Estrogen suppression of EGFR expression in breast cancer cells: A possible mechanism to modulate growth

Journal of Cellular Biochemistry

Volumn 81, Issue SUPPL. 36, 2001, Pages 232-246

  Powers, James F ^a,c   Misra, Suniti ^a   Schelling, Kimberly ^a   Varticovski, Lyuba ^b   Tischler, Arthur S ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST ELIZABETH'S MEDICAL CENTER   (United States)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

Anti estrogens; Apoptosis; Breast cancer cells; Cell proliferation; EGF; EGF receptor; Estrogen; Estrogen receptor; TGF

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; MESSENGER RNA; TRANSFORMING GROWTH FACTOR ALPHA; EPIDERMAL GROWTH FACTOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ARTICLE; BREAST CARCINOMA; CANCER CELL; CELL DEATH; CELL GROWTH; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE ASSOCIATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOGENESIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; BREAST TUMOR; CELL CULTURE; CELL DIVISION; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; NEOPLASM; PHOSPHORYLATION; SERODIAGNOSIS; WESTERN BLOTTING;

BLOTTING, WESTERN; BREAST NEOPLASMS; CELL DIVISION; EPIDERMAL GROWTH FACTOR; ESTROGEN RECEPTOR MODULATORS; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASMS, HORMONE-DEPENDENT; PHOSPHORYLATION; PRECIPITIN TESTS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ESTROGEN; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR CELLS, CULTURED;

EID: 0035036735     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.1142     Document Type: Article

References (57)

1. Expression of transforming growth factor-α and its messenger RNA in human breast cancer: Its regulation by estrogen and its possible functional significance
2. Epidermal growth factor receptor synthesis is stimulated by phorbol ester and epidermal growth factor
3. Simplification of the nuclear run-off transcription assay
4. Single step method of RNA isolation by acid guanidinium thiocyanate phenol-chloroform extraction
5. Chromatin structure of the EGFR gene suggests a role for intron 1 sequences in its regulation in breast cancer cells
6. Epidermal growth factor regulates the expression of its own receptor
7. The effect of constitutive expression of TGF-α on the growth of MCF-7 human breast cancer cells in vitro and in vivo
8. Epidermal growth factor receptor gene expression in estrogen positive and negative human breast cancer cell lines
9. Effect of sodium butyrate on estrogen receptor and epidermal growth factor receptor gene expression in human breast cancer cell lines
10. Over-expression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH-3T3 cells
11. Estrogen induced factors of breast cancer cells partially replace estrogen to promote tumor growth
12. Immunocytochemical localization of the progesterone receptors in breast cancer with anti-human receptor monoclonal antibodies
13. Anti-epidermal growth factor receptor antibodies inhibit the autocrine-stimulated growth of MDA-468 human breast cancer cells
14. Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen and progestin receptor levels
15. Prevalence of abberent expression of the epidermal growth factor receptor in human cancers
16. Contributory effects of denovo transcription and premature transcript termination in the regulation of human epidermal growth factor receptor proto-oncogene RNA synthesis
17. Estrogen control of progesterone receptor in human breast cancer: Role of estradiol and antiestrogens
18. A. Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element
19. Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene
20. Epidermal growth factor receptor gene promoter. Deletion analysis and identification of nuclear protein binding sites
21. Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
22. Molecular cloning and characterization of a human DNA binding factor that repress transcription
23. Epidermal growth factor receptor-negative tumors are predominantly confined to the subgroup of estradiol receptor-positive human primary breast cancer
24. Modulation of estrogen receptor and epidermal growth factor receptor mRNA by phorbol ester in MCF-7 breast cancer cells
25. A retinoic acid response element that overlaps an estrogen responsive element mediates multihormonal sensitivity in transcriptional activation of the lactoferrin gene
26. Estrogen regulation of epidermal growth factor receptor messenger ribonucleic acid
27. The effects of estrogens and antiestrogens on hormone responsive human breast cancer in long term tissue culture
28. COUP-TF acts as a competitive repressor for estrogen receptor-mediated activation of the mouse lactoferrin gene
29. Mutual transrepression of Fos and the glucocorticoid receptor: Involvement of a functional domain in Fos which is absent in FosB
30. Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines
31. Cloning of cDNA sequences of hormone regulated genes from the MCF-7 human breast cancer cell line
32. p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin
33. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
34. Emergence of MCF-7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: Evidence for a role of EGFR in breast cancer growth and progression
35. Evidence for involvement of transforming growth factor-α and epidermal growth factor receptor autocrine growth mechanism in primary human ovarian cancer
36. Regulation of epidermal growth factor receptor by estrogen
37. Epidermal growth factor receptor expression in breast cancer: Association with response to endocrine therapy
38. Epidermal growth factor receptor as a marker for poor prognosis in node negative breast cancer patients: Neu and tamoxifen failure
39. Epidermal growth factor-related peptides in the patogenesis of human breast cancer
40. The value of estrogen and progesterone receptors in the treatment of breast cancer
41. Nuclear receptor/AP-1 interaction
42. The type I growth factor receptors in human breast cancer
43. Inhibition of estrogen-induced breast cancer cell proliferation by reduction in autocrine transforming growth factor-α expression
44. Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor
45. Negative transcriptional regulation by nuclear receptors
46. Positive and negative effects of nuclear receptors on transcription by AP-1 of the human choline acetyltransferase proximal promoter
47. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
48. Post-transcriptional destabilization of estrogen receptor mRNA in MCF-7 cells by 12-O-tetradecanoylphorbol-13 acetate
49. Double immunohistochemical assay of receptors for estrogen (ER) and epidermal growth factor (EGFR)
50. Expression of estrogen receptors in estrogen receptor-negative human breast carcinoma cells: Modulation of epidermal growth factor-receptor and transforming growth factor-α gene expression
51. Strain dependent epithelial defects in mice lacking the EGF receptor
52. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-KB and C/EBPβ
53. Characterization of the metabolic turnover of epidermal growth factor receptor protein in A-431 cells
54. Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype
55. Ectopic expression of epidermal growth factor receptors induce hormone independence in ZR-75-1 human breast cancer cells
56. Transcriptional interference between cJun and glucocorticoid receptor: Mutual inhibition of DNA-binding due to direct protein-protein interaction
57. Bimodal regulation of epidermal growth factor receptor by estrogen in breast cancer cells