Effect of Losartan, an angiotension II antagonist, on secondary biliary cirrhosis

Hepato-Gastroenterology

Volumn 49, Issue 48, 2002, Pages 1499-1502

  Ramalho, Leandra N Z ^a   Ramalho, Fernando S ^a   Zucoloto, Sérgio ^a   Castro e Silva Jr , Orlando ^a   Corrěa, Fernando M A ^a   Elias Jr , Jorge ^a   Magalhães, José F G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Hepatic stellate cells; Losartan; Secondary biliary cirrhosis

Indexed keywords

ANGIOTENSIN II ANTAGONIST; COLLAGEN TYPE 4; LOSARTAN; ANTIHYPERTENSIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT LIGATION; BILIARY CIRRHOSIS; CELL POPULATION; CONTROLLED STUDY; DRUG EFFECT; LIVER CELL; LIVER FIBROSIS; LIVER WEIGHT; MALE; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; RAT; RAT STRAIN; SECONDARY BILIARY CIRRHOSIS; SPLEEN WEIGHT; STELLATE CELL; ANALYSIS OF VARIANCE; ANIMAL; BLOOD FLOW VELOCITY; DISEASE MODEL; HEMODYNAMICS; LIVER CIRRHOSIS; LIVER FUNCTION TEST; NONPARAMETRIC TEST; TREATMENT OUTCOME; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD FLOW VELOCITY; DISEASE MODELS, ANIMAL; HEMODYNAMIC PROCESSES; HYPERTENSION, PORTAL; LIVER CIRRHOSIS; LIVER CIRRHOSIS, BILIARY; LIVER FUNCTION TESTS; LOSARTAN; MALE; RATS; RATS, WISTAR; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME;

EID: 0036827163     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Kawada N: The hepatic perisinusoidal stellate cell. Histol Histophatol 1997; 12:1069-1080.
2. Knittel T, Kobold D, Piscaglia F, Saile B, Neubauer K, Mehde M, Timpi R, Ramadori G: Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair. Histochem Cell Biol 1999; 112:387-401.
3. Ramadori G, Veit T, Schwogler S, Dienes HP, Knittel T, Rieder H, Meyer zum Buschenfeide KH: Expression of the gene of the α-smooth muscle-actin isoform in rat liver and in fat storing (ITO) cells. Virchows Arch (B) 1990; 59:349-357.
4. Rippe RA: Life or death: the fate of the hepatic stellate cell following hepatic injury. Hepatology 1998; 27: 1447-1448.
5. Bosch J, Enriquez R, Grozmann RJ, Storer EH: Chronic bile duct ligation in the dog: hemodynamic characterization of a portal hipertensive model. Hepatology 1983; 3:1002-1007.
6. Schneider AW, Kalk JF, Klein CP: Effect of losartan, an angiotensin II receptor antagonist, on portal pressure cirrhosis. Hepatology 1999; 29:334-339.
7. Council for International Organizations of Medical Sciences (CIOMS) Switzerland: International Guiding Principles for Biomedical Research Involving Animals. 1985; pp. 1-28.
8. Roselino JE, Castro e Silva Jr. O, Ceneiva R: Lack of control of liver gluconeogenesis in cholestatic rats with reduced portal blood flow. Hepatology 1992; 16:1055-1060.
9. Zimmermann A, Zimmermann H, Fellay M, Reichen J: Cells with morphological and immunohistochemical features of hepatic stellate cells (Ito cells) form an extralittoral (extrasinusoidal) compartment in the cirrhotic rat liver. Histol Histophatol 1999; 14:719-727.
10. Zimmermann H, Fellay M, Zimmermann A; Hepatic stellate cell (Ito cells) but not collagen IV may partly be responsible for lower portal pressure after reversing secondary biliary cirrhosis in the rat. J Hepatol 1997; 26:158-166.
11. Kontouras J, Billing BH, Sheuer PJ: Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br J Exp Path 1984; 65:305-311.
12. Hines JE, Johnson SJ, Burt AD: In vivo responses of macrophages and perisinusoidal cells to cholestatic liver injury. Am J Pathol 1993; 142:511-518.
13. Bataller R, Gines P, Nicolas JM, Gorbig MN, Garcia-Ramallo E, Gasull- Bosch J, Arroyo V, Rodes J: Angiotensin II induces contraction and proliferation of human hepatic stellate cells. Gastroenterology 2000; 118:1149-1156.