Insensitivity to Aβ42-lowering nonsteroidal anti-inflammatory drugs and γ-secretase inhibitors is common among aggressive presenilin-1 mutations

Journal of Biological Chemistry

Volumn 282, Issue 34, 2007, Pages 24504-24513

  Czirr, Eva ^a,f   Leuchtenberger, Stefanie ^a,f   Dorner Ciossek, Cornelia ^b   Schneider, Anna ^a   Jucker, Mathias ^c   Koo, Edward H ^d   Pietrzik, Claus U ^a   Baumann, Karlheinz ^e   Weggen, Sascha ^a,f  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e F HOFFMANN LA ROCHE LTD   (Switzerland)

^f HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; CELLULAR DRUG RESPONSE; DRUG DISCOVERY; ENDOPROTEOLYSIS; NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAID); PRESENILIN-1 (PS1);

AMINO ACIDS; BIOASSAY; DISEASE CONTROL; GENE EXPRESSION; GENETIC ENGINEERING; PATHOLOGY;

DRUG PRODUCTS;

AMYLOID BETA PROTEIN[1-42]; GAMMA SECRETASE INHIBITOR; LY 411575; NONSTEROID ANTIINFLAMMATORY AGENT; NOTCH RECEPTOR; PRESENILIN 1; SULINDAC SULFIDE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); ENZYME INHIBITOR; PEPTIDE FRAGMENT; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; ENZYME INHIBITION; GENE EXPRESSION; GENE MUTATION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; TRANSGENICS; AMINO ACID SEQUENCE; ANIMAL; CHO CELL; CRICETULUS; DRUG ANTAGONISM; GENETICS; HAMSTER; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; SEQUENCE HOMOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME INHIBITORS; HUMANS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE FRAGMENTS; PRESENILIN-1; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 34548317423     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700618200     Document Type: Article

References (48)

1. Hardy, J., and Selkoe, D. J. (2002) Science 297, 353-356
2. Mount, C., and Downton, C. (2006) Nat. Med. 12, 780-784
3. Citron, M. (2004) Nat. Rev. Neurosci. 5, 677-685
4. Wolfe, M. S. (2006) Biochemistry 45, 7931-7939
5. Beher, D., and Graham, S. L. (2005) Expert Opin. Investig. Drugs 14, 1385-1409
6. Tomita, T., and Iwatsubo, T. (2006) Curr. Pharm. Des. 12, 661-670
7. Beher, D., Clarke, E. E., Wrigley, J. D., Martin, A. C., Nadin, A., Churcher, I., and Shearman, M. S. (2004) J. Biol. Chem. 279, 43419-43426
8. Czirr, E., and Weggen, S. (2006) Neurodegen. Dis. 3, 298-304
9. Eriksen, J. L., Sagi, S. A., Smith, T. E., Weggen, S., Das, P., McLendon, D. C., Ozols, V. V., Jessing, K. W., Zavitz, K. H., Koo, E. H., and Golde, T. E. (2003) J. Clin. Investig. 112, 440-449
10. Morihara, T., Chu, T., Ubeda, O., Beech, W., and Cole, G. M. (2002) J. Neurochem. 83, 1009-1012
11. Takahashi, Y., Hayashi, I., Tominari, Y., Rikimaru, K., Morohashi, Y., Kan, T., Natsugari, H., Fukuyama, T., Tomita, T., and Iwatsubo, T. (2003) J. Biol. Chem. 278, 18664-18670
12. Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., Kang, D. E., Marquez-Sterling, N., Golde, T. E., and Koo, E. H. (2001) Nature 414, 212-216
13. Younkin, S. G. (1998) J. Physiol. (Paris) 92, 289-292
14. Weggen, S., Eriksen, J. L., Sagi, S. A., Pietrzik, C. U., Golde, T. E., and Koo, E. H. (2003) J. Biol. Chem. 278, 30748-30754
15. Fraering, P. C., Ye, W., Strub, J. M., Dolios, G., LaVoie, M. J., Ostaszewski, B. L., van Dorsselaer, A., Wang, R., Selkoe, D. J., and Wolfe, M. S. (2004) Biochemistry 43, 9774-9789
16. Weggen, S., Eriksen, J. L., Sagi, S. A., Pietrzik, C. U., Ozols, V., Fauq, A., Golde, T. E., and Koo, E. H. (2003) J. Biol. Chem. 278, 31831-31837
17. Lleo, A., Berezovska, O., Herl, L., Raju, S., Deng, A., Bacskai, B. J., Frosch, M. P., Irizarry, M., and Hyman, B. T. (2004) Nat. Med. 10, 1065-1066
18. Ikeuchi, T., Dolios, G., Kim, S. H., Wang, R., and Sisodia, S. S. (2003) J. Biol. Chem. 278, 7010-7018
19. Perez-Tur, J., Froelich, S., Prihar, G., Crook, R., Baker, M., Duff, K., Wragg, M., Busfield, F., Lendon, C., Clark, R. F., Roques, P., Fuldner, R. A., Johnston, J., Cowburn, R., Forsell, C., Axelman, K., Lilius, L., Houlden, H., Karran, E., Roberts. G. W., Rossor, M., Adams, M. D., Hardy, J., Goate, A., Lannfeld, L., and Hutton, M. (1995) Neuroreport 7, 297-301
20. Steiner, H., Romig, H., Grim, M. G., Philipp, U., Pesold, B., Citron, M., Baumeister, R., and Haass, C. (1999) J. Biol. Chem. 274, 7615-7618
21. Thinakaran, G., Borchelt, D. R., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N. A., Copeland, N. G., Price, D. L., and Sisodia, S. S. (1996) Neuron 17, 181-190
22. Podlisny, M. B., Citron, M., Amarante, P., Sherrington, R., Xia, W., Zhang, J., Diehl, T., Levesque, G., Fraser, P., Haass, C., Koo, E. H., Seubert, P., St George-Hyslop, P., Teplow, D. B., and Selkoe, D. J. (1997) Neurobiol. Dis. 3, 325-337
23. Steiner, H., Romig, H., Pesold, B., Philipp, U., Baader, M., Citron, M., Loetscher, H., Jacobsen, H., and Haass, C. (1999) Biochemistry 38, 14600-14605
24. Okochi, M., Ishii, K., Usami, M., Sahara, N., Kametani, F., Tanaka, K., Fraser, P. E., Ikeda, M., Saunders, A. M., Hendriks, L., Shoji, S. I., Nee, L. E., Martin, J. J., Van Broeckhoven, C., St George-Hyslop, P. H., Roses, A. D., and Mori, H. (1997) FEBS Lett. 418, 162-166
25. Brockhaus, M., Grunberg, J., Rohrig, S., Loetscher, H., Wittenburg, N., Baumeister, R., Jacobsen, H., and Haass, C. (1998) Neuroreport 9, 1481-1486
26. Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F. S., and Cole, G. (1996) Science 274, 99-102
27. Radde, R., Bolmont, T., Kaeser, S. A., Coomaraswamy, J., Lindau, D., Stoltze, L., Calhoun, M. E., Jaggi, F., Wolburg, H., Gengler, S., Haass, C., Ghetti, B., Czech, C., Holscher, C., Mathews, P. M., and Jucker, M. (2006) EMBO Rep. 7, 940-946
28. Cruts, M., Backhovens, H., Wang, S. Y., Van Gassen, G., Theuns, J., De Jonghe, C. D., Wehnert, A., De Voecht, J., De Winter, G., Cras, P., Bruyland, M., Datson N., Weissenbach, J., den Dunnen, J. T., Martin, J., Hendriks, L., and van Broeckhoven, C. (1995) Hum. Mol. Genet. 4, 2363-2371
29. Moehlmann, T., Winkler, E., Xia, X., Edbauer, D., Murrell, J., Capell, A., Kaether, C., Zheng, H., Ghetti, B., Haass, C., and Steiner, H. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 8025-8030
30. Wisniewski, T., Dowjat, W. K., Buxbaum, J. D., Khorkova, O., Efthimiopoulos, S., Kulczycki, J., Lojkowska, W., Wegiel, J., Wisniewski, H. M., and Frangione, B. (1998) Neuroreport 9, 217-221
31. Li, Y. M., Xu, M., Lai, M. T., Huang, Q., Castro, J. L., DiMuzio-Mower, J., Harrison, T., Lellis, C., Nadin, A., Neduvelil, J. G., Register, R. B., Sardana, M. K., Shearman, M. S., Smith, A. L., Shi, X. P., Yin, K. C., Shafer, J. A., and Gardell, S. J. (2000) Nature 405, 689-694
32. Morohashi, Y., Kan, T., Tominari, Y., Fuwa, H., Okamura, Y., Watanabe, N., Sato, C., Natsugari, H., Fukuyama, T., Iwatsubo, T., and Tomita, T. (2006) J. Biol. Chem. 281, 14670-14676
33. Dovey, H. F., John, V., Anderson, J. P., Chen, L. Z., de Saint Andrieu, P., Fang, L. Y., Freedman, S. B., Folmer, B., Goldbach, E., Holsztynska, E. J., Hu, K. L., Johnson-Wood, K. L., Kennedy, S. L., Kholodenko, D., Knops, J. E., Latimer, L. H., Lee, M., Liao, Z., Lieberburg, I. M., Motter, R. N., Mutter, L. C., Nietz, J., Quinn, K. P., Sacchi, K. L., Seubert, P. A., Shopp, G. M., Thorsett, E. D., Tung, J. S., Wu, J., Yang, S., Yin, C. T., Schenk, D. B., May, P. C., Altstiel, L. D., Bender, M. H., Boggs, L. N., Britton, T. C., Clemens, J. C., Czilli, D. L., Dieckman-McGinty, D. K., Droste, J. J., Fuson, K. S., Gitter, B. D., Hyslop, P. A., Johnstone, E. M., Li, W. Y., Little, S. P., Mabry, T. E., Miller, F. D., and Audia, J. E. (2001) J. Neurochem. 76, 173-181
34. Lewis, H. D., Perez Revuelta, B. I., Nadin, A., Neduvelil, J. G., Harrison, T., Pollack, S. J., and Shearman, M. S. (2003) Biochemistry 42, 7580-7586
35. Lanz, T. A., Hosley, J. D., Adams, W. J., and Merchant, K. M. (2004) J. Pharmacol. Exp. Ther. 309, 49-55
36. Clarke, E. E., Churcher, I., Ellis, S., Wrigley, J. D., Lewis, H. D., Harrison, T., Shearman, M. S., and Beher, D. (2006) J. Biol. Chem. 281, 31279-31289
37. Esler, W. P., Kimberly, W. T., Ostaszewski, B. L., Diehl, T. S., Moore, C. L., Tsai, J. Y., Rahmati, T., Xia, W., Selkoe, D. J., and Wolfe, M. S. (2000) Nat. Cell Biol. 2, 428-434
38. Kornilova, A. Y., Bihel, F., Das, C., and Wolfe, M. S. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 3230-3235
39. Tian, G., Ghanekar, S. V., Aharony, D., Shenvi, A. B., Jacobs, R. T., Liu, X., and Greenberg, B. D. (2003) J. Biol. Chem. 278, 28968-28975
40. Esler, W. P., Kimberly, W. T., Ostaszewski, B. L., Ye, W., Diehl, T. S., Selkoe, D. J., and Wolfe, M. S. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 2720-2725
41. Tian, G., Sobotka-Briner, C. D., Zysk, J., Liu, X., Birr, C., Sylvester, M. A., Edwards, P. D., Scott, C. D., and Greenberg, B. D. (2002) J. Biol. Chem. 277, 31499-31505
42. Yamasaki, A., Eimer, S., Okochi, M., Smialowska, A., Kaether, C., Baumeister, R., Haass, C., and Steiner, H. (2006) J. Neurosci. 26, 3821-3828
43. Sato, T., Nyborg, A. C., Iwata, N., Diehl, T. S., Saido, T. C., Golde, T. E., and Wolfe, M. S. (2006) Biochemistry 45, 8649-8656
44. Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., Younkin, S. G., and Borchelt, D. R. (2004) Hum. Mol. Genet. 13, 159-170
45. Wen, P. H., Shao, X., Shao, Z., Hof, P. R., Wisniewski, T., Kelley, K., Friedrich, V. L., Jr., Ho, L., Pasinetti, G. M., Shioi, J., Robakis, N. K., and Elder, G. A. (2002) Neurobiol. Dis. 10, 8-19
46. Wang, R., Wang, B., He, W., and Zheng, H. (2006) J. Biol. Chem. 281, 15330-15336
47. Audia, J. E., Hyslop, P. A., Nissen, J. S., Thompson, R. C., Tung, J. S., and Tanner, L. I. (April 6, 2000) Patent WO0019210
48. Wu, J., Tung, J. S., Thorsett, E. D., Pleiss, M. A., Nissen, J. S., Neitz, J., Latimer, L. H., John, V., Freedman, S., Britton, T. C., Audia, J. E., Reel, J. K., Mabry, T. E., Dressman, B. A., Cwi, C. L., Droste, J. J., Henry, S. S., McDaniel, S. L., Scott, W. L., Stucky, R. D., and Potter, W. J. (July 2, 1998) Patent WO9828268