Activation of estrogen receptor α by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7

Molecular Cell

Volumn 6, Issue 1, 2000, Pages 127-137

  Chen, Dongsheng ^a   Riedl, Thilo ^b   Washbrook, Elinor ^a   Pace, Paul E ^a   Coombes, R Charles ^a   Egly, Jean Marc ^b   Ali, Simak ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; ESTROGEN RECEPTOR ALPHA; PHOSPHOTRANSFERASE; PROTEIN SUBUNIT; RECEPTOR SUBUNIT; SERINE; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CONTROLLED STUDY; HUMAN; LIGAND BINDING; MOLECULAR INTERACTION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION;

EID: 0033636597     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(05)00004-3     Document Type: Article

References (46)

1. MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH
2. Production and characterisation of monoclonal antibodies recognising defined regions of the human oestrogen receptor
3. Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region
4. Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor
5. Regulation of activity of the transcription factor GATA-1 by acetylation
6. Molecular basis of agonism and antagonism in the oestrogen receptor
7. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor
8. Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerization
9. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors
10. Molecular mechanism of nucleotide excision repair
11. Increasing the complexity of coactivation in nuclear receptor signaling
12. HIV-1 Tat: Coping with negative elongation factors
13. Purification and interaction properties of the human RNA polymerase B(II) general transcription factor BTF2
14. The coregulator exchange in transcriptional functions of nuclear receptors
15. Transcription activation by estrogen and progesterone receptors
16. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
17. GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8
18. The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors
19. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
20. Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase
21. Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor
22. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
23. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner
24. p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation
25. Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity
26. Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations
27. The nuclear receptor superfamily: The second decade
28. The nuclear receptor ligand-binding domain: Structure and function
29. Cyclin-dependent kinases: Engines, clocks, and microprocessors
30. Cyclin-dependent kinase 7: At the cross-roads of transcription, DNA repair and cell cycle control?
31. Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha
32. Regulatory targets in the RNA polymerase II holoenzyme
33. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
34. The RNA polymerase II general transcription factors: Past, present, and future
35. Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7
36. Nuclear RNA polymerases: Role of general initiation factors and cofactors in eukaryotic transcription
37. Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH
38. Regulation of CAK kinase activity by p53
39. Modulating nuclear receptor function: May the phos be with you
40. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
41. In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein
42. Reconstitution of the transcription factor TFIIH: Assignment of functions for the enzymatic subunits, XPB, XPD, and cdk7
43. Molecular mechanisms of action of steroid/thyroid receptor superfamily members
44. Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine
45. Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53
46. Regulation of CDK7 substrate specificity by MAT1 and TFIIH