메뉴 건너뛰기




Volumn 256, Issue 1, 2007, Pages 1-24

Pathways to tamoxifen resistance

Author keywords

Antiestrogen; Aromatase inhibitor; Estrogen receptor; Fulvestrant; Tamoxifen

Indexed keywords

21 (4 DIETHYLAMINOMETHYL 2 METHOXYPHENOXY) 7ALPHA METHYL 19 NORPREGNA 1,3,5(10) TRIEN 3 OL; 5 AZA 2' DEOXYCYTIDINE; ANASTROZOLE; ANTIESTROGEN; ANTINEOPLASTIC AGENT; AROMATASE INHIBITOR; AZD 0530; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; DIARYLPROPIONITRILE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; EVEROLIMUS; EXEMESTANE; FULVESTRANT; GEFITINIB; GROWTH FACTOR RECEPTOR; HORMONE; LAPATINIB; LETROZOLE; MIFEPRISTONE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TEMSIROLIMUS; TIPIFARNIB; TRASTUZUMAB; TRICHOSTATIN A; UNCLASSIFIED DRUG;

EID: 34548237309     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.03.016     Document Type: Review
Times cited : (226)

References (216)
  • 1
    • 33747466839 scopus 로고    scopus 로고
    • Structure-function relationship of estrogen receptor alpha and beta: impact on human health
    • Ascenzi P., Bocedi A., and Marino M. Structure-function relationship of estrogen receptor alpha and beta: impact on human health. Mol. Aspects Med. 27 (2006) 299-402
    • (2006) Mol. Aspects Med. , vol.27 , pp. 299-402
    • Ascenzi, P.1    Bocedi, A.2    Marino, M.3
  • 2
    • 4344707522 scopus 로고    scopus 로고
    • Steroid receptors and cell cycle in normal mammary epithelium
    • Anderson E., and Clarke R.B. Steroid receptors and cell cycle in normal mammary epithelium. J. Mammary Gland Biol. Neoplasia 9 (2004) 3-13
    • (2004) J. Mammary Gland Biol. Neoplasia , vol.9 , pp. 3-13
    • Anderson, E.1    Clarke, R.B.2
  • 3
    • 0036261086 scopus 로고    scopus 로고
    • Distinct expression patterns of ER alpha and ER beta in normal human mammary gland
    • Speirs V., Skliris G.P., Burdall S.E., and Carder P.J. Distinct expression patterns of ER alpha and ER beta in normal human mammary gland. J. Clin. Pathol. 55 (2002) 371-374
    • (2002) J. Clin. Pathol. , vol.55 , pp. 371-374
    • Speirs, V.1    Skliris, G.P.2    Burdall, S.E.3    Carder, P.J.4
  • 4
    • 0345382876 scopus 로고    scopus 로고
    • Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium
    • Forster C., Makela S., Warri A., Kietz S., Becker D., Hultenby K., et al. Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium. Proc. Natl. Acad. Sci. USA 99 (2002) 15578-15583
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 15578-15583
    • Forster, C.1    Makela, S.2    Warri, A.3    Kietz, S.4    Becker, D.5    Hultenby, K.6
  • 5
    • 28744458215 scopus 로고    scopus 로고
    • Clinical significance of estrogen receptor beta in breast cancer
    • Saji S., Hirose M., and Toi M. Clinical significance of estrogen receptor beta in breast cancer. Cancer Chemother. Pharmacol. 56 Suppl. 1 (2005) 21-26
    • (2005) Cancer Chemother. Pharmacol. , vol.56 , Issue.SUPPL. 1 , pp. 21-26
    • Saji, S.1    Hirose, M.2    Toi, M.3
  • 6
    • 33745111199 scopus 로고    scopus 로고
    • Is oestrogen receptor-beta a predictor of endocrine therapy responsiveness in human breast cancer?
    • Murphy L.C., and Watson P.H. Is oestrogen receptor-beta a predictor of endocrine therapy responsiveness in human breast cancer?. Endocr. Relat. Cancer 13 (2006) 327-334
    • (2006) Endocr. Relat. Cancer , vol.13 , pp. 327-334
    • Murphy, L.C.1    Watson, P.H.2
  • 7
    • 33644550627 scopus 로고    scopus 로고
    • Estrogen receptor (ER) beta modulates ER alpha-mediated transcriptional activation by altering the recruitment of c-fos and c-jun to estrogen-responsive promoters
    • Matthews J., Wihlen B., Tujague M., Wan J., Strom A., and Gustafsson J.A. Estrogen receptor (ER) beta modulates ER alpha-mediated transcriptional activation by altering the recruitment of c-fos and c-jun to estrogen-responsive promoters. Mol. Endocrinol. 20 (2006) 534-543
    • (2006) Mol. Endocrinol. , vol.20 , pp. 534-543
    • Matthews, J.1    Wihlen, B.2    Tujague, M.3    Wan, J.4    Strom, A.5    Gustafsson, J.A.6
  • 8
    • 27144524273 scopus 로고    scopus 로고
    • Estrogen receptors alpha (ER alpha) and beta (ER beta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11
    • Helguero L.A., Faulds M.H., Gustafsson J.A., and Haldosen L.A. Estrogen receptors alpha (ER alpha) and beta (ER beta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene 24 (2005) 6605-6616
    • (2005) Oncogene , vol.24 , pp. 6605-6616
    • Helguero, L.A.1    Faulds, M.H.2    Gustafsson, J.A.3    Haldosen, L.A.4
  • 9
    • 3042681155 scopus 로고    scopus 로고
    • Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ER beta in human osteosarcoma cells: distinct and common target genes for these receptors
    • Stossi F., Barnett D.H., Frasor J., Komm B., Lyttle C.R., and Katzenellenbogen B.S. Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ER beta in human osteosarcoma cells: distinct and common target genes for these receptors. Endocrinology 145 (2004) 3473-3486
    • (2004) Endocrinology , vol.145 , pp. 3473-3486
    • Stossi, F.1    Barnett, D.H.2    Frasor, J.3    Komm, B.4    Lyttle, C.R.5    Katzenellenbogen, B.S.6
  • 10
    • 33748743807 scopus 로고    scopus 로고
    • Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells
    • Chang E.C., Frasor J., Komm B., and Katzenellenbogen B.S. Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells. Endocrinology 147 (2006) 4831-4842
    • (2006) Endocrinology , vol.147 , pp. 4831-4842
    • Chang, E.C.1    Frasor, J.2    Komm, B.3    Katzenellenbogen, B.S.4
  • 11
    • 27844511538 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators (SERMs): mechanisms of anticarcinogenesis and drug resistance
    • Lewis J.S., and Jordan V.C. Selective estrogen receptor modulators (SERMs): mechanisms of anticarcinogenesis and drug resistance. Mutat. Res. 591 (2005) 247-263
    • (2005) Mutat. Res. , vol.591 , pp. 247-263
    • Lewis, J.S.1    Jordan, V.C.2
  • 12
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • Fisher B., Costantino J.P., Wickerham D.L., Redmond C.K., Kavanah M., Cronin W.M., et al. Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J. Natl. Cancer Inst. 90 (1998) 1371-1388
    • (1998) J. Natl. Cancer Inst. , vol.90 , pp. 1371-1388
    • Fisher, B.1    Costantino, J.P.2    Wickerham, D.L.3    Redmond, C.K.4    Kavanah, M.5    Cronin, W.M.6
  • 13
    • 18744383698 scopus 로고    scopus 로고
    • Non-steroidal subtype selective estrogens
    • Veeneman G.H. Non-steroidal subtype selective estrogens. Curr. Med. Chem. 12 (2005) 1077-1136
    • (2005) Curr. Med. Chem. , vol.12 , pp. 1077-1136
    • Veeneman, G.H.1
  • 14
    • 33646473146 scopus 로고    scopus 로고
    • Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta
    • Escande A., Pillon A., Servant N., Cravedi J.P., Larrea F., Muhn P., et al. Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta. Biochem. Pharmacol. 71 (2006) 1459-1469
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1459-1469
    • Escande, A.1    Pillon, A.2    Servant, N.3    Cravedi, J.P.4    Larrea, F.5    Muhn, P.6
  • 16
    • 12144261535 scopus 로고    scopus 로고
    • TAS-108: a novel steroidal antiestrogen
    • Buzdar A.U. TAS-108: a novel steroidal antiestrogen. Clin. Cancer Res. 11 (2005) 906S-908S
    • (2005) Clin. Cancer Res. , vol.11
    • Buzdar, A.U.1
  • 17
    • 33751080415 scopus 로고    scopus 로고
    • Pure oestrogen antagonists for the treatment of advanced breast cancer
    • Howell A. Pure oestrogen antagonists for the treatment of advanced breast cancer. Endocr. Relat. Cancer 13 (2006) 689-706
    • (2006) Endocr. Relat. Cancer , vol.13 , pp. 689-706
    • Howell, A.1
  • 18
    • 1842684035 scopus 로고    scopus 로고
    • Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action
    • Osborne C.K., Wakeling A., and Nicholson R.I. Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action. Br. J. Cancer 90 Suppl. 1 (2004) S2-S6
    • (2004) Br. J. Cancer , vol.90 , Issue.SUPPL. 1
    • Osborne, C.K.1    Wakeling, A.2    Nicholson, R.I.3
  • 19
    • 33749369815 scopus 로고    scopus 로고
    • Update on the use of aromatase inhibitors in breast cancer
    • Brueggemeier R.W. Update on the use of aromatase inhibitors in breast cancer. Expert Opin. Pharmacother. 7 (2006) 1919-1930
    • (2006) Expert Opin. Pharmacother. , vol.7 , pp. 1919-1930
    • Brueggemeier, R.W.1
  • 20
    • 27744501473 scopus 로고    scopus 로고
    • Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer
    • Riggins R.B., Bouton A.H., Liu M.C., and Clarke R. Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer. Vitam. Horm. 71 (2005) 201-237
    • (2005) Vitam. Horm. , vol.71 , pp. 201-237
    • Riggins, R.B.1    Bouton, A.H.2    Liu, M.C.3    Clarke, R.4
  • 22
    • 0034623995 scopus 로고    scopus 로고
    • A pure estrogen antagonist inhibits cyclin E-CDK2 activity in MCF-7 breast cancer cells and induces accumulation of p130-E2F4 complexes characteristic of quiescence
    • Carroll J.S., Prall O.W., Musgrove E.A., and Sutherland R.L. A pure estrogen antagonist inhibits cyclin E-CDK2 activity in MCF-7 breast cancer cells and induces accumulation of p130-E2F4 complexes characteristic of quiescence. J. Biol. Chem. 275 (2000) 38221-38229
    • (2000) J. Biol. Chem. , vol.275 , pp. 38221-38229
    • Carroll, J.S.1    Prall, O.W.2    Musgrove, E.A.3    Sutherland, R.L.4
  • 23
    • 0037549328 scopus 로고    scopus 로고
    • Additive effects of tamoxifen and the farnesyl transferase inhibitor FTI-277 on inhibition of MCF-7 breast cancer cell-cycle progression
    • Doisneau-Sixou S.F., Cestac P., Faye J.C., Favre G., and Sutherland R.L. Additive effects of tamoxifen and the farnesyl transferase inhibitor FTI-277 on inhibition of MCF-7 breast cancer cell-cycle progression. Int. J. Cancer 106 (2003) 789-798
    • (2003) Int. J. Cancer , vol.106 , pp. 789-798
    • Doisneau-Sixou, S.F.1    Cestac, P.2    Faye, J.C.3    Favre, G.4    Sutherland, R.L.5
  • 24
    • 0344844463 scopus 로고    scopus 로고
    • Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens
    • Thiantanawat A., Long B.J., and Brodie A.M. Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens. Cancer Res. 63 (2003) 8037-8050
    • (2003) Cancer Res. , vol.63 , pp. 8037-8050
    • Thiantanawat, A.1    Long, B.J.2    Brodie, A.M.3
  • 25
    • 2542531457 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant)
    • Bouker K.B., Skaar T.C., Fernandez D.R., O'Brien K.A., Riggins R.B., Cao D., et al. Interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant). Cancer Res. 64 (2004) 4030-4039
    • (2004) Cancer Res. , vol.64 , pp. 4030-4039
    • Bouker, K.B.1    Skaar, T.C.2    Fernandez, D.R.3    O'Brien, K.A.4    Riggins, R.B.5    Cao, D.6
  • 27
    • 4444278403 scopus 로고    scopus 로고
    • HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a Southwest Oncology Group Study
    • Arpino G., Green S.J., Allred D.C., Lew D., Martino S., Osborne C.K., et al. HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a Southwest Oncology Group Study. Clin. Cancer Res. 10 (2004) 5670-5676
    • (2004) Clin. Cancer Res. , vol.10 , pp. 5670-5676
    • Arpino, G.1    Green, S.J.2    Allred, D.C.3    Lew, D.4    Martino, S.5    Osborne, C.K.6
  • 28
    • 25844468319 scopus 로고    scopus 로고
    • Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer
    • Gee J.M., Robertson J.F., Gutteridge E., Ellis I.O., Pinder S.E., Rubini M., et al. Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer. Endocr. Relat. Cancer 12 Suppl. 1 (2005) S99-S111
    • (2005) Endocr. Relat. Cancer , vol.12 , Issue.SUPPL. 1
    • Gee, J.M.1    Robertson, J.F.2    Gutteridge, E.3    Ellis, I.O.4    Pinder, S.E.5    Rubini, M.6
  • 29
    • 25844461778 scopus 로고    scopus 로고
    • Growth factor signalling and response to endocrine therapy: The Royal Marsden Experience
    • Dowsett M., Johnston S., Martin L.A., Salter J., Hills M., Detre S., et al. Growth factor signalling and response to endocrine therapy: The Royal Marsden Experience. Endocr. Relat. Cancer 12 Suppl. 1 (2005) S113-S117
    • (2005) Endocr. Relat. Cancer , vol.12 , Issue.SUPPL. 1
    • Dowsett, M.1    Johnston, S.2    Martin, L.A.3    Salter, J.4    Hills, M.5    Detre, S.6
  • 30
    • 17844398046 scopus 로고    scopus 로고
    • Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase
    • Gutierrez M.C., Detre S., Johnston S., Mohsin S.K., Shou J., Allred D.C., et al. Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase. J. Clin. Oncol. 23 (2005) 2469-2476
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2469-2476
    • Gutierrez, M.C.1    Detre, S.2    Johnston, S.3    Mohsin, S.K.4    Shou, J.5    Allred, D.C.6
  • 31
    • 26044443105 scopus 로고    scopus 로고
    • AKT activation predicts outcome in breast cancer patients treated with tamoxifen
    • Kirkegaard T., Witton C.J., McGlynn L.M., Tovey S.M., Dunne B., Lyon A., et al. AKT activation predicts outcome in breast cancer patients treated with tamoxifen. J. Pathol. 207 (2005) 139-146
    • (2005) J. Pathol. , vol.207 , pp. 139-146
    • Kirkegaard, T.1    Witton, C.J.2    McGlynn, L.M.3    Tovey, S.M.4    Dunne, B.5    Lyon, A.6
  • 32
    • 33646940460 scopus 로고    scopus 로고
    • Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients
    • Holm C., Rayala S., Jirstrom K., Stal O., Kumar R., and Landberg G. Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients. J. Natl. Cancer Inst. 98 (2006) 671-680
    • (2006) J. Natl. Cancer Inst. , vol.98 , pp. 671-680
    • Holm, C.1    Rayala, S.2    Jirstrom, K.3    Stal, O.4    Kumar, R.5    Landberg, G.6
  • 34
    • 0037420192 scopus 로고    scopus 로고
    • Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer
    • Osborne C.K., Bardou V., Hopp T.A., Chamness G.C., Hilsenbeck S.G., Fuqua S.A., et al. Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer. J. Natl. Cancer Inst. 95 (2003) 353-361
    • (2003) J. Natl. Cancer Inst. , vol.95 , pp. 353-361
    • Osborne, C.K.1    Bardou, V.2    Hopp, T.A.3    Chamness, G.C.4    Hilsenbeck, S.G.5    Fuqua, S.A.6
  • 35
    • 33751101625 scopus 로고    scopus 로고
    • Phosphorylation of ER alpha at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ER alpha phosphorylation in breast cancer progression
    • Sarwar N., Kim J.S., Jiang J., Peston D., Sinnett H.D., Madden P., et al. Phosphorylation of ER alpha at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ER alpha phosphorylation in breast cancer progression. Endocr. Relat. Cancer 13 (2006) 851-861
    • (2006) Endocr. Relat. Cancer , vol.13 , pp. 851-861
    • Sarwar, N.1    Kim, J.S.2    Jiang, J.3    Peston, D.4    Sinnett, H.D.5    Madden, P.6
  • 37
    • 33644787057 scopus 로고    scopus 로고
    • A multimarker model to predict outcome in tamoxifen-treated breast cancer patients
    • Linke S.P., Bremer T.M., Herold C.D., Sauter G., and Diamond C. A multimarker model to predict outcome in tamoxifen-treated breast cancer patients. Clin. Cancer Res. 12 (2006) 1175-1183
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1175-1183
    • Linke, S.P.1    Bremer, T.M.2    Herold, C.D.3    Sauter, G.4    Diamond, C.5
  • 38
    • 33845923201 scopus 로고    scopus 로고
    • Overexpression of c-Myc and Bcl-2 during progression and distant metastasis of hormone-treated breast cancer
    • Planas-Silva M.D., Bruggeman R.D., Grenko R.T., and Smith J.S. Overexpression of c-Myc and Bcl-2 during progression and distant metastasis of hormone-treated breast cancer. Exp. Mol. Pathol. 82 (2007) 85-90
    • (2007) Exp. Mol. Pathol. , vol.82 , pp. 85-90
    • Planas-Silva, M.D.1    Bruggeman, R.D.2    Grenko, R.T.3    Smith, J.S.4
  • 39
    • 32244436889 scopus 로고    scopus 로고
    • Adverse outcome and resistance to adjuvant antiestrogen therapy in node-positive postmenopausal breast cancer patients-the role of p53
    • Rahko E., Blanco G., Bloigu R., Soini Y., Talvensaari-Mattila A., and Jukkola A. Adverse outcome and resistance to adjuvant antiestrogen therapy in node-positive postmenopausal breast cancer patients-the role of p53. Breast 15 (2006) 69-75
    • (2006) Breast , vol.15 , pp. 69-75
    • Rahko, E.1    Blanco, G.2    Bloigu, R.3    Soini, Y.4    Talvensaari-Mattila, A.5    Jukkola, A.6
  • 41
    • 4344632533 scopus 로고    scopus 로고
    • The molecular determinants of estrogen receptor pharmacology
    • McDonnell D.P. The molecular determinants of estrogen receptor pharmacology. Maturitas 48 Suppl. 1 (2004) S7-S12
    • (2004) Maturitas , vol.48 , Issue.SUPPL. 1
    • McDonnell, D.P.1
  • 42
    • 0030801841 scopus 로고    scopus 로고
    • Differential ligand activation of estrogen receptors ER alpha and ER beta at AP1 sites
    • Paech K., Webb P., Kuiper G.G., Nilsson S., Gustafsson J., Kushner P.J., et al. Differential ligand activation of estrogen receptors ER alpha and ER beta at AP1 sites. Science 277 (1997) 1508-1510
    • (1997) Science , vol.277 , pp. 1508-1510
    • Paech, K.1    Webb, P.2    Kuiper, G.G.3    Nilsson, S.4    Gustafsson, J.5    Kushner, P.J.6
  • 43
    • 0032965145 scopus 로고    scopus 로고
    • Estrogen receptor beta activates the human retinoic acid receptor alpha-1 promoter in response to tamoxifen and other estrogen receptor antagonists, but not in response to estrogen
    • Zou A., Marschke K.B., Arnold K.E., Berger E.M., Fitzgerald P., Mais D.E., et al. Estrogen receptor beta activates the human retinoic acid receptor alpha-1 promoter in response to tamoxifen and other estrogen receptor antagonists, but not in response to estrogen. Mol. Endocrinol. 13 (1999) 418-430
    • (1999) Mol. Endocrinol. , vol.13 , pp. 418-430
    • Zou, A.1    Marschke, K.B.2    Arnold, K.E.3    Berger, E.M.4    Fitzgerald, P.5    Mais, D.E.6
  • 44
    • 1442351143 scopus 로고    scopus 로고
    • Coregulator function: a key to understanding tissue specificity of selective receptor modulators
    • Smith C.L., and O'Malley B.W. Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr. Rev. 25 (2004) 45-71
    • (2004) Endocr. Rev. , vol.25 , pp. 45-71
    • Smith, C.L.1    O'Malley, B.W.2
  • 45
    • 30344479480 scopus 로고    scopus 로고
    • Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting
    • Hall J.M., and McDonnell D.P. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Mol. Interv. 5 (2005) 343-357
    • (2005) Mol. Interv. , vol.5 , pp. 343-357
    • Hall, J.M.1    McDonnell, D.P.2
  • 46
    • 17144416838 scopus 로고    scopus 로고
    • The clinical relevance of steroid hormone receptor corepressors
    • Kumar R., Gururaj A.E., Vadlamudi R.K., and Rayala S.K. The clinical relevance of steroid hormone receptor corepressors. Clin. Cancer Res. 11 (2005) 2822-2831
    • (2005) Clin. Cancer Res. , vol.11 , pp. 2822-2831
    • Kumar, R.1    Gururaj, A.E.2    Vadlamudi, R.K.3    Rayala, S.K.4
  • 47
    • 33745699885 scopus 로고    scopus 로고
    • Role of estrogen receptor alpha transcriptional coregulators in tamoxifen resistance in breast cancer
    • Girault I., Bieche I., and Lidereau R. Role of estrogen receptor alpha transcriptional coregulators in tamoxifen resistance in breast cancer. Maturitas 54 (2006) 342-351
    • (2006) Maturitas , vol.54 , pp. 342-351
    • Girault, I.1    Bieche, I.2    Lidereau, R.3
  • 48
    • 0035101145 scopus 로고    scopus 로고
    • Cellular and molecular pharmacology of antiestrogen action and resistance
    • Clarke R., Leonessa F., Welch J.N., and Skaar T.C. Cellular and molecular pharmacology of antiestrogen action and resistance. Pharmacol. Rev. 53 (2001) 25-71
    • (2001) Pharmacol. Rev. , vol.53 , pp. 25-71
    • Clarke, R.1    Leonessa, F.2    Welch, J.N.3    Skaar, T.C.4
  • 49
    • 0002426053 scopus 로고    scopus 로고
    • Treatment of metastatic disease: hormonal therapy and chemotherapy
    • Harris J.R., Lippman M.E., Morrow M., and Helman S. (Eds), Lippincott-Raven, Philadelphia
    • Honig S.F. Treatment of metastatic disease: hormonal therapy and chemotherapy. In: Harris J.R., Lippman M.E., Morrow M., and Helman S. (Eds). Diseases of the Breast (1996), Lippincott-Raven, Philadelphia 669-734
    • (1996) Diseases of the Breast , pp. 669-734
    • Honig, S.F.1
  • 50
    • 0028318783 scopus 로고
    • Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells
    • Ottaviano Y.L., Issa J.P., Parl F.F., Smith H.S., Baylin S.B., and Davidson N.E. Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Res. 54 (1994) 2552-2555
    • (1994) Cancer Res. , vol.54 , pp. 2552-2555
    • Ottaviano, Y.L.1    Issa, J.P.2    Parl, F.F.3    Smith, H.S.4    Baylin, S.B.5    Davidson, N.E.6
  • 51
    • 0028934347 scopus 로고
    • Estrogen receptor gene analysis in estrogen receptor-positive and receptor-negative primary breast cancer
    • Roodi N., Bailey L.R., Kao W.Y., Verrier C.S., Yee C.J., Dupont W.D., et al. Estrogen receptor gene analysis in estrogen receptor-positive and receptor-negative primary breast cancer. J. Natl. Cancer Inst. 87 (1995) 446-451
    • (1995) J. Natl. Cancer Inst. , vol.87 , pp. 446-451
    • Roodi, N.1    Bailey, L.R.2    Kao, W.Y.3    Verrier, C.S.4    Yee, C.J.5    Dupont, W.D.6
  • 52
    • 33745685866 scopus 로고    scopus 로고
    • Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes
    • Sharma D., Saxena N.K., Davidson N.E., and Vertino P.M. Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Cancer Res. 66 (2006) 6370-6378
    • (2006) Cancer Res. , vol.66 , pp. 6370-6378
    • Sharma, D.1    Saxena, N.K.2    Davidson, N.E.3    Vertino, P.M.4
  • 53
    • 31444449552 scopus 로고    scopus 로고
    • Epigenetic information and estrogen receptor alpha expression in breast cancer
    • Giacinti L., Claudio P.P., Lopez M., and Giordano A. Epigenetic information and estrogen receptor alpha expression in breast cancer. Oncologist 11 (2006) 1-8
    • (2006) Oncologist , vol.11 , pp. 1-8
    • Giacinti, L.1    Claudio, P.P.2    Lopez, M.3    Giordano, A.4
  • 54
    • 0026450958 scopus 로고
    • Activation of estrogen receptor transfected into a receptor-negative breast cancer cell line decreases the metastatic and invasive potential of the cells
    • Garcia M., Derocq D., Freiss G., and Rochefort H. Activation of estrogen receptor transfected into a receptor-negative breast cancer cell line decreases the metastatic and invasive potential of the cells. Proc. Natl. Acad. Sci. USA 89 (1992) 11538-11542
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11538-11542
    • Garcia, M.1    Derocq, D.2    Freiss, G.3    Rochefort, H.4
  • 55
    • 0029113686 scopus 로고
    • Changes in estrogen receptor, progesterone receptor, and PS2 expression in tamoxifen-resistant human breast cancer
    • Johnston S.R., Saccani-Jotti G., Smith I.E., Salter J., Newby J., Coppen M., et al. Changes in estrogen receptor, progesterone receptor, and PS2 expression in tamoxifen-resistant human breast cancer. Cancer Res. 55 (1995) 3331-3338
    • (1995) Cancer Res. , vol.55 , pp. 3331-3338
    • Johnston, S.R.1    Saccani-Jotti, G.2    Smith, I.E.3    Salter, J.4    Newby, J.5    Coppen, M.6
  • 58
    • 0024514882 scopus 로고
    • Characterisation of a tamoxifen-resistant variant of the ZR-75-1 human breast cancer cell line (ZR-75-9a1) and ability of the resistant phenotype
    • van den Berg H.W., Lynch M., Martin J., Nelson J., Dickson G.R., and Crockard A.D. Characterisation of a tamoxifen-resistant variant of the ZR-75-1 human breast cancer cell line (ZR-75-9a1) and ability of the resistant phenotype. Br. J. Cancer 59 (1989) 522-526
    • (1989) Br. J. Cancer , vol.59 , pp. 522-526
    • van den Berg, H.W.1    Lynch, M.2    Martin, J.3    Nelson, J.4    Dickson, G.R.5    Crockard, A.D.6
  • 59
    • 0037534310 scopus 로고    scopus 로고
    • Studies on the development of resistance to the pure antiestrogen faslodex in three human breast cancer cell lines
    • Sommer A., Hoffmann J., Lichtner R.B., Schneider M.R., and Parczyk K. Studies on the development of resistance to the pure antiestrogen faslodex in three human breast cancer cell lines. J. Steroid Biochem. Mol. Biol. 85 (2003) 33-47
    • (2003) J. Steroid Biochem. Mol. Biol. , vol.85 , pp. 33-47
    • Sommer, A.1    Hoffmann, J.2    Lichtner, R.B.3    Schneider, M.R.4    Parczyk, K.5
  • 60
    • 33846207899 scopus 로고    scopus 로고
    • Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant
    • Fan M., Yan P.S., Hartman-Frey C., Chen L., Paik H., Oyer S.L., et al. Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant. Cancer Res. 66 (2006) 11954-11966
    • (2006) Cancer Res. , vol.66 , pp. 11954-11966
    • Fan, M.1    Yan, P.S.2    Hartman-Frey, C.3    Chen, L.4    Paik, H.5    Oyer, S.L.6
  • 61
    • 0030753406 scopus 로고    scopus 로고
    • Resistance of human breast-cancer cells to the pure steroidal anti-estrogen ICI 182,780 is not associated with a general loss of estrogen-receptor expression or lack of estrogen responsiveness
    • Larsen S.S., Madsen M.W., Jensen B.L., and Lykkesfeldt A.E. Resistance of human breast-cancer cells to the pure steroidal anti-estrogen ICI 182,780 is not associated with a general loss of estrogen-receptor expression or lack of estrogen responsiveness. Int. J. Cancer 72 (1997) 1129-1136
    • (1997) Int. J. Cancer , vol.72 , pp. 1129-1136
    • Larsen, S.S.1    Madsen, M.W.2    Jensen, B.L.3    Lykkesfeldt, A.E.4
  • 62
    • 0032945122 scopus 로고    scopus 로고
    • Differential regulation of specific genes in MCF-7 and the ICI 182780-resistant cell line MCF-7/182R-6
    • Jensen B.L., Skouv J., Lundholt B.K., and Lykkesfeldt A.E. Differential regulation of specific genes in MCF-7 and the ICI 182780-resistant cell line MCF-7/182R-6. Br. J. Cancer 79 (1999) 386-392
    • (1999) Br. J. Cancer , vol.79 , pp. 386-392
    • Jensen, B.L.1    Skouv, J.2    Lundholt, B.K.3    Lykkesfeldt, A.E.4
  • 63
    • 15644377090 scopus 로고    scopus 로고
    • MCF7/LCC9: an antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifen
    • Brunner N., Boysen B., Jirus S., Skaar T.C., Holst-Hansen C., Lippman J., et al. MCF7/LCC9: an antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifen. Cancer Res. 57 (1997) 3486-3493
    • (1997) Cancer Res. , vol.57 , pp. 3486-3493
    • Brunner, N.1    Boysen, B.2    Jirus, S.3    Skaar, T.C.4    Holst-Hansen, C.5    Lippman, J.6
  • 64
    • 0027400210 scopus 로고
    • Acquisition of hormone-independent growth in MCF-7 cells is accompanied by increased expression of estrogen-regulated genes but without detectable DNA amplifications
    • Brunner N., Boulay V., Fojo A., Freter C.E., Lippman M.E., and Clarke R. Acquisition of hormone-independent growth in MCF-7 cells is accompanied by increased expression of estrogen-regulated genes but without detectable DNA amplifications. Cancer Res. 53 (1993) 283-290
    • (1993) Cancer Res. , vol.53 , pp. 283-290
    • Brunner, N.1    Boulay, V.2    Fojo, A.3    Freter, C.E.4    Lippman, M.E.5    Clarke, R.6
  • 65
    • 33846827373 scopus 로고    scopus 로고
    • Endocrine therapy resistance can be associated with high estrogen receptor α (ERα) expression and reduced ERα phosphorylation in breast cancer models
    • Kuske B., Naughton C., Moore K., Macleod K.G., Miller W.R., Clarke R., et al. Endocrine therapy resistance can be associated with high estrogen receptor α (ERα) expression and reduced ERα phosphorylation in breast cancer models. Endocr. Relat. Cancer 13 (2006) 1121-1133
    • (2006) Endocr. Relat. Cancer , vol.13 , pp. 1121-1133
    • Kuske, B.1    Naughton, C.2    Moore, K.3    Macleod, K.G.4    Miller, W.R.5    Clarke, R.6
  • 66
    • 13944282293 scopus 로고    scopus 로고
    • The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells
    • Riggins R.B., Zwart A., Nehra R., and Clarke R. The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells. Mol. Cancer Ther. 4 (2005) 33-41
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 33-41
    • Riggins, R.B.1    Zwart, A.2    Nehra, R.3    Clarke, R.4
  • 67
    • 32544448788 scopus 로고    scopus 로고
    • Fulvestrant ('faslodex'): current and future role in breast cancer management
    • Howell A. Fulvestrant ('faslodex'): current and future role in breast cancer management. Crit. Rev. Oncol. Hematol. 57 (2006) 265-273
    • (2006) Crit. Rev. Oncol. Hematol. , vol.57 , pp. 265-273
    • Howell, A.1
  • 68
    • 0025195407 scopus 로고
    • CO cells, genetically unstable and containing estrogen receptor mutations, are a model for the progression of breast cancers to hormone resistance
    • CO cells, genetically unstable and containing estrogen receptor mutations, are a model for the progression of breast cancers to hormone resistance. Cancer Res. 50 (1990) 6208-6217
    • (1990) Cancer Res. , vol.50 , pp. 6208-6217
    • Graham II, M.L.1    Krett, N.L.2    Miller, L.A.3    Leslie, K.K.4    Gordon, D.F.5    Wood, W.M.6
  • 69
    • 0026559007 scopus 로고
    • Heterogeneity of progesterone receptor content and remodeling by tamoxifen characterize subpopulations of cultured human breast cancer cells: analysis by quantitative dual parameter flow cytometry
    • Graham II M.L., Smith J.A., Jewett P.B., and Horwitz K.B. Heterogeneity of progesterone receptor content and remodeling by tamoxifen characterize subpopulations of cultured human breast cancer cells: analysis by quantitative dual parameter flow cytometry. Cancer Res. 52 (1992) 593-602
    • (1992) Cancer Res. , vol.52 , pp. 593-602
    • Graham II, M.L.1    Smith, J.A.2    Jewett, P.B.3    Horwitz, K.B.4
  • 70
    • 10644274482 scopus 로고    scopus 로고
    • Estrogen receptor mutations in human disease
    • Herynk M.H., and Fuqua S.A. Estrogen receptor mutations in human disease. Endocr. Rev. 25 (2004) 869-898
    • (2004) Endocr. Rev. , vol.25 , pp. 869-898
    • Herynk, M.H.1    Fuqua, S.A.2
  • 71
    • 0029865898 scopus 로고    scopus 로고
    • A novel 80 kDa human estrogen receptor containing a duplication of exons 6 and 7
    • Pink J.J., Wu S.Q., Wolf D.M., Bilimoria M.M., and Jordan V.C. A novel 80 kDa human estrogen receptor containing a duplication of exons 6 and 7. Nucleic Acids Res. 24 (1996) 962-969
    • (1996) Nucleic Acids Res. , vol.24 , pp. 962-969
    • Pink, J.J.1    Wu, S.Q.2    Wolf, D.M.3    Bilimoria, M.M.4    Jordan, V.C.5
  • 72
  • 73
    • 0030940071 scopus 로고    scopus 로고
    • An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer
    • Zhang Q.X., Borg A., Wolf D.M., Oesterreich S., and Fuqua S.A. An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer. Cancer Res. 57 (1997) 1244-1249
    • (1997) Cancer Res. , vol.57 , pp. 1244-1249
    • Zhang, Q.X.1    Borg, A.2    Wolf, D.M.3    Oesterreich, S.4    Fuqua, S.A.5
  • 75
    • 0042309797 scopus 로고    scopus 로고
    • Estrogen receptor alpha mutation (A-to-G transition at nucleotide 908) is not found in different types of breast lesions from Japanese women
    • Zhang Z., Yamashita H., Toyama T., Omoto Y., Sugiura H., Hara Y., et al. Estrogen receptor alpha mutation (A-to-G transition at nucleotide 908) is not found in different types of breast lesions from Japanese women. Breast Cancer 10 (2003) 70-73
    • (2003) Breast Cancer , vol.10 , pp. 70-73
    • Zhang, Z.1    Yamashita, H.2    Toyama, T.3    Omoto, Y.4    Sugiura, H.5    Hara, Y.6
  • 76
    • 0043163868 scopus 로고    scopus 로고
    • EGFR family signaling and its association with breast cancer development and resistance to chemotherapy
    • Navolanic P.M., Steelman L.S., and McCubrey J.A. EGFR family signaling and its association with breast cancer development and resistance to chemotherapy. Int. J. Oncol. 22 (2003) 237-252
    • (2003) Int. J. Oncol. , vol.22 , pp. 237-252
    • Navolanic, P.M.1    Steelman, L.S.2    McCubrey, J.A.3
  • 77
    • 9144251561 scopus 로고    scopus 로고
    • Nonendocrine pathways and endocrine resistance: observations with antiestrogens and signal transduction inhibitors in combination
    • Nicholson R.I., Hutcheson I.R., Knowlden J.M., Jones H.E., Harper M.E., Jordan N., et al. Nonendocrine pathways and endocrine resistance: observations with antiestrogens and signal transduction inhibitors in combination. Clin. Cancer Res. 10 (2004) 346S-354S
    • (2004) Clin. Cancer Res. , vol.10
    • Nicholson, R.I.1    Hutcheson, I.R.2    Knowlden, J.M.3    Jones, H.E.4    Harper, M.E.5    Jordan, N.6
  • 79
    • 0034667395 scopus 로고    scopus 로고
    • Inhibition of HER2/neu (ErbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells
    • Kurokawa H., Lenferink A.E., Simpson J.F., Pisacane P.I., Sliwkowski M.X., Forbes J.T., et al. Inhibition of HER2/neu (ErbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. Cancer Res. 60 (2000) 5887-5894
    • (2000) Cancer Res. , vol.60 , pp. 5887-5894
    • Kurokawa, H.1    Lenferink, A.E.2    Simpson, J.F.3    Pisacane, P.I.4    Sliwkowski, M.X.5    Forbes, J.T.6
  • 80
    • 0035664786 scopus 로고    scopus 로고
    • Inhibition of ErbB receptor (HER) tyrosine kinases as a strategy to abrogate antiestrogen resistance in human breast cancer
    • discussion 4411S-4412S
    • Kurokawa H., and Arteaga C.L. Inhibition of ErbB receptor (HER) tyrosine kinases as a strategy to abrogate antiestrogen resistance in human breast cancer. Clin. Cancer Res. 7 (2001) 4436S-4442S discussion 4411S-4412S
    • (2001) Clin. Cancer Res. , vol.7
    • Kurokawa, H.1    Arteaga, C.L.2
  • 81
    • 0037240275 scopus 로고    scopus 로고
    • ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms
    • Kurokawa H., and Arteaga C.L. ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms. Clin. Cancer Res. 9 (2003) 511S-515S
    • (2003) Clin. Cancer Res. , vol.9
    • Kurokawa, H.1    Arteaga, C.L.2
  • 82
    • 0034987631 scopus 로고    scopus 로고
    • Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (faslodex)
    • McClelland R.A., Barrow D., Madden T.A., Dutkowski C.M., Pamment J., Knowlden J.M., et al. Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (faslodex). Endocrinology 142 (2001) 2776-2788
    • (2001) Endocrinology , vol.142 , pp. 2776-2788
    • McClelland, R.A.1    Barrow, D.2    Madden, T.A.3    Dutkowski, C.M.4    Pamment, J.5    Knowlden, J.M.6
  • 83
    • 0037373326 scopus 로고    scopus 로고
    • Elevated levels of epidermal growth factor receptor/c-ErbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
    • Knowlden J.M., Hutcheson I.R., Jones H.E., Madden T., Gee J.M., Harper M.E., et al. Elevated levels of epidermal growth factor receptor/c-ErbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 144 (2003) 1032-1044
    • (2003) Endocrinology , vol.144 , pp. 1032-1044
    • Knowlden, J.M.1    Hutcheson, I.R.2    Jones, H.E.3    Madden, T.4    Gee, J.M.5    Harper, M.E.6
  • 85
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn J., and Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 19 (2000) 6550-6565
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 86
    • 0035036735 scopus 로고    scopus 로고
    • Estrogen suppression of EGFR expression in breast cancer cells: a possible mechanism to modulate growth
    • Yarden R.I., Wilson M.A., and Chrysogelos S.A. Estrogen suppression of EGFR expression in breast cancer cells: a possible mechanism to modulate growth. J. Cell. Biochem. 81 (2001) 232-246
    • (2001) J. Cell. Biochem. , vol.81 , pp. 232-246
    • Yarden, R.I.1    Wilson, M.A.2    Chrysogelos, S.A.3
  • 87
    • 0242721012 scopus 로고    scopus 로고
    • The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro
    • Gee J.M., Harper M.E., Hutcheson I.R., Madden T.A., Barrow D., Knowlden J.M., et al. The antiepidermal growth factor receptor agent gefitinib (ZD1839/Iressa) improves antihormone response and prevents development of resistance in breast cancer in vitro. Endocrinology 144 (2003) 5105-5117
    • (2003) Endocrinology , vol.144 , pp. 5105-5117
    • Gee, J.M.1    Harper, M.E.2    Hutcheson, I.R.3    Madden, T.A.4    Barrow, D.5    Knowlden, J.M.6
  • 88
    • 0842286818 scopus 로고    scopus 로고
    • Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (faslodex, ICI 182,780) in breast cancer cells
    • Okubo S., Kurebayashi J., Otsuki T., Yamamoto Y., Tanaka K., and Sonoo H. Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (faslodex, ICI 182,780) in breast cancer cells. Br. J. Cancer 90 (2004) 236-244
    • (2004) Br. J. Cancer , vol.90 , pp. 236-244
    • Okubo, S.1    Kurebayashi, J.2    Otsuki, T.3    Yamamoto, Y.4    Tanaka, K.5    Sonoo, H.6
  • 89
    • 0029888125 scopus 로고    scopus 로고
    • Overexpression of HER2 modulates Bcl-2, Bcl-xL, and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells
    • Kumar R., Mandal M., Lipton A., Harvey H., and Thompson C.B. Overexpression of HER2 modulates Bcl-2, Bcl-xL, and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells. Clin. Cancer Res. 2 (1996) 1215-1219
    • (1996) Clin. Cancer Res. , vol.2 , pp. 1215-1219
    • Kumar, R.1    Mandal, M.2    Lipton, A.3    Harvey, H.4    Thompson, C.B.5
  • 90
    • 2942652871 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
    • Shou J., Massarweh S., Osborne C.K., Wakeling A.E., Ali S., Weiss H., et al. Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J. Natl. Cancer Inst. 96 (2004) 926-935
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 926-935
    • Shou, J.1    Massarweh, S.2    Osborne, C.K.3    Wakeling, A.E.4    Ali, S.5    Weiss, H.6
  • 91
    • 0036318571 scopus 로고    scopus 로고
    • Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation
    • Lee H., and Bai W. Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation. Mol. Cell. Biol. 22 (2002) 5835-5845
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5835-5845
    • Lee, H.1    Bai, W.2
  • 92
    • 33746883110 scopus 로고    scopus 로고
    • Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b
    • Riggins R.B., Thomas K.S., Ta H.Q., Wen J., Davis R.J., Schuh N.R., et al. Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b. Cancer Res. 66 (2006) 7007-7015
    • (2006) Cancer Res. , vol.66 , pp. 7007-7015
    • Riggins, R.B.1    Thomas, K.S.2    Ta, H.Q.3    Wen, J.4    Davis, R.J.5    Schuh, N.R.6
  • 93
    • 2542454563 scopus 로고    scopus 로고
    • A cytoplasmic substrate of mitogen-activated protein kinase is responsible for estrogen receptor-alpha down-regulation in breast cancer cells: the role of nuclear factor-kappa B
    • Holloway J.N., Murthy S., and El-Ashry D. A cytoplasmic substrate of mitogen-activated protein kinase is responsible for estrogen receptor-alpha down-regulation in breast cancer cells: the role of nuclear factor-kappa B. Mol. Endocrinol. 18 (2004) 1396-1410
    • (2004) Mol. Endocrinol. , vol.18 , pp. 1396-1410
    • Holloway, J.N.1    Murthy, S.2    El-Ashry, D.3
  • 94
    • 28744431757 scopus 로고    scopus 로고
    • Advanced concepts in estrogen receptor biology and breast cancer endocrine resistance: implicated role of growth factor signaling and estrogen receptor coregulators
    • Schiff R., Massarweh S.A., Shou J., Bharwani L., Arpino G., Rimawi M., et al. Advanced concepts in estrogen receptor biology and breast cancer endocrine resistance: implicated role of growth factor signaling and estrogen receptor coregulators. Cancer Chemother. Pharmacol. 56 Suppl. 1 (2005) 10-20
    • (2005) Cancer Chemother. Pharmacol. , vol.56 , Issue.SUPPL. 1 , pp. 10-20
    • Schiff, R.1    Massarweh, S.A.2    Shou, J.3    Bharwani, L.4    Arpino, G.5    Rimawi, M.6
  • 95
    • 2542620761 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells
    • Yang Z., Barnes C.J., and Kumar R. Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells. Clin. Cancer Res. 10 (2004) 3621-3628
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3621-3628
    • Yang, Z.1    Barnes, C.J.2    Kumar, R.3
  • 96
    • 33748068094 scopus 로고    scopus 로고
    • Mechanisms of tumor regression and resistance to estrogen deprivation and fulvestrant in a model of estrogen receptor-positive, HER-2/neu-positive breast cancer
    • Massarweh S., Osborne C.K., Jiang S., Wakeling A.E., Rimawi M., Mohsin S.K., et al. Mechanisms of tumor regression and resistance to estrogen deprivation and fulvestrant in a model of estrogen receptor-positive, HER-2/neu-positive breast cancer. Cancer Res. 66 (2006) 8266-8273
    • (2006) Cancer Res. , vol.66 , pp. 8266-8273
    • Massarweh, S.1    Osborne, C.K.2    Jiang, S.3    Wakeling, A.E.4    Rimawi, M.5    Mohsin, S.K.6
  • 97
    • 0347717953 scopus 로고    scopus 로고
    • Resistance to different antiestrogens is caused by different multi-factorial changes and is associated with reduced expression of IGF receptor 1 alpha
    • Brockdorff B.L., Heiberg I., and Lykkesfeldt A.E. Resistance to different antiestrogens is caused by different multi-factorial changes and is associated with reduced expression of IGF receptor 1 alpha. Endocr. Relat. Cancer 10 (2003) 579-590
    • (2003) Endocr. Relat. Cancer , vol.10 , pp. 579-590
    • Brockdorff, B.L.1    Heiberg, I.2    Lykkesfeldt, A.E.3
  • 98
    • 26844487041 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor
    • Knowlden J.M., Hutcheson I.R., Barrow D., Gee J.M., and Nicholson R.I. Insulin-like growth factor-1 receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor. Endocrinology 146 (2005) 4609-4618
    • (2005) Endocrinology , vol.146 , pp. 4609-4618
    • Knowlden, J.M.1    Hutcheson, I.R.2    Barrow, D.3    Gee, J.M.4    Nicholson, R.I.5
  • 99
    • 25844459070 scopus 로고    scopus 로고
    • Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity
    • Santen R.J., Song R.X., Zhang Z., Kumar R., Jeng M.H., Masamura A., et al. Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity. Endocr. Relat. Cancer 12 Suppl. 1 (2005) S61-S73
    • (2005) Endocr. Relat. Cancer , vol.12 , Issue.SUPPL. 1
    • Santen, R.J.1    Song, R.X.2    Zhang, Z.3    Kumar, R.4    Jeng, M.H.5    Masamura, A.6
  • 100
    • 33646157284 scopus 로고    scopus 로고
    • RNAi-mediated silencing of insulin receptor substrate 1 (IRS-1) enhances tamoxifen-induced cell death in MCF-7 breast cancer cells
    • Cesarone G., Garofalo C., Abrams M.T., Igoucheva O., Alexeev V., Yoon K., et al. RNAi-mediated silencing of insulin receptor substrate 1 (IRS-1) enhances tamoxifen-induced cell death in MCF-7 breast cancer cells. J. Cell Biochem. 98 (2006) 440-450
    • (2006) J. Cell Biochem. , vol.98 , pp. 440-450
    • Cesarone, G.1    Garofalo, C.2    Abrams, M.T.3    Igoucheva, O.4    Alexeev, V.5    Yoon, K.6
  • 101
    • 0027185314 scopus 로고
    • Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of BCAR-1, a common integration site
    • Dorssers L.C., van Agthoven T., Dekker A., van Agthoven T.L., and Kok E.M. Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of BCAR-1, a common integration site. Mol. Endocrinol. 7 (1993) 870-878
    • (1993) Mol. Endocrinol. , vol.7 , pp. 870-878
    • Dorssers, L.C.1    van Agthoven, T.2    Dekker, A.3    van Agthoven, T.L.4    Kok, E.M.5
  • 102
    • 0032525138 scopus 로고    scopus 로고
    • Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells
    • van Agthoven T., van Agthoven T.L., Dekker A., van der Spek P.J., Vreede L., and Dorssers L.C. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J. 17 (1998) 2799-2808
    • (1998) EMBO J. , vol.17 , pp. 2799-2808
    • van Agthoven, T.1    van Agthoven, T.L.2    Dekker, A.3    van der Spek, P.J.4    Vreede, L.5    Dorssers, L.C.6
  • 103
    • 0035474419 scopus 로고    scopus 로고
    • Functions of the adapter protein Cas: signal convergence and the determination of cellular responses
    • Bouton A.H., Riggins R.B., and Bruce-Staskal P.J. Functions of the adapter protein Cas: signal convergence and the determination of cellular responses. Oncogene 20 (2001) 6448-6458
    • (2001) Oncogene , vol.20 , pp. 6448-6458
    • Bouton, A.H.1    Riggins, R.B.2    Bruce-Staskal, P.J.3
  • 104
    • 33646557326 scopus 로고    scopus 로고
    • p130cas: a versatile scaffold in signaling networks
    • Defilippi P., Di Stefano P., and Cabodi S. p130cas: a versatile scaffold in signaling networks. Trends Cell Biol. 16 (2006) 257-263
    • (2006) Trends Cell Biol. , vol.16 , pp. 257-263
    • Defilippi, P.1    Di Stefano, P.2    Cabodi, S.3
  • 107
    • 0041845239 scopus 로고    scopus 로고
    • Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3
    • Riggins R.B., Quilliam L.A., and Bouton A.H. Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. J. Biol. Chem. 278 (2003) 28264-28273
    • (2003) J. Biol. Chem. , vol.278 , pp. 28264-28273
    • Riggins, R.B.1    Quilliam, L.A.2    Bouton, A.H.3
  • 108
    • 2342418621 scopus 로고    scopus 로고
    • p130cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells
    • Cabodi S., Moro L., Baj G., Smeriglio M., Di Stefano P., Gippone S., et al. p130cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. J. Cell Sci. 117 (2004) 1603-1611
    • (2004) J. Cell Sci. , vol.117 , pp. 1603-1611
    • Cabodi, S.1    Moro, L.2    Baj, G.3    Smeriglio, M.4    Di Stefano, P.5    Gippone, S.6
  • 109
    • 34548204967 scopus 로고    scopus 로고
    • M.D. Planas-Silva, K.N. Hamilton, Targeting c-Src kinase enhances tamoxifen's inhibitory effect on cell growth by modulating expression of cell cycle and survival proteins, Cancer Chemother. Pharmacol., in press.
  • 111
    • 0026674221 scopus 로고
    • Characterization of protein tyrosine kinases from human breast cancer: Involvement of the c-Src oncogene product
    • Ottenhoff-Kalff A.E., Rijksen G., van Beurden E.A., Hennipman A., Michels A.A., and Staal G.E. Characterization of protein tyrosine kinases from human breast cancer: Involvement of the c-Src oncogene product. Cancer Res. 52 (1992) 4773-4778
    • (1992) Cancer Res. , vol.52 , pp. 4773-4778
    • Ottenhoff-Kalff, A.E.1    Rijksen, G.2    van Beurden, E.A.3    Hennipman, A.4    Michels, A.A.5    Staal, G.E.6
  • 114
    • 0031979414 scopus 로고    scopus 로고
    • Characterization of human epidermal growth factor receptor and c-Src interactions in human breast tumor cells
    • Biscardi J.S., Belsches A.P., and Parsons S.J. Characterization of human epidermal growth factor receptor and c-Src interactions in human breast tumor cells. Mol. Carcinog. 21 (1998) 261-272
    • (1998) Mol. Carcinog. , vol.21 , pp. 261-272
    • Biscardi, J.S.1    Belsches, A.P.2    Parsons, S.J.3
  • 116
    • 0034730244 scopus 로고    scopus 로고
    • p130cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor
    • Gotoh T., Cai D., Tian X., Feig L.A., and Lerner A. p130cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor. J. Biol. Chem. 275 (2000) 30118-30123
    • (2000) J. Biol. Chem. , vol.275 , pp. 30118-30123
    • Gotoh, T.1    Cai, D.2    Tian, X.3    Feig, L.A.4    Lerner, A.5
  • 117
    • 0037438577 scopus 로고    scopus 로고
    • The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42
    • Cai D., Felekkis K.N., Near R.I., O'Neill G.M., van Seventer J.M., Golemis E.A., et al. The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J. Immunol. 170 (2003) 969-978
    • (2003) J. Immunol. , vol.170 , pp. 969-978
    • Cai, D.1    Felekkis, K.N.2    Near, R.I.3    O'Neill, G.M.4    van Seventer, J.M.5    Golemis, E.A.6
  • 118
    • 13244273515 scopus 로고    scopus 로고
    • AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner
    • Felekkis K.N., Narsimhan R.P., Near R., Castro A.F., Zheng Y., Quilliam L.A., et al. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. Mol. Cancer Res. 3 (2005) 32-41
    • (2005) Mol. Cancer Res. , vol.3 , pp. 32-41
    • Felekkis, K.N.1    Narsimhan, R.P.2    Near, R.3    Castro, A.F.4    Zheng, Y.5    Quilliam, L.A.6
  • 119
    • 33744519337 scopus 로고    scopus 로고
    • Characterization of AND-34 function and signaling
    • Felekkis K., Quilliam L.A., and Lerner A. Characterization of AND-34 function and signaling. Methods Enzymol. 407 (2005) 55-63
    • (2005) Methods Enzymol. , vol.407 , pp. 55-63
    • Felekkis, K.1    Quilliam, L.A.2    Lerner, A.3
  • 120
    • 0037168163 scopus 로고    scopus 로고
    • Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells
    • Yu Y., and Feig L.A. Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells. Oncogene 21 (2002) 7557-7568
    • (2002) Oncogene , vol.21 , pp. 7557-7568
    • Yu, Y.1    Feig, L.A.2
  • 121
    • 33646253672 scopus 로고    scopus 로고
    • AKT signaling and cancer: surviving but not moving on
    • Toker A., and Yoeli-Lerner M. AKT signaling and cancer: surviving but not moving on. Cancer Res. 66 (2006) 3963-3966
    • (2006) Cancer Res. , vol.66 , pp. 3963-3966
    • Toker, A.1    Yoeli-Lerner, M.2
  • 122
    • 0037203546 scopus 로고    scopus 로고
    • AKT: versatile mediator of cell survival and beyond
    • Kim D., and Chung J. AKT: versatile mediator of cell survival and beyond. J. Biochem. Mol. Biol. 35 (2002) 106-115
    • (2002) J. Biochem. Mol. Biol. , vol.35 , pp. 106-115
    • Kim, D.1    Chung, J.2
  • 123
    • 0035971181 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    • Campbell R.A., Bhat-Nakshatri P., Patel N.M., Constantinidou D., Ali S., and Nakshatri H. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J. Biol. Chem. 276 (2001) 9817-9824
    • (2001) J. Biol. Chem. , vol.276 , pp. 9817-9824
    • Campbell, R.A.1    Bhat-Nakshatri, P.2    Patel, N.M.3    Constantinidou, D.4    Ali, S.5    Nakshatri, H.6
  • 124
    • 33749018257 scopus 로고    scopus 로고
    • AKT regulation of estrogen receptor β transcriptional activity in breast cancer
    • Duong B.N., Elliott S., Frigo D.E., Melnik L.I., Vanhoy L., Tomchuck S., et al. AKT regulation of estrogen receptor β transcriptional activity in breast cancer. Cancer Res. 66 (2006) 8373-8381
    • (2006) Cancer Res. , vol.66 , pp. 8373-8381
    • Duong, B.N.1    Elliott, S.2    Frigo, D.E.3    Melnik, L.I.4    Vanhoy, L.5    Tomchuck, S.6
  • 125
    • 0042525911 scopus 로고    scopus 로고
    • Expression of constitutively active AKT-3 in MCF-7 breast cancer cells reverses the estrogen and tamoxifen responsivity of these cells in vivo
    • Faridi J., Wang L., Endemann G., and Roth R.A. Expression of constitutively active AKT-3 in MCF-7 breast cancer cells reverses the estrogen and tamoxifen responsivity of these cells in vivo. Clin. Cancer Res. 9 (2003) 2933-2939
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2933-2939
    • Faridi, J.1    Wang, L.2    Endemann, G.3    Roth, R.A.4
  • 126
  • 127
    • 0036633164 scopus 로고    scopus 로고
    • Constitutive and inducible AKT activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells
    • Clark A.S., West K., Streicher S., and Dennis P.A. Constitutive and inducible AKT activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. Mol. Cancer Ther. 1 (2002) 707-717
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 707-717
    • Clark, A.S.1    West, K.2    Streicher, S.3    Dennis, P.A.4
  • 128
    • 4544352393 scopus 로고    scopus 로고
    • Increased constitutive activity of PKB/AKT in tamoxifen resistant breast cancer MCF-7 cells
    • Jordan N.J., Gee J.M., Barrow D., Wakeling A.E., and Nicholson R.I. Increased constitutive activity of PKB/AKT in tamoxifen resistant breast cancer MCF-7 cells. Breast Cancer Res. Treat. 87 (2004) 167-180
    • (2004) Breast Cancer Res. Treat. , vol.87 , pp. 167-180
    • Jordan, N.J.1    Gee, J.M.2    Barrow, D.3    Wakeling, A.E.4    Nicholson, R.I.5
  • 133
    • 22344446415 scopus 로고    scopus 로고
    • Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer
    • Boulay A., Rudloff J., Ye J., Zumstein-Mecker S., O'Reilly T., Evans D.B., et al. Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer. Clin. Cancer. Res. 11 (2005) 5319-5328
    • (2005) Clin. Cancer. Res. , vol.11 , pp. 5319-5328
    • Boulay, A.1    Rudloff, J.2    Ye, J.3    Zumstein-Mecker, S.4    O'Reilly, T.5    Evans, D.B.6
  • 134
    • 4544315354 scopus 로고    scopus 로고
    • New targets for therapy in breast cancer: mammalian target of rapamycin (mTOR) antagonists
    • Carraway H., and Hidalgo M. New targets for therapy in breast cancer: mammalian target of rapamycin (mTOR) antagonists. Breast Cancer Res. 6 (2004) 219-224
    • (2004) Breast Cancer Res. , vol.6 , pp. 219-224
    • Carraway, H.1    Hidalgo, M.2
  • 135
    • 33748775727 scopus 로고    scopus 로고
    • Targeting downstream effectors of epidermal growth factor receptor/HER2 in breast cancer with either farnesyltransferase inhibitors or mTOR antagonists
    • Johnston S.R. Targeting downstream effectors of epidermal growth factor receptor/HER2 in breast cancer with either farnesyltransferase inhibitors or mTOR antagonists. Int. J. Gynecol. Cancer 16 Suppl. 2 (2006) 543-548
    • (2006) Int. J. Gynecol. Cancer , vol.16 , Issue.SUPPL. 2 , pp. 543-548
    • Johnston, S.R.1
  • 136
    • 0037211754 scopus 로고    scopus 로고
    • Estrogen receptor phosphorylation
    • Lannigan D.A. Estrogen receptor phosphorylation. Steroids 68 (2003) 1-9
    • (2003) Steroids , vol.68 , pp. 1-9
    • Lannigan, D.A.1
  • 137
    • 33751002354 scopus 로고    scopus 로고
    • Potential role of estrogen receptor alpha (ER alpha) phosphorylated at serine(118) in human breast cancer in vivo
    • Murphy L.C., Weitsman G.E., Skliris G.P., Teh E.M., Li L., Peng B., et al. Potential role of estrogen receptor alpha (ER alpha) phosphorylated at serine(118) in human breast cancer in vivo. J. Steroid Biochem. Mol. Biol. 102 (2006) 139-146
    • (2006) J. Steroid Biochem. Mol. Biol. , vol.102 , pp. 139-146
    • Murphy, L.C.1    Weitsman, G.E.2    Skliris, G.P.3    Teh, E.M.4    Li, L.5    Peng, B.6
  • 138
    • 0028833473 scopus 로고
    • Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by Src family tyrosine kinases in vitro
    • Arnold S.F., Obourn J.D., Jaffe H., and Notides A.C. Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by Src family tyrosine kinases in vitro. Mol. Endocrinol. 9 (1995) 24-33
    • (1995) Mol. Endocrinol. , vol.9 , pp. 24-33
    • Arnold, S.F.1    Obourn, J.D.2    Jaffe, H.3    Notides, A.C.4
  • 139
    • 0033607306 scopus 로고    scopus 로고
    • Function of estrogen receptor tyrosine 537 in hormone binding, DNA binding, and transactivation
    • Yudt M.R., Vorojeikina D., Zhong L., Skafar D.F., Sasson S., Gasiewicz T.A., et al. Function of estrogen receptor tyrosine 537 in hormone binding, DNA binding, and transactivation. Biochemistry 38 (1999) 14146-14156
    • (1999) Biochemistry , vol.38 , pp. 14146-14156
    • Yudt, M.R.1    Vorojeikina, D.2    Zhong, L.3    Skafar, D.F.4    Sasson, S.5    Gasiewicz, T.A.6
  • 140
    • 0030445855 scopus 로고    scopus 로고
    • Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein
    • Weis K.E., Ekena K., Thomas J.A., Lazennec G., and Katzenellenbogen B.S. Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein. Mol. Endocrinol. 10 (1996) 1388-1398
    • (1996) Mol. Endocrinol. , vol.10 , pp. 1388-1398
    • Weis, K.E.1    Ekena, K.2    Thomas, J.A.3    Lazennec, G.4    Katzenellenbogen, B.S.5
  • 141
    • 0032031082 scopus 로고    scopus 로고
    • Ligand-independent activation of the estrogen receptors alpha and beta by mutations of a conserved tyrosine can be abolished by antiestrogens
    • Tremblay G.B., Tremblay A., Labrie F., and Giguere V. Ligand-independent activation of the estrogen receptors alpha and beta by mutations of a conserved tyrosine can be abolished by antiestrogens. Cancer Res. 58 (1998) 877-881
    • (1998) Cancer Res. , vol.58 , pp. 877-881
    • Tremblay, G.B.1    Tremblay, A.2    Labrie, F.3    Giguere, V.4
  • 142
    • 0033529557 scopus 로고    scopus 로고
    • Potentiation of human estrogen receptor alpha transcriptional activation through phosphorylation of serines 104 and 106 by the cyclin A-CDK2 complex
    • Rogatsky I., Trowbridge J.M., and Garabedian M.J. Potentiation of human estrogen receptor alpha transcriptional activation through phosphorylation of serines 104 and 106 by the cyclin A-CDK2 complex. J. Biol. Chem. 274 (1999) 22296-22302
    • (1999) J. Biol. Chem. , vol.274 , pp. 22296-22302
    • Rogatsky, I.1    Trowbridge, J.M.2    Garabedian, M.J.3
  • 143
  • 144
    • 0027978187 scopus 로고
    • Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor
    • Arnold S.F., Obourn J.D., Jaffe H., and Notides A.C. Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor. Mol. Endocrinol. 8 (1994) 1208-1214
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1208-1214
    • Arnold, S.F.1    Obourn, J.D.2    Jaffe, H.3    Notides, A.C.4
  • 145
    • 33746555910 scopus 로고    scopus 로고
    • Activation function-1 domain of estrogen receptor regulates the agonistic and antagonistic actions of tamoxifen
    • Glaros S., Atanaskova N., Zhao C., Skafar D.F., and Reddy K.B. Activation function-1 domain of estrogen receptor regulates the agonistic and antagonistic actions of tamoxifen. Mol. Endocrinol. 20 (2006) 996-1008
    • (2006) Mol. Endocrinol. , vol.20 , pp. 996-1008
    • Glaros, S.1    Atanaskova, N.2    Zhao, C.3    Skafar, D.F.4    Reddy, K.B.5
  • 146
    • 33751552134 scopus 로고    scopus 로고
    • Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity
    • Likhite V.S., Stossi F., Kim K., Katzenellenbogen B.S., and Katzenellenbogen J.A. Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity. Mol. Endocrinol. 20 (2006) 3120-3132
    • (2006) Mol. Endocrinol. , vol.20 , pp. 3120-3132
    • Likhite, V.S.1    Stossi, F.2    Kim, K.3    Katzenellenbogen, B.S.4    Katzenellenbogen, J.A.5
  • 147
    • 0032906876 scopus 로고    scopus 로고
    • Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerization
    • Chen D., Pace P.E., Coombes R.C., and Ali S. Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerization. Mol. Cell. Biol. 19 (1999) 1002-1015
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1002-1015
    • Chen, D.1    Pace, P.E.2    Coombes, R.C.3    Ali, S.4
  • 148
    • 0037107380 scopus 로고    scopus 로고
    • p21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium
    • Wang R.A., Mazumdar A., Vadlamudi R.K., and Kumar R. p21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium. EMBO J. 21 (2002) 5437-5447
    • (2002) EMBO J. , vol.21 , pp. 5437-5447
    • Wang, R.A.1    Mazumdar, A.2    Vadlamudi, R.K.3    Kumar, R.4
  • 149
    • 2942568370 scopus 로고    scopus 로고
    • Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells
    • Balasenthil S., Barnes C.J., Rayala S.K., and Kumar R. Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells. FEBS Lett. 567 (2004) 243-247
    • (2004) FEBS Lett. , vol.567 , pp. 243-247
    • Balasenthil, S.1    Barnes, C.J.2    Rayala, S.K.3    Kumar, R.4
  • 150
    • 33745714519 scopus 로고    scopus 로고
    • Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity
    • Rayala S.K., Molli P.R., and Kumar R. Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity. Cancer Res. 66 (2006) 5985-5988
    • (2006) Cancer Res. , vol.66 , pp. 5985-5988
    • Rayala, S.K.1    Molli, P.R.2    Kumar, R.3
  • 151
    • 32944473985 scopus 로고    scopus 로고
    • p21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation
    • Rayala S.K., Talukder A.H., Balasenthil S., Tharakan R., Barnes C.J., Wang R.A., et al. p21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. Cancer Res. 66 (2006) 1694-1701
    • (2006) Cancer Res. , vol.66 , pp. 1694-1701
    • Rayala, S.K.1    Talukder, A.H.2    Balasenthil, S.3    Tharakan, R.4    Barnes, C.J.5    Wang, R.A.6
  • 152
    • 2942544830 scopus 로고    scopus 로고
    • Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer
    • Michalides R., Griekspoor A., Balkenende A., Verwoerd D., Janssen L., Jalink K., et al. Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer. Cancer Cell 5 (2004) 597-605
    • (2004) Cancer Cell , vol.5 , pp. 597-605
    • Michalides, R.1    Griekspoor, A.2    Balkenende, A.3    Verwoerd, D.4    Janssen, L.5    Jalink, K.6
  • 153
    • 0032557452 scopus 로고    scopus 로고
    • Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase
    • Joel P.B., Traish A.M., and Lannigan D.A. Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase. J. Biol. Chem. 273 (1998) 13317-13323
    • (1998) J. Biol. Chem. , vol.273 , pp. 13317-13323
    • Joel, P.B.1    Traish, A.M.2    Lannigan, D.A.3
  • 154
    • 0033636597 scopus 로고    scopus 로고
    • Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7
    • Chen D., Riedl T., Washbrook E., Pace P.E., Coombes R.C., Egly J.M., et al. Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7. Mol. Cell 6 (2000) 127-137
    • (2000) Mol. Cell , vol.6 , pp. 127-137
    • Chen, D.1    Riedl, T.2    Washbrook, E.3    Pace, P.E.4    Coombes, R.C.5    Egly, J.M.6
  • 155
    • 0037173738 scopus 로고    scopus 로고
    • Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera
    • Chen D., Washbrook E., Sarwar N., Bates G.J., Pace P.E., Thirunuvakkarasu V., et al. Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera. Oncogene 21 (2002) 4921-4931
    • (2002) Oncogene , vol.21 , pp. 4921-4931
    • Chen, D.1    Washbrook, E.2    Sarwar, N.3    Bates, G.J.4    Pace, P.E.5    Thirunuvakkarasu, V.6
  • 156
    • 25444468111 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity
    • Medunjanin S., Hermani A., De Servi B., Grisouard J., Rincke G., and Mayer D. Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity. J. Biol. Chem. 280 (2005) 33006-33014
    • (2005) J. Biol. Chem. , vol.280 , pp. 33006-33014
    • Medunjanin, S.1    Hermani, A.2    De Servi, B.3    Grisouard, J.4    Rincke, G.5    Mayer, D.6
  • 158
    • 33750552134 scopus 로고    scopus 로고
    • Estrogen receptor-alpha phosphorylated at ser118 is present at the promoters of estrogen-regulated genes and is not altered due to HER-2 overexpression
    • Weitsman G.E., Li L., Skliris G.P., Davie J.R., Ung K., Niu Y., et al. Estrogen receptor-alpha phosphorylated at ser118 is present at the promoters of estrogen-regulated genes and is not altered due to HER-2 overexpression. Cancer Res. 66 (2006) 10162-10170
    • (2006) Cancer Res. , vol.66 , pp. 10162-10170
    • Weitsman, G.E.1    Li, L.2    Skliris, G.P.3    Davie, J.R.4    Ung, K.5    Niu, Y.6
  • 159
    • 15944379896 scopus 로고    scopus 로고
    • Formation of an IKK alpha-dependent transcription complex is required for estrogen receptor-mediated gene activation
    • Park K.J., Krishnan V., O'Malley B.W., Yamamoto Y., and Gaynor R.B. Formation of an IKK alpha-dependent transcription complex is required for estrogen receptor-mediated gene activation. Mol. Cell 18 (2005) 71-82
    • (2005) Mol. Cell , vol.18 , pp. 71-82
    • Park, K.J.1    Krishnan, V.2    O'Malley, B.W.3    Yamamoto, Y.4    Gaynor, R.B.5
  • 161
    • 25844515780 scopus 로고    scopus 로고
    • Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E
    • Butt A.J., McNeil C.M., Musgrove E.A., and Sutherland R.L. Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E. Endocr. Relat. Cancer 12 Suppl. 1 (2005) S47-S59
    • (2005) Endocr. Relat. Cancer , vol.12 , Issue.SUPPL. 1
    • Butt, A.J.1    McNeil, C.M.2    Musgrove, E.A.3    Sutherland, R.L.4
  • 162
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: positive and negative regulators of G1-phase progression
    • Sherr C.J., and Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13 (1999) 1501-1512
    • (1999) Genes Dev. , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 163
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclin-dependent kinases
    • Sherr C.J., and Roberts J.M. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18 (2004) 2699-2711
    • (2004) Genes Dev. , vol.18 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 164
    • 0036897326 scopus 로고    scopus 로고
    • Constitutive overexpression of cyclin D1 but not cyclin E confers acute resistance to antiestrogens in T-47D breast cancer cells
    • Hui R., Finney G.L., Carroll J.S., Lee C.S., Musgrove E.A., and Sutherland R.L. Constitutive overexpression of cyclin D1 but not cyclin E confers acute resistance to antiestrogens in T-47D breast cancer cells. Cancer Res. 62 (2002) 6916-6923
    • (2002) Cancer Res. , vol.62 , pp. 6916-6923
    • Hui, R.1    Finney, G.L.2    Carroll, J.S.3    Lee, C.S.4    Musgrove, E.A.5    Sutherland, R.L.6
  • 165
    • 8444222836 scopus 로고    scopus 로고
    • Cyclin D1 expression is dependent on estrogen receptor function in tamoxifen-resistant breast cancer cells
    • Kilker R.L., Hartl M.W., Rutherford T.M., and Planas-Silva M.D. Cyclin D1 expression is dependent on estrogen receptor function in tamoxifen-resistant breast cancer cells. J. Steroid Biochem. Mol. Biol. 92 (2004) 63-71
    • (2004) J. Steroid Biochem. Mol. Biol. , vol.92 , pp. 63-71
    • Kilker, R.L.1    Hartl, M.W.2    Rutherford, T.M.3    Planas-Silva, M.D.4
  • 166
    • 33646245004 scopus 로고    scopus 로고
    • Development and therapeutic options for the treatment of raloxifene-stimulated breast cancer in athymic mice
    • O'Regan R.M., Osipo C., Ariazi E., Lee E.S., Meeke K., Morris C., et al. Development and therapeutic options for the treatment of raloxifene-stimulated breast cancer in athymic mice. Clin. Cancer Res. 12 (2006) 2255-2263
    • (2006) Clin. Cancer Res. , vol.12 , pp. 2255-2263
    • O'Regan, R.M.1    Osipo, C.2    Ariazi, E.3    Lee, E.S.4    Meeke, K.5    Morris, C.6
  • 167
    • 33845786458 scopus 로고    scopus 로고
    • Cyclin D1 is necessary for tamoxifen-induced cell cycle progression in human breast cancer cells
    • Kilker R.L., and Planas-Silva M.D. Cyclin D1 is necessary for tamoxifen-induced cell cycle progression in human breast cancer cells. Cancer Res. 66 (2006) 11478-11484
    • (2006) Cancer Res. , vol.66 , pp. 11478-11484
    • Kilker, R.L.1    Planas-Silva, M.D.2
  • 170
    • 4544343901 scopus 로고    scopus 로고
    • Low-molecular-weight cyclin E: the missing link between biology and clinical outcome
    • Akli S., and Keyomarsi K. Low-molecular-weight cyclin E: the missing link between biology and clinical outcome. Breast Cancer Res. 6 (2004) 188-191
    • (2004) Breast Cancer Res. , vol.6 , pp. 188-191
    • Akli, S.1    Keyomarsi, K.2
  • 171
    • 2342593373 scopus 로고    scopus 로고
    • Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer
    • Akli S., Zheng P.J., Multani A.S., Wingate H.F., Pathak S., Zhang N., et al. Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer. Cancer Res. 64 (2004) 3198-3208
    • (2004) Cancer Res. , vol.64 , pp. 3198-3208
    • Akli, S.1    Zheng, P.J.2    Multani, A.S.3    Wingate, H.F.4    Pathak, S.5    Zhang, N.6
  • 172
    • 0037063172 scopus 로고    scopus 로고
    • Ectopic expression of cyclin E in estrogen responsive cells abrogates antiestrogen mediated growth arrest
    • Dhillon N.K., and Mudryj M. Ectopic expression of cyclin E in estrogen responsive cells abrogates antiestrogen mediated growth arrest. Oncogene 21 (2002) 4626-4634
    • (2002) Oncogene , vol.21 , pp. 4626-4634
    • Dhillon, N.K.1    Mudryj, M.2
  • 174
    • 0042591471 scopus 로고    scopus 로고
    • p27(Kip1) induces quiescence and growth factor insensitivity in tamoxifen-treated breast cancer cells
    • Carroll J.S., Lynch D.K., Swarbrick A., Renoir J.M., Sarcevic B., Daly R.J., et al. p27(Kip1) induces quiescence and growth factor insensitivity in tamoxifen-treated breast cancer cells. Cancer Res. 63 (2003) 4322-4326
    • (2003) Cancer Res. , vol.63 , pp. 4322-4326
    • Carroll, J.S.1    Lynch, D.K.2    Swarbrick, A.3    Renoir, J.M.4    Sarcevic, B.5    Daly, R.J.6
  • 175
    • 2342618936 scopus 로고    scopus 로고
    • Multiple roles of the PI3K/PKB (AKT) pathway in cell cycle progression
    • Liang J., and Slingerland J.M. Multiple roles of the PI3K/PKB (AKT) pathway in cell cycle progression. Cell Cycle 2 (2003) 339-345
    • (2003) Cell Cycle , vol.2 , pp. 339-345
    • Liang, J.1    Slingerland, J.M.2
  • 176
    • 24044525270 scopus 로고    scopus 로고
    • WAF1/CIP1 expression during estrogen signaling and antiestrogen resistance in human breast cancer cells
    • WAF1/CIP1 expression during estrogen signaling and antiestrogen resistance in human breast cancer cells. J. Biol. Chem. 280 (2005) 17617-17625
    • (2005) J. Biol. Chem. , vol.280 , pp. 17617-17625
    • Mukherjee, S.1    Conrad, S.E.2
  • 177
    • 0035798683 scopus 로고    scopus 로고
    • Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells
    • Donovan J.C., Milic A., and Slingerland J.M. Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells. J. Biol. Chem. 276 (2001) 40888-40895
    • (2001) J. Biol. Chem. , vol.276 , pp. 40888-40895
    • Donovan, J.C.1    Milic, A.2    Slingerland, J.M.3
  • 178
    • 33646198056 scopus 로고    scopus 로고
    • Benefit from adjuvant tamoxifen therapy in primary breast cancer patients according oestrogen receptor, progesterone receptor, EGF receptor and HER2 status
    • Dowsett M., Houghton J., Iden C., Salter J., Farndon J., A'Hern R., et al. Benefit from adjuvant tamoxifen therapy in primary breast cancer patients according oestrogen receptor, progesterone receptor, EGF receptor and HER2 status. Ann. Oncol. 17 (2006) 818-826
    • (2006) Ann. Oncol. , vol.17 , pp. 818-826
    • Dowsett, M.1    Houghton, J.2    Iden, C.3    Salter, J.4    Farndon, J.5    A'Hern, R.6
  • 179
    • 4344705051 scopus 로고    scopus 로고
    • Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: Inhibition by gefitinib ('Iressa', ZD1839)
    • Hiscox S., Morgan L., Barrow D., Dutkowskil C., Wakeling A., and Nicholson R.I. Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: Inhibition by gefitinib ('Iressa', ZD1839). Clin. Exp. Metastasis 21 (2004) 201-212
    • (2004) Clin. Exp. Metastasis , vol.21 , pp. 201-212
    • Hiscox, S.1    Morgan, L.2    Barrow, D.3    Dutkowskil, C.4    Wakeling, A.5    Nicholson, R.I.6
  • 180
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: twist in development and metastasis
    • Kang Y., and Massague J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118 (2004) 277-279
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.1    Massague, J.2
  • 181
    • 33745402375 scopus 로고    scopus 로고
    • Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells
    • Hiscox S., Morgan L., Green T.P., Barrow D., Gee J., and Nicholson R.I. Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells. Breast Cancer Res. Treat. 97 (2006) 263-274
    • (2006) Breast Cancer Res. Treat. , vol.97 , pp. 263-274
    • Hiscox, S.1    Morgan, L.2    Green, T.P.3    Barrow, D.4    Gee, J.5    Nicholson, R.I.6
  • 182
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: new insights in signaling, development, and disease
    • Lee J.M., Dedhar S., Kalluri R., and Thompson E.W. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J. Cell Biol. 172 (2006) 973-981
    • (2006) J. Cell Biol. , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 183
    • 0041423391 scopus 로고    scopus 로고
    • Combined array comparative genomic hybridization and tissue microarray analysis suggest Pak1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma
    • Schraml P., Schwerdtfeger G., Burkhalter F., Raggi A., Schmidt D., Ruffalo T., et al. Combined array comparative genomic hybridization and tissue microarray analysis suggest Pak1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma. Am. J. Pathol. 163 (2003) 985-992
    • (2003) Am. J. Pathol. , vol.163 , pp. 985-992
    • Schraml, P.1    Schwerdtfeger, G.2    Burkhalter, F.3    Raggi, A.4    Schmidt, D.5    Ruffalo, T.6
  • 184
    • 0141738581 scopus 로고    scopus 로고
    • Association of c-Myc amplification with progression from the in situ to the invasive stage in c-Myc-amplified breast carcinomas
    • Robanus-Maandag E.C., Bosch C.A., Kristel P.M., Hart A.A., Faneyte I.F., Nederlof P.M., et al. Association of c-Myc amplification with progression from the in situ to the invasive stage in c-Myc-amplified breast carcinomas. J. Pathol. 201 (2003) 75-82
    • (2003) J. Pathol. , vol.201 , pp. 75-82
    • Robanus-Maandag, E.C.1    Bosch, C.A.2    Kristel, P.M.3    Hart, A.A.4    Faneyte, I.F.5    Nederlof, P.M.6
  • 185
    • 33746832533 scopus 로고    scopus 로고
    • Activation of PI3K/AKT signaling and hormone resistance in breast cancer
    • Tokunaga E., Kimura Y., Mashino K., Oki E., Kataoka A., Ohno S., et al. Activation of PI3K/AKT signaling and hormone resistance in breast cancer. Breast Cancer 13 (2006) 137-144
    • (2006) Breast Cancer , vol.13 , pp. 137-144
    • Tokunaga, E.1    Kimura, Y.2    Mashino, K.3    Oki, E.4    Kataoka, A.5    Ohno, S.6
  • 186
    • 13244259196 scopus 로고    scopus 로고
    • Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen
    • Shoman N., Klassen S., McFadden A., Bickis M.G., Torlakovic E., and Chibbar R. Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen. Mod. Pathol. 18 (2005) 250-259
    • (2005) Mod. Pathol. , vol.18 , pp. 250-259
    • Shoman, N.1    Klassen, S.2    McFadden, A.3    Bickis, M.G.4    Torlakovic, E.5    Chibbar, R.6
  • 187
    • 0032771839 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer
    • Kenny F.S., Hui R., Musgrove E.A., Gee J.M., Blamey R.W., Nicholson R.I., et al. Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer. Clin. Cancer Res. 5 (1999) 2069-2076
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2069-2076
    • Kenny, F.S.1    Hui, R.2    Musgrove, E.A.3    Gee, J.M.4    Blamey, R.W.5    Nicholson, R.I.6
  • 188
    • 2942533005 scopus 로고    scopus 로고
    • Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients
    • Stendahl M., Kronblad A., Ryden L., Emdin S., Bengtsson N.O., and Landberg G. Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients. Br. J. Cancer 90 (2004) 1942-1948
    • (2004) Br. J. Cancer , vol.90 , pp. 1942-1948
    • Stendahl, M.1    Kronblad, A.2    Ryden, L.3    Emdin, S.4    Bengtsson, N.O.5    Landberg, G.6
  • 189
    • 0042567223 scopus 로고    scopus 로고
    • Cyclin-E is a strong predictor of endocrine therapy failure in human breast cancer
    • Span P.N., Tjan-Heijnen V.C., Manders P., Beex L.V., and Sweep C.G. Cyclin-E is a strong predictor of endocrine therapy failure in human breast cancer. Oncogene 22 (2003) 4898-4904
    • (2003) Oncogene , vol.22 , pp. 4898-4904
    • Span, P.N.1    Tjan-Heijnen, V.C.2    Manders, P.3    Beex, L.V.4    Sweep, C.G.5
  • 190
    • 33750613645 scopus 로고    scopus 로고
    • Impact of cyclins E, neutrophil elastase and proteinase 3 expression levels on clinical outcome in primary breast cancer patients
    • Desmedt C., Ouriaghli F.E., Durbecq V., Soree A., Colozza M.A., Azambuja E., et al. Impact of cyclins E, neutrophil elastase and proteinase 3 expression levels on clinical outcome in primary breast cancer patients. Int. J. Cancer 119 (2006) 2539-2545
    • (2006) Int. J. Cancer , vol.119 , pp. 2539-2545
    • Desmedt, C.1    Ouriaghli, F.E.2    Durbecq, V.3    Soree, A.4    Colozza, M.A.5    Azambuja, E.6
  • 191
    • 0142008438 scopus 로고    scopus 로고
    • Kip1 expression predicts superior relapse-free and overall survival for premenopausal women with early-stage breast cancer receiving adjuvant treatment with tamoxifen plus goserelin
    • Kip1 expression predicts superior relapse-free and overall survival for premenopausal women with early-stage breast cancer receiving adjuvant treatment with tamoxifen plus goserelin. J. Clin. Oncol. 21 (2003) 3594-3600
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3594-3600
    • Pohl, G.1    Rudas, M.2    Dietze, O.3    Lax, S.4    Markis, E.5    Pirker, R.6
  • 193
    • 4444324186 scopus 로고    scopus 로고
    • Phospho-serine-118 estrogen receptor-alpha expression is associated with better disease outcome in women treated with tamoxifen
    • Murphy L.C., Niu Y., Snell L., and Watson P. Phospho-serine-118 estrogen receptor-alpha expression is associated with better disease outcome in women treated with tamoxifen. Clin. Cancer Res. 10 (2004) 5902-5906
    • (2004) Clin. Cancer Res. , vol.10 , pp. 5902-5906
    • Murphy, L.C.1    Niu, Y.2    Snell, L.3    Watson, P.4
  • 194
    • 33646429471 scopus 로고    scopus 로고
    • Activated ERK1/2 and phosphorylated oestrogen receptor alpha are associated with improved breast cancer survival in women treated with tamoxifen
    • Bergqvist J., Elmberger G., Ohd J., Linderholm B., Bjohle J., Hellborg H., et al. Activated ERK1/2 and phosphorylated oestrogen receptor alpha are associated with improved breast cancer survival in women treated with tamoxifen. Eur. J. Cancer 42 (2006) 1104-1112
    • (2006) Eur. J. Cancer , vol.42 , pp. 1104-1112
    • Bergqvist, J.1    Elmberger, G.2    Ohd, J.3    Linderholm, B.4    Bjohle, J.5    Hellborg, H.6
  • 195
    • 33644873967 scopus 로고    scopus 로고
    • Phosphorylation of estrogen receptor alpha serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer
    • Yamashita H., Nishio M., Kobayashi S., Ando Y., Sugiura H., Zhang Z., et al. Phosphorylation of estrogen receptor alpha serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer. Breast Cancer Res. 7 (2005) R753-R764
    • (2005) Breast Cancer Res. , vol.7
    • Yamashita, H.1    Nishio, M.2    Kobayashi, S.3    Ando, Y.4    Sugiura, H.5    Zhang, Z.6
  • 196
    • 0038688478 scopus 로고    scopus 로고
    • Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases
    • Bardou V.J., Arpino G., Elledge R.M., Osborne C.K., and Clark G.M. Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases. J. Clin. Oncol. 21 (2003) 1973-1979
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1973-1979
    • Bardou, V.J.1    Arpino, G.2    Elledge, R.M.3    Osborne, C.K.4    Clark, G.M.5
  • 197
    • 0034017798 scopus 로고    scopus 로고
    • Results of two or five years of adjuvant tamoxifen correlated to steroid receptor and S-phase levels. South Sweden Breast Cancer Group, and South-East Sweden Breast Cancer Group
    • Ferno M., Stal O., Baldetorp B., Hatschek T., Kallstrom A.C., Malmstrom P., et al. Results of two or five years of adjuvant tamoxifen correlated to steroid receptor and S-phase levels. South Sweden Breast Cancer Group, and South-East Sweden Breast Cancer Group. Breast Cancer Res. Treat. 59 (2000) 69-76
    • (2000) Breast Cancer Res. Treat. , vol.59 , pp. 69-76
    • Ferno, M.1    Stal, O.2    Baldetorp, B.3    Hatschek, T.4    Kallstrom, A.C.5    Malmstrom, P.6
  • 198
    • 10744233578 scopus 로고    scopus 로고
    • Letrozole inhibits tumor proliferation more effectively than tamoxifen independent of HER1/2 expression status
    • Ellis M.J., Coop A., Singh B., Tao Y., Llombart-Cussac A., Janicke F., et al. Letrozole inhibits tumor proliferation more effectively than tamoxifen independent of HER1/2 expression status. Cancer Res. 63 (2003) 6523-6531
    • (2003) Cancer Res. , vol.63 , pp. 6523-6531
    • Ellis, M.J.1    Coop, A.2    Singh, B.3    Tao, Y.4    Llombart-Cussac, A.5    Janicke, F.6
  • 200
    • 33646255471 scopus 로고    scopus 로고
    • A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen
    • Goetz M.P., Suman V.J., Ingle J.N., Nibbe A.M., Visscher D.W., Reynolds C.A., et al. A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. Clin. Cancer Res. 12 (2006) 2080-2087
    • (2006) Clin. Cancer Res. , vol.12 , pp. 2080-2087
    • Goetz, M.P.1    Suman, V.J.2    Ingle, J.N.3    Nibbe, A.M.4    Visscher, D.W.5    Reynolds, C.A.6
  • 201
    • 21444453976 scopus 로고    scopus 로고
    • Limits of predictive models using microarray data for breast cancer clinical treatment outcome
    • Reid J.F., Lusa L., De Cecco L., Coradini D., Veneroni S., Daidone M.G., et al. Limits of predictive models using microarray data for breast cancer clinical treatment outcome. J. Natl. Cancer Inst. 97 (2005) 927-930
    • (2005) J. Natl. Cancer Inst. , vol.97 , pp. 927-930
    • Reid, J.F.1    Lusa, L.2    De Cecco, L.3    Coradini, D.4    Veneroni, S.5    Daidone, M.G.6
  • 202
    • 1242338758 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells
    • Frasor J., Stossi F., Danes J.M., Komm B., Lyttle C.R., and Katzenellenbogen B.S. Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells. Cancer Res. 64 (2004) 1522-1533
    • (2004) Cancer Res. , vol.64 , pp. 1522-1533
    • Frasor, J.1    Stossi, F.2    Danes, J.M.3    Komm, B.4    Lyttle, C.R.5    Katzenellenbogen, B.S.6
  • 203
    • 1442330469 scopus 로고    scopus 로고
    • The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis
    • Hur J., Chesnes J., Coser K.R., Lee R.S., Geck P., Isselbacher K.J., et al. The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis. Proc. Natl. Acad. Sci. USA 101 (2004) 2351-2356
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 2351-2356
    • Hur, J.1    Chesnes, J.2    Coser, K.R.3    Lee, R.S.4    Geck, P.5    Isselbacher, K.J.6
  • 204
    • 17144420079 scopus 로고    scopus 로고
    • Letrozole-, anastrozole- and tamoxifen-responsive genes in MCF-7aro cells: a microarray approach
    • Itoh T., Karlsberg K., Kijima I., Yuan Y.C., Smith D., Ye J., et al. Letrozole-, anastrozole- and tamoxifen-responsive genes in MCF-7aro cells: a microarray approach. Mol. Cancer Res. 3 (2005) 203-218
    • (2005) Mol. Cancer Res. , vol.3 , pp. 203-218
    • Itoh, T.1    Karlsberg, K.2    Kijima, I.3    Yuan, Y.C.4    Smith, D.5    Ye, J.6
  • 205
    • 13944282670 scopus 로고    scopus 로고
    • Distinct gene expression patterns in a tamoxifen-sensitive human mammary carcinoma xenograft and its tamoxifen-resistant subline MaCa 3366/TAM
    • Becker M., Sommer A., Kratzschmar J.R., Seidel H., Pohlenz H.D., and Fichtner I. Distinct gene expression patterns in a tamoxifen-sensitive human mammary carcinoma xenograft and its tamoxifen-resistant subline MaCa 3366/TAM. Mol. Cancer Ther. 4 (2005) 151-168
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 151-168
    • Becker, M.1    Sommer, A.2    Kratzschmar, J.R.3    Seidel, H.4    Pohlenz, H.D.5    Fichtner, I.6
  • 206
    • 9944228648 scopus 로고    scopus 로고
    • Interferon-regulatory factor-1 is critical for tamoxifen-mediated apoptosis in human mammary epithelial cells
    • Bowie M.L., Dietze E.C., Delrow J., Bean G.R., Troch M.M., Marjoram R.J., et al. Interferon-regulatory factor-1 is critical for tamoxifen-mediated apoptosis in human mammary epithelial cells. Oncogene 23 (2004) 8743-8755
    • (2004) Oncogene , vol.23 , pp. 8743-8755
    • Bowie, M.L.1    Dietze, E.C.2    Delrow, J.3    Bean, G.R.4    Troch, M.M.5    Marjoram, R.J.6
  • 207
    • 0034194261 scopus 로고    scopus 로고
    • IFN-gamma and TNF regulate macrophage expression of the chemotactic S100 protein S100A8
    • Xu K., and Geczy C.L. IFN-gamma and TNF regulate macrophage expression of the chemotactic S100 protein S100A8. J. Immunol. 164 (2000) 4916-4923
    • (2000) J. Immunol. , vol.164 , pp. 4916-4923
    • Xu, K.1    Geczy, C.L.2
  • 208
    • 24944555022 scopus 로고    scopus 로고
    • Genomics-based prognosis and therapeutic prediction in breast cancer
    • Jeffrey S.S., Lonning P.E., and Hillner B.E. Genomics-based prognosis and therapeutic prediction in breast cancer. J. Natl. Compr. Canc. Netw. 3 (2005) 291-300
    • (2005) J. Natl. Compr. Canc. Netw. , vol.3 , pp. 291-300
    • Jeffrey, S.S.1    Lonning, P.E.2    Hillner, B.E.3
  • 210
    • 32944463609 scopus 로고    scopus 로고
    • Methods for gene expression profiling in clinical trials of adjuvant breast cancer therapy
    • Paik S. Methods for gene expression profiling in clinical trials of adjuvant breast cancer therapy. Clin. Cancer Res. 12 (2006) 1019S-1023S
    • (2006) Clin. Cancer Res. , vol.12
    • Paik, S.1
  • 211
    • 27644476924 scopus 로고    scopus 로고
    • Biological characteristics of the pure antiestrogen fulvestrant: overcoming endocrine resistance
    • Dowsett M., Nicholson R.I., and Pietras R.J. Biological characteristics of the pure antiestrogen fulvestrant: overcoming endocrine resistance. Breast Cancer Res. Treat. 93 Suppl. 1 (2005) S11-S18
    • (2005) Breast Cancer Res. Treat. , vol.93 SUPPL. 1
    • Dowsett, M.1    Nicholson, R.I.2    Pietras, R.J.3
  • 212
    • 32944466881 scopus 로고    scopus 로고
    • Clinical efforts to combine endocrine agents with targeted therapies against epidermal growth factor receptor/human epidermal growth factor receptor 2 and mammalian target of rapamycin in breast cancer
    • Johnston S.R. Clinical efforts to combine endocrine agents with targeted therapies against epidermal growth factor receptor/human epidermal growth factor receptor 2 and mammalian target of rapamycin in breast cancer. Clin. Cancer Res. 12 (2006) 1061S-1068S
    • (2006) Clin. Cancer Res. , vol.12
    • Johnston, S.R.1
  • 213
    • 7444232526 scopus 로고    scopus 로고
    • New targets for therapy in breast cancer: farnesyltransferase inhibitors
    • Head J., and Johnston S.R. New targets for therapy in breast cancer: farnesyltransferase inhibitors. Breast Cancer Res. 6 (2004) 262-268
    • (2004) Breast Cancer Res. , vol.6 , pp. 262-268
    • Head, J.1    Johnston, S.R.2
  • 214
    • 33748578327 scopus 로고    scopus 로고
    • Combination therapy with aromatase inhibitors: the next era of breast cancer treatment?
    • Leary A., and Dowsett M. Combination therapy with aromatase inhibitors: the next era of breast cancer treatment?. Br. J. Cancer 95 (2006) 661-666
    • (2006) Br. J. Cancer , vol.95 , pp. 661-666
    • Leary, A.1    Dowsett, M.2
  • 215
    • 23944439945 scopus 로고    scopus 로고
    • Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
    • Chan S., Scheulen M.E., Johnston S., Mross K., Cardoso F., Dittrich C., et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J. Clin. Oncol. 23 (2005) 5314-5322
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5314-5322
    • Chan, S.1    Scheulen, M.E.2    Johnston, S.3    Mross, K.4    Cardoso, F.5    Dittrich, C.6
  • 216
    • 33846543806 scopus 로고    scopus 로고
    • Clinical benefit of fulvestrant in postmenopausal women with advanced breast cancer and primary or acquired resistance to aromatase inhibitors: final results of phase II Swiss Group for Clinical Cancer Research Trial (SAKK 21/00)
    • Perey L., Paridaens R., Hawle H., Zaman K., Nole F., Wildiers H., et al. Clinical benefit of fulvestrant in postmenopausal women with advanced breast cancer and primary or acquired resistance to aromatase inhibitors: final results of phase II Swiss Group for Clinical Cancer Research Trial (SAKK 21/00). Ann. Oncol. 18 (2007) 64-69
    • (2007) Ann. Oncol. , vol.18 , pp. 64-69
    • Perey, L.1    Paridaens, R.2    Hawle, H.3    Zaman, K.4    Nole, F.5    Wildiers, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.