (2004) 1107-1115
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 1107-1115
    • Sanyal, A.J.1    Mofrad, P.S.2    Contos, M.J.3
  • 15
    • 0042265627 scopus 로고    scopus 로고
    • Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E
    • Kugelmas M., Hill D.B., Vivian B., et al. Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology 38 (2003) 413-419
    • (2003) Hepatology , vol.38 , pp. 413-419
    • Kugelmas, M.1    Hill, D.B.2    Vivian, B.3
  • 16
    • 0035991444 scopus 로고    scopus 로고
    • In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases
    • Seki S., Kitada T., Yamada T., et al. In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. J Hepatol 37 (2002) 56-62
    • (2002) J Hepatol , vol.37 , pp. 56-62
    • Seki, S.1    Kitada, T.2    Yamada, T.3
  • 17
    • 4444382031 scopus 로고    scopus 로고
    • Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis
    • Chalasani N., Deeg M.A., and Crabb D.W. Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 99 (2004) 1497-1502
    • (2004) Am J Gastroenterol , vol.99 , pp. 1497-1502
    • Chalasani, N.1    Deeg, M.A.2    Crabb, D.W.3
  • 18
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning J.D., and Horton J.D. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114 (2004) 147-152
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 19
    • 0033562693 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: another disease of affluence
    • James O., and Day C. Non-alcoholic steatohepatitis: another disease of affluence. Lancet 353 (1999) 1634-1636
    • (1999) Lancet , vol.353 , pp. 1634-1636
    • James, O.1    Day, C.2
  • 20
    • 0031915149 scopus 로고    scopus 로고
    • Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis
    • George D., Goldwurm S., MacDonald G., et al. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology 114 (1998) 311-318
    • (1998) Gastroenterology , vol.114 , pp. 311-318
    • George, D.1    Goldwurm, S.2    MacDonald, G.3
  • 21
    • 0033198317 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis
    • Bonkovsky H.L., Jawaid Q., Tortorelli K., et al. Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis. J Hepatol 31 (1999) 421-429
    • (1999) J Hepatol , vol.31 , pp. 421-429
    • Bonkovsky, H.L.1    Jawaid, Q.2    Tortorelli, K.3
  • 22
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein A.E., Canbay A., Angulo P., et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 125 (2003) 437-443
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3
  • 23
    • 2642583241 scopus 로고    scopus 로고
    • The ins and outs of mitochondrial dysfunction in NASH
    • Fromenty B., Robin M.A., Igoudjil A., et al. The ins and outs of mitochondrial dysfunction in NASH. Diabetes Metab 30 (2004) 121-138
    • (2004) Diabetes Metab , vol.30 , pp. 121-138
    • Fromenty, B.1    Robin, M.A.2    Igoudjil, A.3
  • 24
    • 0034942512 scopus 로고    scopus 로고
    • The therapeutic effects of ursodeoxycholic acid as an anti-apoptotic agent
    • Rodrigues C.M., and Steer C.J. The therapeutic effects of ursodeoxycholic acid as an anti-apoptotic agent. Expert Opin Investig Drugs 10 (2001) 1243-1253
    • (2001) Expert Opin Investig Drugs , vol.10 , pp. 1243-1253
    • Rodrigues, C.M.1    Steer, C.J.2
  • 25
    • 0031950282 scopus 로고    scopus 로고
    • Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production
    • Rodrigues C.M., Fan G., Wong P.Y., et al. Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production. Mol Med 4 (1998) 165-178
    • (1998) Mol Med , vol.4 , pp. 165-178
    • Rodrigues, C.M.1    Fan, G.2    Wong, P.Y.3
  • 26
    • 0032525819 scopus 로고    scopus 로고
    • A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
    • Rodrigues C.M., Fan G., Ma X., et al. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J Clin Invest 101 (1998) 2790-2799
    • (1998) J Clin Invest , vol.101 , pp. 2790-2799
    • Rodrigues, C.M.1    Fan, G.2    Ma, X.3
  • 27
    • 20444443042 scopus 로고    scopus 로고
    • Sampling variability of liver biopsy in nonalcoholic fatty liver disease
    • Ratziu V., Charlotte F., Heurtier A., et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 128 (2005) 1898-1906
    • (2005) Gastroenterology , vol.128 , pp. 1898-1906
    • Ratziu, V.1    Charlotte, F.2    Heurtier, A.3
  • 28
    • 0033200054 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
    • [in process citation]
    • Brunt E.M., Janney C.G., Di Bisceglie A.M., et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. [in process citation]. Am J Gastroenterol 94 (1999) 2467-2474
    • (1999) Am J Gastroenterol , vol.94 , pp. 2467-2474
    • Brunt, E.M.1    Janney, C.G.2    Di Bisceglie, A.M.3
  • 29
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner D.E., Brunt E.M., Van Natta M., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41 (2005) 1313-1321
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.