Apoptosis in the aging process

Cell and Tissue Research

Volumn 301, Issue 1, 2000, Pages 125-132

  Higami, Yoshikazu ^a   Shimokawa, Isao ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Aging; Apoptosis; DNA damage; Fas receptor ligand; Oxidative stress; P53; Tumorigenesis

Indexed keywords

ADULT; AGED; AGING; ANIMAL CELL; APOPTOSIS; CARCINOGENESIS; CELL DAMAGE; CELL LOSS; CELL PROTECTION; CONTROLLED STUDY; DNA DAMAGE; DOG; GENETIC DAMAGE; GENETIC SUSCEPTIBILITY; GLYCATION; HUMAN; HUMAN CELL; HYPOTHESIS; IN VIVO STUDY; INCIDENCE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REVIEW; SOMATIC CELL GENETICS; TUMOR CELL;

ANIMALIA; CANIS FAMILIARIS;

EID: 0033929763     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004419900156     Document Type: Review

References (65)

1. Adachi M, Suematsu S, Kondo T, Ogasawara J, Tanaka T, Yoshida N, Nagata S (1995) Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nat Genet 11:294-300
2. Adams CS, Horton WE Jr (1998) Chondrocyte apoptosis increases with age in the articular cartilage of adult animals. Anat Rec 250:418-425
3. Adams JD, Mukherjee SK, Klaidman LK, Chang ML, Yasharel R (1996) Apoptosis and oxidative stress in the aging brain. Ann NY Acad Sci 786:135-151
4. Aggarwal S, Gupta S (1998) Increased apoptosis of T cell subsets in aging humans altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. J Immunol 160:1627-1637
5. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB (1992) Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89:10114-10118
6. Anderson JM, Hubbard BM, Coghill GR, Slidders W (1983) The effect of advanced old age on the neurone content of the cerebral cortex. Observations with an automatic image analyser point counting method. J Neurol Sci 58:235-246
7. Anglade P, Vyas S, Javoy-Agid F, Herrero MT, Michel PP, Marquez J, Mouatt-Prigent A, Ruberg M, Hirsch EC, Agid Y (1997a) Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol 12:25-31
8. Anglade P, Vyas S, Hirsch EC, Agid Y (1997b) Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging. Histol Histopathol 12:603-610
9. Anversa P, Palackal T, Sonnenblick EH, Olivetti G, Meggs LG, Capasso JM (1990) Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart. Circ Res 67:871-885
10. Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281:1674-1677
11. Buttke TM, Sandstrom PA (1994) Oxidative stress as a mediator of apoptosis. Immunol Today 15:7-10
12. Canman CE, Chen CY, Lee MH, Kastan MB (1994) DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis. Cold Spring Harb Symp Quant Biol 59:277-86
13. Charriaut-Marlangue C, Ben-Ari Y (1995) A cautionary note on the use of the TUNEL stain to determine apoptosis. Neuroreport 29:61-64
14. Chrest FJ, Buchholz MA, Kim YH, Kwon TK, Nordin AA (1995) Anti-CD3-induced apoptosis in T-cells from young and old mice. Cytometry 20:33-42
15. Duran-Reynals ML, Kadish AS, Lilly F (1986) Genetic and epigenetic factors that influence the occurrence of spontaneous lymphoid tumors in crosses of mice of high-and low-incidence strains. Int J Cancer 37:155-160
16. Gross L, Feldman D, Dreyfuss Y (1986) C-type virus particles in spontaneous and virus-induced leukemia and malignant lymphomas in mice and rats. Cancer Res 46:2984-2987
17. Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460
18. Herndon FJ, Hsu HC, Mountz JD (1997) Increased apoptosis of CD45RO-T cells with aging. Mech Ageing Dev 94:123-134
19. Higami Y, Shimokawa I, Okimoto T, Ikeda T (1994) An age-related increase in the basal level of DNA damage and DNA vulnerability to oxygen radicals in the individual hepatocytes of male F344 rats. Mutat Res 316:59-67
20. Higami Y, Shimokawa I, Okimoto T, Tomita M, Yuo T, Ikeda T (1996) Susceptibility of hepatocytes to cell death induced by single administration of cycloheximide in young and old F344 rats. Effect of dietary restriction. Mutat Res 357:225-230
21. Higami Y, Shimokawa I, Okimoto T, Tomita M, Yuo T, Ikeda T (1997a) Effect of aging and dietary restriction on hepatocyte proliferation and death in male F344 rats. Cell Tissue Res 288:69-77
22. Higami Y, Shimokawa I, Tomita M, Okimoto T, Koji T, Kobayashi N, Ikeda T (1997b) Aging accelerates but life-long dietary restriction suppresses apoptosis-related Fas expression on hepatocytes. Am J Pathol 151:659-663
23. Holt PR, Moss SF, Heydari AR, Richardson A (1998) Diet restriction increases apoptosis in the gut of aging rats. J Gerontol A-Biol 53:B168-B172
24. Kajstura J, Cheng W, Sarangarajan R, Li P, Li B, Nitahara JA, Chapnick S, Reiss K, Olivetti G, Anversa P (1996) Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats. Am J Physiol 271:H1215-H1228
25. Kiatipattanasakul W, Nakamura S, Hossain MM, Nakayama H, Uchino T, Shumiya S, Goto N, Doi K (1996) Apoptosis in the aged dog brain. Acta Neuropathol (Berl) 92:242-248
26. Li WP, Chan WY, Lai HW, Yew DT (1997) Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and Alzheimer patients. J Mol Neurosci 8:75-82
27. Liu L, Azhar G, Gao W, Zhang X, Wei JY (1998) Bcl-2 and Bax expression in adult rat hearts after coronary occlusion: age-associated differences. Am J Physiol 275:R315-R322
28. Lucassen PJ, Chung WC, Kamphorst W, Swaab DF (1997) DNA damage distribution in the human brain as shown by in situ end labeling; area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology. J Neuropathol Exp Neurol 56:887-900
29. Lynch DH, Ramsdell F, Alderson MR (1995) Fas and FasL in the homeostatic regulation of immune responses. Immunol Today 16:569-574
30. Masoro EJ (1995) Aging: current concepts. In: Masoro EJ (ed) Aging. (Handbook of Physiology, Sect 11) Oxford University Press, New York, pp 3-21
31. Masui T, Nakanishi H, Inada K, Imai T, Mizoguchi Y, Yada H, Futakuchi M, Shirai T, Tatematsu M (1997) Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes. Cancer Lett 112:33-45
32. Meek DW (1998) Multisite phosphorylation and the integration of stress signals at p53. Cell Signal 10:159-166
33. Migheli A, Cavalla P, Piva R, Giordana MT, Schiffer D (1994) Bcl-2 protein expression in aged brain and neurodegenerative diseases. Neuroreport 5:1906-1908
34. Miller RA (1996) The aging immune system: primer and prospectus. Science 273:70-74
35. Miyawaki T, Uehara T, Nibu R, Tsuji T, Yachie A, Yonehara S, Taniguchi N (1992) Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J Immunol 149:3753-3758
36. Mogi M, Harada M, Kondo T, Mizuno Y, Narabayashi H, Riederer P, Nagatsu T (1996) The soluble form of Fas molecule is elevated in parkinsonian brain tissues. Neurosci Lett 220:195-198
37. Monte SM de la, Sohn YK, Wands JR (1997) Correlates of p53-and Fas (CD95)-mediated apoptosis in Alzheimer's disease. J Neurol Sci 152:73-83
38. Muskhelishvili L, Hart RW, Turturro A, James SJ (1995) Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice. Am J Pathol 147:20-24
39. Nagel JE, Chopra RK, Chrest FJ, McCoy MT, Schneider EL, Holbrook NJ, Adler WH (1988) Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J Clin Invest 81:1096-1102
40. Nitahara JA, Cheng W, Liu Y, Li B, Leri A, Li P, Mogul D, Gambert SR, Kajstura J, Anversa P (1998) Intracellular calcium, DNase activity and myocyte apoptosis in aging Fischer 344 rats. J Mol Cell Cardiol 30:519-535
41. Nunez G, Merino R, Grillot D, Gonzalez-Garcia M (1994) Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival. Immunol Today 15:582-588
42. Obonai T, Mizuguchi M, Takashima S (1998) Developmental and aging changes of Bak expression in the human brain. Brain Res 783:167-170
43. Olivetti G, Melissari M, Capasso JM, Anversa P (1991) Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res 68:1560-1568
44. Otterbein LE, Chin BY, Mantell LL, Stansberry L, Horowitz S, Choi AM (1998) Pulmonary apoptosis in aged and oxygen-tolerant rats exposed to hyperoxia. Am J Physiol 275:L14-L20
45. Phelouzat MA, Arbogast A, Laforge T, Quadri RA, Proust JJ (1996) Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence. Mech Ageing Dev 88:25-38
46. Phelouzat MA, Laforge T, Arbogast A, Quadri RA, Boutet S Proust JJ (1997) Susceptibility to apoptosis of T lymphocytes from elderly humans is associated with increased in vivo expression of functional Fas receptors. Mech Ageing Dev 96:35-46
47. Potestio M, Caruso C, Gervasi F, Scialabba G, D'Anna C, Di Lorenzo G, Balistreri CR, Candore G, Romano GC (1998) Apoptosis and ageing. Mech Ageing Dev 102:221-237
48. Razzaque MS, Shimokawa I, Koji T, Higami Y, Taguchi T (1999) Life-long caloric restriction suppresses age-associated Fas expression in the Fischer 344 rat kidney. Mol Cell Biol Res Commun 1:82-85
49. Reed JC (1997) Double identity for proteins of the Bcl-2 family. Nature 387:773-776
50. Rowan S, Ludwig RL, Haupt Y, Bates S, Lu X, Oren M, Vousden KH (1996) Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J 15:827-838
51. Sakamuro D, Sabbatini P, White E, Prendergast GC (1997) The polyproline region of p53 is required to activate apoptosis but not growth arrest. Oncogene 15:887-898
52. Singh NP, Danner DB, Tice RR, Pearson JD, Brant LJ, Morrell CH, Schneider EL (1991) Basal DNA damage in individual human lymphocytes with age. Mutat Res 256:1-6
53. Sohal RS, Allen RG (1990) Oxidative stress as a causal factor in differentiation and aging: a unifying hypothesis. Exp Gerontol 25:499-522
54. Spaulding CC, Walford RL, Effros RB (1997) The accumulation of nonreplicative, nonfunctional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis. Mech Ageing Dev 93:25-33
55. Strand S, Hofmann WJ, Grambihler A, Hug H, Volkmann M, Otto G, Wesch H, Mariani SM, Hack V, Stremmel W, Krammer PH, Galle PR (1998) Hepatic failure and liver cell damage in acute Wilson's disease involve CD95 (APO-1/Fas) mediated apoptosis. Nat Med 4:588-593
56. Suda T, Takahashi T, Golstein P, Nagata S (1993) Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169-1178
57. Taglialatela G, Gegg M, Perez-Polo JR, Williams LR, Rose GM (1996) Evidence for DNA fragmentation in the CNS of aged Fischer-344 rats. Neuroreport 7:977-980
58. Tompkins MM, Basgall EJ, Zamrini E, Hill WD (1997) Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons. Am J Pathol 150:119-131
59. Wang E (1995) Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res 55:2284-2292
60. Warner HR (1997) Aging and regulation of apoptosis. Curr Top Cell Regul 35:107-121
61. Warner HR, Hodes RJ, Pocinki K (1997) What does cell death have to do with aging? J Am Geriatr Soc 45:1140-1146
62. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S (1992) Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314-317
63. Wirnitzer U, Topfer R, Rosenbruch M (1998) Altered p53 expression in early stages of chemically induced rodent hepatocarcinogenesis. Toxicol Pathol 26:636-645
64. Y and nick-end labeling are positive in spinal motor neurons in amyotrophic lateral sclerosis. Acta Neuropathol (Berl) 88:207-211
65. Zhou T, Edwards CK III, Mountz JD (1995) Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice. J Exp Med 182:129-137