Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis

Clinical Science

Volumn 111, Issue 2, 2006, Pages 135-143

  Portincasa, Piero ^a   Grattagliano, Ignazio ^a   Lauterburg, Bernhard H ^b   Palmieri, Vincenzo O ^a   Palasciano, Giuseppe ^a   Stellaard, Frans ^c  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Chronic liver disease; Fatty liver; Microsomal function; Mitochondrial function; Non alcoholic steatohepatitis; Obesity

Indexed keywords

4 ACETANISIDINE; HEXANOIC ACID DERIVATIVE; HYALURONIC ACID; ISOTOPE; OXOISOCAPROIC ACID; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BREATH ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DECARBOXYLATION; DEMETHYLATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER FUNCTION; MALE; NONALCOHOLIC FATTY LIVER; OBESITY; PRIORITY JOURNAL; SCORING SYSTEM; SCREENING; SENSITIVITY AND SPECIFICITY; STEATOSIS;

ACETAMIDES; ADULT; AGE DISTRIBUTION; BIOLOGICAL MARKERS; BODY MASS INDEX; BODY WEIGHT; BREATH TESTS; CARBON ISOTOPES; FATTY LIVER; FEMALE; HEXANOIC ACIDS; HUMANS; MALE; MICROSOMES, LIVER; MIDDLE AGED; MITOCHONDRIA, LIVER; OBESITY; OVERWEIGHT; SEVERITY OF ILLNESS INDEX;

EID: 33747090739     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20050346     Document Type: Article

References (52)

1. Lauterburg, B. H. (1999) Assessment of liver function prior to hepatic resection. Swiss Surg. 5, 92-96
2. Lashner, B. A., Jonas, R. B., Tang, H. S., Evans, A. A., Ozeran, S. E. and Baker, A. L. (1988) Chronic hepatitis: disease factors at diagnosis predictive of mortality. Am. J. Med. 85, 609-614
3. Luketic, V. A., Shiffman, M. L., Fisher, R. A., Sanyal, A. J., Purdum, III, P. P. and Posner, M. P. (1993) Hepatic lidocaine metabolism is useful in the selection of patients in need of liver transplantation. Transplant. Proc. 25, 1072-1074
4. Reichen, J. (1995) Assessment of hepatic function with xenobiotics. Semin. Liver Dis. 15, 189-201
5. 13C-methacetin breath test to evaluate functional capacity of hepatocyte in chronic liver disease. Dig. Liver Dis. 32, 226-232
6. 13C-methacetin breath test for monitoring hepatic function in cirrhotic patients before and after liver transplantation. Aliment. Pharmacol. Ther. 18, 785-790
7. James, O. F. and Day, C. P. (1998) Non-alcoholic steatohepatitis (NASH): a disease of emerging identity and importance. J. Hepatol. 29, 495-501
8. Ploeg, R. J., D'Alessandro, A. M., Knechtle, S. J. et al. (1993) Risk factors for primary dysfunction after liver transplantation: a multivariate analysis. Transplantation 55, 807-813
9. Bacon, B. R., Farahvash, M. J., Janney, C. G. and Neuschwander-Tetri, B. A. (1994) Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 107, 1103-1109
10. Leclercq, I. A., Field, J., Enriquez, A., Farrell, G. C. and Robertson, G. R. (2000) Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice. Biochem. Biophys. Res. Commun. 268, 337-344
11. Weltman, M. D., Farrell, G. C., Hall, P., Ingelman-Sundberg, M. and Liddle, C. (1998) Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 27, 128-133
12. Caldwell, S. H., Swerdlow, R. H., Khan, E. M. et al. (1999) Mitochondrial abnormalities in non-alcoholic steatohepatitis. J. Hepatol. 31, 430-434
13. Vendemiale, G., Grattagliano, I., Caraceni, P. et al. (2001) Mitochondrial oxidative injury and energy metabolism alteration in rat fatty liver: effect of the nutritional status. Hepatology 33, 808-815
14. Hashimoto, T., Fujita, T., Usuda, N. et al. (1999) Peroxisomal and mitochondrial fatty acid β-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor a and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotype. J. Biol. Chem. 274, 19228-19236
15. Grattagliano, I., Vendemiale, G., Caraceni, P. et al. (2000) Starvation impairs antioxidant defense in fatty livers of rats fed a choline-deficient diet. J. Nutr. 130, 2131-2136
16. Spycher, C., Zimmermann, A. and Reichen, J. (2001) The diagnostic value of liver biopsy. BMC Gastroenterol. 1, 12
17. Regev, A., Berho, M., Jeffers, L. J. et al. (2002) Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am. J. Gastroenterol. 97, 2614-2618
18. Goldin, R. D., Goldin, J. G., Bun, A. D. et al. (1996) Intra-observer and inter-observer variation in the histopathological assessment of chronic viral hepatitis. J. Hepatol. 25, 649-654
19. 13C]ketoisocaproate is impaired in alcoholics. Alcohol Clin. Exp. Res. 18, 951-955
20. 13C] methacetin breath test for evaluation of liver damage. Dig. Dis. Sci. 32, 344-348
21. Lauterburg, B. H., Liang, D., Schwarzenbach, F. A. and Breen, K. J. (1993) Mitochondrial dysfunction in alcoholic patients as assessed by breath analysis. Hepatology 17, 418-422
22. Guengerich, F. P., Krauser, J. A. and Johnson, W. W. (2004) Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P450 1A2. Biochemistry 43, 10775-10788
23. Michaletz, P. A., Cap, L., Alpert, E. and Lauterburg, B. H. (1989) Assessment of mitochondrial function in vivo with a breath test utilizing α-ketoisocaproic acid. Hepatology 10, 829-832
24. 13C-ketoisocaproate (KICA) breath test. J. Hepatol. 42 (Suppl. 2), 246
25. 13C-Breath tests show that liver microsomal and mitochondrial functions are deranged in patients with nonalcoholic steatohepatitis. Gastroenterology 128 (Suppl. 2), A-770
26. Brunt, E. M. (2001) Nonalcoholic steatohepatitis: definition and pathology. Semin. Liver Dis. 21, 3-16
27. Lauterburg, B. H., Grattagliano, I., Gmur, R., Stalder, M. and Hildebrand, P. (1995) Noninvasive assessment of the effect of xenobiotics on mitochondrial function in human beings: studies with acetylsalicylic acid and ethanol with the use of the carbon 13-labeled ketoisocaproate breath test. J. Lab Clin. Med. 125, 378-383
28. 13C]Aminopyrine breath test detects altered liver metabolism caused by low-dose oral contraceptives. Dig. Dis. Sci. 40, 2417-2422
29. 2 data. J. Nucl. Med. 11, 708-710
30. 13C-methacetin breath test for quantitative liver function testing. Z. Gastroenterol. 35, 609-614
31. Lauterburg, B. H., Liang, D., Schwarzenbach, F. A. and Breen, K. J. (1993) Mitochondrial dysfunction in alcoholic patients as assessed by breath analysis. Hepatology 17, 418-122
32. Boyacioglu, S., Gur, G., Yilmaz, U. et al. (2004) Investigation of possible clinical and laboratory predictors of liver fibrosis in hemodialysis patients infected with hepatitis C virus. Transplant. Proc. 36, 50-52
33. Suzuki, A., Angulo, P., Lymp, J., Li, D., Satomura, S. and Lindor, K. (2005) Hyaluronic acid, an accurate serum marker for severe hepatic fibrosis in patients with non-alcoholic fatty liver disease. Liver Int. 25, 779-786
34. Davies, R. J., Saverymuttu, S. H., Fallowfield, M. and Joseph, A. E. (1991) Paradoxical lack of ultrasound attenuation with gross fatty change in the liver. Clin. Radiol. 43, 393-396
35. Harrison, S. A., Torgerson, S. and Hayashi, P. H. (2003) The natural history of nonalcoholic fatty liver disease: a clinical histopathological study. Am. J. Gastroenterol. 98, 2042-2047
36. Kunde, S. S., Lazenby, A. J., Clements, R. H. and Abrams, G. A. (2005) Spectrum of NAFLD and diagnostic implications of the proposed new normal range for serum ALT in obese women. Hepatology 42, 650-656
37. Angulo, P., Keach, J. C., Batts, K. P. and Lindor, K. D. (1999) Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 30, 1356-1362
38. Ratziu, V., Giral, P., Charlotte, F. et al. (2000) Liver fibrosis in overweight patients. Gastroenterology 118, 1117-1123
39. Dixon, J. B., Bhathal, P. S. and O'Brien, P. E. (2001) Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 121, 91-100
40. Park, G. J., Katelaris, P. H., Jones, D. B. et al. (2005) The C-caffeine breath test distinguishes significant fibrosis in chronic hepatitis B and reflects response to lamivudine therapy. Aliment. Pharmacol. Then 22, 395-403
41. Mion, F., Rousseau, M., Brazier, J. L. and Minaire, Y. (1995) Human hepatic macrovesicular steatosis: a noninvasive study of mitochondrial ketoisocaproic acid decarboxylation. Metab., Clin. Exp. 44, 699-700
42. 13C-methionine breath test in patients with macrovesicular steatosis and patients with cirrhosis. Med. Sci. Monit. 9, CR6-CR11
43. 13C] methacetin breath test for evaluation of liver damage. Dig. Dis. Sci. 32, 344-348
44. 13C- Methacetin breath test as liver function test in patients with chronic hepatitis C virus infection. Aliment. Pharmacol. Ther. 21, 179-185
45. Pessayre, D., Berson, A., Fromenty, B. and Mansouri, A. (2001) Mitochondria in steatohepatitis. Semin. Liver Dis. 21, 57-69
46. Perez-Carreras, M., Del, H. P., Martin, M. A. et al. (2003) Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 38, 999-1007
47. 13C-octanoate breath test. Am. J. Gastroenterol. 98, 2335-2336
48. Parra, D., Gonzalez, A., Martinez, J. A., Labayen, I. and Diez, N. (2003) In vivo assessment of the mitochondrial response to caloric restriction in obese women by the 2-keto[1-C]isocaproate breath test. Metab., Clin. Exp. 52, 463-467
49. Colicchio, P., Tarantino, G., Del, G. F. et al. (2005) Non-Alcoholic fatty liver disease in young adult severely obese non-diabetic patients in South Italy. Ann. Nutr. Metab. 49, 289-295
50. Patton, H. M., Patel, K., Behling, C. et al. (2004) The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients. J. Hepatol. 40, 484-490
51. Dixon, J. B., Bhathal, P. S., Hughes, N. R. and O'Brien, P. E. (2004) Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology 39, 1647-1654
52. Fassio, E., Alvarez, E., Dominguez, N., Landeira, G. and Longo, C. (2004) Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 40, 820-826