Antiangiogenic Potency of FK866/K22.175, A New Inhibitor of Intracellular NAD Biosynthesis, in Murine Renal Cell Carcinoma

Anticancer Research

Volumn 23, Issue 6 C, 2003, Pages 4853-4858

  Drevs, Joachim ^a   Löser, Roland ^b   Rattel, Benno ^b   Esser, Norbert ^a  

^a TUMOR BIOLOGY CENTER   (Germany)

^b Pharmacology Department   (Germany)

Author keywords

Angiogenesis; Animal; Endothelial cell; Renal cell carcinoma; Vessel density

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIMETASTATIC AGENT; ANTINEOPLASTIC AGENT; FK 866; FUMAGILLOL CHLOROACETYLCARBAMATE; K 22 175; N [4 (1 BENZOYLPIPERIDIN 4 YL) 3 (PYRIDIN 3 YL)]ACRYLAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BODY WEIGHT; CELL DENSITY; COLOR ULTRASOUND FLOWMETRY; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; DRUG POTENCY; KIDNEY ARTERY; KIDNEY BLOOD FLOW; KIDNEY CARCINOMA; LUNG METASTASIS; LYMPH NODE METASTASIS; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR VOLUME;

ACRYLAMIDES; ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD FLOW VELOCITY; BODY WEIGHT; CARCINOMA, RENAL CELL; KIDNEY NEOPLASMS; MICE; NAD; NEOVASCULARIZATION, PATHOLOGIC; PIPERIDINES; TUMOR CELLS, CULTURED;

EID: 0842333189     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

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3. Drevs J, Muller-Driver R, Wittig C, Fuxius S, Esser N, Hugenschmidt H, Konerding MA, Allegrini PR, Wood J, Hennig J, Unger C and Marme D: PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging. Cancer Res 62: 4015-4022, 2002.
4. Wosikowski K, Mattern K, Schemainda I, Hasmann M, Rattel B and Loser R: WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells. Cancer Res 62: 1057-1062, 2002.
5. Holen KD, Burk K, Schwartz GK, Spriggs D, Hollywood E, Ty V, Alcasaid A, Jill H, Barber W and D K: Dose-finding and pharmacokinetic study of FK866, an inhibitor of NAD biosynthesis. Proc ASCO 2002 21: 87a, 2002.
6. Woskowski et al: manuscript in preparation.
7. Hasmann et al: manuscript in preparation.